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1. 发明授权

US10201340B2 Sheath apparatus and methods for delivering a closure device 有权
公开(公告)号：US10201340B2
公开(公告)日：2019-02-12
申请号：US15356028
申请日：2016-11-18
申请人： Integrated Vascular Systems, Inc.
发明人： Anthony J. Pantages , Ronald J. Jabba , Richard S. Ginn
IPC分类号： A61B17/03 , A61B17/00 , A61B17/064 , A61B17/08
摘要： An apparatus for delivering a clip includes an introducer sheath including an outer surface extending between its proximal and distal ends. A clip is carried on the outer surface, e.g., on a carrier assembly that is slidable along the outer surface from the proximal end towards the distal end. A skin overlies the outer surface of the sheath and the carrier assembly that is separable from the outer surface as the carrier assembly is advanced from the proximal end towards the distal end of the sheath. During use, the distal end of the sheath is inserted into an opening through tissue, e.g., into a puncture communicating with a blood vessel. The carrier assembly is advanced towards the distal end of the sheath, causing the skin to separate from the outer surface of the elongate member, and the clip is deployed from the carrier to seal the opening.

2. 发明授权

US09398914B2 Methods of use of a clip applier 有权
公开(公告)号：US09398914B2
公开(公告)日：2016-07-26
申请号：US14017039
申请日：2013-09-03
申请人： Integrated Vascular Systems, Inc.
发明人： Brian A. Ellingwood , Laveille K. Voss , T. Daniel Gross , Kelly McCrystle
IPC分类号： A61B17/04 , A61B17/10 , A61B17/00 , A61B17/064 , A61B17/068 , A61B17/08 , A61B17/122
CPC分类号： A61B17/10 , A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/083 , A61B17/1227 , A61B2017/00637
摘要： A method for closing an opening formed in a wall of a body lumen or body tissue can include positioning a splittable carrier tube adjacent to the opening, the carrier tube having a splittable distal end with an outer surface retaining a closure element in a substantially tubular configuration or having an asymmetrically-elongated tubular shape with a trapezoidal longitudinal cross-sectional profile. The method including splitting a distal end of the carrier tube with a splitter and deploying the closure element from the carrier flaps of the carrier tube and over the splitter to allow the closure element to engage at least a portion of the wall of the body lumen or the body tissue and substantially close the opening.

3. 发明授权

US09089674B2 Apparatus and methods for positioning a vascular sheath 有权
公开(公告)号：US09089674B2
公开(公告)日：2015-07-28
申请号：US11532325
申请日：2006-09-15
申请人： Richard S. Ginn , W. Martin Belef
发明人： Richard S. Ginn , W. Martin Belef
IPC分类号： A61B17/08 , A61M25/06 , A61B17/00 , A61B17/34 , A61B19/00 , A61M25/00
CPC分类号： A61M25/0662 , A61B17/0057 , A61B17/3417 , A61B17/3498 , A61B2017/00672 , A61B2017/3454 , A61B2090/062 , A61M25/0693 , A61M2025/0079
摘要： An apparatus for positioning an introducer sheath includes a sheath having a distal end including first and second ports, the second port being located distally from the first port. An obturator is slidable within the sheath that includes a distal region that sealingly engages an interior surface of the sheath. The obturator includes first and second openings in the distal region that are alignable with the first and second ports in the sheath. A housing is slidable on the exterior of the sheath that releasably holds a closure element. The sheath may be inserted into an incision communicating with a blood vessel, the first and second ports providing backbleed indication of the depth of the insertion of the sheath into the vessel. The housing is actuated to deploy the closure element to engage and close the incision.

