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1. 发明申请

US20080298756A1 Max entropy optimized retinal camera 失效
公开(公告)号：US20080298756A1
公开(公告)日：2008-12-04
申请号：US12050029
申请日：2008-03-17
申请人： Paul Wiley Truitt , Peter Soliz
发明人： Paul Wiley Truitt , Peter Soliz
IPC分类号： G02B6/00
CPC分类号： A61B3/14 , A61B3/12
摘要： An enhanced entropy camera provides enhanced image quality by utilizing a custom analog-to-digital conversion function. The analog-to-digital conversion occurs according to a custom non-linear quantization function that provides enhanced entropy in the digitized image, yet avoids the harsh artifacts that tend to arise in images quantized according to a maximum entropy function. A plurality of custom non-linear functions are made available for selection depending upon imaging conditions, such as light intensity, pigmentation of the retina, or the part of the retina being imaged. Each of the plural non-linear quantization function comprises a distinct non-linear look up table for each of plural bands (e.g., red, green, and blue color channels).

2. 发明授权

US07118217B2 Device and method for optical imaging of retinal function 有权
标题翻译：视网膜功能光学成像装置及方法
公开(公告)号：US07118217B2
公开(公告)日：2006-10-10
申请号：US10347142
申请日：2003-01-17
申请人： Randy H. Kardon , Young H. Kwon , Daniel Tso , Peter Soliz
发明人： Randy H. Kardon , Young H. Kwon , Daniel Tso , Peter Soliz
IPC分类号： A61B3/14 , A61B3/10
CPC分类号： A61B3/0058 , A61B3/12 , A61B5/14555
摘要： An Optical Imaging Device of Retinal Function has been developed to detect changes in reflectance of near infrared light from the retina of human subjects in response to visual activation of the retina by a pattern stimulus. The measured changes in reflectance correspond in time to the onset and offset of the visual stimulus in the portion of the retina being stimulated. Any changes in reflectance can be measured by interrogating the retina with a light source. The light source may be presented to the retina via the cornea and pupil or through other tissues in and around the eye. Different wavelengths of interrogating light may be used to interrogate various layers of the retina. Additionally, various novel patterns and methods of stimulation have been developed for use with the imaging device and methods.
摘要翻译：已经开发了视网膜功能的光学成像装置，以响应于通过图案刺激的视网膜的视觉激活来检测来自人类受试者的视网膜的近红外光的反射率的变化。测量的反射率的变化在时间上对应于被刺激的视网膜部分中的视觉刺激的开始和偏移。可以通过用光源询问视网膜来测量反射率的任何变化。光源可以通过角膜和瞳孔或通过眼睛中和周围的其它组织呈递到视网膜。不同波长的询问光可用于询问视网膜的各个层。此外，已经开发了用于成像装置和方法的各种新颖的刺激模式和方法。

3. 发明申请

US20150069258A1 DIFFERENTIAL EXCITATION SPECTROSCOPY 有权
标题翻译：差异激发光谱
公开(公告)号：US20150069258A1
公开(公告)日：2015-03-12
申请号：US14473796
申请日：2014-08-29
申请人： Eugene W. Butler , Timothy M. Stratman , Boyd V. Hunter , Paul Harrison , Jason M. Cox
发明人： Eugene W. Butler , Timothy M. Stratman , Boyd V. Hunter , Paul Harrison , Jason M. Cox
IPC分类号： G01N21/62 , G01N22/00 , G01N21/27
CPC分类号： G01N21/35 , G01N21/031 , G01N21/27 , G01N21/3581 , G01N21/636 , G01N22/00 , G01N2021/3125
摘要： A new technique which uses a pump-probe methodology to place a molecule into one or more excited rotational and/or vibrational states. By evaluating spectral changes due to at least one discrete frequency of pump photons a multi-dimensional characterization of the molecule's excited state energy level results. This multi-dimensional characterization typically involves evaluating the changes between excited and unexcited state measurements. The differential nature of the evaluation makes the technique self-referencing and solves problems common to many spectroscopic techniques. The multi-dimensionality of the technique provides high specificity and immunity to interferents. The preferred embodiments involve excitation by using photons suited to pumping the rotational states and evaluating the effects by probing the energy levels of one of more vibrational states. The technique is capable of detecting bulk and trace concentrations of a molecule in gas, liquid and solid phases, both in pure form and in the presence of other molecules.
摘要翻译：一种使用泵浦探针方法将分子置于一个或多个激发的旋转和/或振动状态的新技术。通过评估由于至少一个离散频率的泵浦光子的光谱变化，可以得到分子激发态能级的多维表征。这种多维表征通常包括评估激发态和不精确状态测量之间的变化。评估的差异性使得技术自我参照并且解决了许多光谱技术常见的问题。该技术的多维度为干扰物提供了高度的特异性和免疫性。优选实施例涉及通过使用适于泵送旋转状态的光子并通过探测更多振动状态之一的能量水平来评估效果来激发。该技术能够检测气体，液体和固相中分子的体积和痕量浓度，无论是纯形式还是在其它分子存在下。

