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1. 发明申请

US20110014210A1 CHLAMYDIA VACCINE 有权
公开(公告)号：US20110014210A1
公开(公告)日：2011-01-20
申请号：US12087952
申请日：2007-01-16
申请人： Harlan D. Caldwell , Deborah Crane
发明人： Harlan D. Caldwell , Deborah Crane
IPC分类号： A61K39/395 , A61K39/118 , A61K38/04 , A61K31/7088 , A61K35/12 , C12N15/63 , C12N5/10 , C07K16/12 , C12Q1/02 , C07K2/00 , A61P37/04 , A61P31/04
CPC分类号： A61K39/118 , A61K2039/505 , A61K2039/5158 , A61K2039/5256 , A61K2039/54 , A61K2039/575 , C07K14/295 , C07K16/125 , C07K2317/76
摘要： Compositions and methods for the treatment of Chlamydial infection are disclosed. The compositions provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions, vaccines and diagnostic kits are also disclosed.
摘要翻译：公开了治疗衣原体感染的组合物和方法。提供的组合物包含含有衣原体抗原的至少一个抗原部分的多肽和编码这些多肽的DNA序列。还公开了药物组合物，疫苗和诊断试剂盒。

2. 发明申请

US20090298934A1 Diamidine Inhibitors of TDP1 审中-公开
标题翻译：靛蓝抑制剂TDP1
公开(公告)号：US20090298934A1
公开(公告)日：2009-12-03
申请号：US12225672
申请日：2007-03-27
申请人： Yves Pommier , Christophe Marchand
发明人： Yves Pommier , Christophe Marchand
IPC分类号： A61K31/341 , A61K31/155 , C07C257/00 , C07D307/02
CPC分类号： C07D307/54 , A61K31/155 , A61K31/34 , A61K31/341 , C07D307/81
摘要： The instant invention is directed towards compounds, including diamidines, that inhibit Tdp1 and are useful in the treatment and/or prevention of cancer and parasitic disease.
摘要翻译：本发明涉及抑制Tdp1并可用于治疗和/或预防癌症和寄生虫病的化合物，包括二脒胺。

3. 发明申请

US20100280084A1 Cyp1B1 Genotype 审中-公开
标题翻译： Cyp1B1基因型
公开(公告)号：US20100280084A1
公开(公告)日：2010-11-04
申请号：US11991878
申请日：2006-09-08
申请人： William D. Figg , Alex Sparreboom , Tristan M. Sissung , Douglas K. Price
发明人： William D. Figg , Alex Sparreboom , Tristan M. Sissung , Douglas K. Price
IPC分类号： C12Q1/68 , C40B40/06 , A61K31/337 , A61K31/427 , A61P35/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： The invention relates to pharmacology, pharmacokinetics and toxicology, and more specifically to methods of identifying and predicting inter-patient differences in response to drugs in order to achieve superior efficacy and safety in selected patient populations. It further related to the genetic basis of inter-patient variation in response to therapy, including drug therapy, and to methods for determining and exploiting such differences to improve medical outcomes.
摘要翻译：本发明涉及药理学，药代动力学和毒理学，更具体地涉及鉴定和预测患者对药物的反应差异的方法，以便在选定的患者群体中实现优异的功效和安全性。它还涉及到对治疗（包括药物治疗）的响应的患者间变异的遗传基础，以及用于确定和利用这些差异以改善医学结果的方法。

