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1. 发明授权

US09333300B2 Needle-less injector and method of fluid delivery 有权
公开(公告)号：US09333300B2
公开(公告)日：2016-05-10
申请号：US14019202
申请日：2013-09-05
申请人： PharmaJet, Inc.
发明人： John Bingham , Robert Steinway
IPC分类号： A61M5/30 , A61M5/00 , A61M5/42 , A61M5/20
CPC分类号： A61M5/30 , A61M5/002 , A61M5/3158 , A61M5/425 , A61M2005/208 , A61M2205/6081
摘要： A needle-less injector device for delivering a dose of fluid intradermally, subcutaneously or intramuscularly to an animal or human. The device includes an inner housing having opposed ends. A syringe is disposed in one end of the inner housing. The syringe includes a nozzle for delivering a dose of fluid held within the syringe. A plunger is movably disposed within the syringe. A spring powered hammer is movably disposed within the inner housing. The hammer cooperates with the plunger to drive the dose of medicament from the nozzle. An injection delivery spring for powering the hammer is positioned and compressed between the other end of the inner housing and the spring powered hammer. An outer housing slideably supports the inner housing. A skin tensioning spring is mounted between the inner housing and the outer housing, the skin tensioning spring biasing the nozzle of the syringe against the animal or human. A trigger mechanism is disposed in the outer housing, the trigger mechanism cooperating with the spring powered hammer to release the injection delivery spring, wherein the size of the injection delivery spring and the length of the hammer dictate the amount of dose delivered and whether the dose is delivered intradermally, subcutaneously or intramuscularly to an animal or human.

2. 发明授权

US08778948B2 Substituted phenylpiperazinyl aralkylalcohol derivatives, pharmaceutical compositions containing such derivatives and uses thereof 有权
标题翻译：取代的苯基哌嗪基芳烷基醇衍生物，含有这些衍生物的药物组合物及其用途
公开(公告)号：US08778948B2
公开(公告)日：2014-07-15
申请号：US13141803
申请日：2009-12-22
申请人： Jianqi Li , Guan Wang , Guisen Zhang , Xiangping Yang , Peng Xie , Linjie Zhang , Xiangqing Xu , Yumei Wang
发明人： Jianqi Li , Guan Wang , Guisen Zhang , Xiangping Yang , Peng Xie , Linjie Zhang , Xiangqing Xu , Yumei Wang
IPC分类号： A61K31/495 , A61K31/496 , C07D295/088 , C07D403/08 , C07D417/08
CPC分类号： C07D241/04 , C07D209/34 , C07D235/26 , C07D277/68 , C07D295/08 , C07D295/088 , C07D295/096
摘要： The invention relates to a substituted phenylpiperazine aryl alkanol derivative represented by the following general formula and its salt and hydrate, wherein C1 and C2 represent chiral carbon atoms, and the compound is one of the six isomers: (1RS, 2SR), (1RS, 2RS), (1R, 2S), (1S, 2S), (1R, 2R) or (1S, 2R); and R, R1, R2, R3 and Ar are as defined in the specification. The derivative is non-opioid analgesic, has good analgesic effect and relatively small side effects. The invention also relates to a composition comprising the derivative and its use.
摘要翻译：本发明涉及由以下通式表示的取代苯基哌嗪芳基链烷醇衍生物及其盐和水合物，其中C1和C2代表手性碳原子，该化合物是六种异构体之一：（1RS，2SR），（1RS， 2RS），（1R，2S），（1S，2S），（1R，2R）或（1S，2R）; 并且R，R 1，R 2，R 3和Ar如说明书中所定义。该衍生物为非阿片类镇痛药，镇痛效果好，副作用小。本发明还涉及包含该衍生物及其用途的组合物。

