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1. 发明申请

US20100137210A1 Gastrointestinal proliferative foctor and uses thereof 有权
标题翻译：胃肠道增生症及其用途
公开(公告)号：US20100137210A1
公开(公告)日：2010-06-03
申请号：US12589727
申请日：2009-10-27
申请人： Walter Funk , Makoto Kakitani , Takeshi Oshima , Eun Ju Park , Mikio Yagi , Kazuma Tomizuka
发明人： Walter Funk , Makoto Kakitani , Takeshi Oshima , Eun Ju Park , Mikio Yagi , Kazuma Tomizuka
IPC分类号： A61K38/17 , A61P1/00
CPC分类号： G01N33/5088 , A01K67/0275 , A01K2217/072 , A01K2227/105 , A01K2267/01 , A61K38/1709 , A61K48/005 , C07K14/475 , C12N15/8509 , C12N2799/022 , C12N2800/30
摘要： The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor (GIPF) polynucleotides and polypeptides. The invention further relates to the therapeutic use of GIPF to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.
摘要翻译：本发明涉及包含胃肠增生因子（GIPF）多核苷酸和多肽的药物组合物。本发明还涉及GIPF用于预防或治疗与上皮粘膜变性相关的病症或病症的治疗用途。

2. 发明申请

US20080260747A1 Methods and Materials Relating to CD84-like Polypeptides and Polynucleotides 审中-公开
标题翻译：与CD84样多肽和多核苷酸相关的方法和材料
公开(公告)号：US20080260747A1
公开(公告)日：2008-10-23
申请号：US12100870
申请日：2008-04-10
申请人： Chiaoyun Kuo , Bryan J. Boyle , Jian-Rui Wang , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
发明人： Chiaoyun Kuo , Bryan J. Boyle , Jian-Rui Wang , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00
CPC分类号： C12N9/6432 , A61K38/00 , C07K14/70503 , C07K14/70596 , C07K14/715 , C07K16/00 , C12N9/16 , C12Y304/21006
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted CD84-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human spleen (Hyseq clone identification numbers 2938352 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted CD84-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译：本发明提供由对应于新的人分泌的CD84样多肽的这种多核苷酸和突变体或其变体编码的新的多核苷酸和多肽。这些多核苷酸包含从人脾cDNA文库中分离的核酸序列（Hyseq克隆鉴定号2938352（SEQ ID NO：1））。本发明的其它方面包括含有生产新的人分泌的CD84样多肽的方法的载体和对这些多肽特异的抗体。

3. 发明申请

US20080200388A1 Stem cell factor-like proteins and uses thereof 有权
公开(公告)号：US20080200388A1
公开(公告)日：2008-08-21
申请号：US12080212
申请日：2008-04-01
申请人： Bryan J. Boyle , Peter C.R. Emtage , Walter Funk , Y. Tom Tang , Jingsong Zhao
发明人： Bryan J. Boyle , Peter C.R. Emtage , Walter Funk , Y. Tom Tang , Jingsong Zhao
IPC分类号： A61K38/16 , C07H21/04 , C12N15/00 , C12N5/00 , C07K14/00 , C12P21/06 , C12Q1/68 , G01N33/53 , G01N33/00 , C12N5/02
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor SCFA2, SCFA4 or SCFA4v polynucleotides and polypeptides. The invention further relates to the therapeutic use of SCFA2, SCFA4 or SCFA4v to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.

4. 发明授权

US07411052B2 Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides 失效
公开(公告)号：US07411052B2
公开(公告)日：2008-08-12
申请号：US10488423
申请日：2002-08-30
申请人： Y. Tom Tang
发明人： Y. Tom Tang
IPC分类号： A61K38/24 , C07K1/00 , C07H21/02 , C12Q1/68
CPC分类号： C07K14/475
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptides. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.

