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1. 发明公开

US20240197769A1 METHODS AND COMPOSITIONS FOR TREATING WOUNDS UTILIZING CHITOSAN COMPOUNDS 审中-公开
公开(公告)号：US20240197769A1
公开(公告)日：2024-06-20
申请号：US18333968
申请日：2023-06-13
申请人： SYNEDGEN, INC.
发明人： Shenda M. Baker , William P. Wiesmann , Ruth Baxter
IPC分类号： A61K31/722 , A61K47/61 , A61L26/00 , C08L5/08
CPC分类号： A61K31/722 , A61K47/61 , A61L26/0023 , A61L26/0066 , C08L5/08 , A61L2300/404 , A61L2300/41 , A61L2300/64
摘要： Described herein are methods of treating wounds, the method comprising administering to a subject an effective amount of a composition comprising a soluble or derivatized chitosan wherein the soluble or derivatized chitosan when administered contacts the wound, thereby treating the wound.

2. 发明申请

US20210386774A1 METHODS FOR TREATMENT OR PREVENTION OF DAMAGE RESULTING FROM RADIATION, TRAUMA OR SHOCK 有权
公开(公告)号：US20210386774A1
公开(公告)日：2021-12-16
申请号：US17150406
申请日：2021-01-15
申请人： SYNEDGEN, INC.
发明人： Shenda M. Baker , William P. Wiesmann
IPC分类号： A61K31/726
摘要： Described herein are methods of treating a subject that has been or will be exposed to radiation, trauma or shock, the method comprising identifying a subject that has been or will be exposed to radiation, and treating the subject with a compound that treats, reduces the severity or delays the onset of sepsis or reduces the likelihood of mortality in a subject upon administration of a therapeutically effective amount the compound to the subject.

3. 发明授权

US11077135B2 Derivatized chitosan polymers and methods of treating vascular disorders 有权
公开(公告)号：US11077135B2
公开(公告)日：2021-08-03
申请号：US15752852
申请日：2016-08-12
申请人： Synedgen, Inc.
发明人： Shenda Baker , William P. Wiesmann
IPC分类号： A61K31/715 , A61K9/00 , A61P9/00 , A61K31/726 , A61K45/06 , A61K31/7008
摘要： Described herein are methods for treating inflammation, swelling and secondary damage of the vascular and lymphatic system in a subject, for example of the brain, spinal cord, and lungs; from organ reperfusion, e.g., resulting from endothelial leakage, glycocalyx dysfunction or loss of structural integrity of the glycocalyx.

4. 发明授权

US10022393B2 Methods for treatment or prevention of damage resulting from radiation, trauma or shock 有权
公开(公告)号：US10022393B2
公开(公告)日：2018-07-17
申请号：US14033332
申请日：2013-09-20
申请人： SYNEDGEN, INC.
发明人： Shenda M. Baker , William P. Wiesmann
IPC分类号： A61K31/726
摘要： Described herein are methods of treating a subject that has been or will be exposed to radiation, trauma or shock, the method comprising identifying a subject that has been or will be exposed to radiation, and treating the subject with a compound that treats, reduces the severity or delays the onset of sepsis or reduces the likelihood of mortality in a subject upon administration of a therapeutically effective amount the compound to the subject.

5. 发明申请

US20150224044A1 ORAL CARE METHODS AND COMPOSITIONS UTILIZING CHITOSAN-DERIVATIVE COMPOUNDS 审中-公开
标题翻译：口服护理方法和使用化合物衍生化合物的组合物
公开(公告)号：US20150224044A1
公开(公告)日：2015-08-13
申请号：US14495192
申请日：2014-09-24
申请人： SYNEDGEN, INC.
发明人： Shenda M. Baker , William P. Wiesmann , Stacy Marie Townsend
IPC分类号： A61K8/73 , A61Q17/00 , A61Q11/00
CPC分类号： A61K8/736 , A61K2800/30 , A61Q11/00 , A61Q11/02 , A61Q17/005
摘要： Described herein is a method of reducing bacteria in the mouth of a subject, the method comprising contacting (e.g., rinsing) the mouth with an effective amount of a composition comprising a soluble derivatized chitosan, thereby reducing bacteria in the mouth of the subject.
摘要翻译：本文描述的是减少受试者口腔中的细菌的方法，该方法包括使口部接触（例如，漂洗）有效量的包含可溶性衍生化壳聚糖的组合物，从而减少受试者口腔中的细菌。

6. 发明授权

US09012429B2 Methods and compositions for the prevention of and treatment of infections utilizing chitosan-derivative compounds 有权
标题翻译：使用壳聚糖衍生物化合物预防和治疗感染的方法和组合物
公开(公告)号：US09012429B2
公开(公告)日：2015-04-21
申请号：US12541584
申请日：2009-08-14
申请人： Shenda Baker , William P. Wiesmann
发明人： Shenda Baker , William P. Wiesmann
IPC分类号： A61K31/722
CPC分类号： A61K31/722
摘要： The present invention is directed to the treatment and prevention of nosocomial infections or MRSA infections utilizing soluble chitosan or chitosan derivative compounds. These chitosan-derivative compounds, e.g., chitosan-arginine and chitosan-acid amines, exhibit bactericidal activity against bacterial pathogens, e.g., drug resistant bacteria such as Methicillin-resistant Staphylococcus aureus (MRSA).
摘要翻译：本发明涉及利用可溶性壳聚糖或壳聚糖衍生物化合物治疗和预防医院感染或MRSA感染。这些壳聚糖衍生物化合物，例如壳聚糖 - 精氨酸和壳聚糖酸胺，对细菌病原体，例如抗药性细菌如耐甲氧西林金黄色葡萄球菌（MRSA）表现出杀菌活性。

7. 发明授权

US10765616B2 Oral formulation of polyglucosamine derivatives in combination with a non-fermentable sugar 有权
公开(公告)号：US10765616B2
公开(公告)日：2020-09-08
申请号：US15948446
申请日：2018-04-09
申请人： SYNEDGEN, INC.
发明人： Stacy M. Townsend , Shenda M. Baker , William P. Wiesmann
IPC分类号： A61K8/73 , A61K8/49 , A61K8/92 , A61K8/368 , A61Q17/00 , A61C17/20 , A61K31/155 , A61K31/4164 , A61K31/726 , A61K8/34 , A61K31/047 , A61K31/722 , A61K45/06 , A61Q11/00
摘要： Described herein are methods and compositions that contain a soluble polyglucosamine or polyglucosamine derivative for use in oral health. The compositions are useful for, e.g., reducing bacteria (e.g., by clumping and removing) or disrupting a biofilm in the mouth of a subject, reducing dry mouth, and reducing oral inflammation.

8. 发明申请

US20140301955A1 CHITOSAN-DERIVATIVE COMPOUNDS AND METHODS OF CONTROLLING MICROBIAL POPULATIONS 有权
标题翻译：化合物衍生化合物和控制微生物群体的方法
公开(公告)号：US20140301955A1
公开(公告)日：2014-10-09
申请号：US14153699
申请日：2014-01-13
申请人： Shenda M. Baker , William P. Wiesmann
发明人： Shenda M. Baker , William P. Wiesmann
IPC分类号： A61K31/722
CPC分类号： C08B37/003 , A61K8/736 , A61K31/722 , A61L2/232 , A61L2/235 , A61L2202/23 , A61L2202/24 , A61Q11/00 , A61Q17/005 , C08L5/08 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y02A50/483
摘要： The present invention is directed to chitosan-derivative compounds and structures, methods of making chitosan-derivative compounds and methods for controlling, inhibiting and enhancing microbial populations in a variety of environments. The present invention is also directed to the control, inhibition and enhancement of microbial populations in animals, particularly humans. The microbial populations include bacteria, viruses and other pathogens where control of microbial populations are a necessity. The chitosan-derivative compounds of the present invention include chitosan-arginine compounds, related chitosan-L/D unnatural amino acid compounds, chitosan-acid amine compounds, chitosan-L/D natural amino acid derivative compounds, co-derivatives of the chitosan-derivative compounds, salts of the chitosan derivative compounds, and chitosan-guanidine compounds.
摘要翻译：本发明涉及壳聚糖衍生物化合物和结构，制备壳聚糖衍生物化合物的方法以及在各种环境中控制，抑制和增强微生物群体的方法。本发明还涉及动物，特别是人类中微生物群体的控制，抑制和增强。微生物种群包括细菌，病毒和其他需要控制微生物群落的病原体。本发明的壳聚糖衍生物包括壳聚糖 - 精氨酸化合物，壳聚糖-L / D非天然氨基酸化合物，壳聚糖酸胺化合物，壳聚糖-L / D天然氨基酸衍生物化合物，壳聚糖 - 衍生化合物，壳聚糖衍生物化合物的盐和壳聚糖 - 胍化合物。

