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1. 发明授权

US08409602B2 Sealants for fetal membrane repair 有权
标题翻译：胎膜修复密封剂
公开(公告)号：US08409602B2
公开(公告)日：2013-04-02
申请号：US12845949
申请日：2010-07-29
申请人： Phillip B. Messersmith , Carrie Brubaker , Corinne Zisch
发明人： Phillip B. Messersmith , Carrie Brubaker , Andreas H. Zisch
IPC分类号： A61F2/00
CPC分类号： A61L27/3604 , A61L24/046 , C08L71/02
摘要： The present invention provides a method for preventing or repairing damage to a fetal membrane. In one embodiment, the method comprises contacting a fetal membrane with a composition comprising a four-armed catechol-terminated polyethylene glycol (cPEG) and a biocompatible oxidant. In one embodiment, the four-armed cPEG and the biocompatible oxidant are initially contained in separate solutions, and the solutions are mixed to form the composition just prior to or at the same time that the composition contacts the fetal membrane.
摘要翻译：本发明提供了防止或修复对胎膜的损伤的方法。在一个实施方案中，该方法包括使胎膜与包含四臂的邻苯二酚封端的聚乙二醇（cPEG）和生物相容性氧化剂的组合物接触。在一个实施方案中，四臂cPEG和生物相容性氧化剂最初包含在单独的溶液中，并且将溶液混合以在组合物接触胎膜之前或同时形成组合物。

2. 发明授权

US08022268B2 Transgenic animal model for alzheimer's disease 有权
标题翻译：阿尔茨海默氏病的转基因动物模型
公开(公告)号：US08022268B2
公开(公告)日：2011-09-20
申请号：US12157664
申请日：2008-06-11
申请人： Jan Grimm , Roger Nitsch , Marlen Knobloch , Uwe Konietzko , Markus Rudin , Thomas Müggler , Felicitas Kranz
发明人： Jan Grimm , Roger Nitsch , Marlen Knobloch , Uwe Konietzko , Markus Rudin , Thomas Müggler , Felicitas Kranz
IPC分类号： A01K67/027 , A01K67/00 , A01K67/033
CPC分类号： C07K14/4711 , A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/0312 , A61K39/0007 , C07K14/47 , C12N15/8509 , C12N2830/008 , C12N2830/85
摘要： Provided is a novel APP (amyloid precursor protein) transgenic non-human animal modeling in vivo the pathophysiological effects and effects on cognitive behavior of early intraneuronal and extracellular brain parenchymal amyloid-β (Aβ) deposition and cerebral amyloid angiopathy associated with brain microhemorrhages and reduced vasoreactivity and blood flow. Furthermore, methods of screening for therapeutic or diagnostic agents useful in the treatment or diagnosis of Alzheimer's disease, in particular for improving blood flow to the brain are provided as well as the corresponding therapeutic methods.
摘要翻译：提供了一种新型APP（淀粉样蛋白前体蛋白）转基因非人动物体内模型，对早期神经元和细胞外脑实质淀粉样蛋白的认知行为的病理生理作用和影响。（A＆BGR）沉积和与脑微出血相关的脑淀粉样血管病变，并减少血管反应性和血流量。此外，提供了可用于治疗或诊断阿尔茨海默氏病，特别是用于改善对脑的血流量的治疗或诊断剂的筛选方法以及相应的治疗方法。

3. 发明授权

US07425334B2 Methods of making antibodies that bind Nogo 失效
标题翻译：制备结合Nogo的抗体的方法
公开(公告)号：US07425334B2
公开(公告)日：2008-09-16
申请号：US11044899
申请日：2005-01-26
申请人： Martin E. Schwab , Maio S. Chen
发明人： Martin E. Schwab , Maio S. Chen
IPC分类号： A61K39/00 , A61K38/18
CPC分类号： C07K16/22 , A61K38/00 , C07K14/475 , C07K2317/76
摘要： The present invention relates to the gene, Nogo, its encoded protein products, as well as derivatives and analogs thereof. Production of Nogo proteins, derivatives, and antibodies is also provided. The invention further relates to therapeutic compositions and methods of diagnosis and therapy.
摘要翻译：本发明涉及基因，Nogo，其编码的蛋白质产物，以及其衍生物和类似物。还提供了Nogo蛋白质，衍生物和抗体的生产。本发明还涉及治疗组合物和诊断和治疗方法。

