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1. 发明授权

US09186360B2 Treatment of respiratory disorders using TRPA1 antagonists 有权
标题翻译：使用TRPA1拮抗剂治疗呼吸系统疾病
公开(公告)号：US09186360B2
公开(公告)日：2015-11-17
申请号：US13495271
申请日：2012-06-13
申请人： Neelima Khairatkar-Joshi , Abhay Kulkarni , Indranil Mukhopadhyay , Vidya Ganapati Kattige , Vikram Mansingh Bhosale , Dinesh Pradeep Wale , Abraham Thomas , Sukeerthi Kumar , Sachin Sundarlal Chaudhari
发明人： Neelima Khairatkar-Joshi , Abhay Kulkarni , Indranil Mukhopadhyay , Vidya Ganapati Kattige , Vikram Mansingh Bhosale , Dinesh Pradeep Wale , Abraham Thomas , Sukeerthi Kumar , Sachin Sundarlal Chaudhari
IPC分类号： A61K31/519 , A61K31/517 , A61K31/15 , A61K31/675 , A61K31/522
CPC分类号： A61K31/522 , A61K31/15 , A61K31/517 , A61K31/519 , A61K31/675
摘要： The present patent application relates to treatment of a respiratory disorder using TRPA1 antagonists. Particularly, the present patent application relates to treatment of a respiratory disorder using a TRPA1 antagonist, wherein the TRPA1 antagonist is administered by inhalation route to a subject in need thereof.
摘要翻译：本专利申请涉及使用TRPA1拮抗剂治疗呼吸障碍。特别地，本专利申请涉及使用TRPA1拮抗剂治疗呼吸障碍，其中TRPA1拮抗剂通过吸入途径施用于有需要的受试者。

2. 发明授权

US08952708B2 Impedance resonance sensor for real time monitoring of different processes and methods of using same 有权
标题翻译：阻抗共振传感器用于实时监控不同的过程和使用方法
公开(公告)号：US08952708B2
公开(公告)日：2015-02-10
申请号：US13690859
申请日：2012-11-30
申请人： NeoVision LLC
发明人： Yury Nikolenko
IPC分类号： G01R27/28 , G01R27/26 , G01R27/08 , G01N27/02 , G01R27/02 , G01R27/16 , G01R15/12 , G01R27/00
CPC分类号： G01N27/028 , G01N27/02 , G01R15/12 , G01R27/00 , G01R27/02 , G01R27/16 , G01R27/26
摘要： Processes and apparatuses are provided for contactless measuring or monitoring in-situ and in real time composition or other electromagnetic impedance correlated properties of liquid or gaseous substances or bulk materials. One or more apparatus may include a resonance type impedance sensor having at least two coils, at least one coil of the at least two coils being at least one excitation coil connectable to at least one alternating current source with frequency sweep, at least one other coil of the at least two coils being at least one sensing coil connectable to at least one data processing system. The one or more methods may include calculating changes in amplitude and resonant frequency induced by electromagnetic interaction between said sensor and object to determine impedance of said object under test; and matching said impedance with predetermined calibration data to determine said chemical or physical properties of said object under test.
摘要翻译：提供了用于非接触式测量或监测的液体或气体物质或散装物质的实时组合或其他电磁阻抗相关特性的过程和设备。一个或多个装置可以包括具有至少两个线圈的谐振型阻抗传感器，所述至少两个线圈中的至少一个线圈是至少一个可连接到具有频率扫描的至少一个交流电源的励磁线圈，至少一个其它线圈所述至少两个线圈中的至少一个感测线圈可连接到至少一个数据处理系统。一种或多种方法可以包括计算由所述传感器和物体之间的电磁相互作用引起的振幅和谐振频率的变化，以确定被测物体的阻抗; 以及将所述阻抗与预定的校准数据进行匹配，以确定所述被测物体的所述化学或物理性质。

