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1. 发明公开

US20240190947A1 CAMELID ANTI-SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS ANTIBODIES 审中-公开
公开(公告)号：US20240190947A1
公开(公告)日：2024-06-13
申请号：US18286852
申请日：2022-04-07
申请人： Ernesto Rubin RESNIK , Anna Agnieszka BAJER , Cyrus B MUNSHI , Kerri Ann BOSTROM , Jody BONNEVIER , BIO-TECHNE CORPORATION
发明人： Ernesto R. Resnik , Anna Agnieszka Bajer , Cyrus B. Munshi , Kerri Ann Bostrom , Jody Bonnevier , Christine Andrea Goetz
IPC分类号： C07K16/10 , A61K49/00 , A61P31/14
CPC分类号： C07K16/1003 , A61K49/0058 , A61P31/14 , C07K2317/22 , C07K2317/31 , C07K2317/35 , C07K2317/569 , C07K2317/76
摘要： Anti-SARS-CoV-specific llama single domain antibodies, methods of making and characterizing those antibodies, and methods of using those antibodies are described herein. In some embodiments, the antibodies may bind to both SARS-CoV-1 and SARS-CoV-2. In some embodiments, the antibodies bind to S1 of the spike protein of SARS-CoV-2 including, for example, to the receptor binding domain (RBD) of S1. In some embodiments, the antibodies may block the binding of SARS-CoV-1 and/or SARS-CoV-2 to ACE-2.

2. 发明授权

US11105796B2 Methods for non-invasive profiling of stem cell differentiation 有权
公开(公告)号：US11105796B2
公开(公告)日：2021-08-31
申请号：US15622937
申请日：2017-06-14
申请人： Bio-Techne Corporation
发明人： Richard Karl Fuerstenberg , Joy Lynn Aho , Fabrizio Rinaldi
IPC分类号： G01N33/50 , A61K35/12 , A61K39/395 , C12N5/10 , C12N5/0735 , C12Q1/06 , C12N5/077 , C12N5/074 , C12N5/071 , G01N33/68 , A61K48/00
摘要： A method for characterizing stem cell differentiation includes harvesting differentiation media supernatant containing secreted analytes from key time points during a stem cell differentiation, performing at least one of a qualitative and a quantitative analysis of the differentiation media supernatant with respect to at least one secreted analyte, and identifying trends in analyte expression based on at least one of the qualitative and quantitative analysis of the differentiation media supernatant.

3. 发明授权

US10752689B2 Hybridoma clones, monoclonal antibodies to VSIG-4, and methods of making and using 有权
公开(公告)号：US10752689B2
公开(公告)日：2020-08-25
申请号：US16019011
申请日：2018-06-26
申请人： BIO-TECHNE CORPORATION
发明人： Birte Aggeler , Christine Goetz , Jody Bonnevier , Christopher Carlin Valley , Chris Hammerbeck , Ernesto Ruben Resnik
IPC分类号： C07K16/00 , C12P21/08 , C07K16/28 , A61K31/573 , A61P37/06 , A61P35/00 , C12N5/16
摘要： Described herein are monoclonal antibodies that bind to VSIG-4 including antibodies that block the binding of VSIG-4 to SIGLEC-7, compositions including the monoclonal antibodies, and methods of making and using those antibodies and compositions.

4. 发明授权

US09410182B2 Phosphatase coupled glycosyltransferase assay 有权
标题翻译：磷酸酶偶联糖基转移酶测定
公开(公告)号：US09410182B2
公开(公告)日：2016-08-09
申请号：US13699175
申请日：2010-05-24
申请人： Zhengliang L. Wu
发明人： Zhengliang L. Wu
IPC分类号： C12Q1/48 , C12Q1/42
CPC分类号： C12Q1/42 , C12Q1/48 , G01N2333/91091 , G01N2333/914
摘要： A kit for detecting or measuring glycosyltransferase activity including a first reagent comprising a phosphatase and a second reagent comprising a free phosphate detector, and method of detecting and measuring glycosyltransferase activity. A sugar donor, an acceptor substrate, a glycosyltransferase enzyme and a phosphatase are combined and the amount of free phosphate present in the product is measured and used to calculate the activity of the glycosyltransferase enzyme.
摘要翻译：用于检测或测量糖基转移酶活性的试剂盒，包括含有磷酸酶的第一试剂和包含游离磷酸盐检测器的第二试剂，以及检测和测量糖基转移酶活性的方法。将糖供体，受体底物，糖基转移酶和磷酸酶组合，测量产物中存在的游离磷酸盐的量并用于计算糖基转移酶的活性。

