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1. 发明授权

US07346202B1 Automatically detecting the presence of contrast agent in medical image 有权
标题翻译：自动检测医学影像中造影剂的存在
公开(公告)号：US07346202B1
公开(公告)日：2008-03-18
申请号：US10998238
申请日：2004-11-24
申请人： Alexander C. Schneider
发明人： Alexander C. Schneider
IPC分类号： G06K9/00
CPC分类号： G06K9/00 , G06K2209/05 , Y10S128/922
摘要： A CAD system pre-analyzes a medical image to automatically determine whether contrast agent was introduced into the patient before forming that image. In one embodiment, contrast agent detection is performed by comparing the voxel values in known blood-containing areas to voxel values of known water-containing areas, and if there is a substantial difference above a preferred threshold, then it is determined that this patient was indeed injected with the contrast agent. Upon finding that the patient was indeed injected with contrast agent, the CAD algorithm then automatically performs both a detection algorithm that uses the contrast agent and one that does not and notifies the clinician that both sets of results are available to look at. However, if it is determined that the patient was not injected with contrast agent, the CAD algorithm does not perform the algorithm that uses the contrast agent does not give the user the option to view any results from such algorithm. The invention may be practiced with a variety of imaging technologies some of which may not require an explicit comparison of the voxel values from the blood-containing and water-containing areas.
摘要翻译： CAD系统预先分析医学图像以自动确定在形成该图像之前是否将造影剂引入患者体内。在一个实施例中，通过将已知含血区域的体素值与已知含水区域的体素值进行比较来进行造影剂检测，并且如果在优选阈值之上存在显着差异，则确定该患者是确实注射了造影剂。当发现患者确实注射造影剂时，CAD算法然后自动执行使用造影剂的检测算法，而不是通过临床医生通知两组结果可用于检查。然而，如果确定患者没有注射造影剂，则CAD算法不执行使用造影剂的算法不给予用户从该算法查看任何结果的选项。本发明可以用各种成像技术来实施，其中一些可能不需要来自含血液和含水区域的体素值的显式比较。

2. 发明申请

US20080050020A1 Density nodule detection in-3-D digital images 有权
标题翻译：密度结节检测三维数字图像
公开(公告)号：US20080050020A1
公开(公告)日：2008-02-28
申请号：US11827922
申请日：2007-07-12
申请人： Harlan Romsdahl , Wei Zhang , Alexander Schneider
发明人： Harlan Romsdahl , Wei Zhang , Alexander Schneider
IPC分类号： G06K9/46
CPC分类号： G06K9/4633 , A61B6/502 , G06K9/3233 , G06K9/4638 , G06K9/56 , G06K2209/05 , G06T7/0012
摘要： An algorithm is quickly scans a digital image volume to detect density nodules. A first stage is based on a transform to quickly highlight regions requiring further processing. The first stage operates with somewhat lower sensitivity than is possible with more detailed analyses, but operates to highlight regions for further analysis and processing. The transform dynamically adapts to various nodule sizes through the use of radial zones. A second stage uses a detailed gradient distribution analysis that only operates on voxels that pass a threshold of the first stage.
摘要翻译：一种算法是快速扫描数字图像体积以检测密度结节。第一阶段是基于快速突出需要进一步处理的区域的变换。第一阶段的操作灵敏度低于可能进行更详细分析的灵敏度，但可以突出区域进行进一步的分析和处理。该变换通过使用径向区域动态地适应于各种结节尺寸。第二阶段使用详细的梯度分布分析，其仅对通过第一阶段的阈值的体素进行操作。

