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1. 发明授权

US07361502B2 Nucleic acid molecule encoding a neuronal serine-threonine protein kinase 失效
标题翻译：编码神经元丝氨酸 - 苏氨酸蛋白激酶的核酸分子
公开(公告)号：US07361502B2
公开(公告)日：2008-04-22
申请号：US10276645
申请日：2001-05-17
申请人： Armin Schneider , Bettina Klaussner , Achim Fischer , Dieter Newrzella , Bernhard Götz , Moritz Rossner , Gisela Eisenhardt , Rohini Kuner , Annette Trutzel , Birgitta Kammandel , Stephanie Jomana Naim , Markus Schwaninger
发明人： Armin Schneider , Bettina Klaussner , Achim Fischer , Dieter Newrzella , Bernhard Götz , Moritz Rossner , Gisela Eisenhardt , Rohini Kuner , Annette Trutzel , Birgitta Kammandel , Stephanie Jomana Naim , Markus Schwaninger
IPC分类号： C12N15/00 , C12N7/01 , C07H21/04 , C07K14/435
CPC分类号： A61K51/0491 , A01K2217/05 , A61K38/00 , C12N9/1205
摘要： The present invention relates to a gene and the coded protein thereof that is involved in the development of sequelae of local ischaemia. The new protein is a serine threonine protein kinase and provides a new therapeutic approach to the prophylaxis and therapy of apoplexy.
摘要翻译：本发明涉及参与局部缺血后遗症发展的基因及其编码蛋白质。新蛋白质是丝氨酸苏氨酸蛋白激酶，为预防和治疗中风提供了一种新的治疗方法。

2. 发明授权

US07237505B2 Ovo activation of an egg in the shell 失效
标题翻译：卵子在卵壳中的激活
公开(公告)号：US07237505B2
公开(公告)日：2007-07-03
申请号：US09784575
申请日：2001-02-15
申请人： Tim Cantrell , Andrew Wooten
发明人： Tim Cantrell , Andrew Wooten
IPC分类号： A01K45/00 , A01K67/027 , A61B17/43
CPC分类号： A01K67/02 , A01K45/007 , A61D19/00
摘要： The present invention relates to the field of avian reproduction. In particular, the present invention provides a method of activating an egg in a shell. The invention also provides a method of activating an egg in a shell, whereby a live chick is hatched.
摘要翻译：本发明涉及禽类繁殖领域。特别地，本发明提供了一种在壳中激活卵的方法。本发明还提供了一种在壳中激活卵的方法，由此孵出活鸡。

3. 外观设计

USD545483S1 Light fixture 有权
公开(公告)号：USD545483S1
公开(公告)日：2007-06-26
申请号：US29215618
申请日：2004-10-21
申请人： John T. Mayfield, III , Carl T. Gould , Kevin Leadford , Stephen H. Lydecker
设计人： John T. Mayfield, III , Carl T. Gould , Kevin Leadford , Stephen H. Lydecker

4. 发明授权

US07179640B2 Method and apparatus for detecting conception in animals 失效
标题翻译：动物检测方法及装置
公开(公告)号：US07179640B2
公开(公告)日：2007-02-20
申请号：US11327119
申请日：2006-01-06
申请人： Nancy Tommye Jordan , John Douglas Jordan
发明人： Nancy Tommye Jordan , John Douglas Jordan
IPC分类号： G01N33/558
CPC分类号： G01N33/54386 , C07K14/47 , C07K16/18 , G01N33/558 , G01N2800/367 , G01N2800/368 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/81 , Y10S436/814
摘要： The present invention provides antibodies which specifically bind early conception factor, which can be found in body fluids of animals including but not limited to the cow, cat, dog, horse, human, sheep, and pig. The invention provides methods for detecting conception or the absence of conception in an animal, the latter being recognized by the absence of early conception factor in a suitable body fluid collected from the animal. Apparati for detecting early conception factor in a body fluid from an animal comprising the antibodies which specifically bind early conception factor are also provided.
摘要翻译：本发明提供特异性结合早期受孕因子的抗体，其可以在动物的体液中发现，包括但不限于牛，猫，狗，马，人，绵羊和猪。本发明提供了用于检测动物中的受孕或不存在受孕的方法，后者通过在从动物收集的合适的体液中不存在早期受孕因子来识别。还提供了用于检测来自包含特异性结合早期受孕因子的抗体的动物的体液中的早期受孕因子的装置。

