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1. 发明授权

US08639310B2 System and methods for locating and ablating arrhythomogenic tissues 有权
标题翻译：用于定位和消融假性组织的系统和方法
公开(公告)号：US08639310B2
公开(公告)日：2014-01-28
申请号：US13778900
申请日：2013-02-27
申请人： Peter C. Chen , Alan de la Rama , Cary K. Hata , Vivian Tran
发明人： Peter C. Chen , Alan de la Rama , Cary K. Hata , Vivian Tran
IPC分类号： A61B5/04 , A61B18/04 , A61B18/14
CPC分类号： A61B5/4836 , A61B5/042 , A61B5/0422 , A61B5/6853 , A61B5/6855 , A61B5/6857 , A61B17/2202 , A61B18/1492 , A61B2017/00044 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/22051 , A61N7/022
摘要： The disclosure relates to a variety of systems and methods for sensing electrical events about a selected annulus region of the heart and for treating tissue in the selected annulus region. Wherein the system includes a first catheter that has an expandable member, an ablation element, and a lumen configured to allow a second catheter therethrough. The second catheter includes a distal section in a ring shape and a plurality of electrodes coupled around the ring. Optionally a second lumen can be included through the first catheter that allows for contrast media to be delivered to the distal end of the system.
摘要翻译：本公开涉及用于感测关于心脏的所选环区的电事件并用于治疗所选择的环区中的组织的各种系统和方法。其中系统包括具有可扩张构件，消融元件和构造成允许第二导管穿过其中的内腔的第一导管。第二导管包括环形的远侧部分和围绕环耦合的多个电极。可选地，可以通过第一导管包括允许将造影剂输送到系统的远端的第二腔。

2. 发明申请

US20110288392A1 Kit for Non-Invasive Electrophysiology Procedures and Method of its Use 有权
标题翻译：非侵入性电生理学手册及其使用方法
公开(公告)号：US20110288392A1
公开(公告)日：2011-11-24
申请号：US12982715
申请日：2010-12-30
申请人： Alan de la Rama , Cary Hata , William Du , Yongxing Zhang , James V. Kauphusman , Troy T. Tegg
发明人： Alan de la Rama , Cary Hata , William Du , Yongxing Zhang , James V. Kauphusman , Troy T. Tegg
IPC分类号： A61B18/14 , A61B5/042
CPC分类号： A61M25/0068 , A61B5/04 , A61B18/1492 , A61B2018/00011 , A61B2018/00101 , A61B2018/00577 , A61B2018/00821 , A61B2018/00839 , A61B2090/065 , A61B2217/007 , A61B2218/002 , A61M25/0013 , A61M25/0054 , A61M25/0069 , A61M25/0074 , A61M25/008 , A61M25/0082 , A61M25/0133 , A61M2025/0081 , A61M2025/0681 , B23K26/38 , B23K26/40 , B23K2101/36 , B26D1/00 , B26D3/08
摘要： An electrophysiology catheter for use with a steerable introducer sheath includes a flexible catheter body having a proximal end and a distal end and at least one hollow elongate tip electrode disposed at the distal end of the catheter body. The hollow elongate tip electrode includes a sidewall having at least one elongate gap that provides flexibility allowing the tip electrode to bend relative to a longitudinal axis of the catheter body. The catheter body is an independent, non-steerable structure, and can be moved via movement of the steerable introducer through which it is introduced into a patient.
摘要翻译：用于可引导导管鞘的电生理学导管包括具有近端和远端的柔性导管主体和设置在导管主体远端的至少一个中空细长末端电极。中空细长末端电极包括具有至少一个细长间隙的侧壁，所述细长间隙提供柔性，使尖端电极相对于导管主体的纵向轴线弯曲。导管主体是独立的，不可操纵的结构，并且可以通过可引导引导器的移动而被移动，通过该引导器将其导入患者体内。

