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1. 发明授权

US09701937B2 Carrier for cultivation of cells 有权
公开(公告)号：US09701937B2
公开(公告)日：2017-07-11
申请号：US12319330
申请日：2009-01-06
申请人： Ken Nakata , Kanae Kasai
发明人： Ken Nakata , Kanae Kasai
IPC分类号： C12N5/00
CPC分类号： C12N5/0068 , C12N2533/54
摘要： A carrier for cell cultivation having stress of 10-30 kPa at 10% load, preparing a material, which has physical property similar to cartilage tissue of vivo, by lyophilization using high concentrated collagen dispersion, solution or mixture thereof as a starting material, then performing insolubilizing treatment to regulate physical strength and absorption speed in a living body.

2. 发明授权

US09257055B2 Small intestine endoscope training simulator 有权
标题翻译：小肠内窥镜训练模拟器
公开(公告)号：US09257055B2
公开(公告)日：2016-02-09
申请号：US13394427
申请日：2010-07-27
申请人： Yutaka Endo , Hiroshi Uno
发明人： Yutaka Endo , Hiroshi Uno
IPC分类号： G09B23/30 , G09B23/28 , A61B1/00
CPC分类号： G09B23/285 , A61B1/00057
摘要： It is possible to provide a small intestine endoscope training simulator (11) which allows to obtain a feeling similar to that of inserting an endoscope (38) into the small intestine (34) of the living body (30) and learn the actual operation of the endoscope (38). This training simulator (11) includes a plurality of longitudinal elastic members (32) for applying an elastic force to each of a plurality of portions of a simulated small intestine (13). One end portion sides of the plurality of longitudinal elastic members (32) are respectively attached to the first attachment portions (27) on the simulated small intestine (13) side. The other end portion sides of the plurality of longitudinal elastic members (32) are respectively attached to the second attachment portions (33, 57) on the case (12) side.
摘要翻译：可以提供一种小肠内窥镜训练模拟器（11），其能够获得类似于将内窥镜（38）插入到生物体（30）的小肠（34）中的感觉，并且学习实际操作内窥镜（38）。该训练模拟器（11）包括用于向模拟小肠（13）的多个部分中的每一个施加弹力的多个纵向弹性构件（32）。多个纵向弹性构件（32）的一个端部侧分别安装在模拟的小肠（13）侧上的第一附接部分（27）上。多个纵向弹性构件（32）的另一个端部侧分别安装在壳体（12）侧上的第二安装部分（33,57）上。

3. 发明申请

US20130225492A1 Sustained-Release Pharmaceutical Composition 有权
标题翻译：持续释放药物成分
公开(公告)号：US20130225492A1
公开(公告)日：2013-08-29
申请号：US13824598
申请日：2011-10-14
申请人： Masanori Fukushima , Hiroaki Matsubara , Satoaki Matoba , Shigeki Hijikata , Yu Aso , Tsutomu Sato
发明人： Masanori Fukushima , Hiroaki Matsubara , Satoaki Matoba , Shigeki Hijikata , Yu Aso , Tsutomu Sato
IPC分类号： A61K9/00 , A61K38/18
CPC分类号： A61K9/0002 , A61K9/0024 , A61K9/5123 , A61K31/7004 , A61K31/7008 , A61K38/1808 , A61K38/1816 , A61K38/1825 , A61K38/1858 , A61K38/27 , A61K38/39 , A61K45/06 , A61K47/26 , A61K47/42 , A61K2300/00
摘要： Provided is a pharmaceutical composition, including a drug and a collagen, in which the composition is satisfactory in handleability and has sustained-release property. The sustained-release pharmaceutical composition includes: a drug; a collagen; and at least one kind of sugar selected from monosaccharides, disaccharides, trisaccharides, and tetrasaccharides. The inventors of the present invention have found that the in vivo administration of a collagen solution containing a sugar results in the gelation of a collagen. Based on this finding, the inventors have found that a composition containing a drug, a collagen, and a sugar can control the release rate of the drug, and such composition can be used as a sustained-release pharmaceutical composition.
摘要翻译：本发明提供包含药物和胶原的药物组合物，其组合物的操作性良好且具有缓释性。缓释药物组合物包括：药物; 胶原蛋白和选自单糖，二糖，三糖和四糖中的至少一种糖。本发明的发明人已经发现，含有糖的胶原溶液的体内施用导致胶原蛋白的凝胶化。基于该发现，本发明人发现含有药物，胶原和糖的组合物可以控制药物的释放速度，并且这种组合物可以用作缓释药物组合物。

