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1. 发明授权

US6149607A Multiple sample biopsy device 失效
标题翻译：多个样本活检装置
公开(公告)号：US6149607A
公开(公告)日：2000-11-21
申请号：US128882
申请日：1998-08-04
申请人： Philip J. Simpson , David G. Matsuura , John Kilcoyne
发明人： Philip J. Simpson , David G. Matsuura , John Kilcoyne
IPC分类号： A61B10/00 , A61B10/06 , A61B17/28 , A61B17/32
CPC分类号： A61B10/06 , A61B2017/2926 , A61B2017/2933 , A61B2017/2939 , A61B2017/294 , A61B2017/320064
摘要： A biopsy device for acquiring more than one tissue sample comprises an elongated, flexible actuator shaft which is slidable within an outer sleeve. A jaw portion is coupled to the actuator shaft and the outer sleeve in such a manner as to open when the shaft is moved in a first direction relative to the sleeve and close when the shaft is moved in a second direction relative to the sleeve.
摘要翻译：用于采集多于一个组织样本的活检装置包括可在外套筒内滑动的细长的柔性致动器轴。当轴沿相对于套筒的第一方向移动并且当轴相对于套筒沿第二方向移动时，钳口部分以这样的方式联接到致动器轴和外套筒，以便打开。

2. 发明授权

US08323192B2 Implantable monitoring probe 失效
标题翻译：可植入监测探头
公开(公告)号：US08323192B2
公开(公告)日：2012-12-04
申请号：US10896553
申请日：2004-07-22
申请人： John T. Kilcoyne , Ross Tsukashima , George M. Johnson , Christopher Klecher
发明人： John T. Kilcoyne , Ross Tsukashima , George M. Johnson , Christopher Klecher
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/073 , A61B1/00147 , A61B1/041 , A61B5/0008 , A61B5/0031 , A61B5/037 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/42 , A61B5/4233 , A61B5/6882
摘要： Disclosed is an ambulatory system for monitoring one or more physiological parameters in a body lumen, such as the esophagus. The system includes an implantable probe having a sensor for the physiological parameter and a transmitter for transmitting data to an external receiver. The probe may be used for monitoring any of various physiological parameters, including pH, temperature, and pressure, within the esophagus or other body lumens. Methods and deployment catheters are also disclosed.
摘要翻译：公开了一种用于监测体腔（例如食道）中的一个或多个生理参数的移动系统。该系统包括具有用于生理参数的传感器的可植入探针和用于将数据发送到外部接收器的发射器。探针可用于监测食道或其他体腔内的各种生理参数，包括pH，温度和压力。还公开了方法和部署导管。

3. 发明授权

US6098629A Submucosal esophageal bulking device 有权
标题翻译：黏膜下食管扩张装置
公开(公告)号：US6098629A
公开(公告)日：2000-08-08
申请号：US287607
申请日：1999-04-07
申请人： George Johnson , Ross Tsukashima
发明人： George Johnson , Ross Tsukashima
IPC分类号： A61B17/12 , A61B17/34 , A61F2/00 , A61F2/20 , A61B19/00
CPC分类号： A61B17/12186 , A61B17/12022 , A61B17/12036 , A61B17/12099 , A61B17/12181 , A61F2/0036 , A61B17/3478 , A61F2/20
摘要： Disclosed is a prosthetic bulking device for implantation below the mucosa to treat gastroesophageal reflux disease. The bulking device comprises a flexible body which may have one or more attachment surfaces to allow tissue ingrowth from the adjacent tissue. The bulking device cooperates with residual lower esophageal sphincter (LES) function to increase LES closing pressure.
摘要翻译：公开了一种用于植入粘膜下方以治疗胃食管反流疾病的假体膨胀装置。膨胀装置包括柔性体，其可以具有一个或多个附接表面，以允许组织从相邻组织向内生长。膨胀装置与剩余的食管下括约肌（LES）功能配合以增加LES闭合压力。

4. 发明申请

US20040158138A1 Implantable monitoring probe 审中-公开
公开(公告)号：US20040158138A1
公开(公告)日：2004-08-12
申请号：US10687298
申请日：2003-10-16
申请人： Endonetics, Inc.
发明人： John T. Kilcoyne , Ross Tsukashima , George M. Johnson , Christopher Klecher
IPC分类号： A61B005/05
CPC分类号： A61B5/073 , A61B1/00147 , A61B1/041 , A61B5/0008 , A61B5/0031 , A61B5/037 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/42 , A61B5/4233 , A61B5/6882
摘要： Disclosed is an ambulatory system for monitoring one or more physiological parameters in a body lumen, such as the esophagus. The system includes an implantable probe having a sensor for the physiological parameter and a transmitter for transmitting data to an external receiver. The probe may be used for monitoring any of various physiological parameters, including pH, temperature, and pressure, within the esophagus or other body lumens. Methods and deployment catheters are also disclosed.

