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1. 发明授权

US4753955A Benzimidazole derivatives 失效
标题翻译：苯并咪唑衍生物
公开(公告)号：US4753955A
公开(公告)日：1988-06-28
申请号：US012897
申请日：1987-02-10
申请人： Naoto Matsuishi , Haruki Takeda , Kenichi Iizumi , Kiyokazu Murakami , Akira Hisamitsu
发明人： Naoto Matsuishi , Haruki Takeda , Kenichi Iizumi , Kiyokazu Murakami , Akira Hisamitsu
IPC分类号： C12N9/99 , A61K31/44 , A61K31/4427 , A61P1/04 , A61P43/00 , C07D401/12
CPC分类号： C07D401/12
摘要： Benzimidazole derivatives of the general formula [I] are provided: ##STR1## wherein R.sup.1 is hydrogen, methyl or methoxy, and R.sup.2 and R.sup.3 each is hydrogen or methyl, at least one of R.sup.1, R.sup.2 and R.sup.3 being a member other than hydrogen. The benzimidazole derivatives exhibit an excellent activity of inhibiting the potassium ion-dependent adenosine triphosphatase, as well as a good stability during storage. Therefore, the benzimidazole derivatives are usable for the treatment of gastric and/or duodenal ulcers.

2. 发明授权

US5827825A Synthetic peptide, lung surfactant containing the same and remedy for respiratory distress syndrome 失效
标题翻译：含有相同的合成肽，肺表面活性剂和呼吸窘迫综合征的补救
公开(公告)号：US5827825A
公开(公告)日：1998-10-27
申请号：US652450
申请日：1996-06-05
申请人： Tsunetomo Takei , Eiji Ohtsubo , Hirosi Ohkawa
发明人： Tsunetomo Takei , Eiji Ohtsubo , Hirosi Ohkawa
IPC分类号： A61K38/00 , C07K14/785
CPC分类号： C07K14/785 , A61K38/00
摘要： Synthetic peptides containing the following specific sequence: Xaa-Pro-Val-Xbb-Xcc-Lys-Arg-W (wherein Xaa is absent or represents Cys or Ser, Xbb represents His or Asn, Xcc represents Leu or Ile and W represents a hydrophobic peptide portion.), an intermediate for producing the peptide, a process for producing the peptide, a lung surfactant comprising the peptide and a lipid mixture and a remedy for respiratory distress syndrome containing the surfactant as the active ingredient. The peptide is easy to isolate and purify and suitable for mass production. As it is highly soluble in methanol and the like, it can readily be blended with a lipid mixture and is suited for the preparation of a lung surfactant. As the lung surfactant has a good supensibility and a potent surface activity, it is useful as a remedy for respiratory distress syndrome.
摘要翻译： PCT No.PCT / JP94 / 02057 Sec。 371日期：1996年6月5日 102（e）日期1996年6月5日PCT 1994年12月7日PCT公布。公开号WO95 / 15980 日期：1995年6月15日含有以下具体序列的合成肽：Xaa-Pro-Val-Xbb-Xcc-Lys-Arg-W（其中Xaa不存在或表示Cys或Ser，Xbb表示His或Asn，Xcc表示Leu或Ile W表示疏水性肽部分），生成肽的中间体，肽的制造方法，含有该肽的肺表面活性剂和脂质混合物，以及含有表面活性剂作为活性成分的呼吸窘迫综合症的治疗剂。该肽易于分离和纯化，适合批量生产。由于其高度可溶于甲醇等，因此可容易地与脂质混合物混合，并且适用于制备肺表面活性剂。由于肺表面活性剂具有良好的显着性和强力的表面活性，因此作为呼吸窘迫综合征的治疗方法是有用的。

3. 发明授权

US4977157A Aqueous preparation of 9-methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a])pyrimidin-4-one potassium salt 失效
标题翻译： 9-甲基-3-（1H-四唑-5-基）-4H-吡啶并[1,2-a]）嘧啶-4-酮钾盐的水溶液制备
公开(公告)号：US4977157A
公开(公告)日：1990-12-11
申请号：US264439
申请日：1988-10-27
申请人： Takashi Yazaki , Kazunori Takuma
发明人： Takashi Yazaki , Kazunori Takuma
IPC分类号： A61K31/495 , A61K31/505 , A61K47/02 , A61P17/00 , A61P27/02 , A61P27/14 , A61P27/16 , A61P37/08 , C07D471/04
CPC分类号： A61K31/505 , A61K47/02
摘要： An aqueous preparation for the treatment of allergic diseases comprising 9-methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one potassium salt, dibasic potassium phosphate and monobasic potassium phosphate. The aqueous preparation has no local irritation yet has physicochemical stability during long-term storage.

4. 发明授权

US3957790A N-(3,3-diphenylpropyl)-n'-aralkyl-substituted piperazines 失效
标题翻译： N-（3,3-二苯基丙基）-N'-烷基取代的哌嗪
公开(公告)号：US3957790A
公开(公告)日：1976-05-18
申请号：US555827
申请日：1975-03-06
申请人： Tadayuki Suzuki , Toshiharu Megumi
发明人： Tadayuki Suzuki , Toshiharu Megumi
IPC分类号： C07D295/02 , A61K31/495 , A61P9/08 , A61P9/10 , C07D295/03 , C07D295/08 , C07D295/096 , C07D209/02
CPC分类号： C07D295/03 , C07D295/096
摘要： N-(3,3-Diphenylpropyl)-N'-aralkyl-substituted piperazines which have a structure in which a hydrogen in the N'-benzene ring has been substituted for by --(OCH.sub.3).sub.n (in which n represents an integer from 0 - 3) were synthesized. These compounds are novel compounds that are not found in literature, and have a coronary blood flow increasing action in considerably lower amounts than do conventional piperazine compounds having similar effects.

5. 发明授权

US4808596A Imidazo[4,5-b]pyridine compounds and pharmaceutical compositions containing same 失效
标题翻译：咪唑并[4,5-b]吡啶化合物和含有它们的药物组合物
公开(公告)号：US4808596A
公开(公告)日：1989-02-28
申请号：US77686
申请日：1987-07-24
申请人： Naoto Matsuishi , Haruki Takeda , Kenichi Iizumi , Kiyokazu Murakami , Akira Hisamitsu
发明人： Naoto Matsuishi , Haruki Takeda , Kenichi Iizumi , Kiyokazu Murakami , Akira Hisamitsu
IPC分类号： A61K31/395 , A61K31/435 , A61K31/44 , A61P1/04 , A61P43/00 , C07D231/54 , C07D471/04 , C12N9/99
CPC分类号： C07D471/04
摘要： Imidazo[4,5-b]pyridine compounds of the general formula [I] are provided: ##STR1## where R.sup.1 is straight-chain or branched C.sub.1-8 alkoxy which may be substituted with cycloalkyl, or C.sub.2-4 fluoroalkyloxy, R.sup.2 is H, methyl or methoxy, and R.sup.3 and R.sup.4 are each H or methyl and may be the same or different. All these compounds have good activity of inhibiting potassium ion-dependent adenosine triphosphatase and excellent storage stability, so that they are usable for the treatment of gastric and/or duodenal ulcers.

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