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1. 发明授权

US09066935B2 Production of moldable bone substitute 有权
标题翻译：生产可塑性骨替代品
公开(公告)号：US09066935B2
公开(公告)日：2015-06-30
申请号：US13936585
申请日：2013-07-08
申请人： Promimic AB
发明人： Per Kjellin , Paul Handa
IPC分类号： A61F2/00 , A61K33/42 , A61L27/46 , A61L27/58
CPC分类号： A61K33/42 , A61L27/28 , A61L27/46 , A61L27/502 , A61L27/54 , A61L27/58 , A61L2400/12 , A61L2430/02 , C08L67/04
摘要： Composites and methods of producing a moldable bone substitute are described. A scaffold for bone growth comprises nanocrystalline hydroxyapatite (HA), a bioresorbable plasticizer, and a biodegradable polymer. Plasticizers of the invention include oleic acid, tocopherol, eugenol, 1,2,3-triacetoxypropane, monoolein, and octyl-beta-D-glucopyranoside. Polymers of the invention include poly(caprolactone), poly(D,L-Lactic acid), and poly(glycolide-co lactide). Methods of regulating porosity, hardening speed, and shapeability are also described. Composites and methods are described using nanocrystalline HA produced with and without amino acids. The scaffold for bone growth described herein displays increased strength and shapeability.
摘要翻译：描述了生产可模制骨替代物的复合材料和方法。用于骨生长的支架包括纳米晶羟基磷灰石（HA），生物可再吸收的增塑剂和可生物降解的聚合物。本发明的增塑剂包括油酸，生育酚，丁子香酚，1,2,3-三乙酰氧基丙烷，单油酸酯和辛基-β-D-吡喃葡萄糖苷。本发明的聚合物包括聚（己内酯），聚（D，L-乳酸）和聚（乙交酯 - 丙交酯）。还描述了调节孔隙率，硬化速度和成形性的方法。使用具有和不具有氨基酸的纳米晶体HA描述复合材料和方法。本文所述的用于骨生长的支架显示出增加的强度和可塑性。

2. 发明授权

US08632843B2 Methods and systems of controlled coating of nanoparticles onto micro-rough implant surfaces and associated implants 有权
标题翻译：纳米颗粒在微粗植入物表面和相关植入物上的受控涂覆方法和系统
公开(公告)号：US08632843B2
公开(公告)日：2014-01-21
申请号：US12276664
申请日：2008-11-24
申请人： Martin Andersson , Fredrik Currie , Per Kjellin
发明人： Martin Andersson , Fredrik Currie , Per Kjellin
IPC分类号： B05D1/02 , B05D1/40 , B05D3/04 , A61F2/38 , A61F2/32 , A61F2/62
CPC分类号： A61L27/10 , A61L27/04 , A61L27/32 , A61L27/50 , A61L2400/12 , C23C24/04 , C23C24/08 , C23C26/00
摘要： The invention provides methods and systems that control the application of a material onto micro-rough implant surfaces. Thus, the present invention provides method of applying crystalline nanoparticles onto the surface of an implant to produce an implant with a crystalline nanoparticle layer on its surface, the method comprising: providing an implant substrate body; applying crystalline nanoparticles onto the surface of the implant; and rotating the implant, to produce an implant with a crystalline nanoparticle layer on its surface. This method of nanoparticle application is designed to promote the integration of implants, such as dental and orthopedic screws, into living tissue, and offers the ability to control the thickness and uniformity of the nanoparticle layer, in one or several layers, while simultaneously retaining the microroughness of the implant. Further provided are systems for applying crystalline nanoparticles onto the surface of an implant and implants having a crystalline nanoparticle layer on their surfaces.
摘要翻译：本发明提供了控制材料在微粗植入物表面上的应用的方法和系统。因此，本发明提供了将结晶纳米颗粒施加到植入物的表面上以在其表面上产生具有结晶纳米颗粒层的植入物的方法，所述方法包括：提供植入物基底体; 将结晶纳米颗粒施加到植入物的表面上; 并旋转植入物，以在其表面上产生具有结晶纳米颗粒层的植入物。这种纳米颗粒应用方法旨在促进植入物（如牙科和矫形螺钉）与活组织的整合，并提供一个或多个层面控制纳米颗粒层的厚度和均匀性的能力，同时保留植入物的微粗糙度。还提供了将结晶纳米颗粒施加到植入物的表面上的系统和在其表面上具有结晶纳米颗粒层的植入物。

3. 发明申请

US20210030921A1 ZIRCONIUM AND TITANIUM PHOSPHATE COATINGS FOR IMPLANTS AND OTHER SUBSTRATES 有权
公开(公告)号：US20210030921A1
公开(公告)日：2021-02-04
申请号：US16967047
申请日：2019-02-08
申请人： Promimic AB
发明人： Per Kjellin , Fredrik Currie , Paul Handa , Line Vikingsson
IPC分类号： A61L27/32 , A61L27/54 , A61L27/56 , A61L27/06 , A61L27/04
摘要： This invention is directed to coated substrates, wherein the coating comprises titanium phosphate and/or zirconium phosphate. In certain embodiments the substrate is an implant for use in vivo. The invention is also directed to methods for forming coatings comprising or consisting of titanium phosphate and/or zirconium phosphate on the surface of a substrate.

