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1. 发明公开

US20240207080A1 SYSTEMS AND MEHTODS FOR STABILIZING ANTI-MIGRATION ANCHOR SYSTEM 审中-公开
公开(公告)号：US20240207080A1
公开(公告)日：2024-06-27
申请号：US18288694
申请日：2022-04-28
申请人： MetaModix, Inc.
发明人： Kedar R. Belhe , Werner Schwarz , Todd Stangenes , Parker Hagen , Richard Mattison
IPC分类号： A61F5/00 , A61F2/04 , A61F2/95
CPC分类号： A61F5/0079 , A61F2/9517 , A61F5/0089 , A61F2002/045 , A61F2002/9505 , A61F2220/0008 , A61F2230/0039 , A61F2230/0091 , A61F2250/0039
摘要： A system for delivering an anti-migration anchor to an implantable device includes a locator system having a head portion adapted to mate with the neck portion of the device, a locator capsule coupled to the head portion, and a plurality of arms coupled to the head portion and the locator capsule, the arms having a collapsed and an extended configuration. The system includes a catheter having a distal portion coupled to and extending from the head portion. The system includes a handle coupled to a portion of the catheter, the handle having a mechanism to effect relative motion between an inner and an outer member of the catheter to cause the arms to transition from the collapsed to the extended configuration. The system includes a plurality of elongate elements having a distal end coupled to the arm and configured to facilitate the delivery of an anti-migration anchor to the arm.

2. 发明授权

US10322021B2 Delivery devices and methods for gastrointestinal implants 有权
公开(公告)号：US10322021B2
公开(公告)日：2019-06-18
申请号：US14872990
申请日：2015-10-01
申请人： MetaModix, Inc.
发明人： Kedar R. Belhe , Paul J. Thompson , Alexander D. Grafov , Werner Schwarz
IPC分类号： A61F5/00 , A61F2/04
摘要： Several gastrointestinal surgery procedures are effective as treatments for metabolic disorders such as obesity and diabetes. Minimally invasive procedures including intra-luminal gastrointestinal implants have been proposed to mimic the anatomical, physiological and metabolic changes achieved by these procedures. Many of these designs include long sleeve like elements that prevent contact of food with the walls of the small intestine. It is desirable to have simple delivery systems that can place these implants under endoscopic guidance. However, in order to anchor these sleeve elements safely and reliably, the inventors have previously disclosed anchoring means that anchor the sleeves at the junctions of the stomach and the intestine or the stomach and esophagus.

3. 发明授权

US09044300B2 Gastrointestinal prostheses 有权
标题翻译：胃肠假体
公开(公告)号：US09044300B2
公开(公告)日：2015-06-02
申请号：US14244544
申请日：2014-04-03
申请人： MetaModix, Inc.
发明人： Kedar R. Belhe , Paul J. Thompson
IPC分类号： A61M5/00 , A61F5/00 , A61F2/04
CPC分类号： A61F5/0076 , A61F5/0079 , A61F2002/044 , A61F2002/045
摘要： A system for therapy within a gastrointestinal system includes anchoring or attachment functionality embodied in a low-profile implant technology and removable therapy components, which can be reversibly attached to these low-profile implants to accomplish various therapies. This design allows the physician to tailor the therapy to the patient's needs. The system has the potential to create conduits for diversion and/or restriction of food and organ secretions and to facilitate the treatment of metabolic disorders such as obesity and T2DM.
摘要翻译：用于胃肠系统内治疗的系统包括以低轮廓植入技术和可移除治疗组件体现的锚定或附着功能，其可逆地附着于这些低轮廓植入物以完成各种疗法。这种设计允许医生根据患者的需要量身定做治疗。该系统有可能产生用于转移和/或限制食物和器官分泌物的导管，并且有助于治疗诸如肥胖症和T2DM的代谢性疾病。