3. 发明授权

US07286695B2 Density nodule detection in 3-D digital images 失效
标题翻译： 3-D数字图像中的密度结节检测
公开(公告)号：US07286695B2
公开(公告)日：2007-10-23
申请号：US11087820
申请日：2005-03-23
申请人： Harlan M. Romsdahl , Wei Zhang , Alexander C. Schneider
发明人： Harlan M. Romsdahl , Wei Zhang , Alexander C. Schneider
IPC分类号： G06K9/00
CPC分类号： G06K9/4633 , A61B6/502 , G06K9/3233 , G06K9/4638 , G06K9/56 , G06K2209/05 , G06T7/0012
摘要： An algorithm is quickly scans a digital image volume to detect density nodules. A first stage is based on a transform to quickly highlight regions requiring further processing. The first stage operates with somewhat lower sensitivity than is possible with more detailed analyses, but operates to highlight regions for further analysis and processing. The transform dynamically adapts to various nodule sizes through the use of radial zones. A second stage uses a detailed gradient distribution analysis that only operates on voxels that pass a threshold of the first stage.
摘要翻译：一种算法是快速扫描数字图像体积以检测密度结节。第一阶段是基于快速突出需要进一步处理的区域的变换。第一阶段的操作灵敏度低于可能进行更详细分析的灵敏度，但可以突出区域进行进一步的分析和处理。该变换通过使用径向区域动态地适应于各种结节尺寸。第二阶段使用详细的梯度分布分析，其仅对通过第一阶段的阈值的体素进行操作。

4. 发明授权

US07203348B1 Method and apparatus for correction of mammograms for non-uniform breast thickness 失效
标题翻译：用于校正乳房X线照片的不均匀乳房厚度的方法和装置
公开(公告)号：US07203348B1
公开(公告)日：2007-04-10
申请号：US10054437
申请日：2002-01-18
申请人： Nicolaas Karssemeijer , Alexander Caldwell Schneider
发明人： Nicolaas Karssemeijer , Alexander Caldwell Schneider
IPC分类号： G06K9/00
CPC分类号： G06T5/006 , G06T2207/30068
摘要： A method and apparatus for correcting for a distortion in a mammogram. The method comprises classifying pixels as either likely fat or likely not-fat. The method further comprises identifying a candidate distortion and calculating a histogram of the likely fat and the likely not-fat pixels at the candidate distortion. The method further comprises evaluating a quality of the candidate distortion based on features of the histograms of pixel values in the fat and dense tissue classes. The distortion may be a two dimensional tilt of the plates or a three dimensional deformation of the plates as in a bend.
摘要翻译：一种用于校正乳房X线照片中的畸变的方法和装置。该方法包括将像素分类为可能的脂肪或可能不脂肪。该方法还包括识别候选失真并计算候选失真时可能的脂肪和可能的不胖像素的直方图。该方法还包括基于脂肪和致密组织类别中的像素值的直方图的特征来评估候选失真的质量。变形可以是板的二维倾斜或板的三维变形，如在弯曲中。

5. 发明申请

US20070003119A1 Displaying and navigating computer-aided detection results on a review workstation 有权
标题翻译：在审查工作站上显示和导航计算机辅助检测结果
公开(公告)号：US20070003119A1
公开(公告)日：2007-01-04
申请号：US11173960
申请日：2005-07-01
申请人： Jimmy Roehrig , Julian Marshall
发明人： Jimmy Roehrig , Julian Marshall
IPC分类号： G06K9/00 , G06F19/00
CPC分类号： G06F3/0482 , A61B6/463 , A61B6/502 , G06F3/04817 , G06F3/04845 , G06F19/00 , G06F19/32 , G06F19/321 , G06F2203/04803 , G06Q50/24 , G06T3/40 , G06T7/0012 , G06T7/10 , G06T7/223 , G06T11/001 , G06T19/00 , G06T2207/10072 , G06T2207/30068 , G16H50/20 , G16H50/70
摘要： Display and navigation for multiple computer-aided detection (CAD) detections is described. A medical image is displayed to a viewer, and a request is received to instantiate CAD-assisted viewing. A timewise presentation sequence for the CAD detections is automatically computed according to a predetermined sequencing criterion. For each CAD detection, an expanded presentation window is displayed for its associated location in the medical image, the expanded presentation windows being displayed according to the timewise presentation sequence. Also described is a navigational tool comprising a plot of an operating curve onto which a computed feature associated with the CAD algorithm can be mapped, the operating curve characterizing an application of the CAD algorithm to a reference database of mammographic cases having known diagnoses. The navigational tool further comprises a plurality of CAD pointer icons spatially distributed therealong according to mappings of the computed feature for the CAD detections onto the operating curve.
摘要翻译：描述了多个计算机辅助检测（CAD）检测的显示和导航。向观看者显示医学图像，并且接收到请求以实例化CAD辅助观看。根据预定的排序标准自动计算CAD检测的时间递归序列。对于每个CAD检测，在医学图像中显示其关联位置的扩展的呈现窗口，根据时间呈现序列显示扩展的呈现窗口。还描述了一种导航工具，其包括其上可以映射与CAD算法相关联的计算特征的操作曲线的曲线，将CAD算法的应用表征为具有已知诊断的乳房造影病例的参考数据库的操作曲线。导航工具还包括根据用于在检测曲线上的CAD检测的所计算的特征的映射而沿其空间分布的多个CAD指针图标。