4. 发明授权

US08690910B2 Closure device and methods for making and using them 有权
标题翻译：关闭装置及其制造和使用的方法
公开(公告)号：US08690910B2
公开(公告)日：2014-04-08
申请号：US11396141
申请日：2006-03-31
申请人： Michael T. Carley , Richard S. Ginn , William N. Aldrich , W. Martin Belef , Steven N. Roe , Ronald J. Jabba , Janina Sagastegui
发明人： Michael T. Carley , Javier Sagastegui , Richard S. Ginn , William N. Aldrich , W. Martin Belef , Steven N. Roe , Ronald J. Jabba
IPC分类号： A61B17/08 , A61D1/00
CPC分类号： A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B90/39 , A61B2017/00004 , A61B2017/00579 , A61B2017/00584 , A61B2017/00592 , A61B2017/0061 , A61B2017/00659 , A61B2017/00668 , A61B2017/00867 , A61B2017/0641
摘要： A method for closing an opening in a wall of a body lumen using a clip can include advancing a distal end of an elongate member within the body lumen, the elongate member having a distal portion that assists in presenting the wall for receiving a clip having a plurality of tissue engaging portions having tips that point generally toward a central axis of the clip. The clip can be advanced relative to the elongate member and the wall of the body lumen until the plurality of tissue engaging portions penetrate the wall of the body lumen. Once the clip penetrates the wall, the elongate member can be withdrawn from the body lumen, leaving the clip to substantially close the opening in the wall of the body lumen.
摘要翻译：使用夹子封闭体腔的壁中的开口的方法可以包括将细长构件的远端推进在体腔内，细长构件具有帮助呈现壁的远端部分，用于接收具有多个组织接合部分具有大致朝向夹子的中心轴线指向的尖端。夹子可以相对于细长构件和体腔的壁前进，直到多个组织接合部分穿透体腔的壁。一旦夹子穿过壁，细长构件可以从体腔抽出，留下夹子基本上封闭体腔内的开口。

5. 发明授权

US08597325B2 Apparatus and methods for providing tactile feedback while delivering a closure device 有权
公开(公告)号：US08597325B2
公开(公告)日：2013-12-03
申请号：US12955859
申请日：2010-11-29
申请人： Richard S. Ginn
发明人： Richard S. Ginn
IPC分类号： A61B17/08 , A61B17/10 , A61D17/00
CPC分类号： A61B17/0057 , A61B17/064 , A61B34/76 , A61B2017/00367 , A61B2017/00637 , A61B2017/00654 , A61B2017/00663 , A61B2017/00668 , A61B2017/00672 , A61B2017/081
摘要： An apparatus for sealing a passage through tissue includes a tubular member, a plug, and a locator member. The plug is disposed on a distal end of the tubular member and includes an external thread. The locator member is inserted into a lumen of the tubular member until a distal portion is disposed beyond the plug. The distal portion includes a helically wound wire and a tether coupled to the wire that is movable for causing the wire to buckle. To seal a passage communicating with a blood vessel, the distal portion of the locator member is inserted into the passage, and the plug is threaded into the passage until the distal portion extends into the vessel. The tether is pulled to buckle the wire, and the plug is unthreaded until the buckled wire contacts a wall of the vessel, whereupon the plug is released to seal the passage.

6. 发明授权

US08398656B2 Clip applier and methods of use 有权
标题翻译：夹子施放器和使用方法
公开(公告)号：US08398656B2
公开(公告)日：2013-03-19
申请号：US13039087
申请日：2011-03-02
申请人： Thomas J. Palermo , William M. Belef , Michael T. Carley , Richard S. Ginn , Anthony J. Pantages , Ronald J. Jabba , Brian A. Ellingwood , Laveille Kao Voss , Kelly J. McCrystle , T. Daniel Gross , Arkady Kokish
发明人： Thomas J. Palermo , William M. Belef , Michael T. Carley , Richard S. Ginn , Anthony J. Pantages , Ronald J. Jabba , Brian A. Ellingwood , Laveille Kao Voss , Kelly J. McCrystle , T. Daniel Gross , Arkady Kokish
IPC分类号： A61B17/08 , A61B17/10
CPC分类号： A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/10 , A61B17/1227 , A61B2017/0003 , A61B2017/00106 , A61B2017/00349 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/0649 , A61B2017/12018 , A61B2090/065
摘要： An apparatus for delivering a closure element can include a splittable carrier tube and a splitter to split the tube. The carrier tube can have an outer surface retaining a closure element in a tubular configuration and can be split into radially-expandable flaps. A closure element can have a shape-memory body having a relaxed configuration with a planar-annular body defining a lumen with tines directed inwardly from the body. The clip can be held in a retaining configuration having a substantially asymmetrically-elongated tubular shape with a trapezoidal longitudinal cross-sectional profile and a proximal end having the tines being longitudinally directed with a first tine being more distally oriented compared to a substantially opposite second tine being more proximal, and retracting to a deploying configuration having a tubular shape with a rectangular longitudinal cross-sectional profile with the first tine being even with the second tine when being delivered.
摘要翻译：用于传送闭合元件的装置可以包括可拆卸的载体管和用于分裂管的分离器。载体管可以具有将封闭元件保持为管状构造的外表面，并且可以被分割成径向可膨胀的瓣。封闭元件可以具有形状记忆体，该形状记忆体具有松弛构型，其中平面环形主体限定具有从身体向内指向的尖齿的内腔。夹具可以保持在具有梯形纵截面轮廓的基本上不对称的细长管状形状的保持构造中，并且具有尖端的尖端与第一齿纵向对准，该第一齿与基本上相对的第二齿相比更向远侧取向更靠近并且缩回到具有矩形纵向截面轮廓的管状形状的展开构造，其中第一齿在被递送时与第二齿均匀。