5. 发明申请

US20040133089A1 Implantable monitoring probe 审中-公开
公开(公告)号：US20040133089A1
公开(公告)日：2004-07-08
申请号：US10687336
申请日：2003-10-16
申请人： Endonetics, Inc.
发明人： John T. Kilcoyne , Ross Tsukashima , George M. Johnson , Christopher Klecher
IPC分类号： A61B005/05
CPC分类号： A61B5/073 , A61B1/00147 , A61B1/041 , A61B5/0008 , A61B5/0031 , A61B5/037 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/42 , A61B5/4233 , A61B5/6882
摘要： Disclosed is an ambulatory system for monitoring one or more physiological parameters in a body lumen, such as the esophagus. The system includes an implantable probe having a sensor for the physiological parameter and a transmitter for transmitting data to an external receiver. The probe may be used for monitoring any of various physiological parameters, including pH, temperature, and pressure, within the esophagus or other body lumens. Methods and deployment catheters are also disclosed.

6. 发明授权

US6139508A Articulated medical device 失效
标题翻译：铰接医疗器械
公开(公告)号：US6139508A
公开(公告)日：2000-10-31
申请号：US248361
申请日：1999-02-10
申请人： Philip J. Simpson , David G. Matsuura , John Kilcoyne
发明人： Philip J. Simpson , David G. Matsuura , John Kilcoyne
IPC分类号： A61B10/00 , A61B10/06 , A61B17/28 , A61B17/32
CPC分类号： A61B10/06 , A61B2017/2926 , A61B2017/2933 , A61B2017/2939 , A61B2017/294 , A61B2017/320064 , A61B2090/035
摘要： An articulated medical device as disclosed, incorporated in one embodiment into a biopsy device. The biopsy embodiment comprises an elongated actuator shaft which is slidable within an outer sleeve. A jaw portion coupled to the actuator shaft and the outer sleeve opens when the shaft is moved in a first direction relative to the sleeve and closes when the shaft is moved in a second direction relative to the sleeve.
摘要翻译：如在一个实施例中所披露的，结合在活检装置中的关节式医疗装置。活检实施例包括可在外套筒内滑动的细长致动器轴。当轴相对于套筒沿第一方向移动时，连接到致动器轴和外部套筒的钳口部分打开，并且当轴沿相对于套筒的第二方向移动时关闭。

7. 发明申请

US20050043601A1 Implantable monitoring probe 审中-公开
标题翻译：可植入监测探头
公开(公告)号：US20050043601A1
公开(公告)日：2005-02-24
申请号：US10687296
申请日：2003-10-16
申请人： John Kilcoyne , Ross Tsukashima , George Johnson , Christopher Klecher
发明人： John Kilcoyne , Ross Tsukashima , George Johnson , Christopher Klecher
IPC分类号： G01N27/416 , A61B5/00 , A61B5/03 , A61B5/07
CPC分类号： A61B5/073 , A61B1/00147 , A61B1/041 , A61B5/0008 , A61B5/0031 , A61B5/037 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/42 , A61B5/4233 , A61B5/6882
摘要： Disclosed is an ambulatory system for monitoring one or more physiological parameters in a body lumen, such as the esophagus. The system includes an implantable probe having a sensor for the physiological parameter and a transmitter for transmitting data to an external receiver. The probe may be used for monitoring any of various physiological parameters, including pH, temperature, and pressure, within the esophagus or other body lumens. Methods and deployment catheters are also disclosed.
摘要翻译：公开了一种用于监测体腔（例如食道）中的一个或多个生理参数的移动系统。该系统包括具有用于生理参数的传感器的可植入探针和用于将数据发送到外部接收器的发射器。探针可用于监测食道或其他体腔内的各种生理参数，包括pH，温度和压力。还公开了方法和部署导管。

8. 发明申请

US20040260164A1 Implantable monitoring probe 失效
公开(公告)号：US20040260164A1
公开(公告)日：2004-12-23
申请号：US10896553
申请日：2004-07-22
申请人： Endonetics, Inc.
发明人： John T. Kilcoyne , Ross Tsukashima , George M. Johnson , Christopher Klecher
IPC分类号： A61B005/00
CPC分类号： A61B5/073 , A61B1/00147 , A61B1/041 , A61B5/0008 , A61B5/0031 , A61B5/037 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/42 , A61B5/4233 , A61B5/6882
摘要： Disclosed is an ambulatory system for monitoring one or more physiological parameters in a body lumen, such as the esophagus. The system includes an implantable probe having a sensor for the physiological parameter and a transmitter for transmitting data to an external receiver. The probe may be used for monitoring any of various physiological parameters, including pH, temperature, and pressure, within the esophagus or other body lumens. Methods and deployment catheters are also disclosed.

