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1. 发明授权

US08491549B2 Ophthalmic microsurgical system 有权
标题翻译：眼科显微外科系统
公开(公告)号：US08491549B2
公开(公告)日：2013-07-23
申请号：US10496254
申请日：2002-11-21
申请人： Stanley R. Conston , Ronald K. Yamamoto
发明人： Stanley R. Conston , Ronald K. Yamamoto
IPC分类号： A61M35/00 , A61M5/00
CPC分类号： A61B17/32002 , A61B17/3421 , A61B2017/00867 , A61B2017/305 , A61B2017/320044 , A61B2090/306 , A61F9/00763 , A61F9/00781 , A61F9/0133
摘要： An ophthalmic microsurgical system is described for treatment of eye diseases, such as glaucoma, using minimally invasive surgical techniques. The microsurgical system includes a thin walled outer sheath microcannula 1 slidably disposed about an inner member 4, which extends slightly beyond the distal end of the microcannula 1. The inner member 4 may be straight or curved and may optionally include a surgical instrument and/or a sensor or signaling beacon. The microsurgical system is used in a surgical procedure for opening Schlemm's Canal to provide drainage of aqueous fluid in order to relieve excess intraocular pressure that results from glaucoma and other diseases of the eye.
摘要翻译：描述了一种眼科显微外科系统，用于使用微创手术技术治疗诸如青光眼的眼部疾病。显微外科系统包括可滑动地设置在内部构件4周围的薄壁外护套微型插管1，其稍微延伸超出微型插管1的远端。内部构件4可以是直的或弯曲的，并且可以可选地包括外科器械和/或传感器或信号灯。显微手术系统用于开放施莱姆运河的外科手术，以提供含水液体的排水，以缓解由青光眼和其他眼睛疾病引起的过多的眼内压。

2. 发明申请

US20130245600A1 APPARATUS AND FORMULATIONS FOR SUPRACHORIDAL DRUG DELIVERY 审中-公开
公开(公告)号：US20130245600A1
公开(公告)日：2013-09-19
申请号：US13842288
申请日：2013-03-15
申请人： ISCIENCE INTERVENTIONAL CORPORATION
发明人： Ronald Yamamoto , Stanley R. Conston , David Sierra
IPC分类号： A61F9/00
CPC分类号： A61K9/0048 , A61F9/0017 , A61F9/0026 , A61F9/007 , A61K9/0051 , A61K9/14 , A61K9/1635 , A61K31/717 , A61K31/718 , A61K31/722 , A61K31/728 , A61K31/737 , A61K47/36
摘要： Drug formulations, devices and methods are provided to deliver biologically active substances to the eye. The formulations are delivered into scleral tissues adjacent to or into the suprachoroidal space without damage to the underlying choroid. One class of formulations is provided wherein the formulation is localized in the suprachoroidal space near the region into which it is administered. Another class of formulations is provided wherein the formulation can migrate to another region of the suprachoroidal space, thus allowing an injection in the anterior region of the eye in order to treat the posterior region.

3. 发明授权

US08425473B2 Subretinal access device 失效
标题翻译：视网膜下进入装置
公开(公告)号：US08425473B2
公开(公告)日：2013-04-23
申请号：US12359157
申请日：2009-01-23
申请人： Friedrich Ho , Stanley R. Conston , Ronald K. Yamamoto
发明人： Friedrich Ho , Stanley R. Conston , Ronald K. Yamamoto
IPC分类号： A61M25/00 , A61M31/00 , A61M1/00 , A61M5/32 , A61M35/00
CPC分类号： A61F9/007 , A61B1/313 , A61B3/102 , A61B3/12 , A61B5/0066 , A61B17/3421 , A61B2017/306 , A61F9/0017 , A61F9/008 , A61F2009/00863 , A61F2009/00874
摘要： The invention provides surgical devices that provide access to the sub-retinal space using delicate traction to hold the sensory retina to create and maintain a patent sub-retinal space of sufficient size to introduce and perform treatments on the eye. Such treatments may include the introduction of illumination or imaging agents or tools, surgical tools, the infusion of pharmaceutical or biological agents, and the placement of grafts, transplants or implants and the closure of the site through the delivery of a sealant.
摘要翻译：本发明提供了外科装置，其使用微妙的牵引力提供对次视网膜空间的接近以保持感觉视网膜以产生和维持足够尺寸的专利视网膜空间以引入和执行对眼睛的治疗。这样的治疗可以包括引入照明或成像剂或工具，手术工具，药物或生物制剂的输注，以及移植物，移植物或植入物的放置以及通过递送密封剂来封闭部位。

