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1. 发明授权

US07892784B2 Lactam ring-opening enzyme and use thereof 有权
标题翻译：内酰胺开环酶及其用途
公开(公告)号：US07892784B2
公开(公告)日：2011-02-22
申请号：US11710612
申请日：2007-02-26
申请人： Hiroshi Takagi , Yoshimitsu Hamano
发明人： Hiroshi Takagi , Yoshimitsu Hamano
IPC分类号： C12P1/00 , C12P17/00 , C12P17/16 , C12P15/00
CPC分类号： C12N9/86 , C12P19/28
摘要： An enzyme capable of reducing the antibiotic activity (i.e., toxicity) of streptothricin with respect to eukaryotic cells without sacrificing antibiotic activity with respect to prokaryotic cells is provided along with a streptothricin derivative having reduced toxicity with respect to eukaryotic cells while retaining antibiotic activity with respect to prokaryotic cells, and a manufacturing method thereof. By opening the lactam ring of streptothricin, a protein having the amino acid sequence according to SEQ ID NO: 2, 4, 6, 8, 10, 12, 14 or 16 of the invention can reduce the antibiotic activity of streptothricin D with respect to eukaryotic cells without sacrificing antibiotic activity with respect to prokaryotic cells.
摘要翻译：提供能够降低链霉素相对于真核细胞的抗生素活性（即毒性）而不牺牲相对于原核细胞的抗生素活性的酶以及相对于真核细胞毒性降低的链球菌素衍生物，同时保持抗生素活性原核细胞及其制造方法。通过打开链霉素的内酰胺环，具有根据本发明的SEQ ID NO：2,4,6,8,10,12,14或16的氨基酸序列的蛋白质可以降低链球菌D的抗生素活性，相对于真核细胞，而不牺牲相对于原核细胞的抗生素活性。

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