9. 发明授权

US6112123A Device and method for ablation of tissue 失效
标题翻译：组织消融的装置和方法
公开(公告)号：US6112123A
公开(公告)日：2000-08-29
申请号：US123509
申请日：1998-07-28
申请人： Brian S. Kelleher , Corbett Stone , Michael Jones
发明人： Brian S. Kelleher , Corbett Stone , Michael Jones
IPC分类号： A61B18/00 , A61B18/12 , A61B18/14 , A61F7/12
CPC分类号： A61B18/1492 , A61B18/1206 , A61B2018/00065 , A61B2018/00214 , A61B2018/00261 , A61B2018/00482 , A61B2018/00494 , A61B2018/00684 , A61B2018/00761 , A61B2018/00821 , A61B2018/00875 , A61B2018/00982 , A61B2018/1425 , A61B2018/1435 , A61B2018/1472
摘要： A device and method for performing electrolyte assisted tissue ablation of metaplasia in the esophagus includes a shaft with an expandable barrier which is deployable from the shaft's distal end. Also included in the device are an electrode and a temperature/impedance sensor which are each mounted on the shaft. Alternatively, the shaft may be a catheter formed with several lumens which are used independently for housing optical elements and for transferring fluid. In the operation of the device, the distal end of the shaft or catheter is placed in the esophagus proximal the cardia. The barrier is then deployed to the cardia and expanded to seal the esophagus from the stomach. The esophageal volume between the barrier and the catheter is partially flooded with a conducting medium and an electrode is deployed into the conducting medium. The sensor is also deployed into contact with the tissue to be ablated. Using open-loop control, or using temperature, impedance, or visual monitoring for closed-loop control, the metaplasia is ablated by passing radio frequency energy from the electrode and through the conducting medium for contact with the tissue being ablated.
摘要翻译：用于进行食道中化生物电解质辅助组织消融的装置和方法包括具有可从轴的远端展开的可扩张屏障的轴。装置中还包括各自安装在轴上的电极和温度/阻抗传感器。或者，轴可以是形成有多个腔的导管，其独立地用于容纳光学元件和用于传送流体。在装置的操作中，将轴或导管的远端放置在食管近端的贲门。然后将屏障部署到贲门并扩大以从胃部密封食道。屏障和导管之间的食管体积部分地被导电介质淹没，并且将电极部署到导电介质中。传感器也被部署成与要消融的组织接触。使用开环控制或使用温度，阻抗或视觉监控进行闭环控制，通过从射线通过射频能量并通过导电介质与被消融的组织接触来消除化生。

10. 发明授权

US5980454A Endoscopic imaging system employing diffractive optical elements 失效
$Endoscopic imaging system employing diffractive optical elements$
标题翻译：使用衍射光学元件的内窥镜成像系统
公开(公告)号：US5980454A
公开(公告)日：1999-11-09
申请号：US982305
申请日：1997-12-01
申请人： Barry Broome
发明人： Barry Broome
IPC分类号： A61B1/05 , G02B5/18 , G02B23/24 , A61B1/07 , G02B27/44
CPC分类号： G02B27/4205 , A61B1/05 , G02B23/243 , G02B27/4272 , G02B5/1895
摘要： An improved endoscope comprises an objective including a diffractive optical element juxtaposed to a solid-state imaging element at the distal tip of the endoscope. An inexpensive halogen lamp at the proximal end of the endoscope is employed as the illumination source. A fiber-optic bundle carries light to the distal tip of the endoscope, where diffractive optical elements are provided to disperse light, illuminating the field of view.
摘要翻译：改进的内窥镜包括物镜，其包括与内窥镜的远侧末端处的固态成像元件并置的衍射光学元件。在内窥镜的近端使用廉价的卤素灯作为照明源。光纤束将光传送到内窥镜的远端，其中提供衍射光学元件以分散光，照亮视场。

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