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1. 发明授权

US08283147B2 Pancreatin and method for reducing the viral and microbial contamination of pancreatin 有权
标题翻译：胰蛋白酶和减少胰腺炎病毒和微生物污染的方法
公开(公告)号：US08283147B2
公开(公告)日：2012-10-09
申请号：US12403697
申请日：2009-03-13
申请人： Manfred Kurfürst , Christian Rämsch , Thomas Schräder , Thomas Moest
发明人： Manfred Kurfürst , Christian Rämsch , Thomas Schräder , Thomas Moest
IPC分类号： C12N9/94
CPC分类号： C12N9/94 , A61L2/0023
摘要： The invention relates to a method for producing pancreatin with reduced viral and microbial contamination, comprising the steps of (a) providing the pancreatin in solid form with a residual moisture of 0.5 weight % or less, down to almost zero, based on the pancreatin provided; (b) subjecting the pancreatin provided in step (a) to a heat treatment at a temperature of 84° C., preferably 80° C. and below; wherein, the biological activity of the pancreatin obtained in step (b) corresponds to at least 50% of the biological activity of the pancreatin provided in step (a); and the viral infectiousness of the pancreatin obtained in step (b) has been reduced by a factor of more than 1 log10 in comparison with the viral infectiousness of the pancreatin provided in step (a), as well as a pancreatin produced according to this method and its use for producing a medicine or a nutritional supplement.
摘要翻译：本发明涉及一种生产具有减少的病毒和微生物污染的胰酶的方法，其包括以下步骤：（a）基于所提供的胰酶，提供固体形式的胰酶，残留水分为0.5重量％或更少，至少几乎为零 ; （b）使步骤（a）中提供的胰酶在84℃，优选80℃及以下的温度下进行热处理; 其中，步骤（b）中获得的胰酶的生物活性对应于步骤（a）中提供的胰酶的生物活性的至少50％。与步骤（a）中提供的胰酶的病毒感染性相比，步骤（b）中获得的胰酶的病毒感染性已经降低了大于1log10的因子，以及根据该方法制备的胰酶及其用于生产药物或营养补充剂的用途。

2. 发明授权

US5453280A Production of pellets composed of an ephedrine derivative 失效
标题翻译：生产由麻黄碱衍生物组成的丸粒
公开(公告)号：US5453280A
公开(公告)日：1995-09-26
申请号：US117285
申请日：1993-09-07
申请人： Thomas Moest , Uwe Loeffler , Hans Waiblinger
发明人： Thomas Moest , Uwe Loeffler , Hans Waiblinger
IPC分类号： A61K9/16 , A61K31/135 , A61K31/137 , A61K9/54 , B29B9/08 , B29B9/16
CPC分类号： A61K31/135 , A61K9/1688
摘要： A process for producing pellets which are markedly spherical and have a particle size in the range from 0.1 to 4 mm and an apparent density above 0.5 g/cm.sup.3, and which are composed of 90-100% by weight of an ephedrine derivative and 0-10% by weight of a pharmaceutical aid, entails suspending ephedrine derivative powder with an average particle size of from 0.5 to 50 .mu.m at 0.degree.-90.degree. C. with stirring in a water-immiscible non solvent with a boiling point in the range from 60.degree. to 160.degree. C., adding 5-60% by weight, based on the ephedrine derivative, of an agglomerating liquid while continuing stirring, and, if there has been previous heating, cooling to from -5 to 25.degree. C. at 5-40K per hour, with the stirring speed being adjusted after the agglomeration of the powder particles to a value which is necessary for the required average particle size, and removing and drying the resulting pellets. A drug which contains the active ingredient in the form of such pellets, with or without slowing of release, is also described.
摘要翻译：一种制备显影球形，粒径为0.1〜4mm，表观密度为0.5g / cm 3以上的颗粒的方法，由90-100重量％的麻黄碱衍生物和0〜 10重量％的药物助剂，需要在0〜90℃下搅拌平均粒度为0.5〜50μm的麻黄碱衍生物粉末，在沸点范围内的不溶于水的非溶剂中搅拌从60℃升至160℃，在连续搅拌的同时加入约5-60重量％的基于麻黄碱衍生物的附聚液，如果先前加热，冷却至-5〜25℃ 以每小时5-40K的速度调整粉末颗粒附聚后的搅拌速度至所需的平均颗粒尺寸所需的值，并除去和干燥所得的颗粒。还描述了含有这种丸剂形式的活性成分的药物，其具有或没有减缓释放。