5. 发明授权

US4465377A Magnetic stirrer apparatus with guided, floating stirrer 失效
标题翻译：磁力搅拌器带导向浮动搅拌器
公开(公告)号：US4465377A
公开(公告)日：1984-08-14
申请号：US502619
申请日：1983-06-07
申请人： Norman A. de Bruyne
发明人： Norman A. de Bruyne
IPC分类号： B01F13/08
CPC分类号： B01F13/0818 , B01F13/0827 , B01F13/0863
摘要： A magnetic stirrer apparatus includes a vessel for liquid and a floating stirrer. The floating stirrer is rotated by a magnet driven by a magnetic field generator laterally of the vessel, and a guide rod through the floating stirrer restricts its movement to rotary movement and substantially vertical movement with change in the liquid level. The magnetic field generator is operative at any level of the liquid in the vessel.
摘要翻译：磁力搅拌器装置包括用于液体的容器和浮动搅拌器。浮动搅拌器由磁体驱动的磁体在容器的侧面驱动旋转，通过浮动搅拌器的导杆将其运动限制在旋转运动和基本上垂直的运动，随着液面的变化。磁场发生器在容器中的液体的任何水平处操作。

6. 发明公开

US20230143582A1 METHODS OF USING A TGF-beta KNOCKOUT CELL LINE AND COMPOSITIONS RESULTING THEREFROM 审中-公开
公开(公告)号：US20230143582A1
公开(公告)日：2023-05-11
申请号：US17797496
申请日：2021-03-23
申请人： BIO-TECHNE CORPORATION
发明人： Anthony D. Person , John E. Humphrey
IPC分类号： C07K14/475 , C12N5/00 , C12N15/90 , C07K14/51
CPC分类号： C07K14/475 , C12N5/00 , C12N15/907 , C07K14/51
摘要： This disclosure describes protein compositions including minimal TGFβ1 contamination, methods for making those protein compositions, and methods for using those protein compositions. In one aspect, this disclosure describes protein compositions produced by a TGFβ1 knockout cell line and methods for using those compositions including, for example, in research or as a therapeutic or prophylactic. In another aspect, this disclosure describes a TGFβ1 knockout cell line and methods of making that cell line.

7. 发明申请

US20210380649A1 WNT/SFRP COMPLEXES, WNT-CONTAINING COMPOSITIONS, WNT-EXPRESSING CELLS, AND METHODS OF MAKING, PURIFYING, AND USING SAME 有权
公开(公告)号：US20210380649A1
公开(公告)日：2021-12-09
申请号：US17351452
申请日：2021-06-18
申请人： BIO-TECHNE CORPORATION
发明人： Anthony Person , Liwen Xiong , Ming Bi , Camrin Tracy
IPC分类号： C07K14/47 , C07K14/71 , C12Q1/6897 , C07K14/475 , C07K19/00
摘要： This disclosure describes isolated protein complexes including a Wnt and a sFRP; compositions including a Wnt; a cell overexpressing a Wnt and a sFRP; compositions including a cell overexpressing a Wnt and a cell overexpressing a sFRP; methods of making the protein complexes, compositions, and cells; and methods of using the isolated protein complexes, compositions, and cells. This disclosure further describes methods of forming a complex including a Wnt and a sFRP and methods for isolating a Wnt. Also described herein are methods that may be used to purify a Wnt without the use of a detergent.