3. 发明申请

US20110257499A1 Dual-Deflecting Electrophysiology Catheter 有权
标题翻译：双偏转电生理导管
公开(公告)号：US20110257499A1
公开(公告)日：2011-10-20
申请号：US12760337
申请日：2010-04-14
申请人： Alan de la Rama , Phuong-Oanh Phung , Pianka Roy
发明人： Alan de la Rama , Phuong-Oanh Phung , Pianka Roy
IPC分类号： A61B5/04
CPC分类号： A61M25/0147 , A61B5/0422 , A61B5/6855 , A61B5/6856
摘要： An electrophysiology catheter includes a tubular body having a proximal region, a neck region, and a distal region predisposed into a loop and including electrodes. A first deflection wire extends through at least a portion of the proximal region of the catheter body and includes a first flattened section, while a second deflection wire extends through the neck region and at least a portion of the distal region and includes a second flattened section within the neck region. A first activation wire is joined to the flattened section of the first deflection wire, while a second activation wire is joined to the flattened section of the second deflection wire. Thus, forces acting on the first and second activation wires, such as forces imposed by a handle-based actuator, are respectively transmitted to the first and second deflection wires, thereby deflecting the proximal and neck regions, respectively.
摘要翻译：电生理导管包括具有近端区域，颈部区域和倾向于环路并包括电极的远端区域的管状体。第一偏转线延伸穿过导管主体的近端区域的至少一部分并且包括第一扁平部分，而第二偏转线延伸穿过颈区域和远端区域的至少一部分，并且包括第二平坦部分在颈部区域内。第一激活线接合到第一偏转线的平坦部分，而第二激活线接合到第二偏转线的平坦部分。因此，作用在第一和第二激活线上的力（例如由基于手柄的致动器施加的力）分别被传递到第一和第二偏转线，从而分别偏转近端和颈部区域。

4. 发明申请

US20090012517A1 MAGNETICALLY GUIDED CATHETER 有权
标题翻译： MAGNETICALLY指导导管
公开(公告)号：US20090012517A1
公开(公告)日：2009-01-08
申请号：US12167736
申请日：2008-07-03
申请人： Alan de la Rama , Kirk Kochin Wu , Yongxing Zhang
发明人： Alan de la Rama , Kirk Kochin Wu , Yongxing Zhang
IPC分类号： A61B18/18 , A61B19/00
CPC分类号： A61B18/1492 , A61B34/73 , A61B2018/00577 , A61B2218/002 , A61M25/0127
摘要： A catheter includes a flexible tubing having a proximal end and a distal end. The catheter also includes an electrode assembly attached to the distal end of the flexible tubing and having a first magnet therein. The electrode assembly further includes an electrically conductive tip electrode and an electrically nonconductive coupler which is connected between the tip electrode and the distal end of the flexible tubing. The coupler and the tip electrode are coupled by an interlocking connection. The catheter also includes a second magnet spaced from the electrode assembly along a longitudinal axis of the tubing. The first magnet and the second magnet are responsive to an external magnetic field to selectively position and guide the electrode assembly within a body of a patient.
摘要翻译：导管包括具有近端和远端的柔性管。导管还包括附接到柔性管的远端并且其中具有第一磁体的电极组件。电极组件还包括导电尖端电极和连接在尖端电极和柔性管的远端之间的非导电耦合器。耦合器和尖端电极通过互锁连接耦合。导管还包括沿着管道的纵向轴线与电极组件间隔开的第二磁体。第一磁体和第二磁体响应于外部磁场来选择性地将电极组件定位并引导到患者体内。

5. 发明申请

US20070038056A1 System and methods for locating and ablating arrhythomogenic tissues 审中-公开
标题翻译：用于定位和消融假性组织的系统和方法
公开(公告)号：US20070038056A1
公开(公告)日：2007-02-15
申请号：US11583263
申请日：2006-10-19
申请人： Carlo Pappone , Peter Chen , Alan de la Rama , Cary Hata , Vivian Tran , David Chi
发明人： Carlo Pappone , Peter Chen , Alan de la Rama , Cary Hata , Vivian Tran , David Chi
IPC分类号： A61B18/04 , A61B5/04
CPC分类号： A61B5/4836 , A61B5/042 , A61B5/0422 , A61B5/6853 , A61B5/6855 , A61B5/6857 , A61B17/2202 , A61B18/1492 , A61B2017/00044 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/22051 , A61N7/022
摘要： A catheter for sensing electrical events about a selected annulus region of the heart and for treating tissue in the selected annulus region has a handle assembly, a shaft having a proximal end coupled to the handle assembly, a first expandable member provided at the distal end of the shaft, and a second expandable member positioned adjacent to, but spaced apart from, the first expandable member. The second expandable member has an ablation element that emits energy to a radially surrounding area to ablate tissue.
摘要翻译：用于感测关于心脏的所选择的环形区域并且用于处理所选择的环形区域中的组织的电子事件的导管具有手柄组件，具有联接到手柄组件的近端的轴，设置在所述手柄组件的远端处的第一可扩展构件所述轴和第二可膨胀构件定位成与所述第一可膨胀构件相邻但间隔开。第二可膨胀构件具有消融元件，其向径向周围区域发射能量以烧蚀组织。

