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1. 发明授权

US07887830B2 Medical devices having polymeric regions based on styrene-isobutylene copolymers 有权
标题翻译：具有基于苯乙烯 - 异丁烯共聚物的聚合物区域的医疗装置
公开(公告)号：US07887830B2
公开(公告)日：2011-02-15
申请号：US12070806
申请日：2008-02-21
申请人： Jeffrey S. Lindquist , Frederick H. Strickler , Mark Boden , Jan Seppala , Paul J. Miller
发明人： Jeffrey S. Lindquist , Frederick H. Strickler , Mark Boden , Jan Seppala , Paul J. Miller
IPC分类号： A61F2/00
CPC分类号： A61L31/048 , A61L27/16 , A61L27/34 , A61L29/041 , A61L29/085 , A61L31/10 , C08L53/02
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions. These polymeric regions, in turn, contain one or more polymers, at least one of which is a copolymer that includes a styrene monomer and an isobutylene monomer. Moreover, the styrene monomer content of the copolymer typically ranges from 25 to 50 mol %.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物区域。这些聚合物区域又包含一种或多种聚合物，其中至少一种是包括苯乙烯单体和异丁烯单体的共聚物。此外，共聚物的苯乙烯单体含量通常为25〜50摩尔％。

2. 发明授权

US07851189B2 Microencapsulated compositions for endoluminal tissue engineering 有权
标题翻译：用于腔内组织工程的微胶囊组合物
公开(公告)号：US07851189B2
公开(公告)日：2010-12-14
申请号：US11073433
申请日：2005-03-07
申请人： Toby M. Freyman , Joseph A. Levendusky
发明人： Toby M. Freyman , Joseph A. Levendusky
IPC分类号： C12N11/04
CPC分类号： C12N5/0012 , A61L27/3804 , A61L27/3839 , A61L27/58
摘要： A tissue engineering composition adapted for application to an interior surface of a body lumen of a patient. The composition comprises (a) a carrier medium that is adapted to flow and to stably adhere the composition to the body lumen and (b) microcapsules, which are dispersed within the carrier medium and which contain one or more living cells encapsulated within a coating that includes a biodegradable polymer. The composition promotes growth of the cells on the lumen surface subsequent to application of the composition to the lumen.
摘要翻译：适用于患者体腔内表面的组织工程组合物。组合物包含（a）适于流动和稳定地将组合物粘附到体腔的载体介质和（b）微胶囊，其分散在载体介质中并且包含一个或多个包封在涂层内的活细胞，包括可生物降解的聚合物。组合物在将组合物施用于内腔后促进细胞在内腔表面上的生长。

3. 发明授权

US07850645B2 Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 失效
标题翻译：用于与电力源一起递送治疗剂的内部医疗装置
公开(公告)号：US07850645B2
公开(公告)日：2010-12-14
申请号：US11055930
申请日：2005-02-11
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61M29/00
CPC分类号： A61N1/325 , A61N1/05 , A61N1/306 , A61N1/327
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译：本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。此外，治疗剂源适于将治疗剂引入电场。另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

4. 发明授权

US08252633B2 Subassembly that includes a power semiconductor die and a heat sink having an exposed surface portion thereof 有权
标题翻译：子组件，其包括功率半导体管芯和具有暴露表面部分的散热器
公开(公告)号：US08252633B2
公开(公告)日：2012-08-28
申请号：US13031658
申请日：2011-02-22
申请人： Wan-Lan Chiang , Kuang Hann Lin , Chih-Ping Peng
发明人： Wan-Lan Chiang , Kuang Hann Lin , Chih-Ping Peng
IPC分类号： H01L21/00
CPC分类号： H01L23/367 , H01L23/4093 , H01L23/4334 , H01L23/49562 , H01L2924/0002 , H01L2924/00
摘要： The semiconductor assembly includes a first subassembly having a heat sink. Solder material is disposed on the exposed portion of a first surface of heat sink. A power semiconductor die is located on the first surface of the heat sink and is thermally coupled thereto by the solder material. A packaging patterned polymer layer is disposed on a second surface of the heat sink opposing the first surface and defines an interior surface portion of the heat sink. A semiconductor package is provided in which the first subassembly, solder material and die are located such that the interior surface portion of the second surface of the heat sink is not enclosed by the semiconductor package.
摘要翻译：半导体组件包括具有散热器的第一子组件。焊料设置在散热片的第一表面的暴露部分上。功率半导体管芯位于散热器的第一表面上并且通过焊料材料热耦合到其上。封装图案化聚合物层设置在散热器的与第一表面相对的第二表面上并且限定散热器的内表面部分。提供了半导体封装，其中第一子组件，焊料材料和管芯被定位成使得散热器的第二表面的内表面部分不被半导体封装封闭。

