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1. 发明授权

US08551044B2 Multiple reservoir implantable drug infusion device and method 有权
公开(公告)号：US08551044B2
公开(公告)日：2013-10-08
申请号：US12074570
申请日：2008-03-05
申请人： Paul F. Burke , Joshua L. Buckman , Patrick J. O'Connor
发明人： Paul F. Burke , Joshua L. Buckman , Patrick J. O'Connor
IPC分类号： A61M37/00 , A61M1/00 , A61M5/00
CPC分类号： A61M5/14276 , A61M5/1486 , A61M5/16809 , A61M5/16827
摘要： Multiple reservoir implantable valve accumulator pump for the delivery of medication, and method of infusate delivery. The apparatus includes at least first and second infusate reservoirs in a common pressure chamber, each in fluid communication with a metering assembly. The metering assembly includes an accumulator that is preferably a fixed volume accumulator having an inlet and an outlet. A first valve is in fluid communication with the first infusate reservoir and an inlet of the accumulator, and a second valve is in fluid communication with the second infusate reservoir and an inlet of the accumulator. An outlet valve is in fluid communication with the outlet of the accumulator. The accumulator can be filled with infusate from the first and second infusate reservoirs sequentially, can be filled from the first infusate reservoir multiple times consecutively, the second infusate reservoir multiple times consecutively, or any combination or permutation thereof.

2. 发明授权

US08273058B2 Two way accumulator programmable valve pump 有权
标题翻译：双向蓄能器可编程阀门泵
公开(公告)号：US08273058B2
公开(公告)日：2012-09-25
申请号：US11906826
申请日：2007-10-04
申请人： Paul F. Burke , Patrick O'Connor
发明人： Paul F. Burke , Patrick O'Connor
IPC分类号： A61M1/00 , A61M5/00
CPC分类号： G01F11/086 , A61M5/14276 , A61M5/14586 , A61M5/14593 , A61M5/16809 , A61M2005/14513
摘要： An improved implantable valve accumulator pump for the delivery of medication is disclosed. The implantable pump comprises a pressurized drug reservoir. The medication metering assembly comprises a fixed volume accumulator positioned between a pair of valves. The valves alternately open and close to admit medication from the reservoir into the accumulator and to dispense a precise volume pulse to an outlet catheter. In order to improve the pump's accuracy and to increase pumping volume while optimizing the pump's overall size and energy usage a two way diaphragm accumulator is used. The unit can be externally programmed or can be used in a fixed rate configuration that is never programmed but set at the factory or in the current programmable configuration.
摘要翻译：公开了一种用于输送药物的改进的可植入阀蓄能器泵。可植入泵包括加压药物储存器。药物计量组件包括位于一对阀之间的固定容积蓄积器。阀交替地打开和关闭，以将药物从储存器进入蓄能器并且将精确的体积脉冲分配给出口导管。为了提高泵的精度和增加泵送量，同时优化泵的总体尺寸和能量使用，使用双向隔膜蓄能器。该单元可以进行外部编程，也可以以固定速率配置使用，从未编程，但在出厂时或当前的可编程配置中设置。

3. 发明授权

US09968734B2 Patient programmer for implantable drug delivery device 有权
公开(公告)号：US09968734B2
公开(公告)日：2018-05-15
申请号：US15723378
申请日：2017-10-03
申请人： Flowonix Medical Incorporated
发明人： Paul Burke , Steve Adler
IPC分类号： G08C19/22 , A61M5/142 , A61B5/00 , G06F19/00
CPC分类号： A61M5/14276 , A61B5/0026 , A61B5/0031 , A61M2005/14208 , A61M2205/04 , A61M2205/3523 , A61M2205/3553 , A61M2205/3592 , A61M2205/52 , G06F19/00 , G06F19/3468 , G16H20/17
摘要： Methods for programming an implantable drug delivery device using a mobile computing device that include establishing a connection with a telemetry unit configured for wireless communication with the implantable drug delivery device, displaying user-selectable drug delivery settings for the implantable drug delivery device, receiving at least one selection of a drug delivery setting, translating the received selection into a signal format readable by the telemetry unit, and sending the translated signal to the telemetry unit to program the implantable drug delivery device. Further embodiments include telemetry units for communication with an implantable drug delivery device, and patient programmers and a method for patient modification to a programmed drug delivery regimen.