7. 发明授权

US08236026B2 Closure device and methods for making and using them 有权
标题翻译：关闭装置及其制造和使用的方法
公开(公告)号：US08236026B2
公开(公告)日：2012-08-07
申请号：US11390586
申请日：2006-03-27
申请人： Michael T. Carley , Richard S. Ginn , Javier Sagastegui , Ronald J. Jabba , William N. Aldrich , W. Martin Belef
发明人： Michael T. Carley , Richard S. Ginn , Javier Sagastegui , Ronald J. Jabba , William N. Aldrich , W. Martin Belef
IPC分类号： A61B17/08 , A61D1/00
CPC分类号： A61B17/08 , A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/083 , A61B90/39 , A61B2017/00004 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/00867 , A61B2017/0641 , A61B2017/081 , H03K3/356139 , H03K3/356156
摘要： A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.
摘要翻译：用于接合组织的夹具包括限定平面并围绕垂直于平面延伸的中心轴设置的大致环形的主体。主体包括交替的内部和外部弯曲区域，围绕夹子的周边限定Z字形图案。身体偏向平面构型，该平面构型位于平面内，并可朝向延伸出平面的横向构型偏转。齿从内部弯曲区域延伸，尖齿在平面构型中朝向中心轴线定向，并且在横向构型中平行于中心轴线。尖齿可以包括比主尖齿短的主要尖齿和次要尖齿。主尖齿可以设置在相对的内部弯曲区域上并且朝向彼此定向，使得它们在平面构造中重叠。

8. 发明申请

US20110230897A1 CLIP APPLIER AND METHODS OF USE 有权
标题翻译：夹具应用和使用方法
公开(公告)号：US20110230897A1
公开(公告)日：2011-09-22
申请号：US13039087
申请日：2011-03-02
申请人： Thomas J. Palermo , William M. Belef , Michael T. Carley , Richard S. Ginn , Anthony J. Pantages , Ronald J. Jabba , Brian A. Ellingwood , Laveille Kao Voss , Kelly J. McCrystle , T. Daniel Gross , Arkady Kokish
发明人： Thomas J. Palermo , William M. Belef , Michael T. Carley , Richard S. Ginn , Anthony J. Pantages , Ronald J. Jabba , Brian A. Ellingwood , Laveille Kao Voss , Kelly J. McCrystle , T. Daniel Gross , Arkady Kokish
IPC分类号： A61B17/10
CPC分类号： A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/10 , A61B17/1227 , A61B2017/0003 , A61B2017/00106 , A61B2017/00349 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/0649 , A61B2017/12018 , A61B2090/065
摘要： An apparatus for delivering a closure element can include a splittable carrier tube and a splitter to split the tube. The carrier tube can have an outer surface retaining a closure element in a tubular configuration and can be split into radially-expandable flaps. A closure element can have a shape-memory body having a relaxed configuration with a planar-annular body defining a lumen with tines directed inwardly from the body. The clip can be held in a retaining configuration having a substantially asymmetrically-elongated tubular shape with a trapezoidal longitudinal cross-sectional profile and a proximal end having the tines being longitudinally directed with a first tine being more distally oriented compared to a substantially opposite second tine being more proximal, and retracting to a deploying configuration having a tubular shape with a rectangular longitudinal cross-sectional profile with the first tine being even with the second tine when being delivered.
摘要翻译：用于传送闭合元件的装置可以包括可拆卸的载体管和用于分裂管的分离器。载体管可以具有将封闭元件保持为管状构造的外表面，并且可以被分割成径向可膨胀的瓣。封闭元件可以具有形状记忆体，该形状记忆体具有松弛构型，其中平面环形主体限定具有从身体向内指向的尖齿的内腔。夹具可以保持在具有梯形纵截面轮廓的基本上不对称的细长管状形状的保持构造中，并且具有尖端的尖端与第一齿纵向对准，该第一齿与基本上相对的第二齿相比更向远侧取向更靠近并且缩回到具有矩形纵向截面轮廓的管状形状的展开构造，其中第一齿在被递送时与第二齿均匀。

