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1. 发明申请

US20100185268A1 IMPLANTABLE MEDICAL DEVICES AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：可植入医疗器械及相关系统及方法
公开(公告)号：US20100185268A1
公开(公告)日：2010-07-22
申请号：US12414626
申请日：2009-03-30
申请人： Brad C. Fowler , Jay Miazga , Matt L. Bielstein
发明人： Brad C. Fowler , Jay Miazga , Matt L. Bielstein
IPC分类号： A61N1/05
CPC分类号： A61N1/0529 , A61N1/0551 , A61N1/3605 , A61N1/3756
摘要： Implantable medical devices and associated systems and methods are disclosed. An implantable device in accordance with one embodiment can include a signal generator positioned to be implanted in a patient. The signal generator includes a housing and a plurality of selectively electrically activatable portions at an external surface of the housing. The implantable device can also include a remote electrode device having at least one electrode positioned to be implanted beneath the patient's skull, and a lead coupleable to the electrode device and the signal generator.
摘要翻译：公开了可植入医疗装置及相关系统和方法。根据一个实施例的可植入装置可以包括定位成植入患者体内的信号发生器。信号发生器包括外壳和在壳体的外表面处的多个选择性电可激活部分。可植入装置还可以包括远程电极装置，其具有定位成植入患者颅骨下方的至少一个电极以及可耦合到电极装置和信号发生器的引线。

2. 外观设计

USD595839S1 Magnet receptacle 有权
标题翻译：磁铁容器
公开(公告)号：USD595839S1
公开(公告)日：2009-07-07
申请号：US29280769
申请日：2007-06-06
申请人： Jay Miazga
设计人： Jay Miazga

3. 发明申请

US20090118788A1 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
标题翻译：影响患者神经功能变化的方法和装置
公开(公告)号：US20090118788A1
公开(公告)日：2009-05-07
申请号：US12353340
申请日：2009-01-14
申请人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner
发明人： Andrew D. Firlik , Jeffrey Balzer , Bradford Evan Gliner
IPC分类号： A61N1/05 , A61N2/00
CPC分类号： A61N1/36017 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36014 , A61N1/36025 , A61N1/36082 , A61N1/361 , A61N1/375 , A61N1/3756
摘要： The present disclosure suggests methods of selecting a stimulation site for stimulating a patient's brain or methods of effectuating a neural-function of a patient associated with an impaired body function. In one exemplary implementation, such a neural function may be effectuated by selecting a stimulation site, positioning at least a first electrode at the stimulation site, and applying an electrical potential to pass a current through the first electrode. If one aspect, this stimulation site may be selected by a) identifying a second body function that is a corollary to the impaired body function, and b) determining a corollary location of the patient's brain that is associated with the second body function and is ipsilateral to the impaired body function.
摘要翻译：本公开内容提出了选择用于刺激患者的大脑的刺激部位的方法或者与受损的身体功能相关联的患者的神经功能的方法。在一个示例性实施方案中，可以通过选择刺激部位，在刺激部位定位至少第一电极，以及施加电势以使电流通过第一电极来实现这样的神经功能。如果一个方面，则可以通过以下方式来选择该刺激部位：a）识别作为受损身体功能的推论的第二身体功能，以及b）确定与第二身体功能相关并且是同侧的患者的大脑的推论位置对身体功能受损。