4. 发明授权

US08282598B2 External anchoring configurations for modular gastrointestinal prostheses 有权
标题翻译：模块化胃肠假体的外部锚定配置
公开(公告)号：US08282598B2
公开(公告)日：2012-10-09
申请号：US12833605
申请日：2010-07-09
申请人： Kedar R. Belhe , Paul J. Thompson
发明人： Kedar R. Belhe , Paul J. Thompson
IPC分类号： A61M39/00
CPC分类号： A61F5/0076 , A61F5/003
摘要： Components may be used separately or in combination to create anchoring systems for intra-luminal implants for the treatment of metabolic disorders such as obesity and diabetes. Various systems include an external component adapted for deployment around a portion of the gastrointestinal tract (e.g., the duodenum) and an internal component adapted for implantation within the gastrointestinal tract. Various systems use anchors that are based on mechanical interference, elasticity, spring force, shape memory transformation, magnetic attraction, repulsion and/or levitation. Various embodiments rely on longitudinal anchoring of the implants with minimal force against tissue.
摘要翻译：组分可以单独使用或组合使用以产生腔内植入物用于治疗代谢紊乱如肥胖症和糖尿病的锚定系统。各种系统包括适于部署在胃肠道的一部分（例如，十二指肠）周围的外部部件和适于植入胃肠道内部的内部部件。各种系统使用基于机械干涉，弹性，弹簧力，形状记忆变换，磁吸引，排斥和/或悬浮的锚。各种实施例依赖于对组织的最小力的植入物的纵向锚固。

5. 发明授权

US11793839B2 System and method for affecting intestinal microbial flora 有权
公开(公告)号：US11793839B2
公开(公告)日：2023-10-24
申请号：US16111169
申请日：2018-08-23
申请人： MetaModix, Inc.
发明人： Kedar R. Belhe , Todd Stangenes
IPC分类号： A61F5/00 , A61F2/04 , A61K35/741
CPC分类号： A61K35/741 , A61F2/04 , A61F5/0076 , A61F2002/044 , A61F2002/045
摘要： Described is a system for affecting intestinal microbial flora. The system includes an intestinal sleeve that is implanted in a patient and bypasses a section of the intestine; and probiotics, prebiotics or pharmacologic therapy used in combination with the intestinal sleeve. Also described are related methods.

6. 发明授权

US11666470B2 Pyloric anchor retrieval tools and methods 有权
公开(公告)号：US11666470B2
公开(公告)日：2023-06-06
申请号：US16843691
申请日：2020-04-08
申请人： MetaModix, Inc.
发明人： Todd Stangenes , Werner Schwarz , Kedar R. Belhe , Mathew Ziebol , Edward Anderson
IPC分类号： A61F5/00 , A61B17/00 , A61F2/95
CPC分类号： A61F5/0089 , A61B17/00234 , A61F5/0079 , A61B2017/00292 , A61B2017/00336 , A61B2017/00349 , A61B2017/00362 , A61B2017/00818 , A61F2002/9528
摘要： A retrieval device comprising a hook assembly and a capsule assembly. The hook assembly has an attachment feature at a first end. The capsule assembly includes a capsule, a capsule shaft, and a handle connected in series and defining an inner bore. The capsule has a first end defining an opening. The inner bore of the capsule assembly is configured to slidably receive the hook assembly. The handle has a central portion, a first extension portion attached to the capsule shaft, and a second extension portion with a hook assembly lock at a second end. The hook assembly lock is configured to lock the hook assembly to the second extension portion. The second extension portion is configured to pull the hook assembly relative to the capsule shaft, and the first extension portion is configured to push the capsule shaft relative to the hook assembly along the central longitudinal axis.

7. 发明授权

US10729573B2 Pyloric anchors and methods for intestinal bypass sleeves 有权
公开(公告)号：US10729573B2
公开(公告)日：2020-08-04
申请号：US15489444
申请日：2017-04-17
申请人： METAMODIX, INC.
发明人： Todd Stangenes , Werner Schwarz , Kedar R. Belhe , Mathew Ziebol , Edward Anderson
IPC分类号： A61M25/04 , A61F5/00
摘要： A gastrointestinal device for implanting within a patient's gastrointestinal tract, the device having a central axis and a first expandable portion comprising a hollow tubular braided structure of wire and having a first cylinder extending parallel to the central axis, the first cylinder having a length and a first face; a neck portion extending from the first face of the first expandable portion parallel to the central axis, the neck portion having a first end, a second end, a wall extending between the first end and second end, and a diameter sized to fit within a pylorus; and a second expandable portion comprising a hollow tubular braided structure of wire and having a second cylinder extending parallel to the central axis, the second cylinder having a second face located at the proximal end of the second cylinder and oriented transverse to the central axis.