4. 发明授权

US09125982B2 Methods and systems for providing metered doses of a compound to an individual 有权
标题翻译：向个体提供化合物的计量剂量的方法和系统
公开(公告)号：US09125982B2
公开(公告)日：2015-09-08
申请号：US12556184
申请日：2009-09-09
申请人： Daniel John Frey
发明人： Daniel John Frey
IPC分类号： A61M5/168 , A61M5/142 , A61M5/148
CPC分类号： A61M5/14276 , A61M5/1483 , A61M5/16809 , A61M2205/8212 , A61M2205/8231
摘要： An implantable pump for providing metered doses of a compound to an individual is described. The implantable pump includes a chamber for storing an individual dose of the compound, an inlet valve fluidly coupled to the chamber for controlling a flow of the compound into the chamber, and an outlet valve fluidly coupled to the chamber for controlling a flow of the compound out of the chamber and into the individual. The pump includes an inlet valve driver circuit operable for opening and closing the inlet valve, and an outlet valve driver circuit operable for opening and closing the outlet valve. A battery and a charging circuit that includes a capacitor are included in the implantable pump. The charging circuit is operatively coupled to the battery for charging of the capacitor. The charged capacitor is operable for supplying power to the valve driver circuits.
摘要翻译：描述了用于向个体提供计量剂量的化合物的可植入泵。可植入泵包括用于存储单个剂量的化合物的腔室，流体耦合到腔室的入口阀，用于控制化合物进入腔室的流体，以及流体耦合到腔室的出口阀，用于控制化合物的流动离开房间，进入个人。泵包括可操作以打开和关闭入口阀的入口阀驱动器电路和可操作以打开和关闭出口阀的出口阀驱动器电路。包括电容器的电池和充电电路包括在可植入泵中。充电电路可操作地耦合到电池用于电容器的充电。充电的电容器可操作用于向阀驱动器电路供电。

5. 发明申请

US20140194851A1 Flow Actuated Valve for Implantable Drug Delivery Device 审中-公开
标题翻译：用于可植入药物输送装置的流动致动阀
公开(公告)号：US20140194851A1
公开(公告)日：2014-07-10
申请号：US14136948
申请日：2013-12-20
申请人： Flowonix Medical Incorporated
发明人： Paul BURKE , Steve ADLER , Benjamin PIECUCH , Steve HANTMAN
IPC分类号： A61M5/168 , A61M5/172 , A61M5/142
CPC分类号： A61M5/16881 , A61M5/14276 , A61M2039/2413 , A61M2039/242 , A61M2039/2433 , A61M2039/2466 , A61M2039/2473
摘要： An “MRI-safe” implantable infusion apparatus and method that includes a flow actuated valve (FAV) that closes to prevent a free flow of infusate to a patient during an MRI procedure, and a release mechanism that opens the valve so that the device may return to normal operation following the MRI procedure. In this manner, patient safety is improved and the inconvenience of having to empty the pump reservoir before undergoing an MRI procedure may be avoided.
摘要翻译：一种“MRI安全”植入式输注装置和方法，其包括关闭流动致动阀（FAV），以防止在MRI过程期间向患者自由流动的患者;以及释放机构，其打开所述阀，使得所述装置可 MRI程序后恢复正常。以这种方式，可以改善患者的安全性，并且可以避免在经历MRI过程之前必须清空泵储存器的不便。

6. 发明授权

US10173004B2 Flow actuated valve for implantable drug delivery device 有权
公开(公告)号：US10173004B2
公开(公告)日：2019-01-08
申请号：US14136948
申请日：2013-12-20
申请人： Flowonix Medical Incorporated
发明人： Paul Burke , Steve Adler , Benjamin Piecuch , Steve Hantman
IPC分类号： A61M5/168 , A61M5/142 , A61M39/24
摘要： An “MRI-safe” implantable infusion apparatus and a method that include a flow actuated valve (FAV) that closes to prevent a free flow of an infusate to a patient during an MRI procedure, and a release mechanism that opens the valve so that the apparatus may return to normal operation following the MRI procedure. In this manner, patient safety is improved and an inconvenience of having to empty a pump reservoir before undergoing the MRI procedure may be avoided.

