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1. 发明公开

US20240060104A1 ATP-PRT VARIANT WITH REDUCED FEEDBACK INHIBITION BY HISTIDINE, AND HISTIDINE-PRODUCING STRAIN EXPRESSING SAME 审中-公开
公开(公告)号：US20240060104A1
公开(公告)日：2024-02-22
申请号：US18269694
申请日：2021-04-26
申请人： DAESANG CORPORATION
发明人： Jong Yun HAN , Chel Min YANG , Yong Soo KIM , Young Il JO
IPC分类号： C12P17/10 , C12N9/10
CPC分类号： C12P17/10 , C12N9/1077 , C12R2001/19 , C12Y204/02017
摘要： The present invention relates to an E. coli hisG-derived ATP-phosphoribosyltransferase variant having a reduced feedback inhibition by histidine and a strain expressing the same. The variant may maintain its activity even at a high histidine concentration, thus increasing histidine production.

2. 发明公开

US20230220429A1 METHOD OF PRODUCING FLAVOR BY MIXED FERMENTATION OF HETEROLOGOUS MICROORGANISMS 审中-公开
公开(公告)号：US20230220429A1
公开(公告)日：2023-07-13
申请号：US17864715
申请日：2022-07-14
申请人： DAESANG CORPORATION
发明人： Hyun Ho KIM , Sun Hee LEE , Dong Hyun KIM , Hyun Sook KIM , Seok Hyun PARK , Joon Hyun PARK
IPC分类号： C12P13/14 , C12P13/08 , C12N1/20 , A23L27/24 , A23L27/22
CPC分类号： C12P13/14 , C12P13/08 , C12N1/205 , A23L27/24 , A23L27/22 , C12R2001/15
摘要： The present invention relates to a method of producing a flavor by a co-fermentation process using mixed fermentation of two or more different microorganisms producing different products. The method of producing a flavor may produce a natural flavor capable of improving the taste and aroma of food and the overall sensory properties of food through a fermentation broth containing amino acids, nucleic acids and/or organic acids, which is produced by mixed fermentation of different microorganisms producing different products, that is, different kinds of amino acids, nucleic acids and/or organic acids. This flavor may be used in various food fields.

3. 发明授权

US11634740B2 Allulose epimerase variant, method for preparing the same, and method for preparing allulose using the same 有权
公开(公告)号：US11634740B2
公开(公告)日：2023-04-25
申请号：US17788620
申请日：2021-04-27
申请人： DAESANG CORPORATION
发明人： Hyung Seop Youn , Eun Seok Choi , Ji Ha Lee , Suok Su Kim , Seung Woo Cho , Tae Yong Kim , Hak Jun Kim
IPC分类号： C12P19/02 , C12P19/24 , C12N9/90 , C12N15/52
摘要： The present invention provides: a novel allulose epimerase variant in which an amino acid residue present at a specific position of an amino acid sequence of a wild-type D-allulose 3-epimerase derived from Flavonifractor plautii is substituted with another amino acid residue; and various uses of the novel allulose epimerase variant. The novel allulose epimerase variant according to the present invention has a higher conversion rate of fructose to allulose compared to that of the wild-type D-allulose 3-epimerase derived from Flavonifractor plautii, and has excellent thermal stability especially under high temperature conditions of 60° C. or higher, and thus can prevent contamination during an industrial-scale enzymatic conversion reaction for the mass production of allulose, shorten production time, and reduce production costs.

4. 发明申请

US20220411834A1 STRAIN WITH IMPROVED AROMATIC AMINO ACID PRODUCTION CAPACITY BY YEEO GENE INACTIVATION 有权
公开(公告)号：US20220411834A1
公开(公告)日：2022-12-29
申请号：US17772813
申请日：2020-06-26
申请人： DAESANG CORPORATION
发明人： Won Joo SHIN , Young Il JO , Sun Hee LEE , Hyun Young KIM , Yong Soo KIM , Cheol Min YANG
IPC分类号： C12P13/22 , C07K14/245 , C12N15/70
摘要： Disclosed is a mutant strain having improved aromatic amino acid production capability due to inactivation or weakening of activity of an FMN/FAD exporter protein which is expressed by yeeO gene.

