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1. 发明授权

US07297687B2 Method of treating infectious diseases with polysaccharide derivatives 失效
标题翻译：用多糖衍生物治疗感染性疾病的方法
公开(公告)号：US07297687B2
公开(公告)日：2007-11-20
申请号：US10500807
申请日：2003-01-10
申请人： Vera Haack , Thomas Heinze , Michaela Schmidtke , Ute Möllmann , Hans-Martin Dahse , Albert Härtl
发明人： Vera Haack , Thomas Heinze , Michaela Schmidtke , Ute Möllmann , Hans-Martin Dahse , Albert Härtl
IPC分类号： A61K31/718 , A61K31/715 , C08B31/00
CPC分类号： A61K31/717 , A61K31/715 , A61K31/716 , A61K31/718 , A61K31/719 , A61K31/721
摘要： The present invention relates to a method of treating infectious diseases, that involves: (a) providing an alpha-glycosidically linked starch polysaccharide derivative; and (b) inhibiting the growth of an infectious disease by administering a composition comprising the alpha-glycosidically linked starch polysaccharide derivative. The alpha-glycosidically linked starch polysaccharide derivative represented by the following general formula I, in which: the alpha-glycosidically linked starch polysaccharide derivative has a degree of quaternary ammonium group substitution of from 0.4 to 2.0; n is 2-4; R1 is selected from the group consisting of C1-4 alkyl, benzyl and benzyl substituted with a member selected from the group consisting of C1-3 alkyl, halogen, alcoxy, carbamoyl, alkoxycarbonyl, cyano, dialkylamino and hydrogen; R2 and R3 are each independently selected from the group consisting of C1-4 alkyl, benzyl and benzyl substituted with a member selected from the group consisting of C1-3 alkyl, halogen, alcoxy, carbamoyl, alkoxycarbonyl, cyano and dialkylamino; and X is an anion selected from the group consisting of halide, hydroxide, sulfate, hydrogen sulfate and carboxylate.
摘要翻译：本发明涉及一种治疗感染性疾病的方法，其涉及：（a）提供α-糖苷连接的淀粉多糖衍生物; 和（b）通过施用包含α-糖苷连接的淀粉多糖衍生物的组合物来抑制感染性疾病的生长。由以下通式I表示的α-糖苷连接的淀粉多糖衍生物，其中：α-糖苷连接的淀粉多糖衍生物的季铵基取代度为0.4〜2.0; n为2-4; R 1选自C 1-4烷基，苄基和被选自C 1-3烷基的成员取代的苄基，烷基，卤素，烷氧基，氨基甲酰基，烷氧基羰基，氰基，二烷基氨基和氢; R 2和R 3各自独立地选自C 1-4烷基，苄基和被选自以下的成员取代的苄基：由C 1-3烷基，卤素，烷氧基，氨基甲酰基，烷氧基羰基，氰基和二烷基氨基组成的组; X是选自卤化物，氢氧化物，硫酸盐，硫酸氢盐和羧酸盐的阴离子。

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