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1. 发明授权

US10350275B2 Methods of cytotoxic gene therapy to treat tumors 有权
公开(公告)号：US10350275B2
公开(公告)日：2019-07-16
申请号：US14490940
申请日：2014-09-19
申请人： Carlos Estuardo Aguilar-Cordova
发明人： Carlos Estuardo Aguilar-Cordova
IPC分类号： A01N63/00 , A61K38/45 , A61K31/522 , A61K38/19 , A61K38/50 , C07K16/28
摘要： A method is disclosed for decreasing or retarding an increase in the size of a localized or metastatic tumor by using a combination of an immune stimulating cytotoxic gene therapy and immune-checkpoint modulating agent, in conjunction with other therapies, including radiation therapy, chemotherapy, surgery, and immunotherapies.

2. 发明授权

US10065998B2 Proteins specific for pyoverdine and pyochelin 有权
公开(公告)号：US10065998B2
公开(公告)日：2018-09-04
申请号：US15726577
申请日：2017-10-06
申请人： SANOFI
发明人： Carsten Corvey , Heike Stump , Jochen Kruip , Bernhard Calandra , Astrid Rey , Nathalie Karst , Michael Mourez , Laurent Fraisse , Christine Rothe , Andrea Allersdorfer , Alexander Wiedenmann , Marlon Hinner , Bradley Lunde , Kristian Jensen , Martin Hülsmeyer
IPC分类号： C07K14/47 , A61K38/01 , A61K38/00
摘要： The present disclosure provides hNGAL muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical applications, for example, to inhibit or reduce growth of P. aeruginosa. The present disclosure also concerns methods of making one or more pyoverdine- or pyochelin-binding muteins described herein as well as compositions comprising one or more of such muteins. The present disclosure further relates to nucleic acid molecules encoding such muteins and to methods for generation of such muteins and nucleic acid molecules. In addition, the application discloses therapeutic and/or diagnostic uses of these muteins as well as compositions comprising one or more of such muteins.

3. 发明授权

US09897778B2 Four-surface narrow field-of-view compound lens 有权
公开(公告)号：US09897778B2
公开(公告)日：2018-02-20
申请号：US14993347
申请日：2016-01-12
申请人： OmniVision Technologies, Inc.
发明人： Chuen-Yi Yin , Jau-Jan Deng
IPC分类号： G02B9/00 , G02B13/00 , G02B27/00 , G06K7/14
CPC分类号： G02B13/0015 , G02B13/0005 , G02B13/004 , G02B13/006 , G02B27/0025 , G06K7/1413
摘要： A four-surface narrow field-of-view compound lens includes a first biplanar substrate between a first lens and a second lens, the first lens being plano-convex and the second lens being plano-concave. The compound lens also includes a second biplanar substrate between a third lens and a fourth lens, the third lens being plano-convex and the fourth lens being plano-concave. The second lens and third lens are between the first biplanar substrate and the second biplanar substrate. The first lens, second lens, third lens, and fourth lens are coaxial and are formed of materials having a first, second, third, and fourth Abbe number respectively and focal lengths F1, F2, F3, and F4 respectively. The first Abbe number exceeds the second Abbe number and the third Abbe number exceeds the fourth Abbe number. Ratio F1/F2 may satisfy −0.32

4. 发明授权

US10371210B2 Slinger for roller bearing seal, and associated assemblies and methods 有权
公开(公告)号：US10371210B2
公开(公告)日：2019-08-06
申请号：US15621898
申请日：2017-06-13
申请人： Amsted Rail Company, Inc.
发明人： James A. Hargraves , Michael A. Mason
IPC分类号： F16C33/76 , F16C33/78 , F16C33/80 , F16C13/00 , F16J15/3264 , F16J15/447
摘要： A slinger for a roller bearing seal includes (a) an inner section extending at least in a first direction parallel to a rotation axis of the slinger, encircling the rotation axis and forming a plurality of tabs configured to pressure fit the slinger onto a rotor of a roller bearing seal, (b) an outer section extending at least in the first direction at a greater distance than the inner section from the rotation axis and encircling the rotation axis, and (c) a middle section encircling the rotation axis and spanning between the inner section and the outer section, wherein the inner section, the middle section, and the outer section define respective portions of a single continuous part.

5. 发明授权

US09085590B2 Protecting groups for boronic acids 有权
标题翻译：保护硼酸的基团
公开(公告)号：US09085590B2
公开(公告)日：2015-07-21
申请号：US14213433
申请日：2014-03-14
申请人： Wisconsin Alumni Research Foundation
发明人： Ronald T. Raines , Brett VanVeller , Matthew Aronoff
IPC分类号： C07F5/04 , C07F5/02
CPC分类号： C07F5/025 , C07F5/02 , C07F5/04 , Y02P20/55
摘要： Di- and trivalent protecting groups for organoboronic acids including phenyl boronic acids, benzoxaboroles and benzoxaborins, which are prepared from precursor compounds of formula I: where: R1 is a methyl, ethyl or a —(CH2)n—OH group, where n is 2 or 3; R2 and R3 are independently methyl or ethyl groups; R4 and R5 are independently halogens or hydrogens; R6 and R7 are independently hydrogens, halogens, or nitro groups; and R8 and R9 are independently hydrogens, halogens or nitro groups or R8 and R9 together with a portion of the naphthalene ring form a 5-member ring, where when R1 is —CH2—CH2—OH then the protecting group is a trivalent protecting group. Also provided are protected organoboronic acids including protected phenyl boronic acids, benzoxaboroles and benzoxaborins. Also provides are methods for conducting reactions employing protected organoboronic acids.
摘要翻译：由式I的前体化合物制备的包括苯基硼酸，苯并恶唑和苯并恶灵素在内的有机硼酸的二价和三价保护基：其中：R1是甲基，乙基或 - （CH2）n-OH基团，其中n是 2或3; R2和R3独立地是甲基或乙基; R4和R5独立地是卤素或氢; R6和R7独立地是氢，卤素或硝基; R8和R9独立地为氢，卤素或硝基，或R8和R9与一部分萘环一起形成5-元环，其中当R1为-CH2-CH2-OH时，则保护基为三价保护基。还提供了保护的有机硼酸，包括保护的苯基硼酸，苯并恶唑和苯并恶灵。还提供了使用保护的有机硼酸进行反应的方法。

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