8. 发明授权

US10624773B2 Pyloric anchors and methods for intestinal bypass sleeves 有权
公开(公告)号：US10624773B2
公开(公告)日：2020-04-21
申请号：US15489444
申请日：2017-04-17
申请人： METAMODIX, INC.
发明人： Todd Stangenes , Werner Schwarz , Kedar R. Belhe , Mathew Ziebol , Edward Anderson
IPC分类号： A61M25/04 , A61F5/00
摘要： A gastrointestinal device for implanting within a patient's gastrointestinal tract, the device having a central axis and a first expandable portion comprising a hollow tubular braided structure of wire and having a first cylinder extending parallel to the central axis, the first cylinder having a length and a first face; a neck portion extending from the first face of the first expandable portion parallel to the central axis, the neck portion having a first end, a second end, a wall extending between the first end and second end, and a diameter sized to fit within a pylorus; and a second expandable portion comprising a hollow tubular braided structure of wire and having a second cylinder extending parallel to the central axis, the second cylinder having a second face located at the proximal end of the second cylinder and oriented transverse to the central axis.

9. 发明申请

US20120184893A1 ANCHORS AND METHODS FOR INTESTINAL BYPASS SLEEVES 有权
标题翻译：专用旁路系统的锚杆和方法
公开(公告)号：US20120184893A1
公开(公告)日：2012-07-19
申请号：US13360689
申请日：2012-01-28
申请人： Paul J. Thompson , Kedar R. Belhe , Alexander D. Grafov
发明人： Paul J. Thompson , Kedar R. Belhe , Alexander D. Grafov
IPC分类号： A61M1/00
CPC分类号： A61F5/0076 , A61F2/04 , A61F2/24 , A61F5/0079 , A61F2002/044 , A61F2002/045 , A61F2220/0008
摘要： A gastrointestinal device for implanting within a pylorus, a duodenal bulb, and a duodenum of a patient's gastrointestinal tract includes an expandable structure including a proximal portion having a plurality of spring arms and a distal portion having a plurality of spring arms, the proximal and distal portions coupled by a rigid central cylinder having a diameter capable of fitting within the pylorus and having a length greater than a width of the pylorus. An intestinal bypass sleeve is coupled to at least one of the proximal and distal portions of the expandable structure and having a length sufficient to extend at least partially into the duodenum. In the expanded configuration, the proximal portion has a diameter larger than a maximum opening diameter of the pylorus and further wherein, in the expanded configuration, the distal portion has a diameter larger than a maximum opening diameter of the pylorus.
摘要翻译：用于植入在幽门，十二指肠球和患者胃肠道十二指肠内的胃肠装置包括可扩张结构，其包括具有多个弹簧臂的近端部分和具有多个弹簧臂的远侧部分，近端和远端部分通过刚性中心圆柱体联接，所述刚性中心圆柱体具有能够配置在幽门内并且具有大于幽门宽度的长度的直径。肠旁路套管联接到可扩张结构的近端部分和远端部分中的至少一个，并且具有足以至少部分延伸到十二指肠的长度。在扩张构造中，近侧部分具有大于幽门的最大开口直径的直径，此外，在扩张构造中，远侧部分的直径大于幽门的最大开口直径。

10. 发明授权

US08211186B2 Modular gastrointestinal prostheses 有权
标题翻译：模块化胃肠假体
公开(公告)号：US08211186B2
公开(公告)日：2012-07-03
申请号：US12752697
申请日：2010-04-01
申请人： Kedar R. Belhe , Paul J. Thompson
发明人： Kedar R. Belhe , Paul J. Thompson
IPC分类号： A61F2/04
CPC分类号： A61F5/0076 , A61F5/0079 , A61F2002/044 , A61F2002/045
摘要： A modular system for therapy within a gastrointestinal system. The system includes anchoring or attachment functionality embodied in a low-profile implant technology and removable therapy components, which can be reversibly attached to these low-profile implants to accomplish various therapies. This modular design allows the physician to tailor the therapy to the patient's needs. The modular system has the potential to create conduits for diversion and/or restriction of food and organ secretions and to facilitate the treatment of metabolic disorders such as obesity and T2DM.
摘要翻译：用于胃肠系统内治疗的模块化系统。该系统包括实施在低轮廓植入技术和可移除治疗部件中的锚固或附接功能，其可逆地附接到这些低轮廓植入物以完成各种治疗。这种模块化设计允许医师根据患者的需要定制治疗。模块化系统有可能为食物和器官分泌物的转移和/或限制创建导管，并有助于治疗代谢性疾病如肥胖和T2DM。

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