4. 发明申请

US20080274545A1 Bioreactor Chamber Apparatus, and Method and System for Fabricating and Mechanically Stimulating Natural and Engineered Tissues 审中-公开
标题翻译：生物反应器室设备，以及用于制造和机械刺激天然和工程组织的方法和系统
公开(公告)号：US20080274545A1
公开(公告)日：2008-11-06
申请号：US11885488
申请日：2006-03-02
申请人： Catherine K. Kuo , Rocky S. Tuan , Mard A. Winslow
发明人： Catherine K. Kuo , Rocky S. Tuan , Mard A. Winslow
IPC分类号： C12N5/02 , C12M3/00
CPC分类号： C12M23/34 , C12M23/00
摘要： A bioreactor chamber assembly including a bioreactor chamber and an outer chamber assembly is provided. In one design, the bioreactor chamber includes an upper grip assembly having a plurality of struts extending downward terminating in upper grips, each strut terminating in an upper grip, and a lower grip assembly containing one or more sample compartments and a lower grip. A sample can be formed in situ via injection into a sleeve contained within the sample compartment, where the sleeve encloses the upper and lower grips and enables a construct to form attached to these grips. In a second design, a split mold is received in the bioreactor chamber, the split mold having a cavity for receiving the upper and lower grips. Tissue explants and engineered constructs can be held within these grips. Medium level in the sample compartment is controlled, and different lengths of samples can be accommodated in the sample compartment. The height of the upper grip is adjustable by raising or lowering an extension rod that passes through a dynamic seal to the environment outside the chamber. The bioreactor chamber sample compartment includes a window to permit visualization of the sample as well as light-mediated transformation of biomaterials within the sample compartment. The samples held by grips within these chambers can be subject to uniaxial mechanical stimulation. Medium is perfused around the samples, and medium may be sampled via access ports.
摘要翻译：提供了包括生物反应器室和外室组件的生物反应器室组件。在一种设计中，生物反应器腔室包括上夹持组件，其具有向下延伸的多个支柱，终止于上把手，每个支柱终止于上握柄，下夹具组件包含一个或多个样品室和下把手。可以通过注射将样品原位形成在包含在样品室中的套筒中，其中套筒包围上部和下部夹具，并且使得能够形成附接到这些夹具的构造体。在第二种设计中，分裂模具容纳在生物反应器腔室中，分体模具具有用于接收上部和下部把手的空腔。组织外植体和工程结构可以在这些把手内。控制样品室中的中等水平，样品室中可以容纳不同长度的样品。通过将通过动态密封件的延伸杆升高或降低到室外的环境，可以调节上部手柄的高度。生物反应器室样品室包括允许样品可视化的窗口以及光介导的样品室内生物材料的转化。在这些腔室内握持的样品可以进行单轴机械刺激。介质在样品周围灌注，介质可以通过进样口取样。

5. 发明申请

US20080242602A1 Methods and Compositions For the Inhibition of Hiv-1 Replication 失效
标题翻译：用于抑制HIF-1复制的方法和组合物
公开(公告)号：US20080242602A1
公开(公告)日：2008-10-02
申请号：US10578536
申请日：2004-11-03
申请人： Sharon M. Wahl , Nancy Vazquez-Maldonado , Teresa Greenwell-Wild
发明人： Sharon M. Wahl , Nancy Vazquez-Maldonado , Teresa Greenwell-Wild
IPC分类号： A61K38/16 , A61K31/711 , A61K31/192 , A61P31/18
CPC分类号： C12N15/1132 , A61K38/00 , A61K48/00 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315
摘要： This invention relates to methods and compositions for the attenuation of HIV-1 replication in human cells, and especially in human macrophages. The invention particularly concerns the use of inhibitors of P21 (CDKN1A) expression to attenuate such replication. The invention particularly concerns the use of antisense P21 oligonucleotides, siRNA and/or 2-cyano-3,12-dioxooleana-1,9-dien28-oic (CDDO) to attenuate such replication.
摘要翻译：本发明涉及用于减轻人细胞中尤其是人类巨噬细胞中HIV-1复制的方法和组合物。本发明特别涉及使用P21（CDKN1A）表达的抑制剂来减弱这种复制。本发明特别涉及使用反义P21寡核苷酸，siRNA和/或2-氰基-3,12-二氧杂环戊烯-1,9-二烯-28- ic（CDDO）来减弱这种复制。

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