专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09119794B2 Process to form a tablet and apparatus suitable for applying this process 有权
标题翻译：形成适用于该方法的片剂和装置的方法
公开(公告)号：US09119794B2
公开(公告)日：2015-09-01
申请号：US13266510
申请日：2010-04-28
申请人： Hans Almer Middelbeek , Jozefus A. C. Smit
发明人： Hans Almer Middelbeek , Jozefus A. C. Smit
IPC分类号： B29C39/38 , B65D85/00 , B28B7/42 , A61K9/20 , A61J3/10 , A61J7/00 , A61K9/00
CPC分类号： A61K9/2095 , A61J3/10 , A61J7/0007 , A61K9/0056
摘要： The present invention pertains to a process for the preparation of a fast-disintegrating tablet (30) containing a medicinal substance, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element (100) having formed therein at least one cavity, (101) cooling the solid element (100) to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity (101) to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to a system for performing such a process and a package containing the resulting tablet.
摘要翻译：本发明涉及一种制备含有药物的快速崩解片剂（30）的方法，包括以下步骤：提供包含药物的流体制剂，提供其中形成有至少一种空腔，（101）将固体元件（100）冷却至低于制剂的冷冻温度的温度，用流体制剂填充空腔，在存在于空腔（101）中时固化制剂以形成固体颗粒，其包含药物物质，而不主动地塑造颗粒的整个表面，将颗粒从空腔中取出并在真空中干燥沉淀物以获得片剂。本发明还涉及用于执行这种方法的系统和包含所得到的片剂的包装。

2. 发明授权

US09051557B2 Method for continuously culturing Ehrlichia canis 有权
标题翻译：连续培养伊朗杆菌的方法
公开(公告)号：US09051557B2
公开(公告)日：2015-06-09
申请号：US12674114
申请日：2008-09-11
申请人： Jane Kwun-Lai Battles , Kimberly D. Proudfoot , Brenda L. Meding , Patrick G. Funk , R. Monty Warthen , F. Randall Bethke , Eric A. Ellis , Amy Y. Purse
发明人： Jane Kwun-Lai Battles , Kimberly D. Proudfoot , Brenda L. Meding , Patrick G. Funk , R. Monty Warthen , F. Randall Bethke , Eric A. Ellis , Amy Y. Purse
IPC分类号： C12N1/20
CPC分类号： C12N1/20
摘要： The present invention relates to a method of culturing bacterial organisms belonging to the family Anaplasmataceae in mammalian embryonic or fetal cells. In particular, the present invention is directed to growth of bacterial organisms belonging to the family Anaplasmataceae including organisms belonging to the Anaplasma, Ehrlichia and Neorickettsia genera. The bacterial organisms may be cultured in mammalian embryonic or fetal host cells including feline embryonic host cells. Bacterial material cultured according to the methods described herein may be used as the basis for vaccines against diseases associated with the Anaplasmataceae bacteria, or as the basis for diagnostic applications useful for diagnosing diseases associated with the Anaplasmataceae bacteria.
摘要翻译：本发明涉及一种在哺乳动物胚胎或胎儿细胞中培养属于Anaplasmataceae的细菌生物的方法。特别地，本发明涉及属于Anaplasmataceae的细菌生物，包括属于Anaplasma，Ehrlichia和Neorickettsia属的生物。细菌生物可以在哺乳动物胚胎或胎儿宿主细胞中培养，包括猫胚胎宿主细胞。根据本文所述的方法培养的细菌物质可以用作针对与阿扁丝藓科细菌相关的疾病的疫苗的基础，或者可用作用于诊断与阿扁ace科细菌有关的疾病的诊断应用的基础。