6. 发明授权

US07171275B2 High torque balloon catheter possessing multi-directional deflectability and methods thereof 失效
标题翻译：具有多方向偏转能力的高扭矩球囊导管及其方法
公开(公告)号：US07171275B2
公开(公告)日：2007-01-30
申请号：US10647695
申请日：2003-08-25
申请人： Cary Hata , Alan de la Rama , Weng-Kwen Raymond Chia
发明人： Cary Hata , Alan de la Rama , Weng-Kwen Raymond Chia
IPC分类号： A61N1/00
CPC分类号： A61N1/06
摘要： A flexible catheter shaft with a balloon on the distal section suitable for inserting into a body of a patient comprising a deflectable, high torque transmission assembly of a slit tubular element that has either a plurality of rows of slits with anchors or at least one continuously spiraling slit on said slit tubular element and has sufficient bending and torque properties ensuring that a substantial fraction of the bending, rotational and displacement forces provided along said flexible catheter shaft are translated to bending, rotational and displacement forces at a distal end of said flexible catheter shaft, facilitating the placement of the catheter distal section and using the balloon for blocking the vessel ostium and injecting contrast medium through an open distal tip.
摘要翻译：一种柔性导管轴，其在远端部分上具有适于插入患者体内的气囊的柔性导管轴，其包括切口管状元件的可偏转的高扭矩传递组件，所述可变形的高扭矩传递组件具有多排具有锚的狭缝或至少一个连续螺旋狭缝在所述狭缝管状元件上并且具有足够的弯曲和扭矩特性，确保沿所述柔性导管轴提供的弯曲，旋转和移位力的相当大的一部分平移到所述柔性导管轴的远端处的弯曲，旋转和移位力促进导管远端部分的放置，并且使用气囊来阻塞血管口并通过开口的远端注入造影剂。

7. 发明授权

US06611720B2 High torque catheter possessing multi-directional deflectability and methods thereof 有权
标题翻译：具有多方向偏转能力的高扭矩导管及其方法
公开(公告)号：US06611720B2
公开(公告)日：2003-08-26
申请号：US09878689
申请日：2001-06-11
申请人： Cary Hata , Alan de La Rama , Weng-Kwen Raymond Chia
发明人： Cary Hata , Alan de La Rama , Weng-Kwen Raymond Chia
IPC分类号： A61N100
CPC分类号： A61N1/06
摘要： A flexible catheter shaft suitable for inserting into a body of a patient comprising a deflectable, high torque transmission assembly of a slit tubular element that has either a plurality of rows of slits with anchors or at least one continuously spiraling slit on said slit tubular element and has sufficient bending and torque properties ensuring that a substantial fraction of the bending, rotational and displacement forces provided along said flexible catheter shaft are translated to bending, rotational and displacement forces at a distal end of said flexible catheter shaft.
摘要翻译：适于插入患者体内的柔性导管轴，包括可折叠的高扭矩传递组件，其具有狭缝管状元件，该狭缝管状元件具有多排带狭缝的狭缝或在所述狭缝管状元件上具有至少一个连续螺旋狭缝，具有足够的弯曲和扭矩特性，确保沿着所述柔性导管轴提供的弯曲，旋转和位移力的相当大的一部分平移到所述柔性导管轴的远端处的弯曲，旋转和移位力。