5. 发明授权

US07901702B2 Implantable or insertable medical devices for controlled delivery of a therapeutic agent 有权
标题翻译：可植入或可插入的医疗装置，用于治疗剂的控制递送
公开(公告)号：US07901702B2
公开(公告)日：2011-03-08
申请号：US11518647
申请日：2006-09-11
申请人： Marlene C. Schwarz
发明人： Marlene C. Schwarz
IPC分类号： A61F13/00 , A61F2/00
CPC分类号： A61L31/10 , A61L27/34 , A61L27/56 , A61L29/085 , A61L29/16 , A61L2300/416 , A61L2300/602
摘要： The present invention is directed to novel implantable or insertable medical devices that provide controlled release of a therapeutic agent. According to an embodiment of the present invention, a therapeutic-agent-releasing medical device is provided, which comprises: (a) an implantable or insertable medical device; (b) a release layer disposed over at least a portion of the implantable or insertable medical device; and (c) a therapeutic agent. The release layer comprises a styrene copolymer and at least one additional polymer. The release layer regulates the rate of release of the therapeutic agent from the medical device upon implantation or insertion of the device into a patient. The present invention is also directed to methods of forming the above implantable or insertable medical devices, methods of administering a therapeutic agent to a patient using such devices, and methods of modulating the release of therapeutic agent from such devices.
摘要翻译：本发明涉及提供治疗剂受控释放的新型可植入或可插入的医疗装置。根据本发明的一个实施方案，提供了一种治疗剂释放医疗装置，其包括：（a）可植入或可插入的医疗装置; （b）设置在所述可植入或可插入医疗装置的至少一部分上的释放层; 和（c）治疗剂。脱模层包含苯乙烯共聚物和至少一种另外的聚合物。释放层调节在将装置植入或插入患者体内治疗剂从医疗装置释放的速率。本发明还涉及形成上述可植入或可插入医疗装置的方法，使用这种装置向患者施用治疗剂的方法，以及调节治疗剂从这些装置释放的方法。

6. 发明授权

US09958426B2 Device and method for determining mixing ratios of flowing media 有权
公开(公告)号：US09958426B2
公开(公告)日：2018-05-01
申请号：US14916257
申请日：2014-08-25
申请人： W.O.M. World of Medicine GmbH
发明人： Matthias Koelm , Peter Juelg
IPC分类号： G01N33/00 , G01F1/36 , G01F1/68 , G01N11/08 , G01N7/00
CPC分类号： G01N33/004 , G01F1/36 , G01F1/68 , G01N7/00 , G01N11/08
摘要： The present invention relates to a device and a method for determining mixing ratios of flowing media, in particular for determining the mixing ratios of two gases by using two flow resistances with different characteristic curves, each flow resistance containing a differential pressure sensor and being connected in series, where one flow resistance is formed by a sintered metal filter and another flow resistance is formed by an orifice.

7. 发明授权

US07914807B2 Medical devices having improved performance 有权
标题翻译：具有改进性能的医疗设备
公开(公告)号：US07914807B2
公开(公告)日：2011-03-29
申请号：US11714029
申请日：2007-03-05
申请人： Shaina Brito , Frederick H. Strickler
发明人： Shaina Brito , Frederick H. Strickler
IPC分类号： C08L53/00 , A61L31/00 , A61L27/00 , A61L29/00
CPC分类号： A61L31/048 , A61L27/16 , A61L29/041 , C08F293/00 , C08L53/02
摘要： In accordance with various aspects of the invention, implantable and insertable medical devices are provided, which contain one or more polymeric regions. In one aspect, the polymeric regions comprise (a) a block copolymer that comprises a polyaromatic block and a polyalkene block admixed with (b) a sulfonated high Tg polymer. In another aspect, the polymeric regions comprise a block copolymer that comprises (a) a sulfonated polymer block and (b) fluorinated polymer block.
摘要翻译：根据本发明的各个方面，提供了可植入和可插入的医疗装置，其包含一个或多个聚合物区域。在一个方面，聚合物区域包含（a）嵌段共聚物，其包含与（b）磺化的高Tg聚合物混合的多芳族嵌段和聚烯烃嵌段。另一方面，聚合物区域包含嵌段共聚物，其包含（a）磺化聚合物嵌段和（b）氟化聚合物嵌段。