4. 发明申请

US20090076567A1 Electrode Configurations for Reducing Invasiveness and/or Enhancing Neural Stimulation Efficacy, and Associated Methods 审中-公开
标题翻译：减少侵袭性和/或增强神经刺激功效的电极配置及相关方法
公开(公告)号：US20090076567A1
公开(公告)日：2009-03-19
申请号：US12234455
申请日：2008-09-19
申请人： Brad Fowler , Bradford Evan Gliner
发明人： Brad Fowler , Bradford Evan Gliner
IPC分类号： A61N1/36
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/36017 , A61N1/36082
摘要： Electrode configurations for reducing invasiveness and/or enhancing neural stimulation efficacy, and associated methods, are disclosed. A method in accordance with one embodiment of the invention for treating a brain disorder includes identifying a target neural structure within a patient's skull and implanting an electrode device within the patient's skull so that an axis that is generally normal to the skull proximate to the electrode device and that passes through at least one electrical contact of the electrode device is offset from the target neural structure. The method further includes stimulating the target neural structure by applying an electrical signal to the at least one electrical contact. In particular embodiments, the electrode device can be positioned between, along, across, or adjacent to a fissure, recess, groove, and/or vascular structure of the patient's brain.
摘要翻译：公开了用于降低侵入性和/或增强神经刺激功效的电极配置及相关方法。根据用于治疗脑疾病的本发明的一个实施例的方法包括识别患者颅骨内的目标神经结构并且在患者的颅骨内植入电极装置，使得通常垂直于颅骨的轴线靠近电极装置并且通过电极装置的至少一个电接触偏离目标神经结构。该方法还包括通过向至少一个电触点施加电信号来刺激目标神经结构。在特定实施例中，电极装置可以位于患者大脑的裂缝，凹槽，凹槽和/或血管结构之间，沿着，横过或相邻。

5. 发明授权

US07483747B2 Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy 有权
标题翻译：用于增强或影响神经刺激效率和/或功效的系统和方法
公开(公告)号：US07483747B2
公开(公告)日：2009-01-27
申请号：US11182713
申请日：2005-07-15
申请人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
发明人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
IPC分类号： A61N1/00
CPC分类号： H04L67/2842 , A61N1/0531 , A61N1/0534 , A61N1/3606 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36103 , A61N1/36135 , A61N1/36146 , A61N1/37252 , G06F13/385 , H04L49/90 , H04L49/901 , H04L67/2823
摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.
摘要翻译：公开了用于增强或影响神经刺激效率和/或功效的系统和方法。在一个实施例中，系统和/或方法可以根据第一组刺激参数以及根据第二组刺激参数在第二时域上对第一时域的患者神经系统施加电磁刺激。第一和第二时域可以是顺序的，同时的或嵌套的。刺激参数可以根据一种或多种类型的占空比，幅度，脉冲重复频率，脉冲宽度，时空和/或极性变化而变化。刺激可以在一个或多个周期性，非周期性（例如混沌）和/或伪随机方式中的亚阈值，阈值和/或超阈值水平下应用。在一些实施例中，刺激可以包括具有对应于固有脑波频率的突发频率以及规则和/或变化的腹内刺激参数的突发模式。在中等或显着的电源耗尽之前，可以施加具有至少足够的症状缓解的降低功耗的刺激信号。

6. 发明授权

US07437196B2 Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of Parkinson's disease, other movement disorders, and/or drug side effects 有权
标题翻译：用于选择刺激部位并进行治疗的系统和方法，包括治疗帕金森病症状，其他运动障碍和/或药物副作用
公开(公告)号：US07437196B2
公开(公告)日：2008-10-14
申请号：US11489076
申请日：2006-07-18
申请人： Allen Wyler , Brad Fowler
发明人： Allen Wyler , Brad Fowler
IPC分类号： A61N1/36
CPC分类号： A61N1/36067 , A61N1/0531 , A61N1/0534
摘要： Methods and systems for treating movement disorders are disclosed. A method in accordance with one embodiment can include determining that the movement disorder affects the patient's gait, oral functioning, and/or other functioning, and applying electrical stimulation proximate to the interhemispheric fissure, the Sylvian fissure, or between the two fissures, respectively. In another embodiment, the method can include selecting at least one neural process from among a plurality of processes sequentially carried out by a patient to cause a muscle movement in the patient (e.g., a planning process, an initiation process, and an execution process), and applying electrical stimulation to a location of the patient's brain associated with the at least one neural process.
摘要翻译：公开了用于治疗运动障碍的方法和系统。根据一个实施例的方法可以包括确定运动障碍影响患者的步态，口腔功能和/或其他功能，以及分别在大脑间裂缝，西尔维亚裂缝或两个裂缝之间施加电刺激。在另一个实施例中，该方法可以包括从由患者依次执行的多个进程中选择至少一个神经过程以引起患者的肌肉运动（例如，计划过程，发起过程和执行过程）并且将电刺激施加到与所述至少一个神经过程相关联的患者脑部的位置。