4. 发明授权

US07988287B1 Objective traumatic brain injury assessment system and method 有权
标题翻译：目的创伤性脑损伤评估系统及方法
公开(公告)号：US07988287B1
公开(公告)日：2011-08-02
申请号：US12170374
申请日：2008-07-09
申请人： Gene Butler , Gavin Erry , Paul Harrison
发明人： Gene Butler , Gavin Erry , Paul Harrison
IPC分类号： A61B3/14
CPC分类号： A61B3/1015
摘要： A system and method for determining the neurological function of a patient by examining ocular responses.
摘要翻译：通过检查眼睛反应来确定患者的神经功能的系统和方法。

5. 发明授权

US07638768B1 Laser wavefront characterization 有权
标题翻译：激光波前表征
公开(公告)号：US07638768B1
公开(公告)日：2009-12-29
申请号：US11820651
申请日：2007-06-19
申请人： Leonard John Otten, III , Paul Harrison , Desirae L. Cuevas , Paul Fournier
发明人： Leonard John Otten, III , Paul Harrison , Desirae L. Cuevas , Paul Fournier
IPC分类号： G01J5/00
CPC分类号： G01J9/00
摘要： The device and method of the present invention are useful for determining the characteristics of an infrared wavefront. The present invention involves positioning a beam of light containing the infrared wavefront to be characterized onto a distorted grating, using the grating to produce a plurality of images, determining the infrared wavefront from the plurality of images and analyzing the infrared wavefront for features that characterize the infrared wavefront.
摘要翻译：本发明的装置和方法可用于确定红外波前的特性。本发明涉及将包含要表征的红外波前的光束定位在失真的光栅上，使用光栅产生多个图像，从多个图像中确定红外波前，并分析红外波阵面的特征，红外波前。

6. 发明授权

US09395311B2 Differential excitation spectroscopy 有权
标题翻译：差分激发光谱
公开(公告)号：US09395311B2
公开(公告)日：2016-07-19
申请号：US14473796
申请日：2014-08-29
申请人： Eugene W. Butler , Timothy M. Stratman , Boyd V. Hunter , Paul Harrison , Jason M. Cox
发明人： Eugene W. Butler , Timothy M. Stratman , Boyd V. Hunter , Paul Harrison , Jason M. Cox
IPC分类号： G01N21/27 , G01N22/00 , G01N21/35 , G01N21/31
CPC分类号： G01N21/35 , G01N21/031 , G01N21/27 , G01N21/3581 , G01N21/636 , G01N22/00 , G01N2021/3125
摘要： A new technique which uses a pump-probe methodology to place a molecule into one or more excited rotational and/or vibrational states. By evaluating spectral changes due to at least one discrete frequency of pump photons a multi-dimensional characterization of the molecule's excited state energy level results. This multi-dimensional characterization typically involves evaluating the changes between excited and unexcited state measurements. The differential nature of the evaluation makes the technique self-referencing and solves problems common to many spectroscopic techniques. The multi-dimensionality of the technique provides high specificity and immunity to interferents. The preferred embodiments involve excitation by using photons suited to pumping the rotational states and evaluating the effects by probing the energy levels of one of more vibrational states. The technique is capable of detecting bulk and trace concentrations of a molecule in gas, liquid and solid phases, both in pure form and in the presence of other molecules.
摘要翻译：一种使用泵浦探针方法将分子置于一个或多个激发的旋转和/或振动状态的新技术。通过评估由于至少一个离散频率的泵浦光子的光谱变化，可以得到分子激发态能级的多维表征。这种多维表征通常包括评估激发态和不精确状态测量之间的变化。评估的差异性使得技术自我参照并且解决了许多光谱技术常见的问题。该技术的多维度为干扰物提供了高度的特异性和免疫性。优选实施例涉及通过使用适于泵送旋转状态的光子并通过探测更多振动状态之一的能量水平来评估效果来激发。该技术能够检测气体，液体和固相中分子的体积和痕量浓度，无论是纯形式还是在其它分子存在下。

7. 发明授权

US07668351B1 System and method for automation of morphological segmentation of bio-images 失效
标题翻译：生物图像形态分割自动化的系统和方法
公开(公告)号：US07668351B1
公开(公告)日：2010-02-23
申请号：US10760923
申请日：2004-01-20
申请人： Peter Soliz , Mark Wilson , Balaji Raman
发明人： Peter Soliz , Mark Wilson , Balaji Raman
IPC分类号： G06K9/00
CPC分类号： G06T7/155 , G06T2207/10048 , G06T2207/10064 , G06T2207/20012 , G06T2207/30041
摘要： Medical images are automatically segmented by customizing the morphological segmentation of features identified in the image based upon statistical analysis of the features within each region to be analyzed. The statistical description of the features, as reported through a feature vector, informs the system as to which input variables to select for further segmentation analysis for features residing within the region of the image analyzed. By customizing the automatic segmentation analysis to produce an enhanced image, features within the image are characterized more efficiently and precisely. False positive identification of lesions are minimized without sacrifice of true positive identifications.
摘要翻译：基于要分析的每个区域内的特征的统计分析，通过定制图像中识别的特征的形态分割来自动分割医学图像。通过特征向量报告的特征的统计描述向系统通知要选择哪些输入变量用于进一步分析分析图像区域内的特征。通过定制自动分割分析以产生增强图像，图像内的特征被更有效和精确地表征。假阳性识别病变最小化，而不牺牲真正的阳性鉴定。

