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1. 外观设计

USD670400S1 Blood analyzer 有权
标题翻译：血液分析仪
公开(公告)号：USD670400S1
公开(公告)日：2012-11-06
申请号：US29391286
申请日：2011-05-05
申请人： Daniel O'Sullivan , Christopher Labak , James Rudolph , Zachary S. Hastings , Joseph O. St. Cyr
设计人： Daniel O'Sullivan , Christopher Labak , James Rudolph , Zachary S. Hastings , Joseph O. St. Cyr

2. 发明申请

US20120262704A1 Measuring Volume and Constituents of Cells 有权
标题翻译：测量体积和细胞成分
公开(公告)号：US20120262704A1
公开(公告)日：2012-10-18
申请号：US13447045
申请日：2012-04-13
申请人： Michael Zahniser , Russell Zahniser
发明人： Michael Zahniser , Russell Zahniser
IPC分类号： G01N33/49
CPC分类号： G01N15/0227 , G01N15/1475 , G01N33/49 , G01N2015/0073 , G01N2015/1472 , G06K9/00127 , G06K9/0014 , G06T7/62 , G06T2207/10056 , G06T2207/30024
摘要： A method for determining a mean cell volume for a blood sample includes: illuminating the sample with incident light at a plurality of illumination wavelengths and obtaining a two-dimensional image of the sample at each of the plurality of illumination wavelengths; identifying a plurality of cells that appear in each of the images; for each one of the plurality of cells, determining an integrated optical density corresponding to each of the plurality of illumination wavelengths; for each one of the plurality of cells, determining a cell volume based on the integrated optical densities corresponding to each of the plurality of illumination wavelengths; and determining the mean cell volume for the blood sample from the cell volumes for each one of the plurality of cells.
摘要翻译：用于确定血液样本的平均细胞体积的方法包括：用多个照明波长的入射光照射样品，并在多个照明波长中的每一个处获得样品的二维图像; 识别出现在每个图像中的多个单元格; 对于所述多个单元中的每一个单元，确定与所述多个照明波长中的每一个相对应的积分光密度; 对于所述多个单元中的每一个单元，基于对应于所述多个照明波长中的每一个的所述积分光密度来确定单元体积; 以及从所述多个细胞中的每个细胞的细胞体积确定所述血液样品的平均细胞体积。

3. 发明授权

US08445284B2 Fixative and staining solutions 有权
标题翻译：固定和染色方案
公开(公告)号：US08445284B2
公开(公告)日：2013-05-21
申请号：US13526164
申请日：2012-06-18
申请人： Daniel Lapen , Kerri Licari
发明人： Daniel Lapen , Kerri Licari
IPC分类号： G01N31/00
CPC分类号： G01N1/30 , Y10T436/10 , Y10T436/101666 , