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1. 发明授权

US5756747A 1H-imidazo�4,5-c!quinolin-4-amines 失效
标题翻译： 1H-咪唑并[4,5-c]喹啉-4-胺
公开(公告)号：US5756747A
公开(公告)日：1998-05-26
申请号：US455273
申请日：1995-05-31
申请人： John F. Gerster
发明人： John F. Gerster
IPC分类号： C07D215/42 , C07D471/04
CPC分类号： C07D215/42
摘要： Novel 1H-imidazo�4,5-c!quinolin-4-amines are disclosed. The compounds function as antiviral agents and they are potential synthetic intermediates in the preparation of known antiviral agents and labeled known antiviral agents. Processes for the preparation of the compounds, methods for their antiviral use, and methods of inducing interferon biosynthesis, are also described.
摘要翻译：公开了新的1H-咪唑并[4,5-c]喹啉-4-胺。该化合物作为抗病毒剂起作用，并且它们是制备已知抗病毒剂和标记的已知抗病毒剂的潜在的合成中间体。还描述了制备化合物的方法，其抗病毒用途的方法和诱导干扰素生物合成的方法。

2. 发明授权

US5750134A Bioadhesive composition and patch 失效
公开(公告)号：US5750134A
公开(公告)日：1998-05-12
申请号：US510046
申请日：1995-05-31
申请人： Matthew T. Scholz , Robert A. Scherrer , Nelda M. Marecki , Yen-Lane Chen , Joan K. Barkhaus
发明人： Matthew T. Scholz , Robert A. Scherrer , Nelda M. Marecki , Yen-Lane Chen , Joan K. Barkhaus
IPC分类号： A61K9/00 , A61K9/70 , A61L15/58 , A61K47/32
CPC分类号： A61K9/7053 , A61K9/006 , A61L15/585
摘要： A bioadhesive composition that adheres suitably to a mucosal surface and is capable of delivering drugs in sustained fashion, and a patch comprising the bioadhesive composition. Methods of using and processes for preparing the bioadhesive composition are also described.

3. 发明授权

US5238944A Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine 失效
标题翻译：含有1-异丁基-1H-咪唑并[4,5-c]喹啉-4-胺的局部制剂和透皮递送系统
公开(公告)号：US5238944A
公开(公告)日：1993-08-24
申请号：US845323
申请日：1992-03-03
申请人： Steven M. Wick , Helen J. Schultz , Gregory R. Nelson , Amit K. Mitra , Stephen M. Berge
发明人： Steven M. Wick , Helen J. Schultz , Gregory R. Nelson , Amit K. Mitra , Stephen M. Berge
IPC分类号： A61K9/00 , A61K9/70 , A61K31/47 , A61K31/4709 , A61K47/12
CPC分类号： A61K9/7061 , A61K31/47 , A61K31/4709 , A61K47/12 , A61K9/0014 , Y10S514/947
摘要： Pharmaceutical formulations and adhesive-coated sheet materials for the topical and/or transdermal delivery of 1-isobutyl-1H-imidazo[4,5-c]-quinolin-4-amine, including creams, ointments and pressure-sensitive adhesive compositions. Pharmacological methods of using the formulations and the adhesive-coated sheet materials of the invention in the treatment of viral infections.
摘要翻译：药物制剂和用于局部和/或透皮递送1-异丁基-1H-咪唑并[4,5-c] - 喹啉-4-胺（包括霜剂，软膏和压敏粘合剂组合物）的粘合剂涂层片材。使用本发明的制剂和粘合剂包被的片材的药理学方法来治疗病毒感染。

4. 发明授权

US5066822A Di-t-butylphenols substituted by an alkoxy or benzyloxy group or a benzylthio group 失效
标题翻译：被烷氧基或苄氧基或苄硫基取代的二叔丁基酚
公开(公告)号：US5066822A
公开(公告)日：1991-11-19
申请号：US571925
申请日：1990-06-29
申请人： Mark A. Rustad
发明人： Mark A. Rustad
IPC分类号： C07C59/68 , C07C65/24 , C07C255/53 , C07D257/04
CPC分类号： C07D257/04 , C07C255/00 , C07C323/00 , C07C59/68 , C07C65/24
摘要： Novel compounds which are 2,6-di-t-butylphenols substituted in the 4 position by an alkoxy or benzyloxy group or a benzylthio group, which alkoxy or benzyloxy group is directly substituted by a tetrazole ring, and which benzylthio group is directly substituted by carboxy or tetrazolyl are useful as inhibitors of leukotriene biosynthesis and as antiallergic agents. Synthetic intermediates for preparing such compounds are also described.
摘要翻译：通过烷氧基或苄氧基或苄硫基取代4位的2,6-二叔丁基酚的新型化合物，该烷氧基或苄氧基直接被四唑环取代，该苄硫基直接被四唑环取代羧基或四唑基可用作白三烯生物合成的抑制剂和抗过敏药。还描述了用于制备这种化合物的合成中间体。

5. 发明授权

US5049572A Substituted di-t-butylphenols and anti-allergic use thereof 失效
标题翻译：取代的二叔丁基酚及其抗过敏应用
公开(公告)号：US5049572A
公开(公告)日：1991-09-17
申请号：US593342
申请日：1990-10-01
申请人： Robert A. Scherrer , Mark A. Rustad
发明人： Robert A. Scherrer , Mark A. Rustad
IPC分类号： A61K31/325 , C07C233/64 , C07D257/04
CPC分类号： C07D257/04 , C07C255/00
摘要： Novel compounds which are 2,6-di-t-butylphenols substituted in the 4 position by a carbamyl or acylamino group, which carbamyl or acylamino group is substituted by a group which includes an acidic substituent are useful as inhibitors of leukotriene biosynthesis and as antiallergic agents. Pharmacological methods for using such compounds and synthetic intermediates for preparing such compounds are also disclosed.
摘要翻译：作为氨基甲酰基或酰氨基取代4位的2,6-二叔丁基酚的新型化合物，该氨基甲酰基或酰氨基被包含酸性取代基的基团取代，可用作白三烯生物合成抑制剂和抗过敏药代理商还公开了使用这些化合物和合成中间体制备这些化合物的药理学方法。

6. 发明授权

US4860740A Powder inhalation device 失效
标题翻译：粉末吸入装置
公开(公告)号：US4860740A
公开(公告)日：1989-08-29
申请号：US13191
申请日：1987-02-10
申请人： William F. Kirk , Anthony C. L. Wass , Eric A. Baum , Ian P. Tansey , William G. Meredith
发明人： William F. Kirk , Anthony C. L. Wass , Eric A. Baum , Ian P. Tansey , William G. Meredith
IPC分类号： A61M13/00 , A61M15/00
CPC分类号： A61M15/0028 , A61M15/0031 , A61M15/0065 , A61M2202/064
摘要： A device facilitating the inhalation of powdered medicaments from within a container. The device comprises a body having walls partially defining a chamber, an inlet port into the chamber for the entry of air, and a mouthpiece having a central through opening communicating with the chamber. A support member also partially defines the chamber and is manually movable relative to the body to convey a first portion of the container from (1) a first position spaced from the chamber to (2) a predetermined dispense position within the chamber with an open end of the first capsule portion uppermost so that airflow into the inlet port and through the chamber induced by suction at the mouthpiece will cause the powdered medicament in the first container portion to become entrained in the airflow; and an extractor is mounted for movement relative to the body to remove a second container portion and open the container prior to positioning of the first container portion at the dispense position.
摘要翻译：一种便于从容器内吸入粉末状药物的装置。该装置包括具有部分地限定腔室的壁的主体，进入空气入口的入口端口以及具有与腔室连通的中心通孔的接口管。支撑构件还部分地限定腔室并且可手动地相对于主体移动以将容器的第一部分从（1）与腔隔开的第一位置传送到（2）腔室内的预定分配位置，开口端第一胶囊部分最上部，使得通过吸嘴处的吸引引入入口和通过腔室的气流将导致第一容器部分中的粉末药物被夹带在气流中; 并且提取器被安装成相对于主体移动以去除第二容器部分并且在将第一容器部分定位在分配位置之前打开容器。

7. 发明授权

US4710515A Substituted biphenyl derivatives 失效
标题翻译：取代的联苯衍生物
公开(公告)号：US4710515A
公开(公告)日：1987-12-01
申请号：US26877
申请日：1987-03-17
申请人： Alan R. Kirk , Robert A. Scherrer
发明人： Alan R. Kirk , Robert A. Scherrer
IPC分类号： C07C233/25 , A61K31/165 , A61K31/19 , A61K31/194 , A61K31/195 , A61K31/215 , A61K31/225 , A61P11/00 , A61P37/08 , A61P43/00 , C07C67/00 , C07C231/00 , C07C233/60 , C07C233/75 , C07C235/16
CPC分类号： A61K31/195
摘要： Novel compounds which are 2,6-di-tertiary-butylphenols substituted in the 4 position by an acylaminophenyl group, which acylaminophenyl group is substituted by a moiety which includes a carboxyl group, are useful as inhibitors of leukotriene biosynthesis and as antiallergic agents.

8. 发明授权

US4689338A 1H-Imidazo[4,5-c]quinolin-4-amines and antiviral use 失效
标题翻译： 1H-咪唑并[4,5-c]喹啉-4-胺和抗病毒用途
公开(公告)号：US4689338A
公开(公告)日：1987-08-25
申请号：US798385
申请日：1985-11-15
申请人： John F. Gerster
发明人： John F. Gerster
IPC分类号： A61K31/47 , C07D215/42 , C07D471/04
CPC分类号： C07D471/04 , C07D215/42
摘要： 1H-Imidazo[4,5-c]quinolin-4-amines which are antivirals. Pharmacological methods of using such compounds and pharmaceutical compositions containing such compounds are also described.
摘要翻译： 1H-咪唑并[4,5-c]喹啉-4-胺，其为抗病毒剂。还描述了使用这些化合物的药理学方法和含有这些化合物的药物组合物。

9. 发明授权

US4642384A Process for the preparation of derivatives of pyrrolidine and piperidine 失效
标题翻译：制备吡咯烷和哌啶衍生物的方法
公开(公告)号：US4642384A
公开(公告)日：1987-02-10
申请号：US772470
申请日：1985-09-04
申请人： Charles M. Leir
发明人： Charles M. Leir
IPC分类号： C07C43/225 , C07C45/46 , C07C45/63 , C07C49/84 , C07C65/21 , C07D211/26 , C07C49/80
CPC分类号： C07D211/26 , C07C43/225 , C07C45/46 , C07C45/63 , C07C49/84 , C07C65/21
摘要： Processes and intermediates for the preparation of the antiarrhythmic agent 2,5-bis(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)benzamide.
摘要翻译：用于制备抗心律不齐剂2,5-双（2,2,2-三氟乙氧基）-N-（2-哌啶基甲基）苯甲酰胺的方法和中间体。

10. 发明授权

US4572910A Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings 失效
标题翻译：由含氮杂环取代的三唑并[1,5-c]嘧啶
公开(公告)号：US4572910A
公开(公告)日：1986-02-25
申请号：US471836
申请日：1983-03-03
申请人： James J. Wade
发明人： James J. Wade
IPC分类号： C07D239/42 , C07D239/48 , C07D487/04 , A61K31/505 , A61K31/535 , A61K31/54 , C07D471/04
CPC分类号： C07D239/42 , C07D239/48 , C07D487/04
摘要： 1,2,4-Triazolo[1,5-c]pyrimidines substituted at the 5 or 7 positions through a nitrogen atom which is part of a heterocyclic ring have been found to have potent bronchodilator activity. Methods for inducing bronchodilation, pharmaceutical compositions and synthetic processes are also disclosed.
摘要翻译：已经发现通过作为杂环的一部分的氮原子在5或7位取代的1,2,4-三唑并[1,5-c]嘧啶具有有效的支气管扩张剂活性。还公开了诱导支气管扩张的方法，药物组合物和合成方法。

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