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1. 发明授权

US11842428B2 System for geospatial mapping of cemetery properties 有权
公开(公告)号：US11842428B2
公开(公告)日：2023-12-12
申请号：US17099651
申请日：2020-11-16
申请人： NorthStar Memorial Group, LLC
发明人： Joshua P. Lintz , David Montgomery
IPC分类号： G06T11/20 , G06Q50/16 , G06Q30/0283 , G06T11/60
CPC分类号： G06T11/206 , G06Q30/0283 , G06Q50/16 , G06T11/203 , G06T11/60
摘要： A cemetery geospatial mapping system and methods are provided for interactive map-based searching of cemetery properties. The cemetery geospatial mapping system comprises a mapping tools system that includes a component systems package. The component systems package comprises a mapping system that enables end-users to add GPS coordinates to cemetery property records, automates mapping and overlaying of the cemetery properties onto satellite imagery, and enables the end-users to visually interact with information associated with the cemetery properties. A dynamic pricing system uses machine-learning algorithms to analyze data so as to provide the end-users with an optimal price recommendation for each property and unit of inventory. The dynamic pricing system maximizes profits based on predefined characteristics associated with the properties and units of inventory. A host site is stored on an application server system and accessible to the end-users by way of a communications network, such as the Internet.

2. 发明授权

US09772333B2 Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals 有权
公开(公告)号：US09772333B2
公开(公告)日：2017-09-26
申请号：US14193418
申请日：2014-02-28
申请人： Waters Technologies Corporation
发明人： Darryl W. Brousmiche , Ying-Qing Yu
IPC分类号： G01N33/00 , G01N33/58 , C07D207/46
CPC分类号： G01N33/58 , C07D207/46 , C09B19/00 , C09B57/02 , C09B57/08 , G01N33/582 , G01N2400/00 , G01N2400/12 , G01N2458/15 , G01N2458/20 , Y10T436/143333
摘要： Mass spectrometry (MS) active, fluorescent rapid tagging reagent is provided having three substituent groups: (a) a tertiary amino group or other MS active atom; (b) a highly fluorescent moiety; and (c) a reactive group that can react with an amine. The reactive group provides rapid tagging of desired bio-molecules. The fluorescent moiety provides the fluorescent signal. The tertiary amino group provides the MS signal.

3. 发明授权

US08642351B2 Apparatus and methods of fluid chromatography 有权
标题翻译：流体色谱仪的设备和方法
公开(公告)号：US08642351B2
公开(公告)日：2014-02-04
申请号：US12441732
申请日：2007-09-17
申请人： Hongji Liu , Jeffrey W. Finch
发明人： Hongji Liu , Jeffrey W. Finch
IPC分类号： G01N30/38
CPC分类号： G01N30/34 , G01N30/463
摘要： The invention provides improved methods and apparatus for fluid chromatography, and is particularly appropriate to high-pressure liquid chromatography carried out using eluent flow rates less than 1 μl/minute, for example on nanoflow columns. In both single- and multi-dimensional chromatography systems, especially those comprising trapping media to facilitate injection of relatively large volumes of sample on to nanoflow columns, the on-line addition of a diluting solvent enables stronger eluents and sample solvents to be employed without causing premature release of analytes from the trapping media or the degradation of the second dimension chromatographic separation. The invention may be advantageously used for two-dimension reverse phase/reverse phase separations, especially for the separation of complex mixtures of peptides.
摘要翻译：本发明提供用于流体色谱法的改进的方法和装置，并且特别适用于使用小于1mul /分钟的洗脱液流速进行的高压液相色谱法，例如在纳流方柱上。在单维和多维色谱系统中，特别是包含捕集介质以促进将相对较大体积的样品注入纳流柱上的系统，在线添加稀释溶剂使得能够使用更强的洗脱液和样品溶剂而不引起从捕集介质过早释放分析物或第二维色谱分离的降解。本发明可有利地用于二维反相/反相分离，特别是用于分离肽的复杂混合物。

