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1. 发明申请

US20100221241A1 CONSTRAINED HIV ENVELOPE-BASED IMMUNOGEN THAT SIMULTANEOUSLY PRESENTS RECEPTOR AND CORECEPTOR BINDING SITES 审中-公开
标题翻译：受约束的基于艾滋病毒的基于免疫学的同时存在受体和修饰物结合位点的免疫学
公开(公告)号：US20100221241A1
公开(公告)日：2010-09-02
申请号：US11994870
申请日：2006-07-06
申请人： Anthony L. DeVico , George Lewis , Lai-Xi Wang
发明人： Anthony L. DeVico , George Lewis , Lai-Xi Wang
IPC分类号： A61K39/395 , C07K14/00 , A61K39/00 , A61P31/18 , A61P37/04
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/6031 , A61K2039/622 , A61K2039/64 , C07K2319/73 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates to a soluble binding complex comprising a soluble gp120 trimer, in which only two gp120 protomers have CD4 binding sites occupied by interconnecting CD4 mimetic moieties, thereby allowing for the exposure of CD4-induced epitopes on the mimetic-bound protomers and an unoccupied CD4 binding site on the third gp120 protomer.
摘要翻译：本发明涉及包含可溶性gp120三聚体的可溶性结合复合物，其中仅两个gp120反转录酶具有通过互连CD4模拟部分占据CD4结合位点，从而允许CD4-诱导的表位暴露于模拟结合的检测器上，第三个gp120原生质体上未被占据的CD4结合位点。

2. 发明申请

US20090325199A1 NANOSTRUCTURES FOR POLARIZED IMAGING AND RECEPTOR/LIGAN QUANTIZATION: BREAKING THE DIFFRACTION LIMIT FOR IMAGING 有权
标题翻译：用于极化成像和受体/配体量化的纳米结构：打破成像的衍射极限
公开(公告)号：US20090325199A1
公开(公告)日：2009-12-31
申请号：US11997778
申请日：2006-08-02
申请人： Chris D. Geddes
发明人： Chris D. Geddes
IPC分类号： G01N33/574 , G01N33/53 , G01N21/51
CPC分类号： G01N33/587 , G01N33/54346 , G01N33/54373 , Y10S436/805
摘要： The present invention relates to affinity biosensing using polarization of light scattering of aggregated noble metallic nanostructures to determine concentration of an analyte in a test sample. This new sensing system utilizes the changes in polarized plasmonic scattering from nanostructures as the nanostructures aggregate due to binding of the analyte to a binding partner attached to the surface of the metallic nanostructure.
摘要翻译：本发明涉及使用聚集的贵金属纳米结构的光散射的偏振来确定测试样品中分析物的浓度的亲和生物传感。由于分析物与附着于金属纳米结构表面的结合对象的结合，纳米结构聚集了纳米结构的极化等离子体飞散的这种新的感测系统。

3. 发明授权

US07604804B2 Enhancing anti-HIV efficiency through multivalent inhibitors targeting oligomeric gp120 失效
标题翻译：通过靶向寡聚gp120的多价抑制剂提高抗HIV效能
公开(公告)号：US07604804B2
公开(公告)日：2009-10-20
申请号：US11054398
申请日：2005-02-09
申请人： Lai-Xi Wang , Hengguang Li
发明人： Lai-Xi Wang , Hengguang Li
IPC分类号： A61K39/385 , A61K39/12 , A61K39/21
CPC分类号： G01N33/56988 , A61K31/522 , A61K31/551 , A61K31/675 , A61K38/1767 , A61K38/1774 , A61K47/55 , A61K47/62 , G01N2333/16
摘要： The present invention relates to multivalent HIV inhibitors that bind to multiple sites on a trimeric gp120 complex thereby blocking the CD4 binding site on the trimeric gp120 complex and inhibiting the attachment and entry of HIV through gp120-CD4 interactions.
摘要翻译：本发明涉及结合三聚体gp120复合物上的多个位点的多价HIV抑制剂，从而阻断三聚体gp120复合物上的CD4结合位点并抑制HIV通过gp120-CD4相互作用的附着和进入。

4. 发明申请

US20090215066A1 METHOD AND ASSAY FOR EARLY DIAGNOSIS OF PROSTATE CANCER 有权
标题翻译：早期诊断早期癌症的方法和测定
公开(公告)号：US20090215066A1
公开(公告)日：2009-08-27
申请号：US12419924
申请日：2009-04-07
申请人： Hafiz Ahmed , Gerardo Raul Vasta
发明人： Hafiz Ahmed , Gerardo Raul Vasta
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154 , C12Q2600/16
摘要： A method and assay are described for determining prostate cancer and the general stage of progression of such cancer by quantifying levels of promoter methylation of gal-3, optionally in combination with the quantification of the level of GSTP1 promoter methylation, where the method and assay are non-invasive to a subject and can detect any of Stages I-IV prostate cancer.
摘要翻译：描述了通过量化gal-3的启动子甲基化水平来确定前列腺癌和这种癌症的进展的一般阶段的方法和测定，任选地与定量GSTP1启动子甲基化水平的组合，其中方法和测定法对受试者无侵害性，可检测I-IV期前列腺癌中的任何一种。