4. 发明申请

US20100131062A1 METHODS AND SYSTEMS OF CONTROLLED COATING OF NANOPARTICLES ONTO MICRO-ROUGH IMPLANT SURFACES AND ASSOCIATED IMPLANTS 有权
标题翻译：纳米颗粒在微孔表面和相关植入物上的控制涂层的方法和系统
公开(公告)号：US20100131062A1
公开(公告)日：2010-05-27
申请号：US12276664
申请日：2008-11-24
申请人： Martin Andersson , Fredrik Currie , Per Kjellin
发明人： Martin Andersson , Fredrik Currie , Per Kjellin
IPC分类号： A61F2/02 , B05D1/02 , B05D1/18 , B05C13/00
CPC分类号： A61L27/10 , A61L27/04 , A61L27/32 , A61L27/50 , A61L2400/12 , C23C24/04 , C23C24/08 , C23C26/00
摘要： The invention provides methods and systems that control the application of a material onto micro-rough implant surfaces. Thus, the present invention provides method of applying crystalline nanoparticles onto the surface of an implant to produce an implant with a crystalline nanoparticle layer on its surface, the method comprising: providing an implant substrate body; applying crystalline nanoparticles onto the surface of the implant; and rotating the implant, to produce an implant with a crystalline nanoparticle layer on its surface. This method of nanoparticle application is designed to promote the integration of implants, such as dental and orthopedic screws, into living tissue, and offers the ability to control the thickness and uniformity of the nanoparticle layer, in one or several layers, while simultaneously retaining the microroughness of the implant. Further provided are systems for applying crystalline nanoparticles onto the surface of an implant and implants having a crystalline nanoparticle layer on their surfaces.
摘要翻译：本发明提供了控制材料在微粗植入物表面上的应用的方法和系统。因此，本发明提供了将结晶纳米颗粒施加到植入物的表面上以在其表面上产生具有结晶纳米颗粒层的植入物的方法，所述方法包括：提供植入物基底体; 将结晶纳米颗粒施加到植入物的表面上; 并旋转植入物，以在其表面上产生具有结晶纳米颗粒层的植入物。这种纳米颗粒应用方法旨在促进植入物（如牙科和矫形螺钉）与活组织的整合，并提供一个或多个层面控制纳米颗粒层的厚度和均匀性的能力，同时保留植入物的微粗糙度。还提供了将结晶纳米颗粒施加到植入物的表面上的系统和在其表面上具有结晶纳米颗粒层的植入物。

5. 发明授权

US09782435B2 Production of moldable bone substitute 有权
公开(公告)号：US09782435B2
公开(公告)日：2017-10-10
申请号：US14737741
申请日：2015-06-12
申请人： Promimic AB
发明人： Per Kjellin , Paul Handa
IPC分类号： A61K33/42 , A61L27/50 , A61L27/54 , A61L27/28 , A61L27/46 , A61L27/58
CPC分类号： A61K33/42 , A61L27/28 , A61L27/46 , A61L27/502 , A61L27/54 , A61L27/58 , A61L2400/12 , A61L2430/02 , C08L67/04
摘要： Composites and methods of producing a mouldable bone substitute are described. A scaffold for bone growth comprises nanocrystalline hydroxyapatite (HA), a bioresorbable plasticizer, and a biodegradable polymer. Plasticizers of the invention include oleic acid, tocopherol, eugenol, 1,2,3-triacetoxypropane, monoolein, and octyl-beta-D-glucopyranoside. Polymers of the invention include poly(caprolactone), poly(D,L-Lactic acid), and poly(glycolide-co lactide). Methods of regulating porosity, hardening speed, and shapeability are also described. Composites and methods are described using nanocrystalline HA produced with and without amino acids. The scaffold for bone growth described herein displays increased strength and shapeability.