4. 发明申请

US20080206778A1 Feline Hemoplasma Isolate 有权
标题翻译：猫血浆分离
公开(公告)号：US20080206778A1
公开(公告)日：2008-08-28
申请号：US12112151
申请日：2008-04-30
申请人： Barbara Willi , Regina Hofmann-Lehmann , Hans Lutz , Felicitas S. Boretti
发明人： Barbara Willi , Regina Hofmann-Lehmann , Hans Lutz , Felicitas S. Boretti
IPC分类号： C12Q1/68 , C12Q1/02
CPC分类号： C12Q1/689 , C07K14/30
摘要： A newly identified hemoplasma agent, Candidatus Mycoplasma turicensis, is disclosed. Also disclosed are detection methods, screening methods and methods of diagnosis for the hemoplasma agent.
摘要翻译：披露了一种新鉴定的血浆病原体（Candidatus Mycoplasma turicensis）。还公开了血浆药物的检测方法，筛选方法和诊断方法。

5. 发明授权

US07358227B2 Pharmaceutical compositions comprising bone morphogenetic protein monomers for inhibiting bone formation 失效
标题翻译：包含用于抑制骨形成的骨形态发生蛋白单体的药物组合物
公开(公告)号：US07358227B2
公开(公告)日：2008-04-15
申请号：US11346673
申请日：2006-02-03
申请人： Hermann Sailer , Franz Weber
发明人： Hermann Sailer , Franz Weber
IPC分类号： A61K38/16 , A61K38/17 , A61K38/18 , A61K38/19 , C07K14/51
CPC分类号： A61K38/1875
摘要： The present invention relates to a pharmaceutical composition containing a mixture of stable folding variants of recombinant bone morphogenic proteins (rBMPs) and its use in therapy, especially in the treatment of orthopaedic and dental patients. Specifically, the present invention relates to a pharmaceutical composition containing a mixture of stable folding variants of at least two rBMPs or their monomers or mutants in a suitable carrier system.
摘要翻译：本发明涉及包含重组骨形态发生蛋白（rBMP）的稳定折叠变体的混合物的药物组合物及其在治疗中的用途，特别是在矫形和牙科患者的治疗中。具体地说，本发明涉及含有至少两种rBMP的稳定折叠变体或其单体或突变体在合适载体体系中的混合物的药物组合物。

6. 发明公开

US20230302050A1 Single Domain Antibodies and Their Use in Cancer Therapies 审中-公开
公开(公告)号：US20230302050A1
公开(公告)日：2023-09-28
申请号：US17925411
申请日：2021-05-20
申请人： Institut Curie , Centre National de la Recherche Scientifique , The University of Zurich , Honing Biosciences
发明人： Sandrine Moutel , Franck Perez , Michele Bernasconi , Nagjie Laila Alijaj , Zélia Gouveia
IPC分类号： A61K35/17 , C12N15/63 , C07K16/28 , G01N33/574
CPC分类号： A61K35/17 , C12N15/63 , C07K16/2863 , G01N33/574 , C07K2317/565 , C07K2317/569 , C07K2317/567
摘要： The present application relates to fully humanized anti-FGFR4 single domain antibodies (sdAbs) and variants thereof. The present invention further relates to functionalized drug nanocarriers, nucleic acids, vectors, host cells, immune cells comprising said sdAbs, and compositions comprising thereof, as well as their use for therapy.