5. 发明申请

US20090142847A1 METAL ENHANCED FLUORESCENCE-BASED SENSING METHODS 有权
标题翻译：金属增强荧光传感方法
公开(公告)号：US20090142847A1
公开(公告)日：2009-06-04
申请号：US11917804
申请日：2006-06-19
申请人： Chris D. Geddes , Sanjiv Amin
发明人： Chris D. Geddes , Sanjiv Amin
IPC分类号： G01N33/00 , G01N27/64
CPC分类号： G01N21/6428 , G01N21/648 , G01N33/728 , G01N2021/6432 , Y10T436/14 , Y10T436/143333 , Y10T436/145555 , Y10T436/146666
摘要： The present invention relates to metallic-surface detection systems for determining target substances including free bilirubin in neonatal serum in the presence of a predominantly high background of bilirubin bound Human Serum Albumin (HSA) or sensing and isolating target nucleotide sequences wherein a fluorescence signal is enhanced by close proximity of the target substances near metallic surfaces.
摘要翻译：本发明涉及金属表面检测系统，用于在存在主要高背景的胆红素结合人血清白蛋白（HSA）或检测和分离其中荧光信号增强的靶核苷酸序列的情况下测定新生儿血清中的游离胆红素的目标物质靠近金属表面附近的目标物质。

6. 发明申请

US20090142429A1 SILICIBACTER SP. STRAIN USEFUL FOR GENETIC TRANSFORMATION OF MARINE ALGAE AND PRODUCTION OF ANTIBIOTIC AGENTS 审中-公开
标题翻译： SILICIBACTER SP。应用于海洋藻类的遗传转化和抗生素的生产
公开(公告)号：US20090142429A1
公开(公告)日：2009-06-04
申请号：US11915331
申请日：2006-05-23
申请人： Robert Belas , Todd R. Miller , Jesper Bartholin Bruhn
发明人： Robert Belas , Todd R. Miller , Jesper Bartholin Bruhn
IPC分类号： A61K35/00 , C12N1/20 , C12N1/13 , A61P31/04 , C12N15/74 , C12P21/00
CPC分类号： C12R1/01 , A61K39/0208 , C07K14/195 , C12N1/20 , C12N15/8202
摘要： A Silicibacter sp. strain useful for genetic transformation of marine algae and production of antibiotic agents is described. Silicibacter sp. TM1040 is a genetically tractable member of the marine Roseobacter clade of bacteria that forms an intimate and obligate interaction with algae, and is useful as a probiotic for producing antibacterial agents that are cidally effective against pathogenic bacteria such as Mycobacterium marinum, Vibrio anguillarum, V. coralliilyticus, and V. shiloi bacteria.
摘要翻译：硅胶菌描述了对海藻的遗传转化和抗生素的生产有用的菌株。硅胶菌 TM1040是海藻类细菌分枝杆菌的遗传易感成分，与藻类形成亲密且专一的相互作用，可用作生产抗菌剂的益生菌，对抗病原菌（如分枝杆菌分枝杆菌，鳗弧菌）有效。 coralliilyticus和V.Shiloi细菌。

7. 发明申请

US20080318281A1 Thermostabillization of Dna Polymerase by Protein Folding Pathway from a Hyperthermophile Archaeon, Pyrococcus Furiosus 有权
标题翻译：通过蛋白质折叠途径从嗜热菌菌体，热球菌（Pyrococcus furiosus）对Dna聚合酶进行热释放
公开(公告)号：US20080318281A1
公开(公告)日：2008-12-25
申请号：US12065152
申请日：2006-08-29
申请人： Frank T. Robb
发明人： Frank T. Robb
IPC分类号： C12P19/34 , C07K14/00
CPC分类号： C12Q1/686 , C12Q2527/125
摘要： The present invention relates to maintaining the activity and stability of enzymes and biologically active proteins at increased temperatures by contacting same with a combination of isolated passive and active chaperones from a hyperthermopilic Archaeon, wherein the chaperones may include heat shock proteins, prefoldin and/or chaperonin proteins.
摘要翻译：本发明涉及通过使酶和生物活性蛋白质在高温下保持活性和稳定性，其与来自高热原性考古学的分离的被动和活性伴侣的组合接触，其中伴侣可包括热休克蛋白，预折合蛋白和/或伴侣蛋白蛋白质。