6. 发明申请

US20110282095A1 PRODUCTION OF NANOSIZED CALCIUM PHOSPHATE PARTICLES AS POWDER OR COATING VIA BIFUNCTIONAL PRECURSORS 有权
标题翻译：通过双功能前驱体生产纳米磷酸钙颗粒作为粉末或涂层
公开(公告)号：US20110282095A1
公开(公告)日：2011-11-17
申请号：US12744773
申请日：2008-11-26
申请人： Per Kjellin
发明人： Per Kjellin
IPC分类号： C01B25/32 , B05D3/02 , C07F9/06
CPC分类号： C01B25/32 , A61K6/0643 , A61L27/32 , A61L27/50 , A61L2420/02 , A61L2420/06 , C23C24/08
摘要： Method of producing calcium phosphate particles, such as hydroxyapatite particles, in the form of a powder or coating on a solid support comprising an oxide surface or a polymer surface, such as titanium, titanium alloys, stainless steel, zirconia, glass and poly(styrene), poly(ether ether ketone) (PEEK), and poly(imide) is described. The method comprises I) providing a water solution containing calcium ions and water-soluble organic compound(s) comprising at least two functional groups, II) providing another water solution containing phosphate ions and water-soluble organic compound(s) comprising at least two functional groups, followed by III) mixing the solutions of (I) and (II) to create calcium phosphate particles coated with said water-soluble organic compounds. After washing and drying, the coated particles may be used as scaffolds or for production of a powder of calcium phosphate particles or crystals.
摘要翻译：在包含氧化物表面或聚合物表面如钛，钛合金，不锈钢，氧化锆，玻璃和聚（苯乙烯）的固体支持物上形成粉末或涂层形式的磷酸钙颗粒如羟基磷灰石颗粒的方法），聚（醚醚酮）（PEEK）和聚（酰亚胺）。该方法包括：I）提供含有钙离子的水溶液和至少包含两个官能团的水溶性有机化合物，II）提供另外含有磷酸根离子的水溶液和水溶性有机化合物，所述水溶液包含至少两个官能团，然后III）混合（I）和（II）的溶液以产生涂覆有所述水溶性有机化合物的磷酸钙颗粒。洗涤和干燥后，涂覆的颗粒可用作支架或用于生产磷酸钙颗粒或晶体的粉末。

7. 发明授权

US09975772B2 Production of nanosized calcium phosphate particles as powder or coating via bifunctional precursors 有权
公开(公告)号：US09975772B2
公开(公告)日：2018-05-22
申请号：US12744773
申请日：2008-11-26
申请人： Per Kjellin
发明人： Per Kjellin
IPC分类号： C01B25/32 , C23C24/08 , A61L27/32 , A61L27/50 , A61K6/06
CPC分类号： C01B25/32 , A61K6/0643 , A61L27/32 , A61L27/50 , A61L2420/02 , A61L2420/06 , C23C24/08
摘要： Method of producing calcium phosphate particles, such as hydroxyapatite particles, in the form of a powder or coating on a solid support comprising an oxide surface or a polymer surface, such as titanium, titanium alloys, stainless steel, zirconia, glass and poly(styrene), poly(ether ether ketone) (PEEK), and poly(imide) is described. The method comprises I) providing a water solution containing calcium ions and water-soluble organic compound(s) comprising at least two functional groups, II) providing another water solution containing phosphate ions and water-soluble organic compound(s) comprising at least two functional groups, followed by III) mixing the solutions of (I) and (II) to create calcium phosphate particles coated with said water-soluble organic compounds. After washing and drying, the coated particles may be used as scaffolds or for production of a powder of calcium phosphate particles or crystals.

8. 发明授权

US08460788B2 Synthetic nano-sized crystalline calcium phosphate and method of production 有权
标题翻译：合成纳米级结晶磷酸钙及其生产方法
公开(公告)号：US08460788B2
公开(公告)日：2013-06-11
申请号：US13483482
申请日：2012-05-30
申请人： Per Kjellin , Martin Andersson
发明人： Per Kjellin , Martin Andersson
IPC分类号： B32B5/16 , B05D3/02 , B82Y30/00 , B82Y40/00
CPC分类号： C09D1/00 , B82Y30/00 , C01B25/32 , C01B25/322 , Y10T428/258 , Y10T428/2982
摘要： Synthetic nano-sized crystalline calcium phosphate, particularly hydroxyapatite, having a specific surface area in the range of 150 m2/g to 300 m2/g, is described. The nano-sized crystalline calcium phosphate may be in the form of a powder or in the form of a coating on a surface. A method of producing a nano-sized crystalline calcium phosphate powder or coating is also described.
摘要翻译：描述了比表面积在150m 2 / g至300m 2 / g范围内的合成纳米尺寸的结晶磷酸钙，特别是羟基磷灰石。纳米尺寸的结晶磷酸钙可以是粉末形式或表面上的涂层形式。还描述了制造纳米尺寸的结晶磷酸钙粉末或涂层的方法。