8. 发明授权

US07232999B1 Laser wavefront characterization 有权
标题翻译：激光波前表征
公开(公告)号：US07232999B1
公开(公告)日：2007-06-19
申请号：US10903095
申请日：2004-07-30
申请人： Leonard John Otten, III , Paul Harrison , Desirae L. Cuevas , Paul Fournier
发明人： Leonard John Otten, III , Paul Harrison , Desirae L. Cuevas , Paul Fournier
IPC分类号： G01J5/00
CPC分类号： G01J9/00
摘要： The device and method of the present invention are useful for determining the characteristics of an infrared wavefront. The present invention involves positioning a beam of light containing the infrared wavefront to be characterized onto a distorted grating, using the grating to produce a plurality of images, determining the infrared wavefront from the plurality of images and analyzing the infrared wavefront for features that characterize the infrared wavefront.
摘要翻译：本发明的装置和方法可用于确定红外波前的特性。本发明涉及将包含要表征的红外波前的光束定位在失真的光栅上，使用光栅产生多个图像，从多个图像中确定红外波前，并分析红外波阵面的特征，红外波前。

9. 发明授权

US07104649B2 Wavefront characterization of corneas 有权
标题翻译：角膜的波前表征
公开(公告)号：US07104649B2
公开(公告)日：2006-09-12
申请号：US10115355
申请日：2002-04-02
申请人： Leonard John Otten, III , Gavin R. G. Erry , Simon C. Woods , Paul Harrison
发明人： Leonard John Otten, III , Gavin R. G. Erry , Simon C. Woods , Paul Harrison
IPC分类号： A61B3/10
CPC分类号： A61B3/1015 , A61B3/107 , A61F2/142 , G01J9/00
摘要： Apparatus for determining if a cornea (whether in vitro or in vivo) has been modified (either surgically or otherwise). The method includes the steps of: passing a beam of collimated light a (either coherent or incoherent) through the cornea to produce a distorted wavefront; determining the characteristics of the distorted wavefront; and analyzing the distorted wavefront for characteristics that identify the presence of a modification. The analysis of the distorted wavefront can be for the presence of higher order aberrations, or Gausian characteristics which are indicative of modifications. More particularly, the method includes the steps of providing an optical system that has a pupil plane and an image plane at a detector; positioning the cornea in the pupil plane; passing a collimated beam of light through the cornea to produce at least two images in the image plane; determining the characteristics of the distorted wavefront; and analyzing the distorted wavefront for characteristics that identify the presence of a modification. The apparatus includes: a source of collimated light: an optical system including a distorted grating and an imaging lens (which have a pupil plane, first and second virtual planes, and an image plane); structure for positioning the cornea in the pupil plane; and a computer. The structure for positioning the cornea (which is immersed in a suitable storage fluid) includes first and second plano/plano lenses. The first and second plano lens, which are substantially and perpendicular to and centered with respect to the axis, have less than λ/10 total distortions.
摘要翻译：用于确定角膜（无论是体外或体内）是否已被修改（手术或其他方式）的装置。该方法包括以下步骤：将准直光束（相干或非相干）通过角膜以产生畸变的波前; 确定畸变波前的特征; 并分析畸变波阵面以识别修改的存在的特征。畸变波阵面的分析可以是高阶像差的存在，或表示修改的高斯特性。更具体地说，该方法包括以下步骤：提供在检测器处具有瞳孔平面和图像平面的光学系统; 将角膜定位在瞳孔平面中; 使准直的光束通过角膜，在图像平面中产生至少两个图像; 确定畸变波前的特征; 并分析畸变波阵面以识别修改的存在的特征。该装置包括：准直光源：包括失真光栅和成像透镜（其具有瞳孔平面，第一和第二虚拟平面以及像平面）的光学系统; 用于将角膜定位在瞳孔平面中的结构; 和电脑。用于定位角膜（其浸入合适的储存液体中）的结构包括第一和第二平面/平视镜片。基本上和垂直于和相对于轴居中的第一和第二平面透镜具有小于λ/ 10的总失真。

10. 发明授权

US08500277B1 Objective traumatic brain injury assessment system and method 有权
标题翻译：目的创伤性脑损伤评估系统及方法
公开(公告)号：US08500277B1
公开(公告)日：2013-08-06
申请号：US13196746
申请日：2011-08-02
申请人： Gene Butler , Gavin Erry , Paul Harrison
发明人： Gene Butler , Gavin Erry , Paul Harrison
IPC分类号： A61B3/10
CPC分类号： A61B3/1015
摘要： A system and method for determining the neurological function of a patient by examining ocular responses.
摘要翻译：通过检查眼睛反应来确定患者的神经功能的系统和方法。

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