4. 发明授权

US08616244B2 Tubing and method for manufacture 有权
标题翻译：管道和制造方法
公开(公告)号：US08616244B2
公开(公告)日：2013-12-31
申请号：US12441401
申请日：2007-09-17
申请人： Kenneth R. Plant
发明人： Kenneth R. Plant
IPC分类号： F16L9/18
CPC分类号： F16L9/19 , B21C1/22 , B21C3/02 , B21C37/154 , Y10T137/0318
摘要： An apparatus for conveying fluid comprising a first tube and a second tube. The first tube has a first end and a second end, an inner wall and an outer wall. The inner wall defines a passage for fluid and an outer wall has at least one first receiving section for receiving an inner wail from the second tube. The second tube has a first end and a second end, an inner wall and an outer wall. The inner wall defines a chamber for receiving the first tube and has at least one second receiving section for receiving the outer wall of the first tube wherein at least one of the first tube and the second tube are drawn down such that the first receiving section and the second receiving section of the first tube and the second tube are in close proximity to each other and sealed.
摘要翻译：一种用于输送流体的装置，包括第一管和第二管。第一管具有第一端和第二端，内壁和外壁。内壁限定用于流体的通道，外壁具有用于从第二管接纳内壁的至少一个第一容纳部。第二管具有第一端和第二端，内壁和外壁。内壁限定用于接收第一管的腔室，并具有用于接收第一管的外壁的至少一个第二容纳部分，其中第一管和第二管中的至少一个被拉下，使得第一接收部和第一管和第二管的第二接收部分彼此靠近并被密封。

5. 发明授权

US08299040B2 Methods for treating cancer targeting transglutaminase 失效
标题翻译：治疗癌症靶向转谷氨酰胺酶的方法
公开(公告)号：US08299040B2
公开(公告)日：2012-10-30
申请号：US11867717
申请日：2007-10-05
申请人： Kapil Mehta , Amit Verma , Sushovan Guha , Jansina Fok , Gabriel Lopez-Berestein , Anil Sood
发明人： Kapil Mehta , Amit Verma , Sushovan Guha , Jansina Fok , Gabriel Lopez-Berestein , Anil Sood
IPC分类号： C07H21/02 , C07H21/04 , A61K31/70 , C12Q1/68
CPC分类号： C12Y207/11013 , A61K48/00 , C12N9/1044 , C12N15/1137 , C12N2310/14 , C12Y203/02013
摘要： A method for treating cancer comprising inhibiting transglutaminase activity is provided. Suitable cancer types for which the methods of the present disclosure can be used to treat include, but are not limited to, pancreatic, breast, and ovarian cancers and melanoma. The inhibition of transglutaminase activity may be performed by one or more techniques, including, but not limited to, downregulating transglutaminase expression, inhibiting TG2 translation, or blocking TG2 enzymatic activity, such as with a small molecule inhibitor or intracellular antibody (intrabody).
摘要翻译：提供了一种治疗癌症的方法，包括抑制转谷氨酰胺酶活性。本公开的方法可用于治疗的合适的癌症类型包括但不限于胰腺癌，乳腺癌和卵巢癌以及黑素瘤。转谷氨酰胺酶活性的抑制可以通过一种或多种技术进行，包括但不限于下调转谷氨酰胺酶表达，抑制TG2翻译或阻断TG2酶活性，例如用小分子抑制剂或细胞内抗体（体内）。

6. 外观设计

USD872772S1 Reciprocating gas compressor valve 有权
公开(公告)号：USD872772S1
公开(公告)日：2020-01-14
申请号：US29674024
申请日：2018-12-19
申请人： Delaware Capital Formation, Inc.
设计人： Swapnil S. Khaire , Stephen A. Mish
摘要： FIG. 1 is an overall perspective view of a reciprocating gas compressor valve showing our new design;
FIG. 2 is an overall exploded perspective view thereof;
FIG. 3 is an overall top view thereof;
FIG. 4 is an overall side elevational view thereof;
FIG. 5 is an overall bottom view thereof;
FIG. 6 is a cross-sectional view of the reciprocating gas compressor valve of FIG. 3;
FIG. 7 is a top view of the seat of the reciprocating gas compressor valve of FIG. 1;
FIG. 8 is a side elevational view of the seat thereof;
FIG. 9 is a bottom view of the seat thereof;
FIG. 10 is a perspective view of the cartridge of the reciprocating gas compressor valve of FIG. 1;
FIG. 11 is a bottom perspective view of the cartridge thereof;
FIG. 12 is a top view of the cartridge thereof;
FIG. 13 is a bottom view of the cartridge thereof;
FIG. 14 is a side view of the cartridge thereof;
FIG. 15 is a top view of the sealing element that can be used in the reciprocating gas compressor valve of FIG. 1;
FIG. 16 is a side view of the embodiment of the sealing element thereof;
FIG. 17 is a bottom view of the embodiment of the sealing element thereof;
FIG. 18 is a perspective view of the cartridge of the reciprocating gas compressor valve of FIG. 1 showing the sealing element;
FIG. 19 is a bottom perspective view thereof;
FIG. 20 is a top view thereof;
FIG. 21 is a bottom view thereof;
FIG. 22 is a side view thereof;
FIG. 23 is an overall top view of the guard of the reciprocating gas compressor valve of FIG. 1;
FIG. 24 is a side elevational view of the guard thereof; and,
FIG. 25 is a bottom view of the guard thereof.
The broken lines shown in the figures are for the purpose of illustrating environment which form no part of the claimed design.

