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1. 发明申请

US20120202913A1 DENTAL ADHESIVE MATERIAL KIT 有权
标题翻译：牙膏胶原料
公开(公告)号：US20120202913A1
公开(公告)日：2012-08-09
申请号：US13500656
申请日：2011-03-25
申请人： Michiya Kawana , Hidemi Nakayama , Mitsuru Takei , Kenji Suzuki , Ai Hinamoto
发明人： Michiya Kawana , Hidemi Nakayama , Mitsuru Takei , Kenji Suzuki , Ai Hinamoto
IPC分类号： A61K6/00
CPC分类号： A61K6/0023 , A61K6/0038 , A61K6/005 , A61K6/0052 , A61K6/0076 , A61K6/0088 , C08L43/02 , C08L33/10 , C08L33/08 , C08L33/02 , C08L37/00 , C08L33/26 , C08L29/10 , C08L27/12 , C08L33/00
摘要： The present invention provides a dental adhesive material kit having excellent bond durability. The present invention is represented by a dental adhesive material kit containing a dental aqueous adhesive composition (A) and a multi-part type dental nonaqueous curable composition (B). The dental aqueous adhesive composition (A) contains a polymerizable monomer (a) having an acidic group, an aliphatic polymerizable monomer (b) having no acidic group, water (c), and an amine-based reducing agent (d1) containing no sulfur atom. The multi-part type dental nonaqueous curable composition (B) contains an aliphatic polymerizable monomer (b) having no acidic group, an aromatic polymerizable monomer (e) having no acidic group, a powdery water-soluble reducing compound (f) containing a sulfur atom, an organic peroxide (g), and an amine-based reducing agent (d2) containing no sulfur atom.
摘要翻译：本发明提供了具有优异的粘合耐久性的牙科粘合剂材料试剂盒。本发明由含有牙科用水性粘合剂组合物（A）和多部分型牙科非水硬化性组合物（B）的牙科用粘合剂试剂盒来表示。牙科用水性粘合剂组合物（A）含有具有酸性基团的可聚合单体（a），不具有酸性基团的脂肪族可聚合单体（b），水（c）和不含硫的胺类还原剂（d1）原子。多部分型牙科非水硬化性组合物（B）含有不具有酸性基团的脂肪族聚合性单体（b），不具有酸性基团的芳香族聚合性单体（e），含有硫的粉末状水溶性还原性化合物（f）原子，有机过氧化物（g）和不含硫原子的胺系还原剂（d2）。

2. 发明授权

US08124669B2 Dental composition 有权
标题翻译：牙科组成
公开(公告)号：US08124669B2
公开(公告)日：2012-02-28
申请号：US12526442
申请日：2008-02-05
申请人： Eiichi Terakawa , Akiko Ota , Takahiro Sekiguchi
发明人： Eiichi Terakawa , Akiko Ota , Takahiro Sekiguchi
IPC分类号： A61K6/083 , A61C5/04
CPC分类号： A61K6/083 , Y10S977/919 , C08L33/00 , C08L43/00
摘要： A composition for dental use containing a polymerizable monomer (a) having an aromatic ring and a hydroxyl group, a polymerizable monomer (b) having an aromatic ring without having any hydroxyl groups, and a polymerizable monomer (c) other than the polymerizable monomers (a) and (b), wherein the composition for dental use contains the polymerizable monomers (a), (b), and (c) in an amount of from 10 to 30% by weight, from 50 to 70% by weight, and from 10 to 30% by weight, respectively, of all the polymerizable monomers. The composition for dental use of the present invention can be suitably used as a product capable of substituting a part or all of a natural tooth in the field of dental therapy.
摘要翻译：一种含有具有芳香环和羟基的可聚合单体（a），不具有任何羟基的芳环的可聚合单体（b）和除可聚合单体之外的可聚合单体（c））的牙科用组合物（a）和（b），其中，所述牙科用组合物含有10〜30重量％，50〜70重量％的聚合性单体（a），（b）和（c）分别为所有可聚合单体的10至30重量％。本发明的牙科用组合物可适用于在牙科治疗领域能够代替部分或全部天然牙齿的产品。