4. 发明申请

US20090062184A1 FINE PARTICULATE PREPARATION COMPRISING COMPLEX OF NUCLEIC ACID MOLECULE AND COLLAGEN 审中-公开
标题翻译：包含核酸分子和胶原复合物的精细制备
公开(公告)号：US20090062184A1
公开(公告)日：2009-03-05
申请号：US11909457
申请日：2005-03-24
申请人： Miho Maeda , Yoshiko Kishimoto
发明人： Miho Maeda , Yoshiko Kishimoto
IPC分类号： A61K38/17 , C07K14/435 , A61P43/00
CPC分类号： C12N15/111 , A61K9/1658 , A61K31/7088 , A61K38/17 , A61K47/183 , A61K48/0008 , C12N15/113 , C12N2310/351 , C12N2320/32
摘要： The present invention relates an additive comprising at least one substance selected from arginine, trometamol, meglumine, lysine, histidine, monoethanolamine, diethanolamine, triethanolamine, succinic acid, citric acid, tartaric acid, lactic acid, and salts thereof, which is useful in the prevention of aggregation of fine particulate complexes of a nucleic acid and collagen, and the production of a preparation comprising particulate complexes of controlled size which is suited for transporting a nucleic acid into cells.
摘要翻译：本发明涉及一种添加剂，其包含选自精氨酸，氨丁三醇，葡甲胺，赖氨酸，组氨酸，单乙醇胺，二乙醇胺，三乙醇胺，琥珀酸，柠檬酸，酒石酸，乳酸及其盐中的至少一种物质，其可用于防止核酸和胶原细颗粒复合物的聚集，以及制备包含适合于将核酸输送到细胞中的受控大小的颗粒复合物的制剂。

5. 发明申请

US20020066877A1 Gate valve 有权
标题翻译：闸阀
公开(公告)号：US20020066877A1
公开(公告)日：2002-06-06
申请号：US09876947
申请日：2001-06-11
申请人： IRIE KOKEN CO., LTD.
发明人： Masaharu Nakagawa
IPC分类号： F16K025/00 , F16K003/00
CPC分类号： F16K3/188 , F16K51/02
摘要： A gate valve according to the present invention comprises a first valve plate having a valve opening and a second valve plate connected to the first valve plate via a first bellows, in which the rigidity and the like of the valve plates, a valve rod, and the like can be reduced as compared to that in a conventional art by canceling the differential pressure.
摘要翻译：根据本发明的闸阀包括具有阀开口的第一阀板和经由第一波纹管连接到第一阀板的第二阀板，其中阀板的刚度等，阀杆和与常规技术相比，通过抵消压差可以减少等。

6. 发明授权

US6018606A Fiber fixing device for linear lightguide 失效
标题翻译：线性光导纤维固定装置
公开(公告)号：US6018606A
公开(公告)日：2000-01-25
申请号：US825197
申请日：1997-03-27
申请人： Kazuki Sogabe , Hideya Konda , Toshihiro Nakae , Mitsuyoshi Suzuki
发明人： Kazuki Sogabe , Hideya Konda , Toshihiro Nakae , Mitsuyoshi Suzuki
IPC分类号： G02B6/36 , G02B6/38
CPC分类号： G02B6/3858 , G02B6/3855 , G02B6/3861
摘要： A fiber fixing device for a linear lightguide comprises a tubular chuck and an elastic tubular body. The chuck includes a hollow part along its axis for receiving an optical fiber, a grasp part for grasping the received optical fiber, and a coupling part supporting the grasp part. The elastic tubular body is elastically expanded outwardly in the radial direction and in this state is fitted onto the grasp part of the chuck. Thus, the elastic tubular body exerts an elastic restoring force to radially inwardly press the grasp part which thereby grasps the optical fiber.
摘要翻译：用于线性光导的光纤固定装置包括管状卡盘和弹性管状体。卡盘包括沿其轴线的中空部分，用于容纳光纤，用于抓住所接收的光纤的抓握部分和支撑抓握部件的联接部件。弹性管状体在径向方向上向外弹性膨胀，并且在该状态下被装配到卡盘的夹持部分上。因此，弹性管状体弹性恢复力向径向向内按压抓握部，从而抓住光纤。

7. 发明授权

US5922356A Sustained release formulation 失效
标题翻译：持续释放制剂
公开(公告)号：US5922356A
公开(公告)日：1999-07-13
申请号：US947463
申请日：1997-10-09
申请人： Norimasa Koseki , Akihiko Sano
发明人： Norimasa Koseki , Akihiko Sano
IPC分类号： A61K9/20 , A61K9/14
CPC分类号： A61K9/205 , A61K9/2063
摘要： The present invention relates to a sustained release formulation used for treatment or prevention of the diseases, which contains a therapeutically effective substance as an active ingredient, collagen as a drug carrier, and glycosaminoglycan as an additive. The formulation allows controlled release of the therapeutically effective substance.
摘要翻译：本发明涉及用于治疗或预防疾病的缓释制剂，其包含作为活性成分的治疗有效物质，作为药物载体的胶原蛋白和作为添加剂的糖胺聚糖。制剂允许控制释放治疗有效物质。