5. 发明授权

US07038033B2 Nematode neuromuscular junction GABA receptors subunits 失效
标题翻译：线虫神经肌肉接头GABA受体亚基
公开(公告)号：US07038033B2
公开(公告)日：2006-05-02
申请号：US10156240
申请日：2002-05-24
申请人： Bruce A. Bamber , Erik M. Jorgensen
发明人： Bruce A. Bamber , Erik M. Jorgensen
IPC分类号： C07H21/04 , C07K1/00 , C07K14/00 , C07K17/00 , C12P21/06
CPC分类号： G01N33/9426 , C07K14/4354 , C07K14/70571 , G01N2333/4353 , G01N2500/04
摘要： The present invention relates to the field of GABA receptor structure and function. In one aspect, the present invention relates to impairment of the gamma-aminobutyric acid (GABA) receptors in parasitic nematodes, for the purpose of crop protection and/or soil treatment. The invention includes mutated nematode GABA receptor subunits, nematode GABA neuromuscular junction receptor complexes, nucleic acids which encode the mutated and functional receptor complexes, antibodies which selectively bind the GABA receptor complexes and/or subunits, and assays for compounds which adversely affect nematode GABA neuromuscular junction receptor function. The present invention therefore relates broadly to recombinant DNA technology, molecular biology tools, and crop protection and/or soil treatment.
摘要翻译：本发明涉及GABA受体结构和功能领域。一方面，为了作物保护和/或土壤处理的目的，本发明涉及寄生线虫中γ-氨基丁酸（GABA）受体的损伤。本发明包括突变的线虫GABA受体亚基，线虫GABA神经肌肉接头受体复合物，编码突变和功能受体复合物的核酸，选择性结合GABA受体复合物和/或亚基的抗体，以及对线虫GABA神经肌肉不利影响的化合物的测定结受体功能。因此，本发明广泛涉及重组DNA技术，分子生物学工具以及作物保护和/或土壤处理。

6. 发明授权

US06953380B2 Postoperative bilateral augmentation mammaplasty brassiere 失效
标题翻译：术后双侧隆起乳房成形胸罩
公开(公告)号：US06953380B2
公开(公告)日：2005-10-11
申请号：US10859054
申请日：2004-06-02
申请人： David B. Brothers
发明人： David B. Brothers
IPC分类号： A41C3/00
CPC分类号： A41C3/0007 , A41C3/0064
摘要： A postoperative bilateral augmentation mammaplasty brassiere for use by women with augmented breasts is disclosed. The brassiere provides a support cup shaped to mimic a spherically shaped breast implant. The brassiere further provides an underwire within the construction of the brassiere, the underwire having an arcuate portion to mimic the round base of an augmented breast. A connector is provided between two support cups, each with an associated underwire, such that the distance between proximal ends of the underwires is established for the comfort of the wearer and the attractive appearance of the brassiere.
摘要翻译：公开了一种用于乳房增大的妇女使用的术后双侧增大乳房成形胸罩。胸罩提供支撑杯形状，以模拟球形乳房植入物。胸罩进一步在胸罩的构造中提供了一根线，该线条具有弓形部分，以模仿增大的乳房的圆形基部。连接器设置在两个支撑杯之间，每个支撑杯具有相关联的底线，使得穿线的近端之间的距离被建立用于穿戴者的舒适性和胸罩的吸引人的外观。