3. 发明申请

US20120016094A1 REDOX-CURING TYPE COMPOSITION 有权
标题翻译：氧化固化型组合物
公开(公告)号：US20120016094A1
公开(公告)日：2012-01-19
申请号：US13256729
申请日：2010-03-01
申请人： Mitsuru Takei , Mariko Sugiura
发明人： Mitsuru Takei , Mariko Sugiura
IPC分类号： C08F4/40
CPC分类号： A61K6/0023 , A61K6/005 , A61K6/083 , C08L33/08 , C08L33/10 , C08L43/02
摘要： The present invention provides a redox-curing type composition that penetrates into a wet body, particularly into a tooth structure (dentin), is cured in an accelerated manner by the moisture contained in the wet body, thereby exhibits a higher bond strength than those of conventional redox-curing type compositions, and has satisfactory storage stability. The present invention is a redox-curing type composition including a polymerizable monomer (a) having an acidic group, a polymerizable monomer (b) having no acidic group, a powdery inorganic peroxide (c) with an average particle diameter of 0.01 to 50 μm, an amine-based reducing agent (d), and a polymerization accelerator (e). The amine-based reducing agent (d) includes an aromatic amine (d−1) and an aliphatic amine (d−2), and a weight ratio (d−1):(d−2) therebetween is 5:1 to 1:50.
摘要翻译：本发明提供一种氧化还原固化型组合物，其通过湿体中特别湿化的体内，特别是牙结构（牙本质）进行加速固化，从而表现出比常规的氧化还原固化型组合物，并且具有令人满意的储存稳定性。本发明是包含具有酸性基团的聚合性单体（a），不具有酸性基团的聚合性单体（b）），平均粒径为0.01〜50μm的无机过氧化物（c））的氧化还原型组合物，胺类还原剂（d）和聚合促进剂（e）。胺系还原剂（d）包括芳族胺（d-1）和脂肪族胺（d-2），其中重量比（d-1）：（d-2）为5:1〜1 ：50。

4. 发明申请

US20110257292A1 DENTAL CURABLE COMPOSITION AND COMPOSITE RESIN USING THE SAME 有权
标题翻译：牙齿可固化组合物和使用它的复合树脂
公开(公告)号：US20110257292A1
公开(公告)日：2011-10-20
申请号：US13141381
申请日：2010-12-10
申请人： Masaki Okubayashi , Hirotaka Kita , Yusuke Takahata , Akiko Ota
发明人： Masaki Okubayashi , Hirotaka Kita , Yusuke Takahata , Akiko Ota
IPC分类号： A61K6/083
CPC分类号： A61K6/083 , A61K6/0005 , A61K6/0008 , A61K6/0061 , A61K6/0067 , A61K6/0088 , A61K6/0094 , C08L29/10 , C08L33/00 , C08L25/04 , C08L43/02 , C08L43/04
摘要： The present invention provides a dental curable composition exhibiting both excellent light diffusion and excellent transparency, and having high mechanical strength and surface smoothness and gloss after polishing as a cured product as well as good handling properties as a paste. The present invention is a dental curable composition including: a polymerizable monomer (A) having a refractive index of 1.52 to 1.58 after polymerization; inorganic particles (B) having a refractive index of 1.43 to 1.50; and inorganic particles (C) having a refractive index of 1.52 to 1.58. The inorganic particles (B) are aggregates of inorganic fine particles having an average primary particle size of 2 to 50 nm, and the content of the inorganic particles (B) is 0.1 to 10% by weight.
摘要翻译：本发明提供了具有优异的光散射性和优异的透明性的牙科用固化性组合物，作为固化物具有高的机械强度和表面光滑性以及作为固化物的研磨后的光泽性以及作为糊剂的良好的处理性。本发明是一种牙科用固化性组合物，其含有：聚合后折射率为1.52〜1.58的聚合性单体（A）无机粒子（B）的折射率为1.43〜1.50; 和无机粒子（C）的折射率为1.52〜1.58。无机粒子（B）是平均一次粒径为2〜50nm的无机微粒的聚集体，无机粒子（B）的含量为0.1〜10重量％。

