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1. 发明授权

US5281213A Catheter for ice mapping and ablation 失效
标题翻译：导管用于冰图和消融
公开(公告)号：US5281213A
公开(公告)日：1994-01-25
申请号：US870495
申请日：1992-04-16
申请人： Fredric L. Milder , A Ze'ev Hed
发明人： Fredric L. Milder , A Ze'ev Hed
IPC分类号： A61B17/00 , A61B18/00 , A61B18/02 , A61B18/14 , A61B18/24 , A61B18/28 , A61F7/00 , A61M25/01 , A61B17/36
CPC分类号： A61M25/0147 , A61B18/02 , A61B18/1492 , A61M25/0158 , A61B18/14 , A61B18/24 , A61B18/28 , A61B2017/00022 , A61B2017/00243 , A61B2017/00292 , A61B2017/003 , A61B2018/00011 , A61B2018/00023 , A61B2018/00077 , A61B2018/00095 , A61B2018/00357 , A61B2018/00577 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/0212 , A61B2018/0275 , A61B2018/1253 , A61B2218/002 , A61B2218/003 , A61F2007/0056
摘要： The invention provides a catheter for ice mapping and ablation and a method of ablation using the catheter. The catheter includes at least two lumens for circulating a refrigerating fluid adjacent an ablation device located at the end of a catheter. The refrigerated ablation device is used to chill a localized region of myocardial tissue, thereby permitting the resulting change in electrical activity to be determined. In response to the test results, the ablation device may be used to make a lesion in the myocardial tissue to correct a cardiac arrhythmia. In one embodiment, the ablation device is an electrode which uses radio frequency energy to ablate the myocardial tissue. Alternatively, the ablation device is an electrode adapted for direct current ablation. In another embodiment, the electrode is replaced with an optical fiber in communication with a laser which uses the laser's light energy to ablate tissue. The embodiments may include provisions for steering the catheter and for stabilizing the ablation device at the proposed lesion site.
摘要翻译：本发明提供一种用于冰图和消融的导管以及使用该导管消融的方法。导管包括至少两个流体，用于循环位于导管端部处的消融装置附近的冷冻流体。冷冻消融装置用于冷冻心肌组织的局部区域，从而允许确定所导致的电活动变化。响应于测试结果，消融装置可用于在心肌组织中形成损伤以矫正心律失常。在一个实施例中，消融装置是使用射频能量来消融心肌组织的电极。或者，消融装置是适于直流消融的电极。在另一个实施例中，电极被替换为与使用激光的光能来消融组织的激光器连通的光纤。实施例可以包括用于转向导管并用于在所提出的病变部位处稳定消融装置的装置。

2. 发明授权

US5741224A Iontophoretic material 失效
标题翻译：离子电渗材料
公开(公告)号：US5741224A
公开(公告)日：1998-04-21
申请号：US632843
申请日：1996-04-16
申请人： Fredric L. Milder , Barry D. Weitzner , Lev Ludin
发明人： Fredric L. Milder , Barry D. Weitzner , Lev Ludin
IPC分类号： A61F2/00 , A61F2/30 , A61F2/36 , A61N1/30 , A61M5/32
CPC分类号： A61F2/30767 , A61F2/3662 , A61F2002/30052 , A61F2002/30064 , A61F2002/30677 , A61F2002/30929 , A61F2250/0043 , A61F2310/00113 , A61F2310/00149 , A61F2310/0052 , A61F2310/00562
摘要： An iontophoretic material is provided that uses controlled electrical current derived from two dissimilar galvanic materials to drive oligodynamic metal ions into solution to kill microorganisms on and near the material. Iontophoretic structures or material associated with a medical device are partially or completely covered with one or more covering layers that alter physical, mechanical, chemical, or biological properties of the device and/or the iontophoretic material. In addition to being partially coated or completely enveloped by iontophoretic material or structures, all or a portion of a medical device can be integrated with, impregnated by, or fabricated from an iontophoretic material.
摘要翻译：提供了一种离子电渗材料，其使用由两种不同的电偶材料得到的受控电流，以将低分子量金属离子驱动到溶液中以杀死材料上和附近的微生物。与医疗装置相关联的离子电渗结构或材料部分或完全被一个或多个覆盖层覆盖，所述覆盖层改变了装置和/或离子电渗材料的物理，机械，化学或生物学特性。除了被离子电渗材料或结构部分涂覆或完全包封之外，医疗装置的全部或一部分可以与离子电渗材料整合，浸渍或由其制造。