6. 发明申请

US20020003894A1 Method and apparatus for fast detection of spiculated lesions in digital mammograms 失效
标题翻译：用于快速检测数字乳腺X线照片中的打孔病变的方法和装置
公开(公告)号：US20020003894A1
公开(公告)日：2002-01-10
申请号：US09907585
申请日：2001-07-17
申请人： R2 TECHNOLOGY, INC.
发明人： Jimmy R. Roehrig , Harlan M. Romsdahl , Wei Zhang
IPC分类号： G06K009/00
CPC分类号： G06K9/4633 , A61B6/502 , G06K9/00 , G06K9/3233 , G06K9/4638 , G06K9/56 , G06K2209/05 , G06T7/0012 , G06T2207/30068
摘要： A method and apparatus for the fast detection of spiculated lesions in a digital mammogram, the method for use in a computer aided diagnosis system for assisting a radiologist in identifying and recognizing the spiculations among a multiplicity of lines corresponding to standard fibrous breast tissue. A line and direction image is created from a digital mammogram, and a region of potential intersection for substantially every pixel in the digital mammogram image is determined. The region of potential intersection for each pixel is a predetermined pattern, such as a high aspect ratio rectangle or trapezoid, positioned around the pixel and rotated in a direction corresponding to direction information for that pixel. The regions of potential intersection are accumulated among the pixels to produce a cumulative array, and information in the cumulative array is processed for identifying spiculations in the digital mammogram.
摘要翻译：一种用于在数字乳腺X线照片中快速检测打孔损伤的方法和装置，该方法用于计算机辅助诊断系统，用于辅助放射科医师识别并识别对应于标准纤维性乳房组织的多条线之间的突起。从数字乳房X线照片产生线和方向图像，并且确定数字乳房X线照片图像中基本上每个像素的电位交叉区域。每个像素的电位交叉区域是围绕像素定位并沿与该像素的方向信息相对应的方向旋转的预定图案，例如高宽高比矩形或梯形。在像素之间累积潜在的交叉点的区域以产生累积阵列，并且处理累积阵列中的信息以识别数字乳腺X线照片中的spiculations。

7. 发明授权

US07397937B2 Region growing in anatomical images 有权
标题翻译：解剖图像区域增长
公开(公告)号：US07397937B2
公开(公告)日：2008-07-08
申请号：US10261182
申请日：2002-09-30
申请人： Alexander C. Schneider , Susan A. Wood
发明人： Alexander C. Schneider , Susan A. Wood
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06F19/00 , G06F19/321 , G06K9/342 , G06K2009/00932 , G06K2209/05 , G06T7/11 , G06T7/187 , G06T2207/10081 , G06T2207/20156 , G06T2207/30061 , G06T2207/30064 , G06T2207/30101 , G16H15/00 , G16H50/20
摘要： A region-growing method for identifying nodules in an anatomical volume segments a 3-D image volume by controlled voxel growth from seed points. The process is based on creation and use of a distance map for tracking the distance of vessel voxels from a predetermined location. A volume map is created that identifies the largest sphere that can pass between a voxel and a predetermined location without touching a non-vessel voxel. The ratio between the distance map and the volume map is analyzed to find regions more likely to contain nodules, the features of which can be extracted or otherwise highlighted.
摘要翻译：用于鉴定解剖体积中的结节的区域生长方法通过从种子点的受控体素生长来分割3-D图像体积。该过程基于创建和使用距离图来跟踪血管体素与预定位置的距离。创建体积图，其识别可以在体素与预定位置之间通过的最大球体，而不触及非血管体素。分析距离图与体积图之间的比例，以发现更可能包含结节的区域，其特征可被提取或突出显示。