5. 发明申请

US20110046261A1 DENTAL COMPOSITION AND COMPOSITE RESIN 有权
标题翻译：牙齿组合物和复合树脂
公开(公告)号：US20110046261A1
公开(公告)日：2011-02-24
申请号：US12990077
申请日：2009-04-28
申请人： Yoshiko Kuboe , Masaki Okubayashi , Koichi Okada , Keisuke Ohtsuka
发明人： Yoshiko Kuboe , Masaki Okubayashi , Koichi Okada , Keisuke Ohtsuka
IPC分类号： A61K6/08
CPC分类号： A61K6/0088 , A61K6/083 , C08L33/04
摘要： A dental composition of the present invention includes: a polymerizable monomer component (A); and an amorphous filler (B) having an average particle size of 1 to 20 μm and including silica-based fine particles and coatings of an oxide that cover the surfaces of the silica-based fine particles. The oxide contains a zirconium atom, a silicon atom, and an oxygen atom. The dental composition contains 20 to 500 parts by weight of the filler (B) per 100 parts by weight of the polymerizable monomer component (A). The dental composition has a viscosity of 10 to 800 Pa·s. It is preferable that the filler (B) contain spherical particles, and that the percentage of the spherical particles in the filler (B) be at least 60%.
摘要翻译：本发明的牙科用组合物包括：可聚合单体组分（A）; 和平均粒径为1〜20μm的无定形填料（B），其包含二氧化硅系微粒和覆盖二氧化硅系微粒表面的氧化物涂层。氧化物含有锆原子，硅原子和氧原子。牙科用组合物每100重量份的可聚合单体组分（A）含有20-500重量份的填料（B）。牙科用组合物的粘度为10〜800Pa·s。填料（B）优选含有球状颗粒，并且填料（B）中的球形颗粒的百分比为至少60％。

6. 发明授权

US07820733B2 Dental polymerizable core build-up material of separately packed type 有权
标题翻译：单独包装型牙科可聚合核心堆积材料
公开(公告)号：US07820733B2
公开(公告)日：2010-10-26
申请号：US11575356
申请日：2005-09-01
申请人： Yasujiro Ohara
发明人： Yasujiro Ohara
IPC分类号： A61K6/083 , A61C5/04
CPC分类号： C08F2/44 , A61K6/0073 , A61K6/083 , C08F2/48 , C08L33/04
摘要： The invention provides a divided type dental polymeric core build-up material including a first paste (A) and a second paste (B), in which each of the pastes is a paste obtained by mixing at least a (meth)acrylate monomer, a filler having a particle size distribution within a range of 0.1 through 40 μm and an average particle diameter of 0.7 through 10 μm, and a fine particle filler having an average particle diameter of primary particles of 0.001 through 0.050 μm, and having a viscosity at 25° C. of 280 through 470 P, and in which one of the pastes includes an oxidant and the other includes a reductant and at least one of the pastes includes a photopolymerization catalyst. The divided type dental polymeric core build-up material of this invention has high operability in core build-up and forms a polymerically cured substance with a good mechanical property.
摘要翻译：本发明提供了一种分割型牙科聚合物芯堆积材料，其包括第一浆料（A）和第二糊料（B），其中每种糊料是通过将至少一种（甲基）丙烯酸酯单体，粒径分布范围为0.1〜40μm，平均粒径为0.7〜10μm的平均粒径为0.001〜0.050μm的平均粒径的微粒填充剂，其粘度为25 280℃至470℃，其中一个浆料包含氧化剂，另一个包含还原剂，并且至少一个糊料包括光聚合催化剂。本发明的分割型牙科聚合物芯材堆积材料在芯堆积中具有高可操作性，并形成具有良好机械性能的聚合物固化物质。