7. 发明授权

US06949173B2 Continuous coating system 失效
标题翻译：连续涂层系统
公开(公告)号：US06949173B2
公开(公告)日：2005-09-27
申请号：US10445101
申请日：2003-05-23
申请人： Andreas Sauer
发明人： Andreas Sauer
IPC分类号： C23C14/56 , H01L21/00 , C23C14/34 , C23C16/00
CPC分类号： H01L21/67126 , C23C14/568
摘要： A continuous coating system has several treatment chambers (1, 2) that are arranged one after the other in such a way that in each case, a wall (3) of one treatment chamber (1) having a passage (5) contacts a wall (4) in the adjacent treatment chamber (2) that also has a passage (6). One of the passages (5) is provided in a sealing insert (7), which supports itself on the same side with a first support surface (9) on the wall (3) of one treatment chamber (1) and with a second support surface (10) against the wall (4) of the adjacent treatment chamber (2). Between the two support surfaces (9, 10) and the respective walls (3, 4), in each case there is a surrounding gasket (13, 14) against the respective support surface (9, 10) and the wall (3, 4).
摘要翻译：连续涂覆系统具有几个处理室（1,2），其以这样的方式一个接一个地布置，使得在每种情况下，具有通道（5）的一个处理室（1）的壁（3）接触壁（4）在也具有通道（6）的相邻处理室（2）中。通道（5）中的一个设置在密封插入件（7）中，所述密封插入件（7）在一个处理室（1）的壁（3）上的第一支撑表面（9）的同一侧上自身支撑，并且具有第二支撑表面（10）抵靠相邻处理室（2）的壁（4）。在两个支撑表面（9,10）和相应的壁（3,4）之间，在每种情况下都有一个围绕相应的支撑表面（9,10）的周围的垫圈（13,14）和壁（3,4））。

8. 外观设计

USD504536S1 Luminaire 失效
公开(公告)号：USD504536S1
公开(公告)日：2005-04-26
申请号：US29207819
申请日：2004-06-18
申请人： Jon Mark Emory , Jeffrey Douglas McClow , Ashraf Alfayez , Rick Martin Kelly
设计人： Jon Mark Emory , Jeffrey Douglas McClow , Ashraf Alfayez , Rick Martin Kelly

9. 发明授权

US06869767B1 Detection of Streptococcus pneumoniae and immunization against Streptococcus pneumoniae infection 失效
标题翻译：检测肺炎链球菌和肺炎链球菌感染免疫
公开(公告)号：US06869767B1
公开(公告)日：2005-03-22
申请号：US10168602
申请日：1999-06-14
申请人： Jacqueline S. Sampson , Katherine E. Morrison , Jennifer Crook Whitmon , Edwin Ades , George M. Carlone
发明人： Jacqueline S. Sampson , Katherine E. Morrison , Jennifer Crook Whitmon , Edwin Ades , George M. Carlone
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , Y10S435/975
摘要： The present invention relates to oligonucleotide primers, and methods of diagnosis using the primers, wherein particular primer pairs prime the universal amplification of an amplicon for specific Streptococcus pneumoniae from all 90 known serotypes. The amplicon includes at least a portion of the psaA gene of Steptococcus pneumoniae. In the methods, amplification of a biological sample using the primer pairs of the invention provide an amplicon only if the sample contains a serotype of Streptococcus pneumoniae. The invention further relates to an isolated nucleic acid including a nucleic acid amplicon obtained using a pair of oligonucleotide primers of the invention. In still a further aspect, the invention discloses a polypeptide including an amino acid sequence encoded by a nucleic acid amplicon obtained using oligonucleotide primers. Additionally, methods of stimulating an immune response against a serotype of Streptococcus pneumoniae in a mammal include either administering a polypeptide encoded by a nucleic acid amplicon obtained using the pair of oligonucleotide primers of the invention, or administering a nucleic acid containing a nucleic acid amplicon obtained using the pair of oligonucleotide primers of the invention.
摘要翻译：本发明涉及寡核苷酸引物，以及使用引物进行诊断的方法，其中特定的引物对引发来自所有90种已知血清型的特异性肺炎链球菌特异性肺炎链球菌的扩增子的通用扩增。扩增子包括肺炎链球菌的psaA基因的至少一部分。在该方法中，使用本发明的引物对的生物样品的扩增仅在样品含有肺炎链球菌血清型时提供扩增子。本发明还涉及包含使用本发明的一对寡核苷酸引物获得的核酸扩增子的分离的核酸。在另一方面，本发明公开了一种多肽，其包含由寡核苷酸引物获得的核酸扩增子编码的氨基酸序列。此外，哺乳动物刺激针对肺炎链球菌血清型的免疫应答的方法包括施用由本发明的一对寡核苷酸引物获得的核酸扩增子编码的多肽，或施用含有获得的核酸扩增子的核酸使用本发明的一对寡核苷酸引物。