3. 发明授权

US08865163B2 Pharmaceutical compositions and methods of treatment 有权
标题翻译：药物组合物和治疗方法
公开(公告)号：US08865163B2
公开(公告)日：2014-10-21
申请号：US13135893
申请日：2011-07-15
申请人： Oleg Iliich Epshtein , Svetlana Alexandrovna Sergeeva , Liudmila Fyodorovna Dolgovyh , Irina Anatolievna Kheyfets , Julia Leonidovna Dugina , Julia Alexandrovna Zabolotneva , Sergey Alexandrovich Tarasov
发明人： Oleg Iliich Epshtein , Svetlana Alexandrovna Sergeeva , Liudmila Fyodorovna Dolgovyh , Irina Anatolievna Kheyfets , Julia Leonidovna Dugina , Julia Alexandrovna Zabolotneva , Sergey Alexandrovich Tarasov
IPC分类号： A61K39/395 , C07K16/28 , C07K16/24 , A61K41/00 , A61Q19/06 , A61K8/64 , A61K39/00
CPC分类号： C07K16/28 , A61K8/64 , A61K41/0004 , A61K2039/505 , A61K2039/507 , A61K2039/545 , A61K2800/78 , A61Q19/06 , C07K16/24
摘要： The present invention provides pharmaceutical compositions comprising an activated potentiated form of an antibody to human cannabinoid receptor and use in the treatment of obesity and related metabolic disorders. The present invention further provides pharmaceutical compositions comprising an activated potentiated form of an antibody to human cannabinoid receptor and activated potentiated form of an antibody to protein S-100 for use in the treatment of addiction to psychoactive substances.The present invention provides methods for treating obesity and related metabolic disorders and substance abuse.
摘要翻译：本发明提供药物组合物，其包含活化的强化形式的抗人大麻素受体的抗体并用于治疗肥胖症和相关的代谢紊乱。本发明进一步提供药物组合物，其包含活化的增强形式的抗人类大麻素受体的抗体和对蛋白质S-100的抗体的活化增强形式，用于治疗对精神活性物质的成瘾。本发明提供了治疗肥胖症和相关的代谢紊乱和药物滥用的方法。

4. 发明授权

US08851689B2 Interferometer, and optical assembly each having a three-pin mount for mounting an optical element at at least three points or areas and method of mounting same 有权
标题翻译：干涉仪和光学组件各自具有用于在至少三个点或区域上安装光学元件的三针安装座和安装相同的方法
公开(公告)号：US08851689B2
公开(公告)日：2014-10-07
申请号：US13560583
申请日：2012-07-27
申请人： Zvi Bleier , Alexander Jacobson , Itai Vishnia
发明人： Zvi Bleier , Alexander Jacobson , Itai Vishnia
IPC分类号： G02B7/182
CPC分类号： G01B9/02051 , G01B9/02058 , G01J3/0202 , G01J3/0286 , G01J3/45 , G02B1/02 , G02B27/1073 , G02B27/144 , Y10T29/49826 , Y10T29/49895
摘要： A frame for optics used in interferometers that may include different materials having substantially similar, identical, or as close as practicable coefficients of thermal expansion from the material(s) used to make the beamsplitter and/or compensator without warping, bending, tilting or distorting the optics. The beamsplitter and/or compensator are mounted onto the frame of the interferometer using a three-point method of mounting, preferably using three pins for each component. Preferably, the pins are made of the same material as the beamsplitter and compensator, and all three components are made of Potassium Bromide (“KBr”) or Calcium Fluoride (“CaF2”) such that the optic instrument can operate to scan into the mid or far infrared. Stability in optical alignment is therefore achieved without requiring the optic instrument include only one material. The invention provides stability in situations where it is not possible to utilize a single material for every component of the interferometer.
摘要翻译：用于干涉仪的光学框架可以包括不同材料，其具有与用于制造分束器和/或补偿器的材料的实际可能的热膨胀系数基本相似，相同或相近的材料，而没有翘曲，弯曲，倾斜或变形光学。分束器和/或补偿器使用三点安装方法安装在干涉仪的框架上，优选地，每个部件使用三个引脚。优选地，销由与分束器和补偿器相同的材料制成，并且所有三个部件由溴化钾（“KBr”）或氟化钙（“CaF 2”）制成，使得光学仪器可以操作以扫描到中间或远红外线。因此，在不需要光学仪器仅包括一种材料的情况下实现光学对准的稳定性。本发明在不可能对干涉仪的每个部件使用单一材料的情况下提供稳定性。