7. 发明申请

US20100056665A1 POLYMERIZABLE MONOMER, POLYMERIZABLE COMPOSITION AND DENTAL MATERIAL 有权
标题翻译：可聚合单体，可聚合组合物和牙科材料
公开(公告)号：US20100056665A1
公开(公告)日：2010-03-04
申请号：US12532289
申请日：2008-03-06
申请人： Takahiro Sekiguchi
发明人： Takahiro Sekiguchi
IPC分类号： A61K6/083 , C08F220/26 , C08F20/58 , C08L33/14 , C08L33/24
CPC分类号： C07C69/54 , A61K6/0023 , C07C271/16 , C08F220/26 , C08F222/1006 , C08L33/00
摘要： The present invention provides a polymerizable composition that imparts excellent adhesive properties with respect to tooth structure (particularly dentin) when applied as a dental material, and provides a polymerizable monomer that is used as a component of the polymerizable composition. The present invention is a compound (A) that is a compound represented by the following formula (1): where G indicates a polymerizable group, m indicates an integer of 2 or more, n indicates an integer of 1 or more, and the sequence order of m units having a polymerizable group and n units having a hydroxyl group is arbitrary. The present invention also is a polymerizable composition containing the compound (A).
摘要翻译：本发明提供了当作为牙科材料使用时赋予牙齿结构（特别是牙本质）优异的粘合性的聚合性组合物，并且提供用作可聚合组合物的组分的可聚合单体。本发明是由下式（1）表示的化合物的化合物（A）：其中，G表示聚合性基团，m表示2以上的整数，n表示1以上的整数，具有聚合性基团的m个单元的顺序和具有羟基的n个单元是任意的。本发明也是含有化合物（A）的聚合性组合物。

8. 发明授权

US07629168B2 Insulin expressing human pancreatic islet cell line capable of reversibly proliferating and use thereof 失效
标题翻译：胰岛素表达人胰岛细胞系，其能够可逆地增殖并使用
公开(公告)号：US07629168B2
公开(公告)日：2009-12-08
申请号：US10578260
申请日：2003-11-10
申请人： Noriaki Tanaka , Naoya Kobayashi , Michiki Narushima , Yoshihito Tanaka
发明人： Noriaki Tanaka , Naoya Kobayashi , Michiki Narushima , Yoshihito Tanaka
IPC分类号： C12P5/06 , C12P21/06 , C12P21/04 , A61K48/00
CPC分类号： C12N5/0676 , A61K35/12 , C12N2510/04
摘要： A reversibly immortalized human pancreatic islet cell line containing an hTERT gene and an SV40T gene each interposed between a pair of LoxP sequences, characterized in that it is capable of producing insulin and enhancing expression of insulin after excising the hTERT gene and the SV40T gene, in particular, NAKT-13 (deposited with International Patent Organism Depository, National Institute of Advanced Industrial Science and Technology, address: AIST Tsukuba Central 6, 1-1, Higashi 1-Chome, Tsukuba-shi, Ibaraki-ken, 305-8566 Japan, deposited date: Sep. 4, 2003, accession number: FERM BP-08461) or a passage cell line thereof; a human pancreatic islet cell obtained by excising the hTERT gene and the SV40T gene from the reversibly immortalized human pancreatic islet cell line or passage cell line thereof; and use of these cells. By using the reversibly immortalized human pancreatic islet cell line of the invention insulin-producing cells can be easily and surely obtained in a number enough to meet the demand.
摘要翻译：一种含有hTERT基因和SV40T基因的可逆永生人胰岛细胞系，每个插入一对LoxP序列之间，其特征在于能够在切除hTERT基因和SV40T基因之后产生胰岛素并增强胰岛素的表达，特别是NAKT-13（保藏于国立先进工业科学与技术研究所国际专利生物保藏中心，地址：日本茨城市茨城市筑波市东1町1-1-1筑波中央6-1号日本305-8566 ，保藏日期：2003年9月4日，登录号：FERM BP-08461）或其传代细胞系; 通过从可逆永生化人胰岛细胞系或其传代细胞系中切除hTERT基因和SV40T基因获得的人胰岛细胞; 并使用这些细胞。通过使用本发明的可逆永生人胰岛细胞系，可以容易且可靠地获得足够数量的胰岛素产生细胞以满足需求。

