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1. 发明申请

US20160029965A1 ARTIFACT AS A FEATURE IN NEURO DIAGNOSTICS 审中-公开
标题翻译：作为神经病学诊断的特征
公开(公告)号：US20160029965A1
公开(公告)日：2016-02-04
申请号：US14777012
申请日：2014-03-12
申请人： Adam J. SIMON , Cerora, Inc.
发明人： Adam J. SIMON
IPC分类号： A61B5/00 , A61B5/16 , A61B5/0476
CPC分类号： A61B5/7203 , A61B5/0476 , A61B5/0484 , A61B5/11 , A61B5/1103 , A61B5/4088 , A61B5/6897 , A61B5/7207 , A61B5/7275 , A61B5/7289 , A61B2562/0204
摘要： A multi-modal physiological assessment device and method enables the simultaneous recording and then subsequent analysis of multiple data streams of biological signal measurements to assess the health and function of the brain. Means and methods are provided to identify and leverage artifact samples within ID and 2D bio signal data streams to help create more accurate predictors and classifiers of brain health states and conditions. One sensor's data is used to gate the relevant portion of another bio sensor's data in order to reduce the noise and increase the signal-to-noise ratio. This is a form of phase locking for multimodal data streams for brain health assessment.
摘要翻译：多模式生理评估装置和方法能够同时记录并随后分析生物信号测量的多个数据流，以评估大脑的健康和功能。提供了方法和方法来识别和利用ID和2D生物信号数据流中的伪像样本，以帮助创建更准确的脑健康状态和状况的预测因子和分类器。一个传感器的数据用于选通另一个生物传感器数据的相关部分，以便降低噪声并提高信噪比。这是用于大脑健康评估的多模态数据流的锁相形式。

2. 发明申请

US20160022167A1 SYSTEM AND SIGNATURES FOR THE MULTI-MODAL PHYSIOLOGICAL STIMULATION AND ASSESSMENT OF BRAIN HEALTH 审中-公开
标题翻译：多模态生理刺激和脑健康评估的系统和标志
公开(公告)号：US20160022167A1
公开(公告)日：2016-01-28
申请号：US14773878
申请日：2014-03-14
申请人： Adam J. SIMON
发明人： Adam J. SIMON
IPC分类号： A61B5/0484 , A61B5/024 , A61B5/053 , A61B5/16 , A61B5/00 , A61B5/0478 , A61B5/145
CPC分类号： A61B5/04842 , A61B5/024 , A61B5/02405 , A61B5/0478 , A61B5/04845 , A61B5/04847 , A61B5/0533 , A61B5/1118 , A61B5/14542 , A61B5/16 , A61B5/163 , A61B5/4064 , A61B5/4088 , A61B5/6803
摘要： A system and diagnostic signatures which are derived from the data collected in the system captures multiple streams of biological sensor data for assessing brain health and functionality of a user. The system includes a plurality of biological sensors adapted to collect biological sensor data from the user as well as the ability to stimulate the brain in a variety of sensory, cognitive, physical, and chemical challenges. Several of the biological sensors are accommodated in an electronics module mounted on the user's head.
摘要翻译：从系统中收集的数据导出的系统和诊断签名捕获多个生物传感器数据流，以评估用户的脑健康和功能。该系统包括适于从用户收集生物传感器数据的多个生物传感器以及在各种感官，认知，物理和化学挑战中刺激大脑的能力。几个生物传感器被容纳在安装在用户头部上的电子模块中。

3. 发明申请

US20170112427A1 MULTIMODAL HEALTH ASSESSMENT WITH NEURO-OPTHALMOLOGICAL SACCADE TESTS 审中-公开
公开(公告)号：US20170112427A1
公开(公告)日：2017-04-27
申请号：US15315092
申请日：2015-05-29
申请人： Adam J. SIMON , CERORA, INC.
发明人： Adam J. SIMON , David M. DEVILBISS
IPC分类号： A61B5/00 , A61B5/11 , A61B5/0496 , A61B3/02 , A61B5/0484
CPC分类号： A61B5/4064 , A61B3/02 , A61B5/04842 , A61B5/0496 , A61B5/1103 , A61B5/1128
摘要： A system and method for assessing brain health includes presenting a saccade test to a subject and capturing biological sensor data of the subject in response to the saccade test using a plurality of biological sensors. Saccade cards are employed to measure the brain health of a subject through collection of eye tracking data, for example. Saccade cards using a variety of design elements besides numbers are used for collection of the eye tracking data and other biological data. The captured biological data is used to create a multi-variate signature of the brain health condition of the subject.

