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1. 发明授权

US6113878A Technetium-99m labeled peptides for imaging 失效
标题翻译：锝-99m标记肽成像
公开(公告)号：US6113878A
公开(公告)日：2000-09-05
申请号：US467567
申请日：1995-06-06
申请人： Richard T. Dean , John Lister-James
发明人： Richard T. Dean , John Lister-James
IPC分类号： A61K51/00 , A61K51/08 , C07K7/06 , C07K7/08 , C07K14/00 , G01N33/60 , A61M36/14
CPC分类号： A61K51/082 , A61K51/088 , A61K2123/00
摘要： This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via Tc-99m binding moieties. In particular, the peptide reagents of the invention are covalently linked to a polyvalent linker moiety, so that the polyvalent linker moiety is covalently linked to a multiplicity of the specific-binding peptides, and the Tc-99m binding moieties are covalently linked to a plurality of the specific-binding peptides, the polyvalent linker moiety, or to both the specific-binding peptides and the polyvalent linker moiety.
摘要翻译：本发明涉及放射性标记的肽及其生产方法。具体地说，本发明涉及用于制备这些肽的肽，方法和试剂盒，以及使用这些肽在通过Tc-99m结合部分标记有锝-99m（Tc-99m）的哺乳动物体中成像位点的方法。特别地，本发明的肽试剂与多价接头部分共价连接，使得多价接头部分与多种特异性结合肽共价连接，并且Tc-99m结合部分共价连接至多个的特异性结合肽，多价连接体部分或特异性结合肽和多价连接体部分。

2. 发明授权

US6107459A Technetium-99m labeled peptides for diagnostic imaging 失效
标题翻译：锝-99m标记的肽用于诊断成像
公开(公告)号：US6107459A
公开(公告)日：2000-08-22
申请号：US505318
申请日：1995-12-07
申请人： Richard T. Dean
发明人： Richard T. Dean
IPC分类号： A61K51/08 , A61K38/00 , A61K51/00 , C07K2/00
CPC分类号： A61K51/088 , A61K2123/00
摘要： This invention relates to reagents, radiolabeled reagents and methods for producing such reagents and radiolabeled reagents. Specifically, the invention relates to technetium-99m (Tc-99m) labeled peptides that specifically bind to sites of infection, inflammation, thrombosis, atherosclerosis and neoplastic growth in vivo, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body.
摘要翻译： PCT No.PCT / US94 / 01894 Sec。 371 1995年12月7日第 102（e）日期1995年12月7日PCT 1994年2月18日PCT PCT。第WO94 / 19024号公报日期1994年9月1日本发明涉及试剂，放射性标记的试剂和制备这些试剂和放射性标记试剂的方法。具体地，本发明涉及特异性结合感染，炎症，血栓形成，动脉粥样硬化和体内肿瘤生长的锝-99m（Tc-99m）标记的肽，用于制备这些肽的方法和试剂盒，以及使用这些肽的方法哺乳动物体内的图像位点。

3. 发明授权

US6083480A Calcitonin receptor binding reagents 失效
标题翻译：降钙素受体结合试剂
公开(公告)号：US6083480A
公开(公告)日：2000-07-04
申请号：US847007
申请日：1997-05-01
申请人： Richard T. Dean , Larry R. Bush , Daniel A. Pearson , John Lister-James
发明人： Richard T. Dean , Larry R. Bush , Daniel A. Pearson , John Lister-James
IPC分类号： A61K51/00 , A61K38/00 , A61K38/23 , A61K49/00 , A61K51/08 , A61P35/00 , C07B59/00 , C07K14/585 , A61M36/14
CPC分类号： C07K14/585 , A61K38/00
摘要： This invention relates to radiotherapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic and radiotherapeutic agents. Specifically, the invention relates to calcitonin receptor binding compounds, preferably peptides, derivatives and analogues of calcitonin, and embodiments of such compounds radiolabeled with a radioisotope, as well as methods and kits for making, radiolabeling and using such compounds, particularly peptides for radiodiagnostic and radiotherapeutic purposes. The invention specifically relates to calcitonin receptor binding peptide derivatives and analogues of calcitonin radiolabeled with technetium-99m and uses thereof as scintigraphic imaging agents. The invention also specifically relates to calcitonin receptor binding peptide derivatives and analogues of calcitonin radiolabeled with cytotoxic radioisotopes such as rhenium-186 (.sup.186 Re) and rhenium-188 (.sup.188 Re) for use as radiotherapeutic agents. Methods and kits for making, radiolabeling and using such peptides diagnostically and therapeutically in a mammalian body are also provided.
摘要翻译：本发明涉及放射治疗试剂和肽，放射诊断试剂和肽，以及用于产生标记的放射诊断和放射治疗剂的方法。具体地，本发明涉及降钙素受体结合化合物，优选降钙素的肽，衍生物和类似物，以及用放射性同位素放射性标记的这种化合物的实施方案，以及用于制备，放射性标记和使用这些化合物的方法和试剂盒，特别是用于放射诊断和放射治疗目的。本发明具体涉及降钙素受体结合肽衍生物和用锝-99m放射性标记的降钙素的类似物及其用作闪烁照相成像剂。本发明还具体涉及降钙素受体结合肽衍生物和放射性标记的细胞毒性放射性同位素如铼-186（186Re）和铼-188（188Re）用作放射治疗剂的降钙素的类似物。还提供了用于在哺乳动物体内制造，放射性标记和诊断和治疗上使用这些肽的方法和试剂盒。

