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1. 发明授权

US08512976B2 Selective growth media 有权
标题翻译：选择性生长培养基
公开(公告)号：US08512976B2
公开(公告)日：2013-08-20
申请号：US12762765
申请日：2010-04-19
申请人： Patrick Druggan
发明人： Patrick Druggan
IPC分类号： C12Q1/04
CPC分类号： C12N1/38 , C12N1/20
摘要： Disclosed is a method of selectively inhibiting for growth of non-target cells in a mixed population of target and non-target cells, the method comprising the steps of: (a) contacting the mixed population with a selective agent which comprises a carrier moiety linked by a scissile linkage to a toxic moiety; wherein the selective agent is able to enter non-target cells in which the scissile linkage is cleaved, releasing the toxic moiety to exert a toxic effect on the non-target cells causing inhibition of the growth of the non-target cells, whereas the selective agent is unable to enter target cells and/or the scissile linkage is not cleaved in target cells and/or toxic moiety, if released from the selective agent, does not exert a toxic effect on the target cell; and (b) culturing the cells in conditions which allow for growth of non-inhibited cells.
摘要翻译：公开了一种选择性抑制靶和非靶细胞混合群体中非靶细胞生长的方法，所述方法包括以下步骤：（a）使混合群体与包含载体部分连接的选择剂接触通过与毒性部分的剪切连接; 其中所述选择剂能够进入其中所述剪切连接被切割的非靶细胞，释放所述毒性部分以对非靶细胞产生毒性作用，从而导致非靶细胞生长的抑制，而所述选择性药剂不能进入靶细胞和/或染色体连接不会在靶细胞和/或毒性部分中被切割，如果从选择剂释放，则不会对靶细胞发挥毒性作用; 和（b）在允许非抑制细胞生长的条件下培养细胞。

2. 发明授权

US4200610A Gas-producing device 失效
标题翻译：气体生产装置
公开(公告)号：US4200610A
公开(公告)日：1980-04-29
申请号：US868059
申请日：1978-01-09
申请人： Derwent Swaine , Henry K. Spong , Brian M. Lewin
发明人： Derwent Swaine , Henry K. Spong , Brian M. Lewin
IPC分类号： C12M1/04 , B01J7/02
CPC分类号： C12M41/34 , Y10S435/801 , Y10S435/81
摘要： A device for providing a non-toxic atmosphere for use in culturing anaerobic micro-organisms comprising: a closed envelope of inert material having a frangible portion which may be ruptured to allow the ingress of liquid; within the envelope a closed sachet, one part of which is formed of a gas- and liquid-permeable membrane; and material disposed within the sachet adjacent to the membrane for reacting with a liquid to generate the desired gaseous atmosphere.
摘要翻译：一种用于提供用于培养厌氧微生物的无毒气氛的装置，包括：具有可破裂以允许液体进入的易碎部分的惰性材料的封闭包层; 在封套内封闭小袋，其中一部分由气体和液体渗透膜形成; 以及布置在所述小袋内的与所述膜相邻的材料以与液体反应以产生所需的气体气氛。

3. 发明授权

US09908912B2 Triclosan derivatives and uses thereof 有权
公开(公告)号：US09908912B2
公开(公告)日：2018-03-06
申请号：US14090402
申请日：2013-11-26
申请人： Oxoid Limited
发明人： Richard Bovill , Gemma Howse
IPC分类号： C07H15/20 , C12Q1/04 , C07H15/203
CPC分类号： C07H15/20 , C07H15/203 , C12Q1/045 , G01N2333/205 , G01N2333/255
摘要： A selective agent comprising a triclosan derivative for use in selective inhibition of non-target cells in a mixed population of target and non-target cells. Preferably the triclosan derivative is a glycoside derivative, more preferably a pyranoside derivative. Suitably a selective medium comprising said selective agent and methods of culturing cells using the selective agent are provided.

4. 外观设计

USD572369S1 Biological test strip 有权
标题翻译：生物试纸条
公开(公告)号：USD572369S1
公开(公告)日：2008-07-01
申请号：US29283335
申请日：2007-08-10
申请人： Stephen Dimmer , Carl Smith , James Anthony Michael Lees-Smith , Bryan Stevon De Caux
设计人： Stephen Dimmer , Carl Smith , James Anthony Michael Lees-Smith , Bryan Stevon De Caux