4. 发明申请

US20150038869A1 SYSTEMS AND METHODS FOR THE PHYSIOLOGICAL ASSESSMENT OF BRAIN HEALTH AND THE REMOTE QUALITY CONTROL OF EEG SYSTEMS 审中-公开
标题翻译：脑保健生理评估系统与方法及脑电系统远程质量控制
公开(公告)号：US20150038869A1
公开(公告)日：2015-02-05
申请号：US14233292
申请日：2012-07-13
申请人： Adam J. Simon , David M. Devilbiss
发明人： Adam J. Simon , David M. Devilbiss
IPC分类号： A61B5/0484 , A61B5/00 , G01D18/00 , A61B5/048
CPC分类号： A61B5/0484 , A61B5/0006 , A61B5/048 , A61B5/4088 , A61B5/7221 , A61B2560/0223 , G01D18/002
摘要： A system for calibrating and/or verifying system performance of a remote portable EEG system having at least one EEG sensor. Embodiments of the invention can provide various reference signals to calibrate and quality control the remote performance of the data acquisition EEG system. In addition a calibration cable connects a reference signal source to the EEG sensors to enable remote calibration and quality control assessment. Further, a diagnostic biomarker is included to assess the state or function of a subject's brain and enables the classification, prognosis, diagnosis, monitoring of treatment, or response to therapy applied to the brain by measuring any one of a list of candidate features extracted from a given cognitive or sensory task, and measuring changes in the EEG feature and task combination over time, among multiple states, or compared to a normative database.
摘要翻译：一种用于校准和/或验证具有至少一个EEG传感器的远程便携式EEG系统的系统性能的系统。本发明的实施例可以提供各种参考信号来校准和质量控制数据采集EEG系统的远程性能。此外，校准电缆将参考信号源连接到EEG传感器，以实现远程校准和质量控制评估。此外，包括诊断性生物标志物以评估受试者的大脑的状态或功能，并且通过测量从大脑中提取的候选特征的列表中的任一个来进行分类，预后，诊断，治疗监测或对大脑应用的反应给定的认知或感官任务，并且在多个状态之间测量EEG特征和任务组合的变化，或与规范数据库进行比较。

5. 发明申请

US20170032098A1 STOCHASTIC OSCILLATOR ANALYSIS IN NEURO DIAGNOSITCS 审中-公开
标题翻译：神经元诊断中的STOCHASTIC振荡器分析
公开(公告)号：US20170032098A1
公开(公告)日：2017-02-02
申请号：US15302535
申请日：2015-04-07
申请人： Parham GHORBANIAN , Hashem ASHRAFIUON , Adam J. SIMON
发明人： Parham GHORBANIAN , Hashem ASHRAFIUON , Adam J. SIMON
IPC分类号： G06F19/00 , A61B5/0476 , A61B5/00
CPC分类号： A61B5/0476 , A61B5/0484 , A61B5/4088 , A61B5/7264 , A61B5/7275 , A61B5/7278 , A61B5/7282 , G16H50/50
摘要： A system and method for modeling bio-signals in the form of non-linear stochastic oscillators by extracting time series data from a subject into a series of summary fit parameters and comparing the unknown fit parameters to a set of normative fit parameters to determine whether the subject should be included in a group or not. The method includes data collection, feature extraction and then comparison of fit parameters from a non-linear stochastic oscillator model to a normative standard to make the in or out determination for a particular group. The system includes a processor programmed to perform the steps of the method.
摘要翻译：一种用非线性随机振荡器形式对生物信号进行建模的系统和方法，其通过从受试者提取时间序列数据为一系列概要拟合参数，并将未知拟合参数与一组规范拟合参数进行比较，以确定是否主题应该包括在一个群组中。该方法包括从非线性随机振荡器模型到规范标准的数据采集，特征提取，然后比较拟合参数，以对特定组进行进出确定。该系统包括被编程为执行该方法的步骤的处理器。