5. 发明申请

US20070264261A1 Methods of Therapy and Diagnosis Using Targeting of Cells that Express Killer Cell Immunoglobulin like Receptor like Proteins 审中-公开
标题翻译：使用靶向表达杀伤细胞免疫球蛋白如受体像蛋白质的细胞进行治疗和诊断的方法
公开(公告)号：US20070264261A1
公开(公告)日：2007-11-15
申请号：US11766911
申请日：2007-06-22
申请人： Peter Emtage , Y. Tang
发明人： Peter Emtage , Y. Tang
IPC分类号： A61K39/395 , A61K38/00 , A61K48/00 , C07H21/04 , C07K14/00 , C07K16/18 , C12N15/00 , C12N5/06 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/705 , A61K38/00 , A61K47/6849 , A61K48/00 , A61K51/1027 , A61K2039/505 , C07K16/2803 , C07K16/3061 , C07K2317/34 , C07K2317/732 , C07K2317/77 , C07K2319/30 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57426 , G01N33/6872 , G01N2333/70503
摘要： Certain cells, including various types of cancer cells, express KIRHy proteins. Targeting using KIRHy polypeptides, nucleic acids encoding for KIRHy polypeptides and anti-KIRHy antibodies provides a method of killing or inhibiting that growth of cancer cells that express the KIRHy protein. Methods of therapy and diagnosis of disorders associated with KIRHy protein-expressing cells, such as acute myelogenous leukemia (AML), are described.
摘要翻译：某些细胞，包括各种类型的癌细胞，表达KIRHy蛋白。使用KIRHy多肽进行靶向，编码KIRHy多肽的核酸和抗KIRHy抗体提供了杀死或抑制表达KIRHy蛋白的癌细胞生长的方法。描述了与KIRHy蛋白表达细胞相关的疾病如急性骨髓性白血病（AML）的治疗和诊断方法。

6. 发明授权

US07067301B2 Methods and materials relating to novel prothrombinase-like polypeptides and polynucleotides 失效
公开(公告)号：US07067301B2
公开(公告)日：2006-06-27
申请号：US10389301
申请日：2003-03-13
申请人： Dana A. Haley , Bryan J. Boyle , Alice S. Ho , Matthew C. Arterburn , Nancy K. Mize
发明人： Dana A. Haley , Bryan J. Boyle , Alice S. Ho , Matthew C. Arterburn , Nancy K. Mize
IPC分类号： C07H21/02 , C07H21/04 , C12N15/63 , C12N1/21 , A61K35/14 , A61K35/16 , C07K14/00
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/505
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human prothrombinase-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human ovary (Hyseq clone identification number 7735656). Other aspects of the invention include vectors containing processes for producing novel human prothrombinase-like polypeptides, and antibodies specific for such polypeptides.

7. 发明申请

US20050266423A1 Novel nucleic acids and polypeptides 审中-公开
公开(公告)号：US20050266423A1
公开(公告)日：2005-12-01
申请号：US11000463
申请日：2004-11-29
申请人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-hong Chen , Xiaohong Qian , Zhi Wang , Tom Wehrman , Jie Zhang , Ping Zhou , Yicheng Cao , Radoje Drmanac
发明人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-hong Chen , Xiaohong Qian , Zhi Wang , Tom Wehrman , Jie Zhang , Ping Zhou , Yicheng Cao , Radoje Drmanac
IPC分类号： A61K38/00 , C07H21/04 , C07K14/47 , C07K14/705 , C07K14/715 , C07K14/775 , C07K16/00 , C12N9/16 , C12N9/64 , C12P21/06 , C12Q1/68
CPC分类号： C12N9/6432 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C07K14/715 , C07K14/775 , C07K16/00 , C12N9/16 , C12Y304/21006
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.

8. 发明授权

US06884872B1 Methods and compositions relating to CD39-like polypeptides and nucleic acids 失效
标题翻译：涉及CD39样多肽和核酸的方法和组合物
公开(公告)号：US06884872B1
公开(公告)日：2005-04-26
申请号：US09905589
申请日：2001-07-13
申请人： Brian Paul Chadwick , Anna-Maria Frischauf
发明人： Brian Paul Chadwick , Anna-Maria Frischauf
IPC分类号： A61K38/00 , C07K14/705 , C12N1/21 , C12N9/14 , C07K16/40 , C12N1/00
CPC分类号： C12Y306/01015 , A61K38/00 , C07K14/70596 , C12N9/14 , Y10S435/81
摘要： The present invention provides polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins. In particular, the polypeptides and polynucleotides of the invention comprise amino acid and nucleic acid sequences of novel CD39-like gene and gene products.
摘要翻译：本发明提供了由这些多核苷酸编码的多核苷酸和蛋白质，以及这些多核苷酸和蛋白质的治疗，诊断和研究用途。特别地，本发明的多肽和多核苷酸包含新型CD39样基因和基因产物的氨基酸和核酸序列。