3. 发明授权

US08727558B2 Medical headlamp for tracking eye locations 有权
标题翻译：用于跟踪眼睛位置的医用前照灯
公开(公告)号：US08727558B2
公开(公告)日：2014-05-20
申请号：US13515766
申请日：2012-02-06
申请人： SungMin Kim , Hyo Joon Kim , Wonha Kim , Sang Hoon Hong
发明人： SungMin Kim , Hyo Joon Kim , Wonha Kim , Sang Hoon Hong
IPC分类号： F21V21/084
CPC分类号： F21V14/025 , A61B3/0008 , A61B34/20 , A61B90/30 , A61B90/35 , A61B2018/00577 , A61B2090/502 , A61F2009/00846 , A61N5/1016 , F21V33/0068
摘要： Provided is a medical headlamp including a main body put on a head, a driving unit installed and connected to one side of the main body and to provide a driving force, a location adjustment unit installed and connected to one side of the driving unit, a lamp unit installed and connected to one side of the location adjustment unit to move along with a movement of the location adjustment unit, and irradiate light onto one side of a front end thereof, a capturing unit installed and connected to one side of the main body and to capture eye locations, a control unit installed and connected to the driving unit and the capturing unit to analyze an image captured by the capturing unit, calculate the eye locations, and operate the driving unit according to the calculated eye calculation, and a power supply unit installed and connected to the control unit, the driving unit, and the lamp unit and to apply a current thereto.
摘要翻译：本发明提供一种医疗用前照灯，包括放置在头部上的主体，安装并连接到主体一侧的驱动单元，提供驱动力，安装并连接到驱动单元一侧的位置调整单元灯单元安装并连接到位置调整单元的一侧，随着位置调整单元的移动而移动，并将光照射到其前端的一侧，捕获单元安装并连接到主体的一侧并且为了捕获眼睛位置，安装并连接到驱动单元和捕获单元的控制单元分析由捕获单元捕获的图像，计算眼睛位置，并根据所计算的眼睛计算来操作驱动单元，以及功率供电单元安装并连接到控制单元，驱动单元和灯单元并且向其施加电流。

4. 发明授权

US08669381B2 Chromone inhibitors of S-nitrosoglutathione reductase 有权
标题翻译： S-亚硝基谷胱甘肽还原酶的色酮抑制剂
公开(公告)号：US08669381B2
公开(公告)日：2014-03-11
申请号：US13912287
申请日：2013-06-07
申请人： N30 Pharmaceuticals, Inc.
发明人： Xicheng Sun , Jian Qiu , Jan Wasley
IPC分类号： C07D409/04 , C07D311/34 , A61K31/352 , A61K31/382
CPC分类号： A61K31/352 , A61K31/381 , C07D311/34 , C07D311/36 , C07D409/04
摘要： The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
摘要翻译：本发明涉及S-亚硝基谷胱甘肽还原酶（GSNOR）的抑制剂，包含这种GSNOR抑制剂的药物组合物及其制备和使用方法。

5. 发明授权

US08653302B2 Processes for preparing poly(pentafluorosulfanyl)aromatic compounds 有权
标题翻译：制备聚（五氟硫烷基）芳族化合物的方法
公开(公告)号：US08653302B2
公开(公告)日：2014-02-18
申请号：US13119367
申请日：2009-09-21
申请人： Teruo Umemoto
发明人： Teruo Umemoto
IPC分类号： C07C323/00
CPC分类号： C07C381/00
摘要： Novel processes for preparing poly(pentafluorosulfanyl)aromatic compounds are disclosed. Processes include reacting an aryl sulfur compound with a halogen and a fluoro salt to form a poly(halotetrafluorosulfanyl)aromatic compound. The poly(halotetrafluorosulfanyl)aromatic compound is reacted with a fluoride source to form a target poly(pentafluorosulfanyl)aromatic compound.
摘要翻译：公开了制备聚（五氟硫烷基）芳族化合物的新方法。方法包括使芳基硫化合物与卤素和氟盐反应以形成聚（卤代四氟硫烷基）芳族化合物。聚（卤代四氟硫烷基）芳族化合物与氟化物源反应形成目标聚（五氟硫烷基）芳族化合物。

6. 发明授权

US08600002B2 Device and method for the automatic counting of medical gauze 有权
标题翻译：医用纱布自动计数装置及方法
公开(公告)号：US08600002B2
公开(公告)日：2013-12-03
申请号：US13029360
申请日：2011-02-17
申请人： Gham Hur , Kim Jong Hyo
发明人： Gham Hur , Kim Jong Hyo
IPC分类号： G01N23/083
CPC分类号： A61B50/37 , A61B90/39 , A61B2050/375 , A61B2090/0805
摘要： Provided is a device and method for the automatic counting of medical gauze, which can automatically count the number of medical gauzes used for absorbing blood and other body fluids generated during surgical operations. This device includes a container, which collects the gauze containing radiopaque markers; a support, which supports the container; a radiographic unit, which radiographs the container at various angles using X-ray; a controller, which receives radiographic information from the container and counts the total number of markers in the container using radiographic information; and a display, which operates the system and displays the number of markers calculated by the controller.
摘要翻译：提供了一种用于自动计数医用纱布的装置和方法，其可以自动计算用于吸收外科手术中产生的血液和其他体液的医用纱布的数量。该装置包括容器，其收集包含不透射线标记的纱布; 支持容器; 射线照相单元，其使用X射线以各种角度对容器进行成像; 控制器，其从容器接收放射线照相信息，并使用放射照相信息对容器中的标记物的总数进行计数; 以及显示器，其操作系统并显示由控制器计算的标记的数量。