4. 发明授权

US07967772B2 Injector for viscous materials 有权
标题翻译：注射器用于粘性材料
公开(公告)号：US07967772B2
公开(公告)日：2011-06-28
申请号：US10585909
申请日：2005-01-12
申请人： John R. McKenzie , Stanley R. Conston , David J. Kupiecki
发明人： John R. McKenzie , Stanley R. Conston , David J. Kupiecki
IPC分类号： A61N1/30
CPC分类号： A61M5/1456 , A61F9/0017 , A61M5/16854 , A61M5/31511 , A61M5/31586 , A61M5/486
摘要： An injector is provided to deliver microquantities of viscous materials into the body, such as the eye, for surgical purposes. The injector comprises a syringe body with a plunger disposed therein coupled to a positive displacement mechanism capable of progressively advancing the plunger to precisely deliver microquantities of materials at a constant or predetermined delivery rate.
摘要翻译：提供注射器用于将粘性物质的微量量输送到体内，例如眼睛，用于外科用途。注射器包括注射器本体，其中设置有柱塞，其联接到能够逐渐前进柱塞的正位移机构，以以恒定或预定的输送速率精确地输送材料的微量。

5. 发明授权

US07931596B2 Ultrasound interfacing device for tissue imaging 有权
标题翻译：用于组织成像的超声界面装置
公开(公告)号：US07931596B2
公开(公告)日：2011-04-26
申请号：US10521045
申请日：2003-07-14
申请人： Daniel Rachlin , Stanley R. Conston
发明人： Daniel Rachlin , Stanley R. Conston
IPC分类号： A61B5/05 , A61B8/00 , A61F9/00
CPC分类号： A61B8/10 , A61B8/4281 , A61B8/4422
摘要： A device (10) used with high frequency ultrasound provides a replaceable barrier between the ultrasound transducer and the tissues being imaged. The device (10) provides an acoustic pathway of minimal effect on the ultrasound signals, and furthermore provides for a safety barrier between a mechanical scanner and the tissues being imaged. The configuration of the device (10) allows it to function as a standoff for the ultrasound transducer to place the focus of the ultrasound beam at the desired depth of tissue for imaging. In addition, the device (10) may be sterilized and replaced as needed, providing sterile tissue contact surfaces. The device (10) has additional features, which are especially advantageous for diagnosis and surgery of the eye.
摘要翻译：与高频超声波一起使用的装置（10）在超声换能器和被成像的组织之间提供可替换的屏障。设备（10）提供对超声信号的影响最小的声学路径，并且还提供机械扫描仪和被成像的组织之间的安全屏障。设备（10）的配置允许其用作超声换能器的支架，以将超声波束的焦点放置在组织的期望深度以进行成像。此外，可以根据需要对装置（10）进行灭菌和更换，从而提供无菌的组织接触表面。装置（10）具有额外的特征，这对于眼睛的诊断和手术是特别有利的。

6. 发明申请

US20100191176A1 SUBRETINAL ACCESS DEVICE 失效
标题翻译： SUBRETINAL访问设备
公开(公告)号：US20100191176A1
公开(公告)日：2010-07-29
申请号：US12359157
申请日：2009-01-23
申请人： Friedrich Ho , Stanley R. Conston , Ronald K. Yamamoto
发明人： Friedrich Ho , Stanley R. Conston , Ronald K. Yamamoto
IPC分类号： A61F9/008 , A61B17/32 , A61F9/007 , A61B1/00
CPC分类号： A61F9/007 , A61B1/313 , A61B3/102 , A61B3/12 , A61B5/0066 , A61B17/3421 , A61B2017/306 , A61F9/0017 , A61F9/008 , A61F2009/00863 , A61F2009/00874
摘要： The invention provides surgical devices that provide access to the sub-retinal space using delicate traction to hold the sensory retina to create and maintain a patent sub-retinal space of sufficient size to introduce and perform treatments on the eye. Such treatments may include the introduction of illumination or imaging agents or tools, surgical tools, the infusion of pharmaceutical or biological agents, and the placement of grafts, transplants or implants and the closure of the site through the delivery of a sealant.
摘要翻译：本发明提供了外科装置，其使用微妙的牵引力提供对次视网膜空间的接近以保持感觉视网膜以产生和维持足够尺寸的专利视网膜空间以引入和执行对眼睛的治疗。这样的治疗可以包括引入照明或成像剂或工具，手术工具，药物或生物制剂的输注，以及移植物，移植物或植入物的放置以及通过递送密封剂来封闭部位。

7. 发明申请

US20120271272A1 DEVICE FOR OCULAR ACCESS 审中-公开
标题翻译： OCULAR ACCESS的设备
公开(公告)号：US20120271272A1
公开(公告)日：2012-10-25
申请号：US13273775
申请日：2011-10-14
申请人： Amy Lee HAMMACK , Stanley R. CONSTON , Ronald YAMAMOTO
发明人： Amy Lee HAMMACK , Stanley R. CONSTON , Ronald YAMAMOTO
IPC分类号： A61M5/00 , A61M5/46 , A61M5/178
CPC分类号： A61F9/0017 , A61F9/00727 , A61M5/46 , A61M5/486 , A61M2005/3103 , A61M2210/0612
摘要： The present invention provides devices to access the suprachoroidal space or sub-retinal space in an eye via a minimally invasive transconjunctival approach. The devices may also be used after a partial dissection, for example after dissection of the outer scleral layer of the eye, and using the device within the dissection to access the suprachoroidal space or the sub-retinal space.
摘要翻译：本发明提供了通过微创结膜手术来接近眼中的脉络膜间隙或视网膜下空间的装置。在部分解剖之后，例如在解剖眼睛的外巩膜层之后并且使用解剖内的装置来访问脉管外的空间或子视网膜空间，也可以使用装置。