3. 发明授权

US5160469A Manufacture of pellets of xanthine derivatives 失效
标题翻译： XANTHINE衍生物颗粒的制备
公开(公告)号：US5160469A
公开(公告)日：1992-11-03
申请号：US578442
申请日：1990-09-07
申请人： Thomas Moest , Claus H. Pich
发明人： Thomas Moest , Claus H. Pich
IPC分类号： A61K9/16 , A61K9/20 , A61K9/32 , A61K9/52 , A61K31/52
CPC分类号： A61K9/1688 , A61K31/52
摘要： A process for the manufacture of pellets which are composed of xanthine derivatives and are predominantly spherical, have a particle size in the range of 0.3 to 4 mm and have a bulk density above 0.5 g/cm.sup.3 by reacting the appropriate xanthine derivative with water or a water/alcohol mixture, entails anhydrous powdered xanthine derivative with an average particle size of from 20 to 200 .mu.m being suspended by stirring at from 40.degree. to 70.degree. C. in a nonsolvent which is immiscible with water and has a boiling point in the range from 60.degree. to 160.degree. C., then adding from 10 to 40% by weight, based on the anhydrous xanthine derivative, of water or a water/alcohol mixture and subsequently allowing to cool to room temperature at from 5.degree. to 20.degree. C. per hour, it being possible to reduce the stirring speed after agglomeration to about 1/3 to 2/3 of the original, and the pellets being separated from the liquid and dried, the pellets being used, possibly with a delayed release coating, as active compound in a drug.
摘要翻译：制造由黄嘌呤衍生物构成的并且主要为球形的颗粒的方法具有0.3-4mm的粒径，并且通过使适当的黄嘌呤衍生物与水或水/醇混合物，使平均粒度为20〜200μm的无水粉末黄嘌呤衍生物在40℃至70℃下搅拌悬浮，在与水不混溶的非溶剂中，并且沸点在范围为60〜160℃，然后以无水黄嘌呤衍生物为基础，以无水黄嘌呤衍生物为10〜40重量％的水或水/醇混合物，然后在5〜20℃下冷却至室温。每小时可以将凝聚后的搅拌速度降低到原料的约1/3至2/3，并将颗粒与液体分离并干燥，使用颗粒，可能具有延迟释放涂层，as 药物中的活性化合物。

4. 发明申请

US20130230922A1 NEUTRAL PROTEASE (NP) AND PRODUCT BY USING NEUTRAL PROTEASE FOR TISSUE DISSOCIATION AS WELL AS METHOD FOR THE PRODUCTION THEREOF 有权
标题翻译：中性蛋白（NP）和产品通过使用中性蛋白作为组织分离作为其生产方法
公开(公告)号：US20130230922A1
公开(公告)日：2013-09-05
申请号：US13862773
申请日：2013-04-15
申请人： NORDMARK, ARZNEIMITTEL GMBH & CO., KG
发明人： Manfred KURFUERST , Christian Raemsch , Nicole Raemsch-Guenther , Olaf Friedrich , Silke Huettler , Daniel Brandhorst , Thierry Berney , Pascal Bucher , Heide Brandhorst
IPC分类号： C12N5/071
CPC分类号： C12N5/0676 , C12N9/52 , C12N9/6491 , C12N2501/999 , C12N2509/00
摘要： The use of a neutral protease (NP) together with a collagenase consists in that a neutral protease which is not contained in a collagenase enzyme preparation and which is not produced by a recombinant production is mixed before the beginning of a tissue dissociation with a collagenase or a collagenase enzyme preparation with an individual dosage of the quantitative proportions of neutral protease and collagenase for improving the isolation results with respect to yield, viability and integrity of the cells.
摘要翻译：将中性蛋白酶（NP）与胶原酶一起使用的原因在于，在胶原酶组织解离开始之前，混合未包含在胶原酶制剂中并且不通过重组生产产生的中性蛋白酶，或胶原酶制剂，具有定量比例的中性蛋白酶和胶原酶的单独剂量，用于改善关于细胞的产量，活力和完整性的分离结果。