9. 发明授权

US08007512B2 Plunger apparatus and methods for delivering a closure device 有权
标题翻译：柱塞装置和用于传送闭合装置的方法
公开(公告)号：US08007512B2
公开(公告)日：2011-08-30
申请号：US10682459
申请日：2003-10-08
申请人： Richard S. Ginn , Anthony Pantages
发明人： Richard S. Ginn , Anthony Pantages
IPC分类号： A61B17/08 , A61B17/10 , A61D1/00
CPC分类号： A61B17/0057 , A61B17/064 , A61B17/08 , A61B2017/00004 , A61B2017/00637 , A61B2017/00659 , A61B2017/00668 , A61B2017/00672 , A61B2017/0641
摘要： An apparatus for delivering a clip includes an introducer sheath including an outer surface extending between its proximal and distal ends, and a hub on the proximal end that includes spacer elements spaced away from the outer surface. An annular clip includes a plurality of tines extending from its distal end and its proximal end is held away from the outer surface of the sheath by the spacer elements. A handle assembly is attached to the hub that includes an actuator member slidable between the spacer elements and the outer surface of the sheath. The actuator member includes radial protrusions for coupling with the clip, whereby distal movement of the actuator member advances the clip towards the distal end of the sheath. Optionally, a skin overlies the outer surface of the sheath and the clip that is separable from the outer surface as the clip is advanced.
摘要翻译：用于递送夹子的装置包括导引鞘，其包括在其近端和远端之间延伸的外表面，以及在近端上的毂，其包括与外表面间隔开的间隔元件。环形夹具包括从其远端延伸的多个尖齿，并且其近端通过间隔元件远离护套的外表面。手柄组件附接到毂，其包括可在间隔元件和护套的外表面之间滑动的致动器构件。致动器构件包括用于与夹子联接的径向突起，由此致动器构件的远端运动使夹子朝向护套的远端前进。任选地，当夹子前进时，皮肤覆盖护套的外表面和夹子，该夹子可与外表面分离。

10. 发明申请

US20110106148A1 CLOSURE SYSTEM AND METHODS OF USE 有权
标题翻译：封闭系统及其使用方法
公开(公告)号：US20110106148A1
公开(公告)日：2011-05-05
申请号：US12941809
申请日：2010-11-08
申请人： Richard S. Ginn , William N. Aldrich , William Martin Belef , Steven N. Roe , Michael T. Carley , Ronald J. Jabba , Stephen M. Salmon , Anthony J. Pantages , Francisco Javier Sagastegui
发明人： Richard S. Ginn , William N. Aldrich , William Martin Belef , Steven N. Roe , Michael T. Carley , Ronald J. Jabba , Stephen M. Salmon , Anthony J. Pantages , Francisco Javier Sagastegui
IPC分类号： A61B17/00
CPC分类号： A61B17/083 , A61B17/0057 , A61B17/064 , A61B17/0643 , A61B17/1285 , A61B18/148 , A61B2017/00623 , A61B2017/00654 , A61B2017/00668 , A61B2017/00672 , A61B2017/00862 , A61B2017/00986 , A61B2017/081 , A61B2018/00595 , A61B2018/0063
摘要： A closure system and methods of use are provided for use in sealing an opening in a body tissue, such as a vascular puncture site. A method of closing the opening in the body tissue can be performed with the closure system having a closure clip. The method can include positioning the closure clip in a first closure clip position adjacent to the opening in the body tissue such that a plurality of spikes of the closure clip are inserted into the tissue at a location outward from a central axis of the opening. Subsequently, the closure clip can be positioned in a second closure clip position such that the plurality of spikes are pulled inward toward the central axis of the opening so as to pull the tissue between the opening and each of the spikes together and close the opening.
摘要翻译：提供封闭系统和使用方法用于密封诸如血管穿刺部位的身体组织中的开口。可以在具有闭合夹的封闭系统中执行关闭身体组织中的开口的方法。该方法可以包括将闭合夹定位在与身体组织中的开口相邻的第一闭合夹具位置中，使得闭合夹的多个尖峰在从开口的中心轴线向外的位置插入到组织中。随后，闭合夹可以被定位在第二闭合夹夹位置中，使得多个钉被向内朝向开口的中心轴线向内拉，以便将开口和每个钉之间的组织拉到一起并关闭开口。

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