5. 发明授权

US08827470B2 Mount for an optical structure and method of mounting an optical structure using such mount 有权
标题翻译：用于光学结构的安装和使用这种安装来安装光学结构的方法
公开(公告)号：US08827470B2
公开(公告)日：2014-09-09
申请号：US13777267
申请日：2013-02-26
申请人： PLX, Inc.
发明人： Zvi Bleier
IPC分类号： G02B7/182 , G02B7/18
CPC分类号： G02B7/182 , G02B7/1805 , Y10T29/49826 , Y10T29/49963 , Y10T74/2164
摘要： An improved mount for, and method of mounting an, optical structure is provided. The mount has a protruding member extending from a surface of the optical structure, a base element having a mounting structure for mounting the mount to another structure and an upper element extending from the base element having a first opening extending therethrough for receipt therein of at least a portion of the protruding member. The first opening defines first and second arms, each of the arms comprising a head portion and each of the head portions ending at an end. A second opening in the upper element extends through one of the head portions and the end thereof in a direction toward the other head portion, while a third opening exists in the upper element through the end of the other head portion in an orientation substantially opposite to and in communication with the second opening so that a tightening mechanism received through the second opening can be received into the third opening. Tightening of the tightening mechanism into the third opening causes the ends of the head portions to draw toward each other so that the first opening of the upper element tightens around the at least a portion of the protruding member.
摘要翻译：提供了一种改进的安装件和安装光学结构的方法。安装座具有从光学结构的表面延伸的突出构件，具有用于将安装件安装到另一结构的安装结构的基座元件和从基座元件延伸的上部元件，该元件具有延伸穿过其中的第一开口，突出部件的一部分。第一开口限定第一和第二臂，每个臂包括头部，并且每个头部末端终止。上部元件中的第二个开口沿朝向另一个头部部分的方向延伸穿过其中一个头部部分和其端部，而第三个开口通过另一个头部部分的端部沿着与第二开口部分并且与第二开口连通，使得通过第二开口接收的紧固机构能够被接收到第三开口中。将紧固机构紧固到第三开口中使得头部的端部彼此拉开，使得上部元件的第一开口围绕突出构件的至少一部分紧固。

6. 发明授权

US08795657B2 Combination pharmaceutical composition and methods of treating diseases or conditions associated with respiratory disease or condition 有权
标题翻译：组合药物组合物和治疗与呼吸系统疾病或病症有关的疾病或病症的方法
公开(公告)号：US08795657B2
公开(公告)日：2014-08-05
申请号：US13135884
申请日：2011-07-15
申请人： Oleg Iliich Epshtein
发明人： Oleg Iliich Epshtein
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K39/3955 , A61K39/39583 , A61K41/0004 , A61K2039/505 , A61K2039/507 , C07K16/26 , C07K16/44
摘要： The present invention is concerned with a combination pharmaceutical composition comprising a) an activated-potentiated form of an antibody to bradykinin, b) an activated-potentiated form of an antibody to histamine and c) an activated-potentiated form of an antibody to morphine and method for treating and preventing upper respiratory tract conditions or disorders and the symptoms associated therewith by administration of the combination composition.
摘要翻译：本发明涉及组合药物组合物，其包含a）活化增强形式的缓激肽抗体，b）活化增强形式的组胺抗体，c）活化增强形式的吗啡抗体和用于治疗和预防上呼吸道状况或病症的方法以及通过给予组合组合物而引起的症状。

7. 发明授权

US08748722B2 Hinged drumstick 失效
标题翻译：铰链鼓槌
公开(公告)号：US08748722B2
公开(公告)日：2014-06-10
申请号：US13772837
申请日：2013-02-21
申请人： HingeStix LLC
发明人： Samuel Ruttenberg
IPC分类号： G10D13/02
CPC分类号： G10D13/003
摘要： A percussion instrument is disclosed that may include a body having a longitudinal axis extending from a butt end to a striking end thereof and at least one hole extending through the thickness of the body substantially along or through an axis that is different from the longitudinal axis; and a grasping mechanism having a first grip plate at a first end thereof and a second grip plate at a second end thereof, and at least one shaft extending through the hole. The percussion instrument may further include a compliance mechanism disposed between the first and second grip plates, enabling the first and second grip plates to move closer together in response to a compressive force applied. One or more recesses or bores may be used for a more compact design, and the at least one hole may be on an angle to accommodate different drumming styles.
摘要翻译：公开了一种打击乐器，其可以包括具有从对接端延伸到其撞击端的纵向轴线的主体和基本上沿着或穿过不同于纵向轴线的轴延伸穿过主体的厚度的至少一个孔; 以及具有在其第一端处具有第一夹持板并且在其第二端具有第二夹持板的抓持机构，以及延伸穿过所述孔的至少一个轴。打击乐器还可以包括设置在第一和第二握持板之间的顺应机构，使得第一和第二夹板能够响应于所施加的压缩力而更靠近地移动。可以使用一个或多个凹部或孔来进行更紧凑的设计，并且至少一个孔可以是一角度以适应不同的鼓风形式。