5. 发明授权

US08728775B2 Method for preparing 2-pyrrolidone using a microorganism containing glutamate decarboxylase 有权
标题翻译：使用含有谷氨酸脱羧酶的微生物制备2-吡咯烷酮的方法
公开(公告)号：US08728775B2
公开(公告)日：2014-05-20
申请号：US13876926
申请日：2011-09-30
申请人： Dong Cheol Park , Ki Kueon Kang , Hyun Jung Park , Seo Hyoung Kim , Jae Young Oh
发明人： Dong Cheol Park , Ki Kueon Kang , Hyun Jung Park , Seo Hyoung Kim , Jae Young Oh
IPC分类号： C12P17/10
CPC分类号： C12P17/10 , C07D207/26 , C12N9/88 , C12P13/005 , C12P2203/00
摘要： The present invention relates to a method for preparing 2-pyrrolidone using biomass, comprising: a step (a) of culturing a microorganism which contains glutamate decarboxylase as a whole-cell catalyst in a culture medium containing glutamic acid or glutamate so as to prepare 4-amino butyric acid; a step (b) of filtering the 4-amino butyric acid from the culture medium in order to obtain the 4-amino butyric acid; and a step (c) of converting the 4-amino butyric acid into 2-pyrrolidone. The present invention provides a series of processes for preparing 2-pyrrolidone from glutamic acid or glutamate using biomass. According to the present invention, 4-amino butyric acid is prepared using a microorganism as a whole cell, and preferably, 4-amino butyric acid which has not undergone a complicated refining process such as a crystallization process is directly used to prepare 2-pyrrolidone at a high yield rate in an economically advantageous manner. According to the present invention, 2-pyrrolidone may be mass-produced at a high yield rate and low production costs. The method of the present invention simplifies processes for preparing 2-pyrrolidone, and thus is suitable for mass production at an industrial scale.
摘要翻译：本发明涉及使用生物质制备2-吡咯烷酮的方法，包括：（a）在含谷氨酸或谷氨酸的培养基中培养含谷氨酸脱羧酶作为全细胞催化剂的微生物，以制备4 - 氨基丁酸; 从培养基中过滤4-氨基丁酸以获得4-氨基丁酸的步骤（b）; 和将4-氨基丁酸转化为2-吡咯烷酮的步骤（c）。本发明提供了使用生物质从谷氨酸或谷氨酸制备2-吡咯烷酮的一系列方法。根据本发明，使用微生物作为全细胞制备4-氨基丁酸，优选直接使用未经历复杂精制方法如结晶过程的4-氨基丁酸制备2-吡咯烷酮以高收益率以经济上有利的方式。根据本发明，2-吡咯烷酮可以高产率大批量生产，生产成本低。本发明的方法简化了制备2-吡咯烷酮的方法，因此适用于工业规模的批量生产。

6. 发明授权

US6090972A Crystallization of .alpha.-L-aspartyl-L-phenylalanine methyl ester 失效
标题翻译： α-L-天冬氨酰-L-苯丙氨酸甲酯的结晶
公开(公告)号：US6090972A
公开(公告)日：2000-07-18
申请号：US356663
申请日：1999-07-19
申请人： See Young Yu , Jin Man Cho , Bun Sam Lim
发明人： See Young Yu , Jin Man Cho , Bun Sam Lim
IPC分类号： C07C227/42 , C07K5/075
CPC分类号： C07K5/0613
摘要： Disclosed is a method of cooling and crystallizing .alpha.-L-aspartyl-L-phenylalanine methyl ester, which is a sweetening agent, commonly referred to as aspartame. An aspartame solution is cooled such that the solution is flown while being continuously in thermal contact with a coolant. As the cooling of the aspartame solution by the thermal contact with the coolant proceeds, the temperature difference between the aspartame solution and the coolant remains substantially constant. The coolant flows in the opposite direction as the aspartame solution flows and cools an upstream part of the aspartame solution as the coolant flows downstream.
摘要翻译：公开了一种冷却和结晶α-L-天冬氨酰基-L-苯丙氨酸甲酯的方法，其是通常称为阿斯巴甜的甜味剂。将阿斯巴甜溶液冷却，使得溶液在与冷却剂连续热接触的同时流动。当通过与冷却剂的热接触冷却阿斯巴甜溶液进行时，阿斯巴甜溶液和冷却剂之间的温差保持基本恒定。冷却剂沿着与阿斯巴甜溶液流动相反的方向流动，并且随着冷却剂向下游流动，冷却了阿斯巴甜溶液的上游部分。