7. 发明申请

US20140228765A1 Needle Penetration Detection Method and Device for Refillable and Implantable Drug Delivery Systems 审中-公开
标题翻译：针刺穿透检测方法和可补充和植入药物递送系统的装置
公开(公告)号：US20140228765A1
公开(公告)日：2014-08-14
申请号：US14171840
申请日：2014-02-04
申请人： Flowonix Medical Incorporated
发明人： Paul BURKE , Steve ADLER , Robert M. HANSEN
IPC分类号： A61M5/142 , G01N27/02 , A61M39/04
CPC分类号： A61M5/14276 , A61M39/0208 , A61M2039/0226 , A61M2039/0244
摘要： A refillable and implantable infusion apparatus and method that includes a needle penetration detector that detects and indications the position of a needle relative to a septum of a drug reservoir of the implantable infusion apparatus. With the needle position data, medical professionals may better ensure they are injecting drugs into the drug reservoir, thus, improving patient safety.
摘要翻译：一种可再灌注和可植入的输注装置和方法，其包括针刺检测器，其检测并指示针相对于可植入式输注装置的药物储存器的隔膜的位置。根据针位数据，医疗专业人员可以更好地确保将药物注入药物库，从而提高患者的安全。

8. 发明授权

US08545477B2 Multiple reservoir implantable drug infusion device and method 有权
公开(公告)号：US08545477B2
公开(公告)日：2013-10-01
申请号：US12288659
申请日：2008-10-22
申请人： Paul F. Burke , Joshua L. Buckman , Patrick J. O'Connor
发明人： Paul F. Burke , Joshua L. Buckman , Patrick J. O'Connor
IPC分类号： A61M31/00 , A61M1/00 , A61M37/00 , A61M5/00
CPC分类号： A61M5/14276 , A61M5/1486 , A61M5/16809 , A61M5/16827
摘要： Multiple reservoir implantable valve accumulator pump for the delivery of medication, and method of infusate delivery. The apparatus includes at least first and second infusate reservoirs in a common pressure chamber, each in fluid communication with a metering assembly. The metering assembly includes an accumulator that is preferably a fixed volume accumulator having an inlet and an outlet. A first valve is in fluid communication with the first infusate reservoir and an inlet of the accumulator, and a second valve is in fluid communication with the second infusate reservoir and an inlet of the accumulator. An outlet valve is in fluid communication with the outlet of the accumulator. The accumulator can be filled with infusate from the first and second infusate reservoirs sequentially, can be filled from the first infusate reservoir multiple times consecutively, the second infusate reservoir multiple times consecutively, or any combination or permutation thereof.

9. 发明授权

US10010670B2 Patient programmer for implantable drug delivery device 有权
公开(公告)号：US10010670B2
公开(公告)日：2018-07-03
申请号：US15632988
申请日：2017-06-26
申请人： Flowonix Medical Incorporated
发明人： Paul Burke , Steve Adler
IPC分类号： G08C19/22 , A61M5/142 , A61B5/00 , G06F19/00
摘要： Methods for programming an implantable drug delivery device using a mobile computing device that include establishing a connection with a telemetry unit configured for wireless communication with the implantable drug delivery device, displaying user-selectable drug delivery settings for the implantable drug delivery device, receiving at least one selection of a drug delivery setting, translating the received selection into a signal format readable by the telemetry unit, and sending the translated signal to the telemetry unit to program the implantable drug delivery device. Further embodiments include telemetry units for communication with an implantable drug delivery device, and patient programmers and a method for patient modification to a programmed drug delivery regimen.

10. 发明授权

US09700669B2 Patient programmer for implantable drug delivery device 有权
公开(公告)号：US09700669B2
公开(公告)日：2017-07-11
申请号：US15098631
申请日：2016-04-14
申请人： Flowonix Medical Incorporated
发明人： Paul Burke , Steve Adler
IPC分类号： G08C19/22 , A61M5/142 , G06F19/00 , A61B5/00
CPC分类号： A61M5/14276 , A61B5/0026 , A61B5/0031 , A61M2005/14208 , A61M2205/04 , A61M2205/3523 , A61M2205/3553 , A61M2205/3592 , A61M2205/52 , G06F19/00 , G06F19/3468 , G16H20/17
摘要： Methods for programming an implantable drug delivery device using a mobile computing device that include establishing a connection with a telemetry unit configured for wireless communication with the implantable drug delivery device, displaying user-selectable drug delivery settings for the implantable drug delivery device, receiving at least one selection of a drug delivery setting, translating the received selection into a signal format readable by the telemetry unit, and sending the translated signal to the telemetry unit to program the implantable drug delivery device. Further embodiments include telemetry units for communication with an implantable drug delivery device, and patient programmers and a method for patient modification to a programmed drug delivery regimen.

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