6. 发明申请

US20160029946A1 WAVELET ANALYSIS IN NEURO DIAGNOSTICS 审中-公开
标题翻译：神经诊断中的波形分析
公开(公告)号：US20160029946A1
公开(公告)日：2016-02-04
申请号：US14777030
申请日：2014-03-14
申请人： Adam J. SIMON , Hashem ASHRAFIUON , Parham GHORBANIAN
发明人： Adam J. SIMON , Hashem ASHRAFIUON , Parham GHORBANIAN
IPC分类号： A61B5/00 , A61B5/04 , A61B5/0476
CPC分类号： A61B5/4088 , A61B5/04012 , A61B5/0476 , A61B5/048 , A61B5/7203 , A61B5/726
摘要： A method of extracting brain frequency sub bands corresponding to a medical condition such as Alzheimer's Disease from EEG time series data of a patient includes the steps of applying wavelet transforms to the EEG time series data to generate a continuous wavelet transformation time series at each wavelet scale, calculating Wavelet Entropy (WE) and Sample Entropy (SE) directly from the Continuous Wavelet Transformation time series at each wavelet scale, calculating arithmetic or geometric means and accumulations across scale ranges of interest; and selecting data from major brain frequency sub-bands as candidate sets of extraction features for analysis as a diagnostic signature for the medical condition. Diagnostic signatures for Alzheimer's disease are found when values of WE or SE are in certain ranges when EEG data is collected and analyzed in connection with certain analytical tasks such as an Eyes Open task.
摘要翻译：从患者的EEG时间序列数据中提取对应于诸如阿尔茨海默病等医学状况的脑频率子带的方法包括以下步骤：将小波变换应用于EEG时间序列数据，以在每个小波尺度产生连续的小波变换时间序列，从每个小波尺度的连续小波变换时间序列直接计算小波熵（WE）和采样熵（SE），计算各种尺度范围内的算术或几何平均值和积分; 并且从主要脑频率子带选择数据作为用于分析的提取特征的候选集合作为医疗状况的诊断签名。当EEG数据收集和分析与某些分析任务如眼睛打开任务相关联时，可以发现阿尔茨海默病的诊断特征，当WE或SE的值在一定范围内。

7. 发明申请

US20160015289A1 FORM FACTORS FOR THE MULTI-MODAL PHYSIOLOGICAL ASSESSMENT OF BRAIN HEALTH 审中-公开
标题翻译：脑组织多元生理生化评估的形式因素
公开(公告)号：US20160015289A1
公开(公告)日：2016-01-21
申请号：US14772996
申请日：2014-03-06
申请人： Adam J. SIMON , Gary S. KATH , Cerora, Inc.
发明人： Adam J. SIMON , Gary S. KATH
IPC分类号： A61B5/0484 , A61B5/0478 , A61B5/16 , A61B7/04 , A61B5/026 , A61B3/14 , A61B5/00 , A61B5/04 , A61B5/1455 , A61B5/0205 , A61B3/113
CPC分类号： A61B5/04842 , A61B3/113 , A61B3/145 , A61B5/0002 , A61B5/0006 , A61B5/0057 , A61B5/01 , A61B5/02055 , A61B5/02416 , A61B5/026 , A61B5/04012 , A61B5/0478 , A61B5/0484 , A61B5/04845 , A61B5/04847 , A61B5/0533 , A61B5/11 , A61B5/1103 , A61B5/1124 , A61B5/14551 , A61B5/14552 , A61B5/162 , A61B5/4041 , A61B5/4094 , A61B5/6803 , A61B5/681 , A61B5/6826 , A61B5/6898 , A61B5/7203 , A61B5/7246 , A61B5/7264 , A61B5/7275 , A61B5/744 , A61B7/04 , A61B2560/0443 , A61B2560/0475 , A61B2562/0204 , A61B2562/0219 , G16H15/00 , G16H20/70 , G16H40/63 , G16H40/67 , G16H50/20
摘要： A multi-modal physiological assessment device and method enables the simultaneous recording and then subsequent analysis of multiple data streams of biological signal measurements to assess the health and function of the brain. The multi-modal assessment system includes at least one channel of EEG brainwave data in combination with cognitive information that provide a two-dimensional data stream of (x(t), y(t)) of cognitive information; voice recordings; motion, position, and stability data; galvanic skin conductance; temperature of the subject; pulse-oximetry data, cerebral blood perfusion data, vaso-motor reactivity data, and the like. The collected data is processed to construct candidate features extracted from multiple biological sensor data streams and correlated with multi-modal signatures to identify data indicative of brain health, disease and injury.
摘要翻译：多模式生理评估装置和方法能够同时记录并随后分析生物信号测量的多个数据流，以评估大脑的健康和功能。多模式评估系统包括至少一个EEG脑波数据通道与认知信息的组合，提供认知信息的（x（t），y（t））的二维数据流; 录音; 运动，位置和稳定性数据; 电流皮肤电导; 受试者的温度; 脉搏血氧饱和度数据，脑血液灌注数据，血管运动反应性数据等。处理收集的数据以构建从多个生物传感器数据流中提取的候选特征，并与多模式签名相关联以识别指示脑健康，疾病和损伤的数据。