5. 发明授权

US08557538B2 Selective growth media 有权
标题翻译：选择性生长培养基
公开(公告)号：US08557538B2
公开(公告)日：2013-10-15
申请号：US13792674
申请日：2013-03-11
申请人： Oxide Limited
发明人： Patrick Druggan , Richard A. Bovill
IPC分类号： C12Q1/04
CPC分类号： C12N1/20 , C12N1/38
摘要： Disclosed is a method of selectively inhibiting growth of non-target cells in a mixed population of target and non-target cells, the method comprising the steps of: (a) contacting the mixed population with a selective agent which comprises a carrier moiety linked by a scissile linkage to a toxic moiety; wherein the selective agent is able to enter non-target cells in which the scissile linkage is cleaved, releasing the toxic moiety to exert a toxic effect on the non-target cells causing inhibition of the growth of the non-target cells, whereas the selective agent is unable to enter target cells and/or the scissile linkage is not cleaved in target cells and/or toxic moiety, if released from the selective agent, does not exert a toxic effect on the target cell; and (b) culturing the cells in conditions which allow for growth of non-inhibited cells.
摘要翻译：公开了选择性抑制靶和非靶细胞混合群体中非靶细胞生长的方法，所述方法包括以下步骤：（a）使混合群体与选择剂接触，所述选择剂包含通过与毒性部分的剪切连接; 其中所述选择剂能够进入其中所述剪切连接被切割的非靶细胞，释放所述毒性部分以对非靶细胞产生毒性作用，从而导致非靶细胞生长的抑制，而所述选择性药剂不能进入靶细胞和/或染色体连接不会在靶细胞和/或毒性部分中被切割，如果从选择剂释放，则不会对靶细胞发挥毒性作用; 和（b）在允许非抑制细胞生长的条件下培养细胞。

6. 发明授权

US06873719B1 Image acquisition apparatus 失效
标题翻译：图像采集装置
公开(公告)号：US06873719B1
公开(公告)日：2005-03-29
申请号：US09762913
申请日：1999-08-11
申请人： John Ernest Foster Holley
发明人： John Ernest Foster Holley
IPC分类号： C12M1/34 , G06K7/10 , G06K9/00
CPC分类号： G06K7/10861 , C12M41/46 , G06K7/10693
摘要： Image acquisition apparatus is used to obtain images of contents of containers for use in, for example, antibiotic susceptibility testing. The apparatus has image capture means, such as a scanner (6) for obtaining images of the contents of the containers which are supported on receiving means (1) for receiving the containers and positioning them within the field of view of the scanner (6). In addition, light deflecting means, such as reflectors, are provided for defecting light from identification markings on the sides of the containers into the scanner (6) to enable the latter also to obtain an image of said markings, and thus to enable the apparatus to identify each container.
摘要翻译：图像采集装置用于获得用于例如抗生素敏感性试验的容器内容物的图像。该装置具有图像捕获装置，例如用于获得容纳物的图像的扫描器（6），所述图像被支撑在用于接收容器并将它们定位在扫描器（6）的视场内的接收装置（1）。此外，提供诸如反射器的光偏转装置，用于将来自容器侧面的识别标记的光从扫描仪（6）中取出，以使得后者也能够获得所述标记的图像，并且因此使装置识别每个容器。

7. 发明申请

US20040137554A1 Diagnosis and treatment of bacterial infections 审中-公开
标题翻译：细菌感染的诊断和治疗
公开(公告)号：US20040137554A1
公开(公告)日：2004-07-15
申请号：US10751947
申请日：2004-01-07
申请人： Oxoid Limited
发明人： Peter A. Lambert , Thomas S.J. Elliott
IPC分类号： C12Q001/04 , C07K009/00
CPC分类号： A61K31/70 , A61K39/085 , C07H3/04 , C07K1/00 , C07K16/1271 , C12N1/20
摘要： Disclosed is an isolated compound having the structure shown in FIG. 2, wherein n is an integer between 3 and 10 (inclusive) and X may be H, OH, alkyl, aryl, amyl, or an amino acid residue (optionally substituted) or a sugar residue (optionally substituted), and wherein R and R1 are hydrophobic hydrocarbon or fatty acid chains (R may be the same as R1 or different), a method of preparing compositions comprising the compound, and a diagnostic method comprising use of the composition.
摘要翻译：公开了具有图1所示结构的分离化合物。 2，其中n是3至10（包括端值）的整数，X可以是H，OH，烷基，芳基，戊基或氨基酸残基（任选取代的）或糖残基（任选取代的），其中R和 R 1是疏水性烃或脂肪酸链（R可以与R 1相同或不同），制备包含该化合物的组合物的方法和包括使用该组合物的诊断方法。