8. 发明授权

US08592398B2 2-amino-4-arylthiazole compounds as TRPA1 antagonists 失效
公开(公告)号：US08592398B2
公开(公告)日：2013-11-26
申请号：US13327128
申请日：2011-12-15
申请人： Sukeerthi Kumar , Abraham Thomas , Sachin Sundarlal Chaudhari , Bipin Parsottam Kansagra , Venkata Ramana Yemireddy , Neelima Khairatkar-Joshi , Indranil Mukhopadhyay , Girish Gudi
发明人： Sukeerthi Kumar , Abraham Thomas , Sachin Sundarlal Chaudhari , Bipin Parsottam Kansagra , Venkata Ramana Yemireddy , Neelima Khairatkar-Joshi , Indranil Mukhopadhyay , Girish Gudi
IPC分类号： A01N57/00 , A01N43/78 , A61K31/675 , A61K31/67 , A61K31/535 , A61K31/425 , C07D277/00
CPC分类号： C07F9/6561 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D513/04 , C07F9/65616
摘要： The present invention is related to 2-amino-4-arylthiazole derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

9. 发明授权

US08535082B2 Apparatus for providing a secure connection between different devices 失效
标题翻译：用于在不同设备之间提供安全连接的设备
公开(公告)号：US08535082B2
公开(公告)日：2013-09-17
申请号：US13029190
申请日：2011-02-17
申请人： Charles Lifson
发明人： Charles Lifson
IPC分类号： H01R13/62
CPC分类号： H01R13/6392
摘要： An apparatus for holding at least two devices together is provided with a first securing member, a second securing member, and a connecting member extending between the first and second securing members. The first securing member may be an elongate member having first and second ends such that the elongate member has a length between said first and second ends sufficient to wrap around one of the at least two devices, and the first end of the first securing member having securing means that operates to connect the first end to the second end. The second securing member may receive at least one other of the at least two devices, and may have at least two substantially linearly aligned receptacles. Each receptacle may receive the at least one other of the at least two devices. The two devices may be one or more cords, extension cords, and electrical plugs.
摘要翻译：一种用于将至少两个装置保持在一起的装置设置有第一固定构件，第二固定构件和在第一和第二固定构件之间延伸的连接构件。第一固定构件可以是具有第一和第二端部的细长构件，使得细长构件具有在所述第一和第二端部之间的长度，足以围绕至少两个装置中的一个，并且第一固定构件的第一端具有操作以将第一端连接到第二端的固定装置。第二固定构件可以容纳至少两个装置中的至少一个，并且可以具有至少两个基本线性对准的容器。每个插座可以接收至少两个装置中的至少一个。两个装置可以是一个或多个绳索，延长线和电插头。

10. 发明授权

US08454176B2 Mount for an optical structure and method of mounting an optical structure using such mount 有权
标题翻译：用于光学结构的安装和使用这种安装来安装光学结构的方法
公开(公告)号：US08454176B2
公开(公告)日：2013-06-04
申请号：US13211507
申请日：2011-08-17
申请人： Zvi Bleier
发明人： Zvi Bleier
IPC分类号： G02B5/08 , G02B7/182
CPC分类号： G02B7/182 , G02B7/1805 , Y10T29/49826 , Y10T29/49963 , Y10T74/2164
摘要： An improved mount for, and method of mounting an, optical structure is provided. The mount has a protruding member extending from a surface of the optical structure, a base element having a mounting structure for mounting the mount to another structure and an upper element extending from the base element having a first opening extending therethrough for receipt therein of at least a portion of the protruding member. The first opening defines first and second arms, each of the arms comprising a head portion and each of the head portions ending at an end. A second opening in the upper element extends through one of the head portions and the end thereof in a direction toward the other head portion, while a third opening exists in the upper element through the end of the other head portion in an orientation substantially opposite to and in communication with the second opening so that a tightening mechanism received through the second opening can be received into the third opening. Tightening of the tightening mechanism into the third opening causes the ends of the head portions to draw toward each other so that the first opening of the upper element tightens around the at least a portion of the protruding member.
摘要翻译：提供了一种改进的安装件和安装光学结构的方法。安装座具有从光学结构的表面延伸的突出构件，具有用于将安装件安装到另一结构的安装结构的基座元件和从基座元件延伸的上部元件，该元件具有延伸穿过其中的第一开口，突出部件的一部分。第一开口限定第一和第二臂，每个臂包括头部，并且每个头部末端终止。上部元件中的第二个开口沿朝向另一个头部部分的方向延伸穿过其中一个头部部分和其端部，而第三个开口通过另一个头部部分的端部沿着与第二开口部分并且与第二开口连通，使得通过第二开口接收的紧固机构能够被接收到第三开口中。将紧固机构紧固到第三开口中使得头部的端部彼此拉开，使得上部元件的第一开口围绕突出构件的至少一部分紧固。

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