3. 发明授权

US08911744B2 Recombinant classical swine fever virus (CSFV) comprising a modified E2 protein and methods for generating said recombinant CSFV 有权
标题翻译：包含修饰的E2蛋白的重组经典猪瘟病毒（CSFV）和产生所述重组CSFV的方法
公开(公告)号：US08911744B2
公开(公告)日：2014-12-16
申请号：US13141182
申请日：2009-12-23
申请人： Jeroen Alexander Kortekaas , Rianka Petronella Maria Vloet
发明人： Jeroen Alexander Kortekaas , Rianka Petronella Maria Vloet
IPC分类号： C12N7/01 , A61P31/14 , C12Q1/70 , C07K16/08 , C12N7/02 , A61K39/12 , C07K14/005 , G01N33/569 , C12N7/00
CPC分类号： C12N7/00 , C07K14/005 , C12N2770/24322 , C12N2770/24361 , G01N33/56983
摘要： The invention relates to a recombinant classical swine fever virus (CSFV). A preferred recombinant CSFV comprises a deletion of at least one amino acid in a “TAVSPTTLR” domain of the E2 protein. The invention further relates to a vaccine comprising the recombinant CSFV, a method for generating a recombinant CSFV, and use of a recombinant CSFV.
摘要翻译：本发明涉及重组典型猪瘟病毒（CSFV）。优选的重组CSFV包含E2蛋白的“TAVSPTTLR”结构域中至少一个氨基酸的缺失。本发明还涉及包含重组CSFV的疫苗，产生重组CSFV的方法和重组CSFV的使用。

4. 发明授权

US08778868B2 Chemically defined vaccine stabiliser 有权
标题翻译：化学定义的疫苗稳定剂
公开(公告)号：US08778868B2
公开(公告)日：2014-07-15
申请号：US11908028
申请日：2006-03-07
申请人： Petrus Theodorus Johannes Andries van Gelder , Arnoldus Theodorus Petrus Loermans , Mathias Arnold Maassen
发明人： Petrus Theodorus Johannes Andries van Gelder , Arnoldus Theodorus Petrus Loermans , Mathias Arnold Maassen
IPC分类号： A61K31/00 , A61K31/04 , A61K31/70 , A61K31/132 , A61K31/047 , A61K31/7004 , A61K31/7016 , A61K31/198 , A61K9/19
CPC分类号： A61K31/00 , A61K9/19 , A61K31/04 , A61K31/047 , A61K31/132 , A61K31/198 , A61K31/70 , A61K31/7004 , A61K31/7016 , A61K39/0275 , A61K39/085 , A61K39/092 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/205 , A61K39/215 , A61K39/245 , A61K39/275 , A61K47/183 , A61K47/26 , A61K47/34 , A61K2300/00 , C12N2710/16734 , C12N2710/24034 , C12N2760/16134 , C12N2760/18534 , C12N2760/18634 , C12N2770/20034 , Y02A50/482
摘要： The present invention relates to a stabilizer composition comprising an amino acid, and a sugar wherein all compounds are chemically defined; to a vaccine composition comprising such a stabilizer composition and a biological molecule and/or a micro-organism; to a method for preparing a pharmaceutical composition comprising admixing such a stabilizer composition with a biological molecule and/or a micro-organism; to the use of such a stabilizer composition, and of vaccines prepared therewith.
摘要翻译：本发明涉及包含氨基酸的稳定剂组合物和其中所有化合物都被化学定义的糖; 涉及包含这种稳定剂组合物和生物分子和/或微生物的疫苗组合物; 涉及一种制备药物组合物的方法，包括将这种稳定剂组合物与生物分子和/或微生物混合; 使用这种稳定剂组合物以及用其制备的疫苗。

5. 发明授权

US08674120B2 Process for manufacturing zeranol 有权
标题翻译：制造Zeranol的方法
公开(公告)号：US08674120B2
公开(公告)日：2014-03-18
申请号：US13127392
申请日：2009-11-03
申请人： John Richard Bethell , Gary Robert Reid , Krista Marie Affleck , Tibor Breining
发明人： John Richard Bethell , Gary Robert Reid , Krista Marie Affleck , Tibor Breining
IPC分类号： C07D493/00
CPC分类号： C07D313/00
摘要： This invention is directed generally to a process for producing Zeranol that eliminates high pressure and high temperature hydrogenations and provides high selectivity for Zeranol at improved yields.
摘要翻译：本发明一般涉及消除高压和高温氢化的Zeranol生产方法，并以提高的产率为Zeranol提供高选择性。