8. 发明授权

US07399473B2 Virus coat protein/receptor chimeras and method of use 有权
标题翻译：病毒外壳蛋白/受体嵌合体及其使用方法
公开(公告)号：US07399473B2
公开(公告)日：2008-07-15
申请号：US11124027
申请日：2005-05-06
申请人： Anthony Louis Devico , Timothy R. Fouts , Robert G. Tuskan
发明人： Anthony Louis Devico , Timothy R. Fouts , Robert G. Tuskan
IPC分类号： A61K39/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/70514 , C07K16/1063 , C07K16/2812 , C07K2317/34 , C07K2319/00 , C07K2319/30 , C07K2319/32 , C07K2319/40 , C07K2319/41 , C07K2319/735 , C12N15/62 , C12N2740/15022 , C12N2740/16122 , G01N33/56983 , G01N33/56988 , G01N2500/00
摘要： The invention relates to chimeric molecules comprising a virus coat sequence and a receptor sequence that can inter-act with each other to form a complex that is capable of binding a co-receptor. Such chimeric molecules therefore exhibit functional properties characteristic of a receptor-coat protein complex and are useful as agents that inhibit virus infection of cells due to occupancy of a co-receptor present on the cell. In particular aspects, the chimeric polypeptide includes an immunodeficiency virus envelope polypeptide, such as that of HIV, SIV, FIV, FeLV, FPV and herpes virus. Receptor sequences suitable for use in a chimeric polypeptide include, for example, CD4 D1D2 and CD4M9 sequences.
摘要翻译：本发明涉及包含能够相互作用以形成能够结合共受体的复合物的病毒外壳序列和受体序列的嵌合分子。因此，这样的嵌合分子表现出受体外壳蛋白复合物特征的功能特性，并且可用作由于细胞上存在的共 - 受体的占据而抑制细胞病毒感染的试剂。在具体方面，嵌合多肽包括免疫缺陷病毒包膜多肽，例如HIV，SIV，FIV，FeLV，FPV和疱疹病毒的多肽。适用于嵌合多肽的受体序列包括例如CD4 D1D2和CD4M9序列。

9. 发明授权

US07314741B2 Anaerobic ammonium oxidation for water treatment in recirculating aquaculture 有权
标题翻译：厌氧铵氧化用于循环水产养殖中的水处理
公开(公告)号：US07314741B2
公开(公告)日：2008-01-01
申请号：US10493179
申请日：2002-10-21
申请人： Yossi Tal , Harold J Schreier
发明人： Yossi Tal , Harold J Schreier
IPC分类号： C02F3/00
CPC分类号： C12R1/01 , A01K63/04 , A01K63/045 , C02F3/34
摘要： Disclosed herein are planctomycetes sp. which convert ammonia to nitrogen under anaerobic conditions, filtration and aquaculture systems comprising said bacteria, filtration media comprising said bacteria, and methods of filtration using said bacteria.
摘要翻译：本文公开的是扁圆菌纲其在厌氧条件下将氨转化为氮，包括所述细菌的过滤和水产养殖系统，包含所述细菌的过滤介质和使用所述细菌的过滤方法。

10. 发明申请

US20070256193A1 PLANTS WITH REDUCED EXPRESSION OF PHOSPHATASE TYPE 2C GENE FOR ENHANCED PATHOGEN RESISTANCE 有权
标题翻译：具有降低磷酸酶2C型基因表达以增强抗病性的植物
公开(公告)号：US20070256193A1
公开(公告)日：2007-11-01
申请号：US11762989
申请日：2007-06-14
申请人： Shunyuan Xiao , Wenming Wang
发明人： Shunyuan Xiao , Wenming Wang
IPC分类号： A01H1/00 , A01H3/00
CPC分类号： C12N15/8279 , C12N15/8218
摘要： The present invention relates to a method for down regulating an Arabidopsis protein phosphatase type 2C gene, referred to as “defense-associated protein phosphatase type 2C one” (DAPP1) that functions as a negative regulator of a plant defense pathway by contacting the gene or gene mRNA with an interfering nucleotide sequence that interacts with the gene and reducing expression thereof. Plants including such interfering nucleotide sequence exhibit increased disease resistance to pathogen even in the absence of R genes. Close homologs of DAPP1 exist in multiple crop species, and as such, the controlled down-regulation of homologous genes in a variety of crop species will enhance disease resistance of target crop species to pathogens.
摘要翻译：本发明涉及用于下调拟南芥属蛋白磷酸酶2C型基因的方法，称为“抗相关蛋白磷酸酶2C型”（DAPP1）（DAPP1），其作为植物防御途径的负调节剂，通过接触基因或基因mRNA与具有与该基因相互作用并减少其表达的干扰核苷酸序列。包括这种干扰核苷酸序列的植物即使在不存在R基因的情况下也表现出对病原体的抗病性。 DAPP1的密切同源物存在于多种作物物种中，因此，各种作物物种中同源基因的受控下调将提高目标作物对病原体的抗病性。

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