7. 发明申请

US20070179584A1 ELECTRODE GEOMETRIES FOR EFFICIENT NEURAL STIMULATION 有权
标题翻译：电极几何用于有效的神经刺激
公开(公告)号：US20070179584A1
公开(公告)日：2007-08-02
申请号：US11697698
申请日：2007-04-06
申请人： Bradford Gliner
发明人： Bradford Gliner
IPC分类号： A61N1/05
CPC分类号： A61N1/0531 , A61N1/0551 , A61N1/0553
摘要： Electrodes designed in accordance with the present invention may selectively employ arc shaped contacts; variations in contact number, positioning, spacing, and/or distribution; variations in contact area, size, or periphery; and/or on-electrode conductive links or interconnections between particular contacts to provide enhanced efficiency neural stimulation, and/or increased electrode reliability.
摘要翻译：根据本发明设计的电极可以选择性地采用弧形触点; 接触编号，定位，间距和/或分布的变化; 接触面积，尺寸或周边的变化; 和/或特定接触之间的电极导电连接或互连，以提供增强的效率神经刺激和/或增加的电极可靠性。

8. 发明申请

US20070055320A1 Methods for treating temporal lobe epilepsy, associated neurological disorders, and other patient functions 审中-公开
标题翻译：治疗颞叶癫痫，相关神经系统疾病和其他患者功能的方法
公开(公告)号：US20070055320A1
公开(公告)日：2007-03-08
申请号：US11518139
申请日：2006-09-07
申请人： Martin Weinand
发明人： Martin Weinand
IPC分类号： A61N1/00
CPC分类号： A61N1/36064 , A61N1/0531 , A61N1/36096 , A61N1/36157 , A61N1/36171
摘要： Methods for treating temporal lobe epilepsy, associated neurological disorders, and other patient functions are disclosed. Methods for treating patients in accordance with several embodiments include implanting a signal delivery device subdurally proximate to a target neural site at a cortical location of a patient. The method can further include applying electrical signals to the target neural site via the signal delivery device, on a generally continual basis at a frequency of from about 0.9 Hz to about 250 Hz. The electrical signals can be applied to epileptic patients to at least reduce ictal and interictal epileptic senicity, and/or to patients functioning at normal or better levels to improve patient functioning.
摘要翻译：公开了治疗颞叶癫痫，相关神经系统疾病和其他患者功能的方法。根据若干实施例的用于治疗患者的方法包括：在患者的皮质位置处将信号递送装置硬膜下地邻近目标神经部位植入。该方法可以进一步包括经由信号传递装置的电信号，在大致连续的基础上以约0.9Hz至约250Hz的频率施加电信号。电信号可以应用于癫痫患者，以至少减少炎症和间歇性癫痫持续性，和/或对正常或更好水平的患者起作用，以改善患者功能。

9. 发明申请

US20060200206A1 Methods and apparatus for effectuating a lasting change in a neural-function of a patient 有权
公开(公告)号：US20060200206A1
公开(公告)日：2006-09-07
申请号：US11355038
申请日：2006-02-15
申请人： Andrew Firlik , Jeffrey Balzer , Bradford Gliner , Alan Levy , Carlton Morgan
发明人： Andrew Firlik , Jeffrey Balzer , Bradford Gliner , Alan Levy , Carlton Morgan
IPC分类号： A61N1/34
CPC分类号： A61N1/375 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain). Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.

10. 发明授权

US07010351B2 Methods and apparatus for effectuating a lasting change in a neural-function of a patient 有权
公开(公告)号：US07010351B2
公开(公告)日：2006-03-07
申请号：US09802808
申请日：2001-03-08
申请人： Andrew D. Firlik , Jeffrey Balzer , Bradford E. Gliner , Alan J. Levy , Carlton B. Morgan
发明人： Andrew D. Firlik , Jeffrey Balzer , Bradford E. Gliner , Alan J. Levy , Carlton B. Morgan
IPC分类号： A61N1/18
CPC分类号： A61N1/375 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as “neuroplasticity.” The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain). Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.

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