6. 发明授权

US08597662B2 Vaccine for protection against Lawsonia intracellularis 有权
公开(公告)号：US08597662B2
公开(公告)日：2013-12-03
申请号：US13657210
申请日：2012-10-22
申请人： Intervet International B.V.
发明人： Antonius Arnoldus Christiaan Jacobs , Paul Vermeij , Ruud Philip Antoon Maria Segers , Carla Christina Schrier
IPC分类号： A61K39/02 , C12N1/20
CPC分类号： A61K39/105 , A61K2039/542 , A61K2039/552 , A61K2039/55566
摘要： The present invention pertains to the use of a non-live carbohydrate containing composition, the carbohydrate being also found in live Lawsonia intracellularis cells in association with the outer cell membrane of these cells, for the manufacture of a vaccine for protection against an infection with Lawsonia intracellularis, the vaccine being in a form suitable for systemic administration.

7. 发明授权

US08557254B2 Lawsonia intracellularis bacterium of a novel serotype, vaccine based on that bacterium, antibodies suitable for diagnosing the novel Lawsonia intracellularis serotype and hybridomas for producing the said antibodies 有权
标题翻译：一种新型血清型的细胞内劳森菌细菌，基于该细菌的疫苗，适用于诊断新型劳森氏菌血清型的抗体和用于产生所述抗体的杂交瘤
公开(公告)号：US08557254B2
公开(公告)日：2013-10-15
申请号：US13054979
申请日：2009-07-20
申请人： Yvonne Maria Johanna Corina Biermann , Mohamad Morsey , Antonius Arnoldus Christiaan Jacobs , Carla Christina Schrier
发明人： Yvonne Maria Johanna Corina Biermann , Mohamad Morsey , Antonius Arnoldus Christiaan Jacobs , Carla Christina Schrier
IPC分类号： A61K39/02
CPC分类号： C12R1/01 , A61K39/105 , A61K2039/521 , A61K2039/55566 , C07K16/12
摘要： This invention pertains to Lawsonia intracellularis bacterium of a serotype which is reactive with monoclonal antibody INT-LIC-02-02 as produced by hybridoma INT-LIC-02-02 deposited with the Collection Nationale de Cultures de Micro-organismes of the Institut Pasteur at Paris France under nr. CNCM I-4049 but which is not reactive with antibody INT-LIC-01-28 as produced by hybridoma INT-LIC-01-28 deposited with the Collection Nationale de Cultures de Micro-organismes of the Institut Pasteur at Paris France under nr. CNCM I-4048. The invention also pertains to vaccines for protection against an infection with Lawsonia intracellularis based on those novel bacteria, antibodies suitable for diagnosing the novel Lawsonia intracellularis serotype and hybridomas for producing the said antibodies.
摘要翻译：本发明涉及与由巴斯夫研究所巴斯德研究所（National Pasteur）的微生物收集国家保藏的杂交瘤INT-LIC-02-02产生的与单克隆抗体INT-LIC-02-02反应的血清型的劳森氏菌细菌巴黎法国nr。 CNCM I-4049，但不与抗体INT-LIC-01-28反应，由保藏于法国巴黎法国巴斯德研究所的微生物培养基的杂交瘤INT-LIC-01-28产生。 CNCM I-4048。本发明还涉及用于基于那些新型细菌，适于诊断新型劳森氏菌血清型的抗体和用于产生所述抗体的杂交瘤来防止胞内劳森氏菌感染的疫苗。