8. 发明授权

US10890586B2 Methods and kits for assaying endoglycosidase activity 有权
公开(公告)号：US10890586B2
公开(公告)日：2021-01-12
申请号：US15725835
申请日：2017-10-05
申请人： Bio-Techne Corporation
发明人： Zhengliang L. Wu , Xinyi Huang , Cheryl M. Ethen
IPC分类号： G01N33/58 , C12Q1/34 , G01N33/573 , C12Q1/48
摘要： A method for assaying endoglycosidase activity includes providing a proteoglycan having a glycosaminoglycan chain with a non-reducing end; treating the proteoglycan with a glycosyltransferase to incorporate a carbohydrate into the non-reducing end of the glycosaminoglycan chain, wherein the carbohydrate includes a click chemistry moiety; adding a label to the proteoglycan, wherein the label includes a click chemistry moiety that reacts to the click chemistry moiety of the carbohydrate such that the label attaches to the carbohydrate to form a labeled proteoglycan; immobilizing the labeled proteoglycan on a multi-well plate, wherein the multi-well plate includes a specific anti-proteoglycan antibody for binding the labeled proteoglycan; treating the labeled proteoglycan with an endoglycosidase specific to the glycosaminoglycan chain; and detecting the labeled proteoglycan.

9. 发明授权

US4759635A Magnetic stirrer apparatus with improved stirring action 失效
标题翻译：具有改善搅拌作用的磁力搅拌器
公开(公告)号：US4759635A
公开(公告)日：1988-07-26
申请号：US904005
申请日：1986-09-04
申请人： Gregory J. MacMichael , Norman A. de Bruyne
发明人： Gregory J. MacMichael , Norman A. de Bruyne
IPC分类号： C12M1/02 , B01F13/08
CPC分类号： B01F13/0818 , B01F13/0827 , B01F13/0863
摘要： A stirrer apparatus for stirring culture medium has a flask with a lid, a floating magnetic stirrer responsive to a moving magnetic field, and a moving field generator including poles and coils. A guide system is provided for the stirrer including a rod which extend upwardly from the stirrer and a tube which extends through the lid, the rod extending into and being rotatable in the tube; the tube has a closed upper end. A stirrer apparatus having a floating magnetic stirrer with a central, downwardly extending, closed end guide tube, and lid with a guide rod extending into the guide tube. The stirrer included one or more continuous impellers extending across the rotational axis of the stirrer; in one embodiment, the impeller is provided by a bar magnet or magnets beneath a float and in another embodiment a bar magnet is within the float, and the impeller is a continuous blade.
摘要翻译：用于搅拌培养基的搅拌器装置具有带盖的烧瓶，响应于移动磁场的浮动磁力搅拌器和包括杆和线圈的运动场发生器。提供了一种用于搅拌器的引导系统，其包括从搅拌器向上延伸的杆和延伸穿过盖的管，杆延伸到管中并且可旋转; 该管具有封闭的上端。一种搅拌器装置，具有带有中心向下延伸的封闭端导管的浮动磁力搅拌器，以及具有延伸到导管中的导向杆的盖子。搅拌器包括一个或多个延伸穿过搅拌器旋转轴线的连续叶轮; 在一个实施例中，叶轮由浮子下方的棒状磁体或磁体提供，在另一个实施例中，杆状磁体位于浮子内，并且叶轮是连续的叶片。

10. 发明公开

US20240168030A1 DIRECT FLUORESCENT GLYCAN LABELING 审中-公开
公开(公告)号：US20240168030A1
公开(公告)日：2024-05-23
申请号：US17773282
申请日：2020-10-30
申请人： BIO-TECHNE CORPORATION
发明人： Zhengliang Wu , Mark Russell Whittaker , Anthony D. Person , Vassilios Kalabokis , James Michael Ertelt
IPC分类号： G01N33/58
CPC分类号： G01N33/582
摘要： This disclosure describes compositions including fluorophore-conjugated sialic acids and fluorophore-conjugated fucose and methods of making and using those compositions. A fluorophore-conjugated sialic acid may include a cytidine monophosphate activated fluorophore-conjugated sialic acids (CMP-f-SA); a fluorophore-conjugated fucose may include a guanosine 5′-diphosphate activated fluorophore-conjugated fucose (GDP-f-Fuc). Methods of using the compositions include enzymatic incorporation of a fluorophore-conjugated sialic acid or a fluorophore-conjugated fucose or both to label and detect N- and O-glycans on glycoproteins. The compositions and methods may allow for the detection of specific glycans.

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