4. 发明授权

US6028056A Pharmaceutical compositions for imaging and treating thrombi 失效
标题翻译：用于成像和治疗血栓的药物组合物
公开(公告)号：US6028056A
公开(公告)日：2000-02-22
申请号：US20086
申请日：1998-02-06
申请人： Richard T. Dean , John Lister-James
发明人： Richard T. Dean , John Lister-James
IPC分类号： A61K49/04 , A61K38/16 , A61K51/08 , A61P7/02 , A61K38/00
CPC分类号： C07K14/705 , A61K51/08 , A61K2123/00
摘要： The invention provides novel precursor reagents used in production of imaging agents derived from apcitide. Imaging agents made using the precursor reagents of the invention are useful for in vivo detection and diagnosis of thrombi. The precursor reagents of the invention may also be used in production of antithrombotic agents derived from apcitide.
摘要翻译：本发明提供了用于生产源自苹果酸的成像剂的新型前体试剂。使用本发明的前体试剂制备的成像剂可用于体内检测和诊断血栓。本发明的前体试剂也可用于生产源自苹果酸的抗血栓形成剂。

5. 发明授权

US6007792A Radiolabeled vasoactive intestinal peptides for diagnosis and therapy 失效
标题翻译：放射性标记的血管活性肠肽用于诊断和治疗
公开(公告)号：US6007792A
公开(公告)日：1999-12-28
申请号：US930845
申请日：1998-01-21
申请人： Richard T. Dean , Daniel A. Pearson , John Lister-James , Edgar R. Civitello
发明人： Richard T. Dean , Daniel A. Pearson , John Lister-James , Edgar R. Civitello
IPC分类号： A61K51/00 , A61K51/08 , A61P35/00 , A61P43/00 , C07B59/00 , C07K7/06 , C07K14/575 , C07K14/775 , A61M36/14
CPC分类号： C07B59/008 , A61K51/08 , A61K51/088 , C07K14/775 , C07K7/06 , A61K2121/00 , A61K2123/00
摘要： This invention relates to radiotherapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic and radiotherapeutic agents. Specifically, the invention relates to vasoactive intestinal peptide receptor binding peptides, derivatives and analogues of vasoactive intestinal peptide, and embodiments of such peptides radiolabeled with a radioisotope, as well as methods and kits for making, radiolabeling and using such peptides for radiodiagnostic and radiotherapeutic purposes. The invention specifically relates to vasoactive intestinal peptide receptor binding peptide derivatives and analogues of vasoactive intestinal peptide radiolabeled with technetium-99m and uses thereof as scintigraphic imaging agents. The invention also specifically relates to vasoactive intestinal peptide receptor binding peptide derivatives and analogues of vasoactive intestinal peptide radiolabeled with cytotoxic radioisotopes such as rhenium-186 (.sup.186 Re) and rhenium-188 (.sup.188 Re) for use as radiotherapeutic agents. Methods and kits for making, radiolabeling and using such peptides diagnostically and therapeutically in a mammalian body are also provided.
摘要翻译： PCT No.PCT / US96 / 04308 Sec。 371日期1998年1月21日 102（e）日期1998年1月21日PCT 1996年3月29日PCT公布。 WO96 / 30055 PCT公开日期1996年10月3日本发明涉及放射治疗试剂和肽，放射诊断试剂和肽，以及用于制备标记的放射性诊断和放射治疗剂的方法。具体地，本发明涉及血管活性肠肽受体结合肽，血管活性肠肽的衍生物和类似物以及用放射性同位素放射性标记的这些肽的实施方案，以及用于制备放射性标记和使用这些肽用于放射诊断和放射治疗目的的方法和试剂盒。本发明具体涉及放射性标记有锝-99m的血管活性肠肽受体结合肽衍生物和血管活性肠肽的类似物及其用作闪烁照相成像剂。本发明还特别涉及放射性标记用细胞毒性放射性同位素如铼-186（186Re）和铼-188（188Re）用作放射治疗剂的血管活性肠肽受体结合肽衍生物和血管活性肠肽的类似物。还提供了用于在哺乳动物体内制造，放射性标记和诊断和治疗上使用这些肽的方法和试剂盒。