8. 发明授权

US08530223B2 Method to grow Lawsonia intracellularis bacteria in persistently infected McCoy cells 有权
标题翻译：在持续感染的McCoy细胞中培养细胞内劳森氏菌细菌的方法
公开(公告)号：US08530223B2
公开(公告)日：2013-09-10
申请号：US13505667
申请日：2010-11-08
申请人： Yvonne Maria Johanna Corina Biermann , Carla Christina Schrier , Petrus Theodorus Johannes Andries Gelder van , Bram Verdellen , Barry Lijsdonk
发明人： Yvonne Maria Johanna Corina Biermann , Carla Christina Schrier , Petrus Theodorus Johannes Andries Gelder van , Bram Verdellen , Barry Lijsdonk
IPC分类号： C12N1/20 , A61P31/04
CPC分类号： C12N1/20 , C12N1/00
摘要： The present invention pertains to a method to obtain McCoy cells persistently infected with Lawsonia intracellularis bacteria, comprising infecting McCoy cells with Lawsonia intracellularis bacteria, growing the infected McCoy cells in a suitable medium at an oxygen concentration less than 18% to arrive at a culture of McCoy cells infected with Lawsonia intracellularis bacteria, passing at least a part of the said culture to fresh medium, and without adding uninfected McCoy cells to the medium, growing the infected McCoy cells contained in the said at least part in the fresh medium at an oxygen concentration less than 18%, to obtain the persistently infected McCoy cells. The invention also pertains to the use of such persistently infected cells to grow and obtain these bacteria in purified form.
摘要翻译：本发明涉及一种获得持续感染细胞内劳森氏菌细菌的McCoy细胞的方法，包括用细胞内劳森氏菌感染McCoy细胞，将感染的McCoy细胞在氧浓度小于18％的合适培养基中培养以获得 McCoy细胞感染细胞内劳森氏菌细菌，将至少一部分所述培养物转移到新鲜培养基中，并且不将未感染的McCoy细胞添加到培养基中，在含氧的新鲜培养基中培养所述至少部分所述至少部分的感染的McCoy细胞浓度小于18％，以获得持续感染的McCoy细胞。本发明还涉及使用这种持续感染的细胞生长并获得纯化形式的这些细菌。

9. 发明授权

US08518900B2 Macrolide synthesis process and solid-state forms 有权
标题翻译：大环内酯合成过程和固态形式
公开(公告)号：US08518900B2
公开(公告)日：2013-08-27
申请号：US13359327
申请日：2012-01-26
申请人： Ralf Warrass , Fritz Blatter , Meinrad Brenner , Guixan Hu , Timo Rager
发明人： Ralf Warrass , Fritz Blatter , Meinrad Brenner , Guixan Hu , Timo Rager
IPC分类号： A61K31/70 , C07H17/08
CPC分类号： C07H17/08
摘要： Described are methods for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, among other uses, may be used to make macrolides. Also described are solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms.
摘要翻译：描述了制备大环内酯类的方法，特别是制备任选取代的20,23-二哌啶基-5-O-碳霉糖基 - 太乐内酯及其衍生物的方法，以及大环内酯类制备药物的用途，使用大环内酯类的治疗方法以及用于制造中间体的方法，除了其它用途之外，可以使用它们来制备大环内酯类。还描述了20,23-二哌啶基-5-O-碳霉糖基 - 太乐内酯的溶剂化和非溶剂化结晶形式，以及制备这种结晶形式的方法，包含（或衍生自）这种结晶形式的药物，制备药物的方法包括（或衍生自）这种结晶形式，使用这种结晶形式的处理方法，以及包含这种结晶形式的试剂盒。

10. 发明申请

US20130045228A1 VACCINE FOR PROTECTION AGAINST LAWSONIA INTRACELLULARIS 有权
标题翻译：疫苗用于保护羊膜细菌
公开(公告)号：US20130045228A1
公开(公告)日：2013-02-21
申请号：US13657210
申请日：2012-10-22
申请人： Intervet International B.V.
发明人： Antonius Arnoldus Christiaan Jacobs , Paul Vermeij , Ruud Philip Antoon Maria Segers , Carla Christina Schrier
IPC分类号： A61K39/02 , A61K39/295 , A61P31/04 , A61K39/04
CPC分类号： A61K39/105 , A61K2039/542 , A61K2039/552 , A61K2039/55566
摘要： The present invention pertains to the use of a non-live carbohydrate containing composition, the carbohydrate being also found in live Lawsonia intracellularis cells in association with the outer cell membrane of these cells, for the manufacture of a vaccine for protection against an infection with Lawsonia intracellularis, the vaccine being in a form suitable for systemic administration.
摘要翻译：本发明涉及含有非活性碳水化合物的组合物的用途，所述碳水化合物也存在于与细胞外细胞膜结合的胞内劳森氏菌细胞内，用于制备用于防止劳森氏菌感染的疫苗细胞内毒素，疫苗是适合全身给药的形式。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式