3. 发明授权

US5275608A Generic endoscopic instrument 失效
标题翻译：通用内窥镜仪器
公开(公告)号：US5275608A
公开(公告)日：1994-01-04
申请号：US777090
申请日：1991-10-16
申请人： Jeffrey L. Forman , Fredric L. Milder , Henri F. deGuillebon , Irving Kalikow , A. Ze'ev Hed
发明人： Jeffrey L. Forman , Fredric L. Milder , Henri F. deGuillebon , Irving Kalikow , A. Ze'ev Hed
IPC分类号： A61B17/28 , A61B17/32
CPC分类号： A61B17/29 , A61B17/2909 , A61B2017/291 , A61B2017/2927
摘要： A surgical tool for operating within a body cavity through a small diameter opening includes a substantially rigid member which is elongated along a first axis and which has a cross-sectional dimension to fit within the opening. A head is mounted on one end of the rigid member for movement in at least one plane through an angle with respect to the first axis. An operable control member is mounted on an opposite end of the rigid member for having at least one degree of manipulability. The control member is coupled to the head member through the rigid member such that manipulation of the control member through an angle with respect to the first axis causes movement of the head member through a corresponding angle. Accordingly, the head member can be steered within a body cavity by control external to the body cavity. In some embodiments, the control member is manipulable to a second degree for actuating an actuating member mounted on the head.
摘要翻译：用于通过小直径开口在体腔内操作的手术工具包括基本上刚性的构件，其沿着第一轴线是细长的，并且具有适合于开口内的横截面尺寸。头部安装在刚性构件的一端上，用于在至少一个平面中相对于第一轴线移动一个角度。可操作的控制构件安装在刚性构件的相对端上，用于具有至少一个操纵程度。控制构件通过刚性构件联接到头部构件，使得控制构件相对于第一轴线的角度的操纵引起头部构件相应角度的移动。因此，通过体腔外部的控制可以将头部构件转向体腔内。在一些实施例中，控制构件可操纵到第二程度，用于致动安装在头部上的致动构件。

4. 发明授权

US2636054A Process for recovery of cyclopentadiene 失效
标题翻译：回收环戊二烯的方法
公开(公告)号：US2636054A
公开(公告)日：1953-04-21
申请号：US77045647
申请日：1947-08-25
申请人： STANDARD OIL DEV CO
发明人： JOHNSON JR HOMER F
IPC分类号： C07C4/22
CPC分类号： C07C4/22 , C07C2601/10 , C07C13/15 , C07C13/00

5. 发明授权

US5725817A Iontophoretic structure for medical devices 失效
公开(公告)号：US5725817A
公开(公告)日：1998-03-10
申请号：US613157
申请日：1996-03-08
申请人： Fredric L. Milder
发明人： Fredric L. Milder
IPC分类号： A61L29/00 , A61N1/30 , B29C47/20
CPC分类号： A61N1/306 , A61N1/303
摘要： An iontophoretic structure for medical devices is provided that uses controlled electrical current derived from two dissimilar galvanic materials to drive oligodynamic metal ions into solution to kill bacteria on and near the device to which the structure is affixed. In one embodiment, a first galvanic material separated from a second galvanic material by a resistive material produces an anti-bacterial current flow when placed in contact with an electrolytic fluid. In another embodiment, a cylindrical elastomeric catheter incorporates a first and a second galvanic material separated by a resistive material which controls a current flow between the galvanic materials when the catheter is immersed in an electrolytic fluid. The galvanic materials can be dissimilar metal powders embedded in a conductive polymer substrate that forms an iontophoretic composite material, or dissimilar metals arranged in layers separated by a resistive layer. In yet another embodiment, the iontophoretic composite material is configured as an infection control sleeve that covers a portion of an ordinary catheter or cannula. Methods of protecting implantable medical devices and body structures with the iontophoretic structures are also provided.