5. 发明申请

US20090233344A1 PANCREATIN AND METHOD FOR REDUCING THE VIRAL AND MICROBIAL CONTAMINATION OF PANCREATIN 有权
标题翻译：胰蛋白酶和减少胰蛋白酶的病毒和微生物污染的方法
公开(公告)号：US20090233344A1
公开(公告)日：2009-09-17
申请号：US12403697
申请日：2009-03-13
申请人： MANFRED KURFURST , Christian Ramsch , Thomas Schrader , Thomas Moest
发明人： MANFRED KURFURST , Christian Ramsch , Thomas Schrader , Thomas Moest
IPC分类号： C12N9/94
CPC分类号： C12N9/94 , A61L2/0023
摘要： The invention relates to a method for producing pancreatin with reduced viral and microbial contamination, comprising the steps of (a) providing the pancreatin in solid form with a residual moisture of 0.5 weight % or less, down to almost zero, based on the pancreatin provided; (b) subjecting the pancreatin provided in step (a) to a heat treatment at a temperature of 84° C., preferably 80° C. and below; wherein, the biological activity of the pancreatin obtained in step (b) corresponds to at least 50% of the biological activity of the pancreatin provided in step (a); and the viral infectiousness of the pancreatin obtained in step (b) has been reduced by a factor of more than 1 log10 in comparison with the viral infectiousness of the pancreatin provided in step (a), as well as a pancreatin produced according to this method and its use for producing a medicine or a nutritional supplement.
摘要翻译：本发明涉及一种生产具有减少的病毒和微生物污染的胰酶的方法，其包括以下步骤：（a）基于所提供的胰酶，提供固体形式的胰酶，残留水分为0.5重量％或更少，至少几乎为零 ; （b）使步骤（a）中提供的胰酶在84℃，优选80℃及以下的温度下进行热处理; 其中，步骤（b）中获得的胰酶的生物活性对应于步骤（a）中提供的胰酶的生物活性的至少50％。与步骤（a）中提供的胰酶的病毒感染性相比，步骤（b）中获得的胰酶的病毒感染性降低了大于1log10的因子，以及根据该方法制备的胰酶及其用于生产药物或营养补充剂的用途。

6. 发明授权

US5270055A Solid pharmaceutical sustained-release form 失效
标题翻译：固体药物缓释形式
公开(公告)号：US5270055A
公开(公告)日：1993-12-14
申请号：US426018
申请日：1989-10-24
申请人： Thomas Moest
发明人： Thomas Moest
IPC分类号： A61K9/22 , A61K9/50 , A61K9/58 , A61K9/62 , A61K9/24 , A61K9/36 , A61K9/42
CPC分类号： A61K9/5073
摘要： A solid pharmaceutical sustained-release form, consisting of a core containing the active compound as well as conventional pharmaceutical auxiliaries, a coat which delays the release of the active compound and an antiadhesive outer layer, wherein the coat consists of a physiologically acceptable fat-like or wax-like hydrophobic layer which melts in the range from 30.degree. to 120.degree. C. and contains, in addition to conventional pharmaceutical auxiliaries, one or more water-insoluble polymers, and a process for its preparation.
摘要翻译：固体药物缓释形式，由含有活性化合物的核心以及常规药物助剂组成，延长活性化合物释放的涂层和抗粘附外层，其中该涂层由生理上可接受的脂肪样或蜡状疏水层，其在30℃至120℃的范围内熔融，并且除常规药物助剂外还含有一种或多种水不溶性聚合物及其制备方法。

7. 发明授权

US08765471B2 Neutral protease (NP) and product by using neutral protease for tissue dissociation as well as method for the production thereof 有权
标题翻译：中性蛋白酶（NP）和产品通过使用中性蛋白酶进行组织解离以及其制备方法
公开(公告)号：US08765471B2
公开(公告)日：2014-07-01
申请号：US13862773
申请日：2013-04-15
申请人： Nordmark, Arzneimittel GmbH & Co., KG
发明人： Manfred Kurfuerst , Christian Raemsch , Nicole Raemsch-Guenther , Olaf Friedrich , Silke Huettler , Daniel Brandhorst , Thierry Berney , Pascal Bucher , Heide Brandhorst
IPC分类号： C12N5/00
CPC分类号： C12N5/0676 , C12N9/52 , C12N9/6491 , C12N2501/999 , C12N2509/00
摘要： The use of a neutral protease (NP) together with a collagenase consists in that a neutral protease which is not contained in a collagenase enzyme preparation and which is not produced by a recombinant production is mixed before the beginning of a tissue dissociation with a collagenase or a collagenase enzyme preparation with an individual dosage of the quantitative proportions of neutral protease and collagenase for improving the isolation results with respect to yield, viability and integrity of the cells.
摘要翻译：将中性蛋白酶（NP）与胶原酶一起使用的原因在于，在胶原酶组织解离开始之前，混合未包含在胶原酶制剂中并且不通过重组生产产生的中性蛋白酶，或胶原酶制剂，具有定量比例的中性蛋白酶和胶原酶的单独剂量，用于改善关于细胞的产量，活力和完整性的分离结果。

