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1. 再颁专利

USRE44711E1 Optoelectronic tweezers for microparticle and cell manipulation 有权
标题翻译：用于微粒和细胞操纵的光电镊子
公开(公告)号：USRE44711E1
公开(公告)日：2014-01-21
申请号：US13287093
申请日：2011-11-01
申请人： Ming Chiang Wu , Pei-Yu Chiou , Aaron T. Ohta
发明人： Ming Chiang Wu , Pei-Yu Chiou , Aaron T. Ohta
IPC分类号： G01N21/86 , G01V8/00
CPC分类号： B03C5/026 , B01L3/502761 , B01L2400/0454 , G01N2035/1046
摘要： An optical image-driven light induced dielectrophoresis (DEP) apparatus and method are described which provide for the manipulation of particles or cells with a diameter on the order of 100 μm or less. The apparatus is referred to as optoelectric tweezers (OET) and provides a number of advantages over conventional optical tweezers, in particular the ability to perform operations in parallel and over a large area without damage to living cells. The OET device generally comprises a planar liquid-filled structure having one or more portions which are photoconductive to convert incoming light to a change in the electric field pattern. The light patterns are dynamically generated to provide a number of manipulation structures that can manipulate single particles and cells or group of particles/cells. The OET preferably includes a microscopic imaging means to provide feedback for the optical manipulation, such as detecting position and characteristics wherein the light patterns are modulated accordingly.
摘要翻译：描述了一种光学图像驱动的光诱导介电电泳（DEP）装置和方法，其提供对具有大约100μm或更小的直径的颗粒或细胞的操纵。该设备被称为光电镊子（OET），并且提供了许多优于常规光学镊子的优点，特别是并行地和大面积地进行操作而不损坏活细胞的能力。 OET装置通常包括具有一个或多个光电导体部分的平面液体填充结构，以将入射光转换成电场图案的变化。光图案被动态地产生以提供可以操纵单个颗粒和细胞或一组颗粒/细胞的多个操纵结构。 OET优选地包括用于为光学操作提供反馈的微观成像装置，例如检测位置和特性，其中相应地调制光图案。

2. 发明授权

US07612355B2 Optoelectronic tweezers for microparticle and cell manipulation 有权
标题翻译：用于微粒和细胞操作的光电镊子
公开(公告)号：US07612355B2
公开(公告)日：2009-11-03
申请号：US11105304
申请日：2005-04-12
申请人： Ming Chiang Wu , Pei Yu Chiou , Aaron T. Ohta
发明人： Ming Chiang Wu , Pei Yu Chiou , Aaron T. Ohta
IPC分类号： G01N21/86 , G01V8/00
CPC分类号： B03C5/026 , B01L3/502761 , B01L2400/0454 , G01N2035/1046
摘要： An optical image-driven light induced dielectrophoresis (DEP) apparatus and method are described which provide for the manipulation of particles or cells with a diameter on the order of 100 μm or less. The apparatus is referred to as optoelectric tweezers (OET) and provides a number of advantages over conventional optical tweezers, in particular the ability to perform operations in parallel and over a large area without damage to living cells. The OET device generally comprises a planar liquid-filled structure having one or more portions which are photoconductive to convert incoming light to a change in the electric field pattern. The light patterns are dynamically generated to provide a number of manipulation structures that can manipulate single particles and cells or groups of particles/cells. The OET preferably includes a microscopic imaging means to provide feedback for the optical manipulation, such as detecting position and characteristics wherein the light patterns are modulated accordingly.
摘要翻译：描述了一种光学图像驱动的光诱导介电电泳（DEP）装置和方法，其提供对具有大约100μm或更小的直径的颗粒或细胞的操纵。该设备被称为光电镊子（OET），并且提供了许多优于常规光学镊子的优点，特别是并行地和大面积地进行操作而不损坏活细胞的能力。 OET装置通常包括具有一个或多个光电导体部分的平面液体填充结构，以将入射光转换成电场图案的变化。动态地产生光图案以提供可操纵单个颗粒和细胞或颗粒/细胞组的多个操作结构。 OET优选地包括用于为光学操作提供反馈的微观成像装置，例如检测位置和特性，其中相应地调制光图案。

3. 发明申请

US20090170186A1 OPTOELECTRONIC TWEEZERS FOR MICROPARTICLE AND CELL MANIPULATION 有权
标题翻译：用于微波和细胞操作的光电二极管
公开(公告)号：US20090170186A1
公开(公告)日：2009-07-02
申请号：US11105304
申请日：2005-04-12
申请人： Ming Chiang Wu , Pei Yu Chiou , Aaron T. Ohta
发明人： Ming Chiang Wu , Pei Yu Chiou , Aaron T. Ohta
IPC分类号： C12M1/36 , B01J19/08
CPC分类号： B03C5/026 , B01L3/502761 , B01L2400/0454 , G01N2035/1046
摘要： An optical image-driven light induced dielectrophoresis (DEP) apparatus and method are described which provide for the manipulation of particles or cells with a diameter on the order of 100 μm or less. The apparatus is referred to as optoelectric tweezers (OET) and provides a number of advantages over conventional optical tweezers, in particular the ability to perform operations in parallel and over a large area without damage to living cells. The OET device generally comprises a planar liquid-filled structure having one or more portions which are photoconductive to convert incoming light to a change in the electric field pattern. The light patterns are dynamically generated to provide a number of manipulation structures that can manipulate single particles and cells or groups of particles/cells. The OET preferably includes a microscopic imaging means to provide feedback for the optical manipulation, such as detecting position and characteristics wherein the light patterns are modulated accordingly.
摘要翻译：描述了一种光学图像驱动的光诱导介电电泳（DEP）装置和方法，其提供对具有大约100μm或更小的直径的颗粒或细胞的操纵。该设备被称为光电镊子（OET），并且提供了许多优于常规光学镊子的优点，特别是并行地和大面积地进行操作而不损坏活细胞的能力。 OET装置通常包括具有一个或多个光电导体部分的平面液体填充结构，以将入射光转换成电场图案的变化。动态地产生光图案以提供可操纵单个颗粒和细胞或颗粒/细胞组的多个操作结构。 OET优选地包括用于为光学操作提供反馈的微观成像装置，例如检测位置和特性，其中相应地调制光图案。

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