6. 发明授权

US5498248A Iontophoretic structure for medical devices 失效
标题翻译：医疗器械的离子电渗结构
公开(公告)号：US5498248A
公开(公告)日：1996-03-12
申请号：US212157
申请日：1994-03-14
申请人： Fredric L. Milder
发明人： Fredric L. Milder
IPC分类号： A61L29/00 , A61N1/30 , A61M5/32 , A61M25/00
CPC分类号： A61N1/306 , A61N1/303
摘要： An iontophoretic structure for medical devices is provided that uses controlled electrical current derived from two dissimilar galvanic materials to drive oligodynamic metal ions into solution to kill bacteria on and near the device to which the structure is affixed. In one embodiment, a first galvanic material separated from a second galvanic material by a resistive material produces an anti-bacterial current flow when placed in contact with an electrolytic fluid. In another embodiment, a cylindrical elastomeric catheter incorporates a first and a second galvanic material separated by a resistive material which controls a current flow between the galvanic materials when the catheter is immersed in an electrolytic fluid. The galvanic materials can be dissimilar metal powders embedded in a conductive polymer substrate that forms an iontophoretic composite material, or dissimilar metals arranged in layers separated by a resistive layer. In yet another embodiment, the iontophoretic composite material is configured as an infection control sleeve that covers a portion of an ordinary catheter or cannula. Methods of protecting implantable medical devices and body structures with the iontophoretic structures are also provided.
摘要翻译：提供了用于医疗装置的离子电渗疗法结构，其使用由两种不相似的电偶材料得到的受控电流，以将低分子量金属离子驱动到溶液中以杀死结构所贴附的装置上和附近的细菌。在一个实施例中，通过电阻材料与第二电偶材料分离的第一电偶材料在放置成与电解液接触时产生抗细菌电流。在另一个实施例中，圆柱形弹性导管包括由电阻材料隔开的第一和第二电偶材料，当电导液浸入电解液中时，其控制电流材料之间的电流。电镀材料可以是嵌入到形成离子电渗复合材料的导电聚合物基底中的异种金属粉末，或者由电阻层分隔开的不同金属。在另一个实施方案中，离子电渗疗法复合材料被配置为覆盖普通导管或套管的一部分的感染控制套管。还提供了用离子电渗结构保护植入式医疗装置和身体结构的方法。

7. 发明授权

US5443474A Meniscectomy knife 失效
标题翻译： Meniscectomy刀
公开(公告)号：US5443474A
公开(公告)日：1995-08-22
申请号：US207363
申请日：1994-03-07
申请人： Peter Sfakianos , Fredric L. Milder
发明人： Peter Sfakianos , Fredric L. Milder
IPC分类号： A61B17/32
CPC分类号： A61B17/320016 , A61B17/1604
摘要： A meniscectomy knife includes a preformed cutting trace through which a cutting element moves in response to motion producing means disposed on a handle. The cutting trace defines an arc having a size and shape which closely correspond to the lines of stress along a meniscus in the meniscal region of a human knee joint.
摘要翻译：半月板切除刀包括预成形的切割痕迹，切割元件响应于设置在手柄上的运动产生装置而移动。切割迹线限定了具有与人膝关节的半月板区域中的半月板的应力线紧密对应的尺寸和形状的弧。

8. 发明授权

US5322520A Iontophoretic structure for medical devices 失效
标题翻译：医疗器械的离子电渗结构
公开(公告)号：US5322520A
公开(公告)日：1994-06-21
申请号：US975597
申请日：1992-11-12
申请人： Fredric L. Milder
发明人： Fredric L. Milder
IPC分类号： A61L29/00 , A61N1/30 , A61M5/32
CPC分类号： A61N1/306 , A61N1/303
摘要： An iontophoretic structure for medical devices is provided that uses controlled electrical current derived from two dissimilar galvanic materials to drive oligodynamic metal ions into solution to kill bacteria on and near the device to which the structure is affixed. In one embodiment, a first galvanic material separated from a second galvanic material by a resistive material produces an anti-bacterial current flow when placed in contact with an electrolytic fluid. In another embodiment, a cylindrical elastomeric catheter incorporates a first and a second galvanic material separated by a resistive material which controls a current flow between the galvanic materials when the catheter is immersed in an electrolytic fluid. The galvanic materials can be dissimilar metal powders embedded in a conductive polymer substrate that forms an iontophoretic composite material, or dissimilar metals arranged in layers separated by a resistive layer. In yet another embodiment, the iontophoretic composite material is configured as an infection control sleeve that covers a portion of an ordinary catheter or cannula. Methods of protecting implantable medical devices and body structures with the iontophoretic structures are also provided.
摘要翻译：提供了用于医疗装置的离子电渗疗法结构，其使用由两种不相似的电偶材料得到的受控电流，以将低分子量金属离子驱动到溶液中以杀死结构所贴附的装置上和附近的细菌。在一个实施例中，通过电阻材料与第二电偶材料分离的第一电偶材料在放置成与电解液接触时产生抗细菌电流。在另一个实施例中，圆柱形弹性导管包括由电阻材料隔开的第一和第二电偶材料，当电导液浸入电解液中时，其控制电流材料之间的电流。电镀材料可以是嵌入到形成离子电渗复合材料的导电聚合物基材中的异种金属粉末，或者由电阻层分隔开的不同金属。在另一个实施方案中，离子电渗疗法复合材料被配置为覆盖普通导管或套管的一部分的感染控制套管。还提供了用离子电渗结构保护植入式医疗装置和身体结构的方法。