8. 发明授权

US06928318B2 System and method for assessing the performance of a pharmaceutical agent delivery system 失效
标题翻译：用于评估药剂递送系统性能的系统和方法
公开(公告)号：US06928318B2
公开(公告)日：2005-08-09
申请号：US09862850
申请日：2001-05-22
申请人： Adam J. Simon
发明人： Adam J. Simon
IPC分类号： A61N1/30 , A61K9/00 , A61K49/00 , A61N1/32 , A61N1/36
CPC分类号： A61N1/325 , A61K49/0002 , A61N1/306
摘要： A system and method for assessing the performance of a system for delivering a pharmaceutical agent to a portion of a body. A pair of electrodes are applied to the portion of the body. A pharmaceutical agent is infused into the portion of the body and the electrodes are energized by a signal generator, electrically stimulating the portion of the body. The voltage and current delivered to the portion of the body are measured using a data acquisition system thereby generating electrical parameter data. An immune response, gene expression level or other biological response to the pharmaceutical agent is measured and the electrical test data is correlated with the biological response to assess the performance of the system.
摘要翻译：用于评估用于将药剂递送到身体的一部分的系统的性能的系统和方法。一对电极被施加到身体的部分。药剂注入身体部位，电极由信号发生器激励，电刺激身体的一部分。使用数据采集系统测量输送到身体部分的电压和电流，从而产生电参数数据。测量对药剂的免疫应答，基因表达水平或其他生物反应，并将电测试数据与生物反应相关联以评估系统的性能。

9. 发明申请

US20160022206A1 MULTI-MODAL PHARMACO-DIAGNOSTIC ASSESSMENT OF BRAIN HEALTH 审中-公开
标题翻译：多元模型药物诊断脑损伤诊断
公开(公告)号：US20160022206A1
公开(公告)日：2016-01-28
申请号：US14773872
申请日：2014-03-14
申请人： Adam J. SIMON , Stephen J. MARTINO
发明人： Adam J. SIMON , Stephen J. MARTINO
IPC分类号： A61B5/00 , A61B19/00
CPC分类号： A61B5/4848 , A61B5/0476 , A61B5/055 , A61B5/224 , A61B5/4064 , A61B5/4082 , A61B5/4088 , A61B5/4094 , A61B5/4824 , A61B5/483 , A61B5/4833 , A61B6/037 , A61B6/481 , A61B6/486 , A61B6/501 , A61B6/5235 , A61B6/5247 , A61B90/37 , A61B2503/10 , A61B2503/22 , A61B2576/026
摘要： A single diagnostic dose of a chemical agent that can bind with molecular specificity or provide a well characterized molecular effect on a mammalian host (including humans) is provided to a patient between brain scans. The method typically comprises at least one pre-dose scan of the subject followed by a waiting period then a second post-dose diagnostic scan. The diagnostic scans can be conventional in nature or of a multi-modal variety. A comparison, in the form of a difference or ratio, between data or extracted features before versus after the diagnostic dose indicates with molecular specificity the tone in the brain of that subject. The resulting data may be used to assess instances of medical fraud and can be used in back to work decisions for brain and soft tissue injuries for which the determinations have traditionally been somewhat subjective in nature.
摘要翻译：在大脑扫描之间向患者提供可以分子特异性结合或提供对哺乳动物宿主（包括人类）的良好表征的分子作用的化学试剂的单一诊断剂量。该方法通常包括对受试者的至少一次剂量前扫描，之后是等待时间，然后进行第二次剂量后诊断扫描。诊断扫描本质上可以是常规的或多模态的。在差异或比例的形式之间，在诊断剂量之前和之后的数据或提取特征之间的比较以分子特异性表示该受试者的脑中的音调。所得到的数据可用于评估医疗欺诈的实例，并且可以用于脑和软组织损伤的返回工作决定，其中测定在传统上本质上具有主观性。

10. 发明授权

US07432414B2 Transgenic mouse having an amyloid precursor protein with a modified beta secretase cleavage site 失效
标题翻译：转基因小鼠具有具有修饰的β分泌酶切割位点的淀粉样蛋白前体蛋白
公开(公告)号：US07432414B2
公开(公告)日：2008-10-07
申请号：US10558656
申请日：2004-05-28
申请人： Richard Z. Chen , Adam J. Simon , Thomas F. Vogt
发明人： Richard Z. Chen , Adam J. Simon , Thomas F. Vogt
IPC分类号： A01K67/027 , G01N33/00
CPC分类号： C07K14/4711 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2227/105 , A01K2267/0312 , C07K16/18 , C12N15/8509 , C12N2800/30
摘要： The present invention provides transgenic animals having an amyloid precursor protein wherein the amino acids flanking the &bgr; secretase cleavage site are NF and EV. The invention also provides tissues and cell lines derived from such animals. The invention further provides methods of screening candidate compounds to determine whether the compounds can alter the rate of cleavage of amyloid precursor protein by &bgr; secretase.
摘要翻译：本发明提供具有淀粉样前体蛋白质的转基因动物，其中β分泌酶切割位点侧翼的氨基酸为NF和EV。本发明还提供了衍生自这些动物的组织和细胞系。本发明进一步提供筛选候选化合物以确定化合物是否可以通过β分泌酶改变淀粉样蛋白前体蛋白的切割速率的方法。

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