9. 发明申请

US20090068123A1 FLUORINE ION-RELEASABLE COMPOSITION FOR DENTAL PURPOSES 审中-公开
标题翻译：用于牙科用途的氟离子可释放组合物
公开(公告)号：US20090068123A1
公开(公告)日：2009-03-12
申请号：US11910319
申请日：2006-03-30
申请人： Mitsuru Takei , Hirotaka Kita , Yasujiro Ohara
发明人： Mitsuru Takei , Hirotaka Kita , Yasujiro Ohara
IPC分类号： A61K8/21 , A61P1/02
CPC分类号： A61K6/093 , A61K6/083 , C08L33/00 , C08L83/04
摘要： The invention provides a fluoride ion releasing dental composition including an inorganic powder (a); a fluoride ion releasing material (b); a monomer (c); and a polymerization initiator (d), in which the inorganic powder (a) is made of composite particles in which a layer of polysiloxane is formed on surfaces of substrate particles made of an inorganic material, and the fluoride ion releasing material (b) is at least one fluoride ion releasing material selected from the group consisting of ammonium fluoride, ammonium hydrogen fluoride, a metal fluoride, a polymer including, as a constitutional unit, a vinyl monomer having an acid fluoride group and a fluorine-containing phosphazene monomer.Since the fluoride ion releasing dental composition of this invention provides dentine with a high cariostatic property over a long period of time by gradually releasing fluoride ions, it is suitably used as a dental adhesive material, a dental filling material, a dental resin used for forming an abutment, a pit and fissure sealant, a dental coating material (manicure), a dental cement and so on.
摘要翻译：本发明提供一种含有无机粉末（a）的氟离子释放牙科用组合物。氟离子释放材料（b）; 单体（c）; 和聚合引发剂（d），其中无机粉末（a）由其中在由无机材料制成的基材颗粒的表面上形成聚硅氧烷层的复合颗粒制成，氟化物离子释放材料（b）为选自氟化铵，氟化氢铵，金属氟化物，作为结构单元的具有酰氟基的乙烯基单体和含氟磷腈单体的聚合物中的至少一种氟化物离子释放材料。由于本发明的氟离子释放牙科用组合物通过逐渐释放氟离子来长时间地提供具有高抑制性牙本质的牙本质，因此适合用作牙科粘合剂，牙科填充材料，用于形成的牙科用树脂基牙，凹坑和裂缝密封剂，牙科涂层材料（修指甲），牙科粘固剂等。

10. 发明申请

US20060078510A1 Dental coating kit 有权
标题翻译：牙科涂层套件
公开(公告)号：US20060078510A1
公开(公告)日：2006-04-13
申请号：US10530558
申请日：2003-10-06
申请人： Mitsuru Takei , Junichi Ohtsuki
发明人： Mitsuru Takei , Junichi Ohtsuki
IPC分类号： A61K8/81
CPC分类号： A61K6/0017 , A61K6/0023 , A61K6/083 , C08L33/10 , C08L33/16
摘要： The invention provides a dental coating kit with high adhesiveness to teeth that contains a primer composition including an acidic group-containing polymeric monomer (a), water (b) and a water-soluble solvent (c) and a surface smoothing composition including a polyfunctional polymeric monomer (f), a volatile solvent (g) and a photopolymerization initiator (h); and a dental coating kit with high adhesiveness to teeth and minimally suffering from chipping and peeling off that contains a primer composition including an acidic group-containing polymeric monomer (a), water (b) and a water-soluble solvent (c), a coating composition including a polymeric monomer (d) and a photopolymerization initiator (e), and a surface smoothing composition including a polyfunctional polymeric monomer (f), a volatile solvent (g) and a photopolymerization initiator (h). Either dental coating kit is particularly useful as a kit for preventing stain and color return of a bleached tooth.
摘要翻译：本发明提供了一种含有高粘合性的牙齿涂层试剂盒，其含有含有酸性基团的聚合单体（a），水（b）和水溶性溶剂（c）的底漆组合物和包含多官能团聚合单体（f），挥发性溶剂（g）和光聚合引发剂（h）; 以及牙齿涂层试剂盒，其对牙齿具有高粘附性，并且最少遭受切屑和剥离，其含有包含含酸性基团的聚合单体（a），水（b）和水溶性溶剂（c）的底漆组合物，包含聚合单体（d）和光聚合引发剂（e）的涂料组合物和包含多官能聚合单体（f），挥发性溶剂（g）和光聚合引发剂（h）的表面平滑化组合物。任何牙科涂层试剂盒特别可用作防止漂白牙齿的染色和着色返回的试剂盒。

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