9. 发明申请

US20140221308A1 METHODS AND COMPOSITIONS OF REDUCING AND PREVENTING BACTERIAL GROWTH AND THE FORMATION OF BIOFILM ON A SURFACE UTILIZING CHITOSAN-DERIVATIVE COMPOUNDS 审中-公开
标题翻译：减少和预防细菌生长的方法和组合物和利用酪氨酸衍生化合物的表面上生物素的形成
公开(公告)号：US20140221308A1
公开(公告)日：2014-08-07
申请号：US14130253
申请日：2012-06-29
申请人： Shenda Baker , William P. Wiesmann , Stacy M. Townsend
发明人： Shenda Baker , William P. Wiesmann , Stacy M. Townsend
IPC分类号： A01N43/16
CPC分类号： A01N43/16 , A01N47/44 , A23B4/20 , A23L3/3463 , A23L3/3526 , A23L3/3562 , C11D3/227 , C11D3/48
摘要： A method of treating a surface, the method comprising contacting (e.g., spraying) an effective amount of a composition comprising a chitosan (e.g., soluble or derivatized chitosan) with the surface, thereby treating the surface. Non-pharmaceutical compositions (e.g., liquid or dry powder compositions) include chitosan (e.g., a soluble or derivatized chitosan). The compounds and compositions described herein are biocompatible (e.g., non-toxic) and/or biodegradable (e.g., eco-friendly). Methods using the compositions described herein include methods of treating a surface (e.g., an inert and/or non-animal surface, e.g., a synthetic or semi-synthetic surface (e.g., cellulose, ceramic, plastic, metal, glass, wood, or stone); or a food or food product surface, the method comprising contacting (e.g., spraying) an effective amount of a composition comprising a chitosan (e.g., a soluble or derivatized chitosan described herein) with the inert and/or non-animal surface, or the food or food product surface, thereby treating the surface.
摘要翻译：一种处理表面的方法，该方法包括将有效量的包含壳聚糖（例如可溶性或衍生化壳聚糖）的组合物与表面接触（例如，喷雾），从而处理表面。非药物组合物（例如液体或干粉组合物）包括壳聚糖（例如，可溶或衍生的壳聚糖）。本文所述的化合物和组合物是生物相容的（例如，无毒的）和/或可生物降解的（例如，环保的）。使用本文所述组合物的方法包括处理表面（例如，惰性和/或非动物表面，例如合成或半合成表面（例如纤维素，陶瓷，塑料，金属，玻璃，木材或石头）;或食品或食品表面，所述方法包括将有效量的包含壳聚糖（例如本文所述的可溶性或衍生化壳聚糖）与惰性和/或非动物表面的组合物（例如，喷雾），或食品或食品表面，从而处理表面。

10. 发明申请

US20140080785A1 METHODS FOR TREATMENT OR PREVENTION OF DAMAGE RESULTING FROM RADIATION, TRAUMA OR SHOCK 有权
标题翻译：用于治疗或预防由辐射，TRAUMA或SHOCK引起的损伤的方法
公开(公告)号：US20140080785A1
公开(公告)日：2014-03-20
申请号：US14033332
申请日：2013-09-20
申请人： SYNEDGEN, INC.
发明人： Shenda M. Baker , William P. Wiesmann
IPC分类号： A61K31/726
CPC分类号： A61K31/726 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： Described herein are methods of treating a subject that has been or will be exposed to radiation, trauma or shock, the method comprising identifying a subject that has been or will be exposed to radiation, and treating the subject with a compound that treats, reduces the severity or delays the onset of sepsis or reduces the likelihood of mortality in a subject upon administration of a therapeutically effective amount the compound to the subject.
摘要翻译：本文描述的是治疗已经或将要暴露于辐射，创伤或休克的受试者的方法，所述方法包括鉴定已经或将要暴露于辐射的受试者，以及用治疗，减少严重性或延迟败血症的发作或减少受试者死亡的可能性，其中给予受试者治疗有效量的化合物。

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