9. 发明授权

US08206813B2 Synthetic nano-sized crystalline calcium phosphate and method of production 有权
标题翻译：合成纳米级结晶磷酸钙及其生产方法
公开(公告)号：US08206813B2
公开(公告)日：2012-06-26
申请号：US11629215
申请日：2005-06-14
申请人： Per Kjellin , Martin Andersson
发明人： Per Kjellin , Martin Andersson
IPC分类号： C01B25/32 , C09D1/00
CPC分类号： C09D1/00 , B82Y30/00 , C01B25/32 , C01B25/322 , Y10T428/258 , Y10T428/2982
摘要： Synthetic nano-sized crystalline calcium phosphate, particularly hydroxyapatite, having a specific surface area in the range of 150 m2/g to 300 m2/g, is described. The nano-sized crystalline calcium phosphate may be in the form of a powder or in the form of a coating on a surface. A method of producing a nano-sized crystalline calcium phosphate powder or coating is also described. The method comprises formation of a liquid crystalline phase in a water solution of calcium, phosphor and a surfactant, placing the phase in an ammonia atmosphere so that nano-sized crystals are formed, followed by either removal of the surfactant with a solvent and recovering the nano-sized crystals to obtain the powder, or diluting the ammonia-treated liquid crystalline phase with a hydrophobic organic solvent to create a microemulsion of the nano-sized crystals in water, dipping an oxide layer-coated surface of an object into the microemulsion, or alternatively saving the step of ammonia treatment of the liquid crystalline phase until after the dipping of the surface of an object into the microemulsion, followed by removal of the organic solvent and the surfactant from the surface to obtain the coating.
摘要翻译：描述了比表面积在150m 2 / g至300m 2 / g范围内的合成纳米尺寸的结晶磷酸钙，特别是羟基磷灰石。纳米尺寸的结晶磷酸钙可以是粉末形式或表面上的涂层形式。还描述了制造纳米尺寸的结晶磷酸钙粉末或涂层的方法。该方法包括在钙，磷和表面活性剂的水溶液中形成液晶相，将相置于氨气氛中，形成纳米尺寸的晶体，然后用溶剂除去表面活性剂，并回收纳米尺寸的晶体以获得粉末，或用疏水性有机溶剂稀释氨处理的液晶相以产生纳米级晶体在水中的微乳液，将物体的氧化物层涂覆的表面浸入微乳液中，或者替代地，保存液体相的氨处理步骤直到将物体表面浸入微乳液中，然后从表面除去有机溶剂和表面活性剂以获得涂层。

10. 发明申请

US20080220233A1 Synthetic Nano-Sized Crystalline Calcium Phosphate and Method of Production 有权
标题翻译：合成纳米结晶磷酸钙及其制备方法
公开(公告)号：US20080220233A1
公开(公告)日：2008-09-11
申请号：US11629215
申请日：2005-06-14
申请人： Per Kjellin , Martin Andersson
发明人： Per Kjellin , Martin Andersson
IPC分类号： C01B25/32 , C09D1/00
CPC分类号： C09D1/00 , B82Y30/00 , C01B25/32 , C01B25/322 , Y10T428/258 , Y10T428/2982
摘要： Synthetic nano-sized crystalline calcium phosphate, particularly hydroxyapatite, having a specific surface area in the range of 150 m2/g to 300 m2/g, is described. The nano-sized crystalline calcium phosphate may be in the form of a powder or in the form of a coating on a surface. A method of producing a nano-sized crystalline calcium phosphate powder or coating is also described. The method comprises formation of a liquid crystalline phase in a water solution of calcium, phosphor and a surfactant, placing the phase in an ammonia atmosphere so that nano-sized crystals are formed, followed by either removal of the surfactant with a solvent and recovering the nano-sized crystals to obtain the powder, or diluting the ammonia-treated liquid crystalline phase with a hydrophobic organic solvent to create a microemulsion of the nano-sized crystals in water, dipping an oxide layer-coated surface of an object into the microemulsion, or alternatively saving the step of ammonia treatment of the liquid crystalline phase until after the dipping of the surface of an object into the microemulsion, followed by removal of the organic solvent and the surfactant from the surface to obtain the coating.
摘要翻译：描述了比表面积在150m 2 / g至300m 2 / g范围内的合成纳米尺寸的结晶磷酸钙，特别是羟基磷灰石。纳米尺寸的结晶磷酸钙可以是粉末形式或表面上的涂层形式。还描述了制造纳米尺寸的结晶磷酸钙粉末或涂层的方法。该方法包括在钙，磷和表面活性剂的水溶液中形成液晶相，将相置于氨气氛中，形成纳米尺寸的晶体，然后用溶剂除去表面活性剂，并回收纳米尺寸的晶体以获得粉末，或用疏水性有机溶剂稀释氨处理的液晶相以产生纳米级晶体在水中的微乳液，将物体的氧化物层涂覆的表面浸入微乳液中，或者替代地，保存液体相的氨处理步骤直到将物体表面浸入微乳液中，然后从表面除去有机溶剂和表面活性剂以获得涂层。

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