8. 发明授权

US06308090B1 Devices and methods for coronary sinus mapping 有权
标题翻译：用于冠状窦造影的装置和方法
公开(公告)号：US06308090B1
公开(公告)日：2001-10-23
申请号：US09332650
申请日：1999-06-14
申请人： Hosheng Tu , Alan de la Rama
发明人： Hosheng Tu , Alan de la Rama
IPC分类号： A61B504
CPC分类号： A61B5/0422 , A61B5/0464 , A61B5/6857 , A61B18/1815 , A61B2018/1475 , A61B2562/0209 , A61B2562/043 , A61N1/06 , A61N2001/0585
摘要： A catheter-based method for coronary sinus mapping, pacing, and ablation, wherein a distal tip portion having longitudinally stretchable/compressible capability is pre-shaped to snugly fit into the coronary sinus with resilience and trauma-free manner, so that the distal tip portion is positioned in the sinus; the distal tip portion is deflected to expose a plurality of electrodes; and RF energy is then applied to the coronary sinus tissue through the electrodes to cause pacing, mapping, and/or ablation.
摘要翻译：一种用于冠状静脉窦定位，起搏和消融的基于导管的方法，其中具有纵向可拉伸/可压缩能力的远侧末端部分被预成形，以适应性和无创伤的方式紧密地配合到冠状窦中，使得远端尖端部分位于窦内; 远侧末端部分被偏转以暴露多个电极; 然后通过电极将RF能量施加到冠状窦组织，以引起起搏，作图和/或消融。

9. 发明授权

US6001095A Catheter system having closely spaced distal bipolar electrodes 失效
标题翻译：具有紧密间隔的远端双极电极的导管系统
公开(公告)号：US6001095A
公开(公告)日：1999-12-14
申请号：US66274
申请日：1998-04-24
申请人： Alan de la Rama , Weng-Kwen Raymond Chia , Hosheng Tu
发明人： Alan de la Rama , Weng-Kwen Raymond Chia , Hosheng Tu
IPC分类号： A61B18/14 , A61N1/05 , A61N1/06 , A61B5/0402 , A61B17/39
CPC分类号： A61N1/06 , A61B18/1492 , A61N1/056 , A61B2017/003 , A61B2017/00473 , A61B2018/00351 , A61B2018/00577 , A61B2018/00791 , A61B2018/00839
摘要： A catheter system suitable for electrophysiology mapping and radiofrequency ablation of cardiac tissue comprises a catheter shaft having a distal end, a proximal handle, and at least a lumen extending therebetween, wherein a distal section of the shaft is either a fixed curve type or a deflectable type; and safety means being provided to maintain the integrity of the catheter by holding the long tip electrode in place, wherein the safety means is a long tip electrode with an extended flexible stem having at least one open groove or slot on the stem.
摘要翻译：适用于心脏组织的电生理学测绘和射频消融的导管系统包括导管轴，其具有远端，近端手柄和至少延伸在其间的腔，其中所述轴的远端部分是固定曲线型或可偏转的类型; 并且提供安全装置以通过将长尖端电极保持在适当位置来保持导管的完整性，其中安全装置是具有延伸柔性杆的长尖端电极，该杆在杆上具有至少一个开放的凹槽或狭槽。

10. 发明授权

US5971968A Catheter probe having contrast media delivery means 有权
标题翻译：导管探针具有造影剂输送装置
公开(公告)号：US5971968A
公开(公告)日：1999-10-26
申请号：US288744
申请日：1999-04-08
申请人： Hosheng Tu , Cary Hata , Alan de la Rama
发明人： Hosheng Tu , Cary Hata , Alan de la Rama
IPC分类号： A61M25/00 , A61M5/00 , A61M29/00 , A61M37/00
CPC分类号： A61M25/007
摘要： A catheter probe and methods for contrast media delivering comprising localized contrast media irrigation means for providing contrast media to the distal tip section, wherein the contrast media irrigation means is externally connected to a contrast media supply source; and shaft opening means for venting the contrast media out of the shaft distal end at an angle in relation to an axial reference line for optimal x-ray imaging, wherein the shaft opening means is connected to and in communication with a conduit of the contrast media irrigation means, and wherein the shaft opening means comprises at least one opening at an angle in relation to an axial reference line.
摘要翻译：导管探针和用于造影剂输送的方法，包括用于向远侧末端部分提供造影剂的局部造影剂冲洗装置，其中造影剂冲洗装置外部连接到造影剂供应源; 以及轴打开装置，用于将造影剂相对于用于最佳x射线成像的轴向参考线以一定角度排出所述轴远端，其中所述轴打开装置连接到造影剂的导管并与其连通冲洗装置，并且其中所述轴打开装置包括相对于轴向参考线成一定角度的至少一个开口。

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