8. 发明授权

US07174515B1 Method and apparatus for independent display in a computer-aided detection system 失效
标题翻译：在计算机辅助检测系统中独立显示的方法和装置
公开(公告)号：US07174515B1
公开(公告)日：2007-02-06
申请号：US09992046
申请日：2001-11-21
申请人： Julian Marshall , Jimmy Roehrig , Sandra J. Stapleton , John R. Johns, II , Paul J. Fehrenbach
发明人： Julian Marshall , Jimmy Roehrig , Sandra J. Stapleton , John R. Johns, II , Paul J. Fehrenbach
IPC分类号： G06F3/00 , A61B8/00
CPC分类号： G16H40/63 , A61B6/5217 , A61B6/563 , G06F19/00
摘要： A method and apparatus for providing an independent display system for a computer aided detection (CAD) system that analyzes medical images. The independent display system comprises a screen to display a medical image including any marked regions of interest and a plurality of icons to interact with the screen. For one embodiment, the screen is a touch screen, such that the independent display system does not require a keyboard or cursor controller.
摘要翻译：一种用于为分析医学图像的计算机辅助检测（CAD）系统提供独立的显示系统的方法和装置。独立显示系统包括显示包括任何标记的感兴趣区域和多个图标以与屏幕交互的医学图像的屏幕。对于一个实施例，屏幕是触摸屏，使得独立显示系统不需要键盘或光标控制器。

9. 发明授权

US07072498B1 Method and apparatus for expanding the use of existing computer-aided detection code 有权
公开(公告)号：US07072498B1
公开(公告)日：2006-07-04
申请号：US10079327
申请日：2002-02-19
申请人： Jimmy Roehrig , Sussan Pourjavid , Xiaolan Zhang , Haili Chui , Akira Hasegawa
发明人： Jimmy Roehrig , Sussan Pourjavid , Xiaolan Zhang , Haili Chui , Akira Hasegawa
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T2207/20081 , G06T2207/30068
摘要： A method and apparatus for analyzing a medical image obtained from one of a plurality of digital modalities, the method comprising transforming or mapping the initial medical image to create a uniform contrast response and appearance regardless of the original modality of the image.

10. 发明申请

US20050169526A1 Density nodule detection in 3-D digital images 失效
公开(公告)号：US20050169526A1
公开(公告)日：2005-08-04
申请号：US11087820
申请日：2005-03-23
申请人： Harlan Romsdahl , Wei Zhang , Alexander Schneider
发明人： Harlan Romsdahl , Wei Zhang , Alexander Schneider
IPC分类号： A61B6/00 , G06K9/32 , G06K9/46 , G06K9/56 , G06T7/00 , G06K9/00 , G06K9/34
CPC分类号： G06K9/4633 , A61B6/502 , G06K9/3233 , G06K9/4638 , G06K9/56 , G06K2209/05 , G06T7/0012
摘要： An algorithm is quickly scans a digital image volume to detect density nodules. A first stage is based on a transform to quickly highlight regions requiring further processing. The first stage operates with somewhat lower sensitivity than is possible with more detailed analyses, but operates to highlight regions for further analysis and processing. The transform dynamically adapts to various nodule sizes through the use of radial zones. A second stage uses a detailed gradient distribution analysis that only operates on voxels that pass a threshold of the first stage.

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