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1. 发明授权

US09448195B2 Electrophysiological recording system and methods of using same 有权
标题翻译：电生理记录系统及其使用方法
公开(公告)号：US09448195B2
公开(公告)日：2016-09-20
申请号：US13810402
申请日：2011-07-15
申请人： Alonso P. Moreno , Gary S. Goldberg , Abhijit Mondal , Ian Harvey , Brian Baker
发明人： Alonso P. Moreno , Gary S. Goldberg , Abhijit Mondal , Ian Harvey , Brian Baker
IPC分类号： C12M3/00 , C12M1/00 , G01N27/00 , C12M1/12 , C12M1/34
CPC分类号： C12N5/0068 , C12M25/02 , C12M41/46 , C12N2535/00 , C12N2537/00 , G01N27/00
摘要： Electrophysiological recording systems for analysis of cultured cells include an recording device and a housing for supporting the electrophysiological recording device. The device has a porous membrane with top and bottom surfaces and a plurality of pores extending between the top and bottom surfaces. The porous membrane defines a first cell culture region disposed on the top surface and an opposed second cell culture region disposed on the bottom surface. The electrophysiological recording device has a plurality of electrodes positioned on the porous membrane in between a first insulation layer and a second insulation layer. The plurality of electrodes extend to the first cell culture region of the porous membrane. Recording ends of the electrodes measure electrical properties of cells cultured within the first and second cell culture regions, while the contact ends of the electrodes are positioned in electrical communication with data acquisition equipment.
摘要翻译：用于分析培养细胞的电生理记录系统包括记录装置和用于支持电生理记录装置的壳体。该装置具有多孔膜，其具有顶表面和底表面以及在顶表面和底表面之间延伸的多个孔。多孔膜限定设置在顶表面上的第一细胞培养区和设置在底表面上的相对的第二细胞培养区。电生理记录装置具有位于第一绝缘层和第二绝缘层之间的多孔膜上的多个电极。多个电极延伸到多孔膜的第一细胞培养区。记录电极的末端测量在第一和第二细胞培养区内培养的细胞的电学性质，而电极的接触末端位置与数据采集设备电连通。

2. 发明申请

US20130196368A1 Electrophysiological Recording System and Methods of Using Same 有权
标题翻译：电生理记录系统及其使用方法
公开(公告)号：US20130196368A1
公开(公告)日：2013-08-01
申请号：US13810402
申请日：2011-07-15
申请人： Alonso P. Moreno , Gary S. Goldberg , Abhijit Mondal , Ian Harvey , Brian Baker
发明人： Alonso P. Moreno , Gary S. Goldberg , Abhijit Mondal , Ian Harvey , Brian Baker
IPC分类号： G01N27/00
CPC分类号： C12N5/0068 , C12M25/02 , C12M41/46 , C12N2535/00 , C12N2537/00 , G01N27/00
摘要： Electrophysiological recording systems for analysis of cultured cells include an recording device and a housing for supporting the electrophysiological recording device. The device has a porous membrane with top and bottom surfaces and a plurality of pores extending between the top and bottom surfaces. The porous membrane defines a first cell culture region disposed on the top surface and an opposed second cell culture region disposed on the bottom surface. The electrophysiological recording device has a plurality of electrodes positioned on the porous membrane in between a first insulation layer and a second insulation layer. The plurality of electrodes extend to the first cell culture region of the porous membrane. Recording ends of the electrodes measure electrical properties of cells cultured within the first and second cell culture regions, while the contact ends of the electrodes are positioned in electrical communication with data acquisition equipment.
摘要翻译：用于分析培养细胞的电生理记录系统包括记录装置和用于支持电生理记录装置的壳体。该装置具有多孔膜，其具有顶表面和底表面以及在顶表面和底表面之间延伸的多个孔。多孔膜限定设置在顶表面上的第一细胞培养区和设置在底表面上的相对的第二细胞培养区。电生理记录装置具有位于第一绝缘层和第二绝缘层之间的多孔膜上的多个电极。多个电极延伸到多孔膜的第一细胞培养区。记录电极的末端测量在第一和第二细胞培养区内培养的细胞的电学性质，而电极的接触末端位置与数据采集设备电连通。

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