6. 发明授权

US5951981A Thrombolytic agents with antithrombotic activity 失效
标题翻译：具有抗血栓活性的溶血剂
公开(公告)号：US5951981A
公开(公告)日：1999-09-14
申请号：US753781
申请日：1996-12-02
申请人： Francis S. Markland, Jr. , Larry R. Bush , Stephen Swenson , Eladio Flores Sanchez
发明人： Francis S. Markland, Jr. , Larry R. Bush , Stephen Swenson , Eladio Flores Sanchez
IPC分类号： A61K47/48 , A61K51/08 , A61P7/02 , C12N9/64 , A61K38/54 , A61K38/46 , C12N9/48 , C12N9/96
CPC分类号： A61K47/48246 , A61K47/48023 , C12N9/6418
摘要： This invention provides thrombolytic agents and methods for making and using thrombolytic agents. Specifically, the invention provides thrombolytic agents comprising a thrombolytic proteinase and a specific binding peptide that specifically binds at the site of blood clots and thrombi in vivo. The invention particularly provides chemically crosslinked conjugates of a thrombolytic proteinase and a plurality of specific binding peptide. Methods for producing such chemically crosslinked conjugates and methods for using such conjugates for eliminating thrombi in vivo to alleviate pathological conditions caused thereby are also provided. The preferred thrombolytic proteinase in the conjugate is fibrolase obtainable from Agkistrodon contortrix confortrix venom.
摘要翻译：本发明提供血栓溶解剂和制造和使用溶栓剂的方法。具体地，本发明提供溶栓剂，其包含在体内血凝块和血栓位置上特异性结合的溶血栓素蛋白酶和特异性结合肽。本发明特别提供了溶栓酶蛋白酶和多种特异性结合肽的化学交联的缀合物。还提供了生产这种化学交联共轭物的方法和使用这种缀合物消除体内血栓以减轻由此引起的病理状况的方法。缀合物中优选的血栓溶解蛋白酶是可从腱蛇毒混合液中获得的纤维素酶。

7. 发明授权

US5951964A Technetium-99m labeled peptides for imaging 失效
标题翻译：锝-99m标记肽成像
公开(公告)号：US5951964A
公开(公告)日：1999-09-14
申请号：US341537
申请日：1995-01-26
申请人： Richard T. Dean , John Lister-James
发明人： Richard T. Dean , John Lister-James
IPC分类号： A61K51/08 , A61K38/00
CPC分类号： A61K51/088 , A61K51/082 , A61K2123/00
摘要： This invention relates to radiolabeled reagents, including specific-binding peptide embodiments thereof, and methods for producing and using such reagents. Specifically, the invention relates to reagents for preparing scintigraphic imaging agents for imaging sites in a mammalian body. Reagents, methods and kits for making such reagents, and methods for using such reagents labeled with technetium-99m (Tc-99m) via Tc-99m binding moieties comprising said reagents, are provided. In particular, the specific-binding peptides and Tc-99m binding moieties comprising the reagents of the invention are covalently linked to a polyvalent linker moiety, so that the polyvalent linker moiety is covalently linked to a multiplicity of the specific-binding peptides, and the Tc-99m binding moieties are covalently linked to a plurality of the specific-binding peptides, the polyvalent linker moiety, or to both the specific-binding peptides and the polyvalent linker moiety.
摘要翻译： PCT No.PCT / US93 / 05372 Sec。 371日期1995年1月26日 102（e）日期1995年1月26日PCT提交1993年6月4日PCT公布。出版物WO93 / 25244 日期1993年12月23日本发明涉及放射性标记的试剂，包括其特异性结合肽实施方案，以及制备和使用这些试剂的方法。具体地，本发明涉及用于制备用于哺乳动物体内成像位点的闪烁照相成像剂的试剂。提供了用于制备这些试剂的试剂，方法和试剂盒，以及通过包含所述试剂的Tc-99m结合部分使用由锝-99m（Tc-99m）标记的试剂的方法。特别地，包含本发明试剂的特异性结合肽和Tc-99m结合部分与多价接头部分共价连接，使得多价接头部分与多种特异性结合肽共价连接， Tc-99m结合部分共价连接到多个特异性结合肽，多价接头部分，或特异性结合肽和多价接头部分。