7. 发明授权

US09351742B2 Drill guide system 有权
标题翻译：钻导系统
公开(公告)号：US09351742B2
公开(公告)日：2016-05-31
申请号：US14543876
申请日：2014-11-17
申请人： DePuy Synthes Products, Inc.
发明人： Andreas Appenzeller , Ladislav Nagy , Andreas Schweizer , Daniel Fluri
IPC分类号： A61B17/58 , A61B17/17
CPC分类号： A61B17/1728 , A61B17/1732 , A61B17/1782 , A61B90/39 , A61B2090/3916
摘要： A drill guide includes a first bone plate that extends along a first middle plane, and a second bone plate that extends along a second middle plane. The drill guide further includes a first articulation and a second articulation that is connected to the first articulation. The first and second articulations are arranged between the first and the second bone plate. Each of the first and second articulations is releasably lockable.
摘要翻译：钻子引导件包括沿着第一中间平面延伸的第一骨板和沿着第二中间平面延伸的第二骨板。钻子引导器还包括连接到第一关节的第一关节和第二关节。第一和第二关节布置在第一和第二骨板之间。第一和第二关节中的每一个都是可释放地锁定的。

8. 发明授权

US07741462B2 Feline hemoplasma isolate 有权
公开(公告)号：US07741462B2
公开(公告)日：2010-06-22
申请号：US11417979
申请日：2006-05-03
申请人： Barbara Willi , Regina Hofmann-Lehmann , Hans Lutz , Felicitas S. Boretti
发明人： Barbara Willi , Regina Hofmann-Lehmann , Hans Lutz , Felicitas S. Boretti
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/689 , C07K14/30
摘要： A newly identified hemoplasma agent, Candidatus Mycoplasma turicensis, is disclosed. Also disclosed are detection methods, screening methods and methods of diagnosis for the hemoplasma agent.

9. 发明授权

US07378395B2 Mutants of bone morphogenetic proteins 失效
标题翻译：骨形态发生蛋白的突变体
公开(公告)号：US07378395B2
公开(公告)日：2008-05-27
申请号：US11452550
申请日：2006-06-14
申请人： Franz Weber
发明人： Franz Weber
IPC分类号： A61K38/00 , A61K38/18
CPC分类号： A61K38/1841 , A61K38/1875 , C07K14/51
摘要： The present invention relates to novel mutants of bone morphogenetic proteins (BMPs) useful as inhibitors of heterotopic ossification. Specifically, the present invention related to novel mutants containing only the entire region involved in the formation of finger 2 including the wrist epitope of a BMP with a specific cysteine residue or specific cysteine residues replaced by a different amino acid. The present invention also relates to pharmaceutical compositions containing these mutants and to methods for using the mutants and pharmaceutical compositions in therapy.
摘要翻译：本发明涉及可用作异位骨化抑制剂的骨形态发生蛋白（BMP）的新突变体。具体而言，本发明涉及仅包含涉及形成包含具有特定半胱氨酸残基的BMP的手腕表皮或由不同氨基酸替代的特定半胱氨酸残基的手指2的整个区域的新突变体。本发明还涉及含有这些突变体的药物组合物以及在治疗中使用突变体和药物组合物的方法。

10. 发明授权

US07074412B2 Pharmaceutical composition 失效
标题翻译：药物组成
公开(公告)号：US07074412B2
公开(公告)日：2006-07-11
申请号：US10354856
申请日：2003-01-30
申请人： Franz Weber
发明人： Franz Weber
IPC分类号： A61K39/00 , A61K38/00 , A61K47/30 , A61F2/00
CPC分类号： A61K31/785 , A61K31/4015 , A61K31/715 , A61K31/765 , A61K31/80 , A61K38/1875 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions containing a synergistic amount of at least one bone morphogenetic protein (BMP) and a synergistic amount of at least one pyrrolidone optionally in a pharmaceutically acceptable carrier, such as a biodegradable polymer. The present invention further relates to methods of treating orthopaedic and dental, including periodontal, diseases by simultaneously administering a synergistic amount of at least one bone morphogenetic protein (BMP) and a synergistic amount of at least one pyrrolidone optionally in a pharmaceutically acceptable carrier to patients in need of such treatment.
摘要翻译：本发明涉及包含协同量的至少一种骨形态发生蛋白（BMP）和协同量的至少一种吡咯烷酮的药物组合物，其任选地在药学上可接受的载体例如可生物降解的聚合物中。本发明还涉及通过在患者中同时施用协同量的至少一种骨形态发生蛋白（BMP）和协同量的至少一种吡咯烷酮，任选地在药学上可接受的载体中来治疗整形外科和牙科（包括牙周病）的方法需要这样的治疗。

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