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2. 发明申请

US20160038422A1 Tablet Composition for Anti-tuberculosis Antibiotics 审中-公开
标题翻译：片剂组合物用于抗结核抗生素
公开(公告)号：US20160038422A1
公开(公告)日：2016-02-11
申请号：US14816377
申请日：2015-08-03
申请人： Thomas J. Manning , Sydney E. B. Plummer , Tess A. Baker
发明人： Thomas J. Manning , Sydney E. B. Plummer , Tess A. Baker
IPC分类号： A61K9/20 , A61K31/4409
CPC分类号： A61K9/2031 , A61K9/2009 , A61K9/2018 , A61K31/4409 , A61K31/496 , A61K31/555 , A61K31/7036 , A61K31/7135 , A61K31/77 , A61K38/12
摘要： Bacterial resistance to antibiotics is increasing worldwide creating a global threat. Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, is a bacterial infectious disease that results in over one million deaths annually. The discovery outlined here involves a tablet composition for patient administration and subsequently a new paradigm in drug delivery vehicles in vivo and in vitro and is applied to existing TB antibiotics in order to increase their efficacy. The drug delivery system is a three component complex that is administered with the TB antibiotic or a combination of TB antibiotics. The components are a saccharide or saccharides, a transition metal ion or a combination of metal ions that can bind a nitrogen and/or oxygen atom(s), and a water soluble polymer capable of aggregating and enclosing the other constituents. The three component molecular delivery approach has demonstrated ability to overcome M. tuberculosis bacterial resistance to an existing antibiotic.
摘要翻译：对抗生素的细菌耐药性在全球日益增加，造成全球威胁。由细菌结核分枝杆菌引起的结核病（TB）是一种细菌感染性疾病，每年导致超过一百万人死亡。这里概述的发现涉及用于患者给药的片剂组合物，并且随后在体内和体外的药物递送载体中的新范例，并且被应用于现有的结核病抗生素以提高它们的功效。药物递送系统是与TB抗生素或结核抗生素组合施用的三组分复合物。组分是可以结合氮和/或氧原子的糖或糖，过渡金属离子或金属离子的组合，以及能够聚集和封闭其它组分的水溶性聚合物。三组分分子传递方法已经证明克服结核分枝杆菌对现有抗生素的细菌耐药性的能力。

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