8. 发明授权

US07906125B2 Solid or semi-solid therapeutic formulations 失效
标题翻译：固体或半固体治疗剂型
公开(公告)号：US07906125B2
公开(公告)日：2011-03-15
申请号：US10664601
申请日：2003-09-18
申请人： Weenna Bucay-Couto , Sheng-Ping Zhong , Arthur Madenjian , Enxin Ma , Barry N. Gellman
发明人： Weenna Bucay-Couto , Sheng-Ping Zhong , Arthur Madenjian , Enxin Ma , Barry N. Gellman
IPC分类号： A61K9/00 , A01N63/00
CPC分类号： A61K9/0024 , A61K9/0034 , A61K9/0092 , A61K9/1652 , A61K9/204 , A61K9/205 , A61K9/2054 , A61K45/06
摘要： An injectable or insertable dosage form comprising a biodisintegrable binder and an ablation agent in a concentration effective to cause tissue necrosis. The injectable dosage form is a solid or semi-solid dosage form. Due to the solid or semi-solid nature of the dosage form, retention at the site of injection or insertion is improved, thereby improving delivery efficiency of the ablation agents within the dosage form and/or reducing the nonspecific tissue damage associated with the dosage form.
摘要翻译：一种可注射或可插入的剂型，其包含生物可分解的粘合剂和消融剂，其浓度有效地引起组织坏死。可注射剂型是固体或半固体剂型。由于剂型的固体或半固体性质，提高注射或插入部位的保留性，从而提高剂型内消融剂的输送效率和/或减少与剂型相关的非特异性组织损伤。

9. 发明授权

US07931932B2 Processes for producing polymer coatings through surface polymerization 失效
标题翻译：通过表面聚合生产聚合物涂层的方法
公开(公告)号：US07931932B2
公开(公告)日：2011-04-26
申请号：US12070275
申请日：2008-02-14
申请人： Robert A. Herrmann , Frederick H. Strickler , Wendy Naimark , Peter L. Dayton
发明人： Robert A. Herrmann , Frederick H. Strickler , Wendy Naimark , Peter L. Dayton
IPC分类号： B05D3/06 , C08F2/46 , C08F295/00 , A61F2/06
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/606
摘要： A medical device with a therapeutic agent-releasing polymer coating. The medical device is provided by a method that comprises: (a) attaching at least one reactive species to a medical device surface, which reactive species leads to chain growth polymerization in the presence of monomer; (b) contacting the reactive species with at least one monomer species, thereby forming a polymer coating on the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating. The therapeutic agent may be incorporated during formation of the polymer coating or after formation of the polymer coating. The at least one reactive species can comprise, for example, a free radical species, a carbanion species, a carbocation species, a Ziegler-Natta polymerization complex, a metallocene complex, and/or an atom transfer radical polymerization initiator. Alternatively, the medical device is provided by a process comprising: (a) immobilizing least one polymerization catalyst at a medical device surface, which polymerization catalyst leads to polymerization in the presence of monomer; (b) contacting the medical device surface with at least one monomer species, thereby forming a polymer coating at the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating.
摘要翻译：具有治疗剂释放聚合物涂层的医疗装置。该医疗装置由一种方法提供，该方法包括：（a）将至少一种反应性物质附着到医疗器械表面上，该反应性物质在单体存在下导致链增长聚合; （b）使反应性物质与至少一种单体物质接触，从而在医疗装置的表面上形成聚合物涂层; 和（c）在聚合物涂层内提供至少一种治疗剂。治疗剂可以在形成聚合物涂层期间或在形成聚合物涂层之后引入。至少一种反应性物质可以包括例如自由基物质，碳负离子物质，碳阳离子物质，齐格勒 - 纳塔聚合配合物，茂金属络合物和/或原子转移自由基聚合引发剂。或者，医疗装置由包括以下步骤的方法提供：（a）在医疗器械表面固定最少一种聚合催化剂，该聚合催化剂在单体存在下导致聚合; （b）使医疗器械表面与至少一种单体物质接触，从而在医疗装置的表面形成聚合物涂层; 和（c）在聚合物涂层内提供至少一种治疗剂。

10. 发明授权

US07896852B2 Anti-infective central venous catheter with diffusion barrier layer 有权
标题翻译：具有扩散阻隔层的抗感染性中心静脉导管
公开(公告)号：US07896852B2
公开(公告)日：2011-03-01
申请号：US11170235
申请日：2005-06-28
申请人： Kristian DiMatteo , Sharon Mi Lyn Tan
发明人： Kristian DiMatteo , Sharon Mi Lyn Tan
IPC分类号： A61M25/00
CPC分类号： A61M25/0017
摘要： A catheter extending from a distal end which, when in an operative position is inserted within a body of a patient, to a proximal end, the catheter comprising a charge holding cavity to which a therapeutic compound is to be supplied and a wall including inner and outer portions, an inner surface of the inner portion surrounding the charge holding cavity with an outer portion surrounding at least a portion of an outer surface of the inner portion, wherein the inner portion is formed so that a first diffusion rate of the therapeutic compound therethrough is different from a second diffusion rate through the outer portion.
摘要翻译：从远端延伸的导管，其在操作位置被插入到患者的身体内时到达近端，所述导管包括电荷保持腔，供给治疗化合物的导管和包括内部和/ 所述内部部分的内表面围绕所述电荷保持腔，外部包围所述内部部分的外表面的至少一部分，其中所述内部部分形成为使得所述治疗化合物通过其中的第一扩散速率与通过外部的第二扩散速度不同。

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