9. 发明授权

US07659054B1 Methods for genetic analysis of DNA to detect sequence variances 失效
标题翻译：遗传分析DNA检测序列差异的方法
公开(公告)号：US07659054B1
公开(公告)日：2010-02-09
申请号：US09697028
申请日：2000-10-25
申请人： Jeffrey Olson , Vincent P. Stanton, Jr.
发明人： Jeffrey Olson , Vincent P. Stanton, Jr.
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/686 , C12Q1/6858 , C12Q2525/313
摘要： The presently claimed invention concerns a method for biasing the amplification of the DNA molecules in a sample such that a nucleic acid molecule having a specific nucleotide at a selected position (e.g., a polymorphic site) is preferentially amplified relative to an otherwise identical nucleic acid molecule not having the specific nucleotide at the selected position. The method entails amplification of target nucleic acid molecules using a pair of primers one of which causes the incorporation into the amplification product of a sequence that interferes with amplification of nucleic acid molecules not having the specific nucleotide at the selected position. The method is useful for preferentially amplifying at least a portion of one allele of a gene relative to another, different allele of the gene in a sample containing both alleles of the gene.
摘要翻译：本发明涉及一种用于偏置样品中DNA分子的扩增的方法，使得在选定位置（例如，多态性位点）具有特定核苷酸的核酸分子相对于其它相同的核酸分子优先扩增在选定位置没有特异性核苷酸。该方法需要使用一对引物扩增靶核酸分子，其中一个引物引入掺入在选定位置不具有特定核苷酸的核酸分子的扩增的序列的扩增产物。该方法可用于相对于含有该基因的两个等位基因的样品中该基因的另一不同等位基因优先扩增一个等位基因的至少一部分。

10. 发明申请

US20090081209A1 METHODS OF THERAPY AND DIAGNOSIS USING TARGETING OF CELLS THAT EXPRESS KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR-LIKE PROTEINS 审中-公开
标题翻译：使用表达杀伤细胞免疫抑制蛋白样受体样蛋白的细胞靶向的治疗方法和诊断方法
公开(公告)号：US20090081209A1
公开(公告)日：2009-03-26
申请号：US12024226
申请日：2008-02-01
申请人： PETER C.R. EMTAGE , Y. TOM TANG
发明人： PETER C.R. EMTAGE , Y. TOM TANG
IPC分类号： A61K39/395 , C07K16/18 , A61K31/7105 , A61K39/00 , A61K38/02 , A61P35/02 , C12Q1/68 , C07H21/00 , C12N15/63 , C12N5/10 , C07K2/00
CPC分类号： C07K14/705 , A61K38/00 , A61K47/6849 , A61K48/00 , A61K51/1027 , A61K2039/505 , C07K16/2803 , C07K16/3061 , C07K2317/34 , C07K2317/732 , C07K2317/77 , C07K2319/30 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57426 , G01N33/6872 , G01N2333/70503
摘要： Certain cells, including various types of cancer cells, express KIRHy proteins. Targeting using KIRHy polypeptides, nucleic acids encoding for KIRHy polypeptides and anti-KIRHy antibodies provides a method of killing or inhibiting that growth of cancer cells that express the KIRHy protein. Methods of therapy and diagnosis of disorders associated with KIRHy protein-expressing cells, such as acute myelogenous leukemia (AML), are described.
摘要翻译：某些细胞，包括各种类型的癌细胞，表达KIRHy蛋白。使用KIRHy多肽进行靶向，编码KIRHy多肽的核酸和抗KIRHy抗体提供了杀死或抑制表达KIRHy蛋白的癌细胞生长的方法。描述了与KIRHy蛋白表达细胞相关的疾病如急性骨髓性白血病（AML）的治疗和诊断方法。

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