7. 发明授权

US12098404B2 Allulose epimerase variant, method of producing the same, and method of producing allulose using the same 有权
公开(公告)号：US12098404B2
公开(公告)日：2024-09-24
申请号：US17295627
申请日：2020-09-25
申请人： DAESANG CORPORATION
发明人： Hyung Seop Youn , Eun Seok Choi , Ji Ha Lee , Suok Su Kim
IPC分类号： C12P19/24 , C12N9/90 , C12N15/70 , C12P19/02
CPC分类号： C12P19/24 , C12N9/90 , C12N15/70 , C12P19/02 , C12Y501/03
摘要： The present invention provides a novel allulose epimerase variant and various uses thereof, in which glycine (Gly), an amino acid residue at position 216 of the amino acid sequence of wild-type D-allulose 3-epimerase derived from Flavonifractor plautii, is substituted with serine (Ser). The novel allulose epimerase variant according to the present invention has a higher conversion activity of fructose to allulose compared to the wild-type D-allulose 3-epimerase derived from Flavonifractor plautii, and in particular, it has excellent thermal stability under high temperature conditions of 60° C. or higher, so that the enzyme conversion reaction is performed at the industrial level for mass production of allulose to prevent contamination, to shorten production time, and to reduce production cost.

8. 发明公开

US20240200111A1 METHOD FOR PRODUCING BRANCHED DEXTRIN WITH IMPROVED WHITE TURBIDITY 审中-公开
公开(公告)号：US20240200111A1
公开(公告)日：2024-06-20
申请号：US17791412
申请日：2021-10-01
申请人： DAESANG CORPORATION
发明人： Min Su KIM , Ju Yeol LEE , Han Joong RYU , Kyoung Ok PARK , Hak Jun KIM
IPC分类号： C12P19/14 , C12P19/04 , C12P19/18
CPC分类号： C12P19/14 , C12P19/04 , C12P19/18
摘要： Provided is a method for producing branched dextrin, the method comprising steps of: adding heat-resistant alpha-amylase to a starch suspension, heating the mixture at 85° C. to 115° C. to perform a liquefaction reaction, immediately heating the mixture at 125° C. to 145° C. to inactivate the heat-resistant alpha-amylase, and obtaining a liquefied starch solution including liquefied starch having a dextrose equivalent (DE) value of 2 to 10, and adding a branching enzyme to the liquefied starch solution in an amount of 0.6% (w/w) or more based on the dry weight of starch, proceeding with a branching reaction for 20 hour or more to generate branched dextrin, and then obtaining a solution with branched dextrin comprising branched dextrin having a dextrose equivalent (DE) value of 2 to 10 which stably controls the dextrose equivalent (DE) value of branched dextrin, and significantly suppresses the white turbidity that occurs during refrigeration.

9. 发明公开

US20240026282A1 MICROORGANISM OF CORYNEBACTERIUM GENUS HAVING ENHANCED L-ARGININE OR L-CITRULLINE PRODUCTIVITY AND A METHOD FOR PRODUCING L-ARGININE OR L-CITRULLINE USING THE SAME 审中-公开
公开(公告)号：US20240026282A1
公开(公告)日：2024-01-25
申请号：US17937828
申请日：2022-10-04
申请人： DAESANG CORPORATION
发明人： Mi RYU , Sun Jun Yoon , In Pyo Hong , Seok Hyun Park
IPC分类号： C12N1/20
CPC分类号： C12N1/205 , C12R2001/15
摘要： The present disclosure relates to a Corynebacterium sp. mutant strain having increased L-arginine or L-citrulline productivity and a method of producing L-arginine or L-citrulline using the same. The Corynebacterium sp. mutant strain has enhanced activity of acetylglutamate kinase involved in the L-arginine biosynthesis pathway, and thus is capable of producing L-arginine or L-citrulline in an increased yield compared to a parent strain.

10. 发明公开

US20230313244A1 CORYNEBACTERIUM GLUTAMICUM MUTANT STRAIN HAVING ENHANCED L-LYSINE PRODUCTIVITY AND METHOD OF PRODUCING L-LYSINE USING THE SAME 审中-公开
公开(公告)号：US20230313244A1
公开(公告)日：2023-10-05
申请号：US18024400
申请日：2021-04-20
申请人： DAESANG CORPORATION
发明人： Mi RYU , In Pyo HONG , Min Jin CHOI , Seok Hyun PARK , Jae Chun HAN
IPC分类号： C12P13/08 , C12N9/10 , C12N15/77
CPC分类号： C12P13/08 , C12N9/1025 , C12Y203/03001 , C12N15/77 , C12N2800/101
摘要： The present disclosure relates to a Corynebacterium glutamicum mutant strain having enhanced L-lysine productivity and a method of producing L-lysine using the same. The Corynebacterium glutamicum mutant strain may produce L-lysine in an improved yield by inhibiting the conversion of oxaloacetate to citrate due to decreased or inhibited expression of the gene encoding the citrate synthase.

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