8. 发明授权

US5888825A Method and device for monitoring changes in an array of sensor containing bottles 失效
标题翻译：用于监测包含瓶子的传感器阵列变化的方法和装置
公开(公告)号：US5888825A
公开(公告)日：1999-03-30
申请号：US917805
申请日：1997-08-27
申请人： Anthony Hugh Carr , Kenneth Cherry , Simon Edward Jackson
发明人： Anthony Hugh Carr , Kenneth Cherry , Simon Edward Jackson
IPC分类号： C12M1/34 , G01N7/20 , G01N35/00 , G01N35/02 , G01N35/04 , C12Q1/04
CPC分类号： C12M41/40 , C12M23/08 , G01N35/0092 , G01N35/026 , G01N2035/00752 , G01N2035/042 , G01N2035/0465 , G01N2035/0498 , Y10T436/11 , Y10T436/114165
摘要： Monitoring apparatus comprises a support device for receiving a plurality of items to be monitored in an array, each item having a unique machine-readable identifying reference associated therewith, the arrangement being such that the items are movable to different positions in the array; a sensor device for intermittently and repeatedly monitoring each item in the array to monitor changes in a variable associated with each item and to read the reference associated with each item; device for supplying data to the monitored variable and machine-readable reference of each item to a computer, wherein the computer relates the monitored variable to the reference to each item independently of the position of the item in the array.
摘要翻译： PCT No.PCT / GB94 / 00253 Sec。 371日期：1995年11月27日 102（e）日期1995年11月27日PCT 1994年2月9日PCT PCT。公开号WO94 / 19698 日期1994年9月1日监视装置包括用于以阵列方式接收要监视的多个项目的支持装置，每个物品具有与之相关联的独特的机器可读标识参考，该装置使得物品可移动到不同位置阵列用于间歇地和重复地监视阵列中的每个物品的传感器装置，以监测与每个物品相关联的变量的变化并读取与每个物品相关的参考; 用于将数据提供给每个项目的监视变量和机器可读参考的计算机的设备，其中计算机将所监视的变量与每个项目的引用相关联，而与项目在阵列中的位置无关。

9. 发明授权

US5863752A Methods and apparatus for monitoring the growth of microorganisms in liquid culture 失效
标题翻译：监测液体培养微生物生长的方法和装置
公开(公告)号：US5863752A
公开(公告)日：1999-01-26
申请号：US30488
申请日：1993-06-02
申请人： Nigel Timothy Court , Richard Paul Hayes-Pankhurst , Neil Laurence Evans , Judith Marjorie Anderson , Roy Holbrook , Peter Richard Stephenson , Arthur Maurice Weightman
发明人： Nigel Timothy Court , Richard Paul Hayes-Pankhurst , Neil Laurence Evans , Judith Marjorie Anderson , Roy Holbrook , Peter Richard Stephenson , Arthur Maurice Weightman
IPC分类号： C12M1/24 , C12M1/34 , C12Q1/02 , C12Q1/06 , C12Q1/04
CPC分类号： C12Q1/06 , C12M23/08 , C12M23/38 , C12M23/48 , C12M41/36 , C12M41/40 , C12Q1/02
摘要： A method of monitoring the growth of microorganisms in liquid culture involving the detection of pressure change in a gas-tight container such as a blood culture bottle incorporating a flexible diaphragm (septum) by detecting displacement of the septum, is characterised by the position or conformation of the diaphragm being repeatedly sensed using a distance-measuring means, such as a laser, preferably capable of detecting a variation in the position or conformation of the diaphragm to an accuracy of 200.mu. or better, with a portion of the container adjacent the diaphragm conveniently being used as a reference to detect any relative positional or conformational change of the diaphragm. Preferably the laser repeatedly scans a plurality of containers mounted in a holder such as a flat bed or a carousel.
摘要翻译： PCT No.PCT / GB92 / 01327 Sec。 371日期：1993年6月2日 102（e）日期1993年6月2日PCT提交1992年7月20日PCT公布。公开号WO93 / 03178 日期：1993年2月18日一种监测液体培养物中微生物生长的方法，涉及通过检测隔膜位移来检测包含柔性隔膜（隔膜）的血培养瓶的气密容器中的压力变化的压力变化。通过使用诸如激光器的距离测量装置重复感测隔膜的位置或构造，优选地能够检测膜片的位置或构象的变化，使其具有200μm或更好的精度，其中一部分邻近隔膜的容器方便地用作参考以检测隔膜的任何相对位置或构象变化。优选地，激光器重复地扫描安装在诸如平板床或转盘中的保持器中的多个容器。

10. 发明授权

US4692417A Immunological identification test for group D streptococci using achromopeptidase 失效
标题翻译：使用无色肽酶对D组链球菌进行免疫鉴定试验
公开(公告)号：US4692417A
公开(公告)日：1987-09-08
申请号：US739462
申请日：1985-05-30
申请人： Martyn F. Webster
发明人： Martyn F. Webster
IPC分类号： C12Q1/14 , C12Q1/37 , G01N33/569 , G01N33/53 , C12Q1/38
CPC分类号： C12Q1/14 , C12Q1/37 , G01N33/56944 , G01N2333/315 , Y10S435/975
摘要： The grouping of a sample of a streptococcus is identified by treating the sample with achromopeptidase prior to contacting the sample with a group-specific antibody bound to minute, insoluble carrier particles. A positive identification is indicated by agglutination of the carrier particles.
摘要翻译：通过在将样品与结合到微小的不溶性载体颗粒的组特异性抗体接触之前用无色肽酶处理样品来鉴定链球菌样品的分组。阳性鉴定由载体颗粒的凝集指示。

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