8. 发明申请

US20120213857A1 Method for Producing Pancreatin Pellets 有权
标题翻译：生产胰岛素颗粒的方法
公开(公告)号：US20120213857A1
公开(公告)日：2012-08-23
申请号：US13368415
申请日：2012-02-08
申请人： Thomas Moest , Walter Doleschal , Manfred Kurfürst
发明人： Thomas Moest , Walter Doleschal , Manfred Kurfürst
IPC分类号： A61K9/14 , A61P1/18 , B29B9/00 , A61K38/54
CPC分类号： A61K9/1688 , A61K9/5021 , A61K9/5073 , A61K9/5089 , A61K35/39 , A61K38/00 , A61K38/48 , C12N9/94
摘要： In order to avoid compromising the pharmacological effect of pancreatin caused by the addition of auxiliary materials or binding agents, a pancreatin pellet having a 100% pancreatin content consists exclusively of pancreatin with a residual moisture content of less than 3% by weight, preferably less than 1% by weight or less than 0.5% by weight.
摘要翻译：为了避免由于添加辅助材料或粘合剂而导致的胰酶的药理作用的损害，具有100％胰酶含量的胰酶颗粒仅由胰酶组成，残留水分含量小于3重量％，优选小于 1重量％或小于0.5重量％。

9. 发明授权

US5320852A Antacid microtablets 失效
标题翻译：抗酸微片
公开(公告)号：US5320852A
公开(公告)日：1994-06-14
申请号：US987559
申请日：1992-12-08
申请人： Thomas Moest
发明人： Thomas Moest
IPC分类号： A61J3/10 , A61K9/20 , A61K33/06 , A61K33/10 , A61K45/08 , A61P1/00 , A61K33/08 , A61K33/12
CPC分类号： A61K33/06 , A61K9/2072 , Y10S514/819 , Y10S514/96
摘要： A biconvex tablet whose height and diameter are approximately equal and are from 1.5 to 4 mm and which, besides conventional pharmaceutical auxiliaries, contains an antacid as active substance is described.
摘要翻译：描述了其高度和直径近似相等并且为1.5至4mm的双凸片，并且除了常规药物助剂之外，还含有作为活性物质的抗酸剂。

10. 发明授权

US5092491A Metering apparatus for lump and powder materials 失效
标题翻译：用于粉末和粉末材料的计量装置
公开(公告)号：US5092491A
公开(公告)日：1992-03-03
申请号：US571282
申请日：1990-08-23
申请人： Ludwig Matz
发明人： Ludwig Matz
IPC分类号： G01F11/04 , G01F11/02 , G01F19/00
CPC分类号： G01F19/00 , G01F11/025 , G01F19/007
摘要： An apparatus for removing powder or lump materials from a storage vessel, obtaining a preselected volume of the material, returning any excess material to the storage vessel, and dispensing the obtained measured material. The apparatus contains a product-receiving part, a handle portion, and a transition area in the shape of a taper which tapers downwardly toward the handle, which transition area connects the product-receiving part with the handle. The handle comprises a tube which is closed by a movable piston. The tube may be marked to facilitate measuring the volume of the material.
摘要翻译：一种用于从储存容器中除去粉末或块状物质的装置，获得材料的预选体积，将任何多余的材料返回到储存容器中，以及分配所获得的测量材料。该装置包括产品接收部分，手柄部分和朝向手柄向下渐缩的锥形形状的过渡区域，该过渡区域将产品接收部分与手柄连接。手柄包括由活动活塞封闭的管。管可以被标记以便于测量材料的体积。

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