8. 发明授权

US5840054A Method for obstructing lacrimal canaliculi with infusable solution or dispersion 失效
标题翻译：用输注溶液或分散液阻塞泪小管的方法
公开(公告)号：US5840054A
公开(公告)日：1998-11-24
申请号：US493282
申请日：1995-06-21
申请人： Takashi Hamano , Teruo Miyata , Takeshi Ogawara
发明人： Takashi Hamano , Teruo Miyata , Takeshi Ogawara
IPC分类号： A61K9/08 , A61F9/007 , A61K38/17 , A61L31/04 , A61L31/14 , A61P27/02 , A61F9/00
CPC分类号： A61L31/145 , A61F9/00772 , A61L31/041 , A61L31/043 , A61L31/044 , A61L2430/16
摘要： A method of obstructing the lacrimal canaliculi by infusing therein a solution or liquid dispersion containing a gel forming material, such having collagen as the main ingredient in the range of 1 mg/ml to 70 mg/ml for improving the symptoms of dry eye.
摘要翻译：通过在其中注入含有凝胶形成材料的溶液或液体分散体，例如以1mg / ml至70mg / ml的胶原作为主要成分，以改善干眼症状的方法来阻塞泪小管。

9. 发明授权

US5360544A Deproteinization filler and cartridge containing same 失效
标题翻译：脱蛋白填料和含有其的药筒
公开(公告)号：US5360544A
公开(公告)日：1994-11-01
申请号：US974733
申请日：1992-11-13
申请人： Yasuji Nakaso , Tsutomu Kawasaki , Wataru Kobayashi , Keiko Gondo , Hiroshi Iwase
发明人： Yasuji Nakaso , Tsutomu Kawasaki , Wataru Kobayashi , Keiko Gondo , Hiroshi Iwase
IPC分类号： B01D39/20 , B01J20/04 , B01J20/281 , C01B25/32 , G01N1/34 , G01N30/14 , G01N30/88 , B01D24/02 , B01D39/04
CPC分类号： G01N1/34 , B01D39/2082 , B01J20/048 , B01J20/28004 , B01J20/28023 , B01J20/28059 , B01J20/28078 , B01J20/282 , B01J20/3007 , B01J20/3078 , B01J2220/54
摘要： A deproteinization filler comprises an aggregate of hydroxyapatite fibers having a three dimensional network structure. The mean radius of pores defined by the aggregate is approximately 0.02 .mu.m to approximately 0.08 .mu.m, the specific surface of the aggregate is approximately 25 m.sup.2 /g to approximately 65 m.sup.2 /g and the mean diameter of particles defined by the aggregate is approximately 1 .mu.m to approximately 30 .mu.m. The filler is produced by a given method. The filler may be contained in a throwaway cartridge.
摘要翻译：脱蛋白填料包含具有三维网状结构的羟基磷灰石纤维聚集体。由骨料限定的孔的平均半径为约0.02μm至约0.08μm，聚集体的比表面积为约25m 2 / g至约65m 2 / g，并且由聚集体限定的颗粒的平均直径约为 1亩至30亩。填料通过给定的方法生产。填料可以包含在一次性的盒中。

10. 发明授权

US5171261A Vascular prosthesis, manufacturing method of the same, and substrate for vascular prothesis 失效
标题翻译：血管生成，其制造方法和血管基质的基质
公开(公告)号：US5171261A
公开(公告)日：1992-12-15
申请号：US508618
申请日：1990-04-13
申请人： Yasuhara Noishiki , Teruo Miyata
发明人： Yasuhara Noishiki , Teruo Miyata
IPC分类号： A61F2/06 , A61L27/50
CPC分类号： A61L27/507 , A61F2/062 , Y10S623/901 , Y10S623/921
摘要： The invention relates to a vascular prosthesis wherein, fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells are deposited and captured within the wall of a vascular prosthesis substrate; a manufacturing method comprising the steps of immersing a vascular prosthesis substrate into a dispersed solution of fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells, and depositing and capturing the cells and/or tissue fragments on the inner wall and within the wall of the vascular prosthesis from one side to the other side of the vascular prosthesis substrate wall by providing a pressure differential between the outside and the inside of the vascular prosthesis substrate; and a substrate suitable for manufacturing a vascular prosthesis having a porous membrane having pores capable of trapping tissue fragments, or a laminate structure with such a membrane and another porous membrane having pores not large enough to pass the cells or tissue fragments.

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