8. 发明授权

US5849260A Technetium-99M labeled peptides for thrombus imaging 失效
标题翻译：锝-99M标记的肽用于血栓成像
公开(公告)号：US5849260A
公开(公告)日：1998-12-15
申请号：US273274
申请日：1994-07-11
申请人： Richard T. Dean , John Lister-James
发明人： Richard T. Dean , John Lister-James
IPC分类号： A61K51/00 , A61K38/00 , A61K51/08 , C07B59/00 , C07K5/10 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/775 , G01N33/60 , A61M34/14
CPC分类号： C07K7/06 , A61K51/088 , C07B59/008 , C07K14/775 , A61K2123/00 , A61K38/00
摘要： This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to specific binding peptides, methods and kits for making such peptides, and methods for using such peptides labeled with technetium-99m via a radiolabel-binding moiety covalently linked to the peptide to image thrombus sites in a mammalian body.
摘要翻译：本发明涉及放射性标记的肽及其生产方法。具体地，本发明涉及用于制备这些肽的特异性结合肽，方法和试剂盒，以及使用通过与肽共价连接的放射性标记结合部分用锝-99m标记的肽的方法来成像哺乳动物体内的血栓位点。

9. 发明授权

US5830856A Radiolabeled compounds for thrombus imaging 失效
公开(公告)号：US5830856A
公开(公告)日：1998-11-03
申请号：US253317
申请日：1994-06-03
申请人： Richard T. Dean , John Lister-James , Edgar R. Civitello , William McBride
发明人： Richard T. Dean , John Lister-James , Edgar R. Civitello , William McBride
IPC分类号： A61K51/00 , A61K51/08 , C07K7/08 , C07K14/00 , A61K38/00 , A61K38/02 , C07K5/00 , C07K7/00
CPC分类号： A61K51/088 , A61K51/082 , A61K2123/00
摘要： This invention relates to radiolabeled scintigraphic imaging agents, and methods and reagents for producing such agents. Specifically, the invention relates to specific binding compounds, including peptides, that bind to a platelet receptor that is the platelet GPIIb/IIIa receptor, methods and kits for making such compounds, and methods for using such compounds labeled with technetium-99m via a covalently-linked radiolabel-binding moiety to image thrombi in a mammalian body.

10. 发明授权

US5770179A Radiolabeled glucans 失效
标题翻译：放射标记的葡聚糖
公开(公告)号：US5770179A
公开(公告)日：1998-06-23
申请号：US476687
申请日：1995-06-07
申请人： Richard T. Dean
发明人： Richard T. Dean
IPC分类号： A61K51/00 , A61K51/04 , C08B37/00 , A61M36/14
CPC分类号： A61K51/0493 , A61K51/0491 , A61K51/0497
摘要： This invention relates to radiodiagnostic agents and reagents for preparing such agents, and also methods for producing radiolabeled radiodiagnostic agents. Specifically, the invention relates to technetium-99m (.sup.99m Tc) labeled agents, methods and kits for making the agents, and methods for using the agents to image pathological sites, including sites of infection, inflammation, cancer and atherosclerosis in a mammalian body. Specifically the agents and reagents are derivatives of oligosaccharides, more specifically .beta.-glucans.
摘要翻译：本发明涉及用于制备这种试剂的放射性诊断剂和试剂，以及用于制备放射性标记的放射诊断剂的方法。具体地，本发明涉及用于制备该试剂的99-锝-99m（99mTc）标记的试剂，方法和试剂盒，以及用于使哺乳动物体内包含感染，炎症，癌症和动脉粥样硬化部位的病理部位成像的方法。具体地，试剂和试剂是寡糖的衍生物，更具体地是β-葡聚糖。

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