7. 发明授权

US08529500B2 Needle-less injector and method of fluid delivery 有权
公开(公告)号：US08529500B2
公开(公告)日：2013-09-10
申请号：US13162302
申请日：2011-06-16
申请人： John Bingham , Robert Steinway
发明人： John Bingham , Robert Steinway
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/002 , A61M5/3158 , A61M5/425 , A61M2005/208 , A61M2205/6081
摘要： A needle-less injector device for delivering a dose of fluid intradermally, subcutaneously or intramuscularly to an animal or human. The device includes an inner housing having opposed ends. A syringe is disposed in one end of the inner housing. The syringe includes a nozzle for delivering a dose of fluid held within the syringe. A plunger is movably disposed within the syringe. A spring powered hammer is movably disposed within the inner housing. The hammer cooperates with the plunger to drive the dose of medicament from the nozzle. An injection delivery spring for powering the hammer is positioned and compressed between the other end of the inner housing and the spring powered hammer. An outer housing slideably supports the inner housing. A skin tensioning spring is mounted between the inner housing and the outer housing, the skin tensioning spring biasing the nozzle of the syringe against the animal or human. A trigger mechanism is disposed in the outer housing, the trigger mechanism cooperating with the spring powered hammer to release the injection delivery spring, wherein the size of the injection delivery spring and the length of the hammer dictate the amount of dose delivered and whether the dose is delivered intradermally, subcutaneously or intramuscularly to an animal or human.

8. 发明授权

US08445535B1 Use of medium chain triglycerides for the treatment and prevention of Alzheimer's disease and other diseases resulting from reduced neuronal metabolism II 有权
标题翻译：使用中链甘油三酸酯治疗和预防阿尔茨海默病和其他由神经元代谢减少引起的疾病II
公开(公告)号：US08445535B1
公开(公告)日：2013-05-21
申请号：US11021920
申请日：2004-12-22
申请人： Samuel T Henderson
发明人： Samuel T Henderson
IPC分类号： A61K31/119 , A61K31/225 , A61K31/20 , A61K31/185
CPC分类号： A61K31/23 , A61K31/12 , A61K31/20 , A61K31/205 , A61K31/215 , A61K31/22 , A61K31/221 , A61K31/25 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for treating or preventing, the occurrence of senile dementia of the Alzheimer's type, or other conditions arising from reduced neuronal metabolism and leading to lessened cognitive function are described. In a preferred embodiment the administration of triglycerides or fatty acids with chain lengths between 5 and 12, to said patient at a level to produce an improvement in cognitive ability.
摘要翻译：描述了用于治疗或预防阿尔茨海默氏型老年性痴呆的发生或由减少的神经元代谢引起的导致认知功能降低的其它病症的方法和组合物。在优选的实施方案中，将链长度为5至12之间的甘油三酯或脂肪酸施用于所述患者，以产生认知能力的改善。

9. 发明授权

US08383589B2 Aegyptin and uses thereof 有权
公开(公告)号：US08383589B2
公开(公告)日：2013-02-26
申请号：US12668177
申请日：2008-07-07
申请人： Eric Calvo , Osvaldo Marinotti , Jose M. C. Ribeiro , Ivo M. Francischetti
发明人： Eric Calvo , Osvaldo Marinotti , Jose M. C. Ribeiro , Ivo M. Francischetti
IPC分类号： A61K38/00 , A61K38/36
CPC分类号： C07K14/43563 , A61K38/00 , A61K38/49 , A61K39/0003 , A61K45/06 , A61K48/00 , G01N2500/04 , A61K2300/00
摘要： The present invention relates to the discovery of the Aegyptin gene and Aegyptin protein, a molecule that interacts with collagen and inhibits platelet adhesion, activation and aggregation. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.

10. 发明授权

US08344062B2 Dispersions of intrinsically conductive polymers 失效
标题翻译：固有导电聚合物的分散体
公开(公告)号：US08344062B2
公开(公告)日：2013-01-01
申请号：US12701111
申请日：2010-02-05
申请人： Bernhard Wessling
发明人： Bernhard Wessling
IPC分类号： C08F222/40
CPC分类号： H01B1/127 , C08F6/14 , C09D5/24 , H01B1/128 , H01G11/48 , Y02E60/13
摘要： A dispersion which contains particles of at least one intrinsically conductive polymer, wherein the particle size is on average (weight) less than 1 μm, and which is characterized in that the dispersant is a liquid at room temperature, and a layer, film or sheet formed from this dispersion has a conductivity of >100 S/cm after removal of the dispersant.
摘要翻译：包含至少一种本征导电聚合物颗粒的分散体，其中颗粒的平均重量小于1μm，其特征在于分散剂在室温下为液体，层，膜或片由该分散体形成的去除分散剂后的电导率> 100S / cm。

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