8. 发明授权

US08172830B2 Composite ophthalmic microcannula 有权
标题翻译：复合眼科微囊
公开(公告)号：US08172830B2
公开(公告)日：2012-05-08
申请号：US11729603
申请日：2007-03-28
申请人： Jeffrey J. Christian , Stanley R. Conston , David J. Kupiecki , John McKenzie
发明人： Jeffrey J. Christian , Stanley R. Conston , David J. Kupiecki , John McKenzie
IPC分类号： A61M25/00
CPC分类号： A61F9/00781 , A61B3/0008 , A61B17/3421 , A61F9/007 , A61M25/005 , A61M2025/0042
摘要： Microcannulae are constructed with multiple components in a composite design, allowing the microcannulae to have varying mechanical and delivery properties that will enable ophthalmic treatments by minimally invasive means. The microcannula includes at least one flexible, tubular communicating element with an outer diameter of 350 microns or less, a proximal connector for introduction of materials, energy or tools. It may also include a reinforcing member attached to the communicating element, which may be designed to create variable stiffness along the length of the microcannula. The microcannula may also include other features such as a signal beacon near the distal tip.
摘要翻译：微复合材料以复合材料设计的多个组分构成，允许微囊具有不同的机械和传递性能，可通过微创手段进行眼科治疗。微型插管包括至少一个具有350微米或更小外径的柔性管状连通元件，用于引入材料，能量或工具的近端连接件。其还可以包括附接到连通元件的加强构件，该加强构件可被设计成沿着微型插管的长度产生可变的刚度。微型插管还可以包括其他特征，例如靠近远端的信号信标。

9. 发明申请

US20130216623A1 APPARATUS AND FORMULATIONS FOR SUPRACHORIDAL DRUG DELIVERY 审中-公开
标题翻译：用于服用药物递送的装置和配方
公开(公告)号：US20130216623A1
公开(公告)日：2013-08-22
申请号：US13842218
申请日：2013-03-15
申请人： ISCIENCE INTERVENTIONAL CORPORATION
发明人： Ronald Yamamoto , Stanley R. Conston , David Sierra
IPC分类号： A61K9/00
CPC分类号： A61K9/0048 , A61F9/0017 , A61F9/0026 , A61F9/007 , A61K9/0051 , A61K9/14 , A61K9/1635 , A61K31/717 , A61K31/718 , A61K31/722 , A61K31/728 , A61K31/737 , A61K47/36
摘要： Drug formulations, devices and methods are provided to deliver biologically active substances to the eye. The formulations are delivered into scleral tissues adjacent to or into the suprachoroidal space without damage to the underlying choroid. One class of formulations is provided wherein the formulation is localized in the suprachoroidal space near the region into which it is administered. Another class of formulations is provided wherein the formulation can migrate to another region of the suprachoroidal space, thus allowing an injection in the anterior region of the eye in order to treat the posterior region.
摘要翻译：提供药物制剂，装置和方法以将生物活性物质递送至眼睛。将制剂递送到邻近或进入脉络膜上空间的巩膜组织中，而不损伤下面的脉络膜。提供一类制剂，其中制剂定位在其施用的区域附近的脉管外空间中。提供另一类制剂，其中制剂可以迁移到脉络膜上空间的另一区域，从而允许在眼前部注射以治疗后部区域。

10. 发明申请

US20120191064A1 METHODS AND APPARATUS FOR SUB-RETINAL CATHETERIZATION 审中-公开
标题翻译：用于分层诱导的方法和装置
公开(公告)号：US20120191064A1
公开(公告)日：2012-07-26
申请号：US13320218
申请日：2010-05-14
申请人： Stanley R. Conston , Ronald Yamamoto
发明人： Stanley R. Conston , Ronald Yamamoto
IPC分类号： A61M5/00 , A61L29/14 , A61M25/00
CPC分类号： A61F9/00727
摘要： Devices and methods are provided for access to the sub-retinal space that lies between the retina and the choroid in order to introduce therapies to the retina and more specifically to the sensory retina and RPE, particularly in the region of the macula. The devices comprise a catheter that incorporates advantageous size, flexibility and tip features to properly, accurately and atraumatically access the sub-retinal space. Ancillary devices to assist in placing catheters into the sub-retinal space are also provided. The catheter devices incorporate a lumen for delivery of therapeutic substances or devices into the eye.
摘要翻译：提供了用于访问位于视网膜和脉络膜之间的子视网膜空间的装置和方法，以便将疗法引入视网膜，并且更具体地引入感觉视网膜和RPE，特别是在黄斑区域。这些装置包括导管，该导管具有有利的尺寸，柔性和尖端特征以适当地，精确地和无创地进入子视网膜空间。还提供辅助设备以帮助将导管置于子视网膜空间中。导管装置包括用于将治疗物质或装置输送到眼睛中的内腔。

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