9. 发明授权

US5228923A Cylindrical thermoelectric cells 失效
标题翻译：圆柱形热电池
公开(公告)号：US5228923A
公开(公告)日：1993-07-20
申请号：US626986
申请日：1991-12-13
申请人： Aharon Z. Hed
发明人： Aharon Z. Hed
IPC分类号： H01L35/32
CPC分类号： H01L35/32
摘要： A thermoelectric device has a cylindrical structure with a hollow central annulus member in which a fluid is pumped so that the heated fluid is pumped from the center of the structure and discharged on the outer surface of an outer annulus member or with the reversal of electrical current, the heated fluid is pumped from the outer periphery and discharged in the central tube. A plurality of thermoelectric cells are positioned in the space between the inner and outer annulus members with the cells being radially directed relative to the axis of the inner annulus member. A thermoelectric device having a similar structure may be used for the conversion of thermal energy to electrical energy when a thermal gradient is imposed between the inner member of the structure and the peripheral surface.
摘要翻译：热电装置具有圆柱形结构，其具有中空的中空环形构件，其中泵送流体，使得加热的流体从结构的中心泵送并排出到外环形构件的外表面上或者与电流的反转加热后的流体从外周被泵送并排放到中心管中。多个热电单元位于内环形构件和外环形构件之间的空间中，其中单元相对于内环形构件的轴线径向地定向。具有相似结构的热电装置可用于在结构的内部构件和外围表面之间施加热梯度时将热能转换成电能。

10. 发明授权

US6060000A Iontophoretic material containing carbon and metal granules 失效
标题翻译：含有碳和金属颗粒的离子电渗材料
公开(公告)号：US6060000A
公开(公告)日：2000-05-09
申请号：US37156
申请日：1998-03-09
申请人： Fredric L. Milder , Robert Hausslein
发明人： Fredric L. Milder , Robert Hausslein
IPC分类号： A61F2/00 , A61F2/28 , A61F2/30 , A61F2/36 , A61L27/30 , A61L27/44 , A61L27/54 , A61L29/10 , A61L29/12 , A61L29/16 , A61L31/08 , A61L31/12 , A61L31/16 , A61N1/05 , A61N1/20 , A61N1/30 , H01B1/06
CPC分类号： A61N1/20 , A61F2/30767 , A61L27/303 , A61L27/306 , A61L27/443 , A61L27/446 , A61L27/54 , A61L29/103 , A61L29/106 , A61L29/126 , A61L29/16 , A61L31/084 , A61L31/086 , A61L31/126 , A61L31/128 , A61L31/16 , A61N1/056 , A61N1/303 , A61N1/306 , A61F2/36 , A61F2/3662 , A61F2002/2821 , A61F2002/30064 , A61F2310/0052 , A61F2310/00574 , A61L2300/102 , A61L2300/104 , A61L2300/108 , A61L2300/404 , A61L2300/62 , A61L2300/80
摘要： A material is provided that uses controlled electrical current derived from two dissimilar galvanic materials to drive oligodynamic metal ions into solution. Exemplary materials include carbon and silver.
摘要翻译：提供了一种材料，其使用由两种不同的电偶材料得到的受控电流以将低分子量金属离子驱动到溶液中。示例性材料包括碳和银。

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