10. 发明授权

US06841536B2 Prodrugs and conjugates of thiol- and selenol-containing compounds and methods of use thereof 失效
标题翻译：硫醇和含硒化合物的前药和缀合物及其使用方法
公开(公告)号：US06841536B2
公开(公告)日：2005-01-11
申请号：US10051463
申请日：2002-01-18
申请人： Jeannette C. Roberts , Britta H. Wilmore , Pamela B. Cassidy , Pamela K. Dominick , Megan D. Short
发明人： Jeannette C. Roberts , Britta H. Wilmore , Pamela B. Cassidy , Pamela K. Dominick , Megan D. Short
IPC分类号： C07D293/06 , C07H5/00 , C07H5/10 , C07H15/26 , C07H17/00 , A61K31/41 , A61K31/70 , C07C205/00 , C07D305/12 , C07H15/00
CPC分类号： C07D293/06 , C07H5/00 , C07H5/10 , C07H15/26 , C07H17/00
摘要： Disclosed is a prodrug of the formula: where A is a sulfur or a selenium, and R is derived from a mono- di- or oligo- saccharide. Also disclosed is a prodrug of the formula: where A is sulfur or selenium, R′ is derived from a sugar and R′ has the formula (CHOH)nCH2OH, where n is 1 to 5, or R′ is an alkyl or aryl group, or R′ is ═O, and the R″ groups may be the same or different and may be hydrogen, alkyl, alkoxy, carboxy. Also disclosed is a conjugate of an antioxidant vitamin and a thiolamine or selenolamine.Also disclosed is a prodrug of the formula; where A is sulfur or selenium, and R′ is derived from a sugar and R′ has the formula (CHOH)nCH2OH, where n is 1 to 5, or R′ is also be an alkyl or aryl group, or R′ is ═O, and R‡ is an alkoxy, or an amine group. Also disclosed is a prodrug of the formula: where R is COOH or H, and R′ is derived from a sugar and R′ has the formula (CHOH)nCH2OH,where n is 1 to 5, or R′ is an alkyl or aryl group, or R′ is ═O.
摘要翻译：公开了下式的前药：其中A是硫或硒，R是衍生自单 - 或低聚糖。还公开了下式的前药：其中A是硫或硒，R' 衍生自糖，R'具有式（CHOH）n CH 2 OH，其中n为1至5，或R'为烷基或芳基，或R'为= O，并且R“可以相同或也可以是氢，烷基，烷氧基，羧基。还公开了抗氧化维生素和硫醇胺或硒胺的缀合物。还公开了下式的前药：其中A是硫或硒，R'衍生自糖和R'具有式（CHOH）nCH 2 OH，其中n为1至5，或R'也为烷基或芳基，或R'为= O，R“为烷氧基或胺基还公开了下式的前药：其中R是COOH或H，R'来自糖，R'具有式（CHOH）n CH 2 OH，其中n为1至5，或R'为烷基或芳基或R'= O。

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