7. 外观设计

USD757907S1 Dampening ring for compressor valve 有权
标题翻译：减压环用于压缩机阀门
公开(公告)号：USD757907S1
公开(公告)日：2016-05-31
申请号：US29515747
申请日：2015-01-26
申请人： Delaware Capital Formation, Inc.
设计人： Walter Foreman , Stephen A. Mish

8. 发明授权

US08524502B2 Apparatus and methods for performing photoreactions and analytical methods and devices to detect photo-reacting compounds 有权
标题翻译：用于进行光反应的装置和方法以及检测光反应化合物的分析方法和装置
公开(公告)号：US08524502B2
公开(公告)日：2013-09-03
申请号：US12989210
申请日：2009-04-22
申请人： Mark Basile , Anthony Jeannotte
发明人： Mark Basile , Anthony Jeannotte
IPC分类号： G01N33/00 , G01N21/00 , B01J19/12
CPC分类号： G01N30/74 , G01N21/631 , G01N21/64
摘要： The present invention is directed to devices and methods for performing photoreactions of photo-reacting compounds in solution. The invention features a vessel defining a chamber and a light source. The chamber has a chamber volume, a first window, an inlet and an outlet. The inlet is placed in fluid communication with a source of photo-reacting compounds in solution. The first window is transparent to light transmission and is placed in optical communication with a light source to receive photons. The chamber receives a solution of one or more photo-reactive compounds over time to define a dwell time. The device further includes a light source, in optical communication with the first window, for emitting photons which photons are received by the first window and transmitted into the chamber.
摘要翻译：本发明涉及用于在溶液中进行光反应化合物的光反应的装置和方法。本发明的特征在于限定腔室和光源的容器。室具有室容积，第一窗口，入口和出口。入口与溶液中的光反应化合物源流体连通。第一个窗口对透光透明，并与光源进行光通信以接收光子。室随时间接收一种或多种光反应性化合物的溶液以限定停留时间。该装置还包括与第一窗口光学通信的光源，用于发射光子，光子被第一窗口接收并被传送到室中。

9. 发明授权

US08252807B2 Methods of inhibiting the interaction between S100 and the receptor for advanced glycation end-products 失效
标题翻译：抑制S100与晚期糖基化终产物受体相互作用的方法
公开(公告)号：US08252807B2
公开(公告)日：2012-08-28
申请号：US12247635
申请日：2008-10-08
申请人： Craig D. Logsdon , William Bornmann
发明人： Craig D. Logsdon , William Bornmann
IPC分类号： A61K31/353 , A61K31/513
CPC分类号： A61K31/352 , A61K31/7068 , A61K2300/00
摘要： A method of inhibiting an interaction between a S100 protein and the receptor for advanced glycation end-products is provided comprising administering to a subject a therapeutically effective amount of cromolyn, C5, or salt, hydrate, or solvate thereof. In some embodiments, the S100 protein is S100P. In some embodiments, the S100 protein is S100P. In addition, the present invention provides a method of treating a cancer comprising administering to a mammal a therapeutically effective amount of cromolyn, C5, or salt, hydrate, or solvate thereof. Additional methods are also provided.
摘要翻译：提供了抑制S100蛋白与用于晚期糖基化终产物的受体之间的相互作用的方法，包括向受试者施用治疗有效量的色甘酸，C5或其盐，水合物或溶剂合物。在一些实施方案中，S100蛋白是S100P。在一些实施方案中，S100蛋白是S100P。此外，本发明提供了一种治疗癌症的方法，包括向哺乳动物施用治疗有效量的色甘酸，C5或其盐，水合物或溶剂合物。还提供了附加的方法。

10. 发明授权

US08143412B2 Inhibitors of proliferation and activation of signal transducer and activator of transcription (STATs) 有权
标题翻译：信号转导和转录激活因子（STAT）的增殖和激活抑制剂
公开(公告)号：US08143412B2
公开(公告)日：2012-03-27
申请号：US12989944
申请日：2009-06-26
申请人： Waldemar Priebe , Stanislaw Skora , Timothy Madden , Izabela Fokt , Charles Conrad
发明人： Waldemar Priebe , Stanislaw Skora , Timothy Madden , Izabela Fokt , Charles Conrad
IPC分类号： C07D213/57 , A61K31/44
CPC分类号： C07D213/57 , A61K31/4402 , C07D213/61
摘要： Pyridine compounds effective in modulation STAT3 and/or STAT5 activation are provided that are useful in the prevention and treatment of proliferative disease and conditions including cancer, inflammation and proliferative skin disorders.
摘要翻译：提供了有效调节STAT3和/或STAT5活化的吡啶化合物，其可用于预防和治疗增殖性疾病和病症，包括癌症，炎症和增殖性皮肤病。

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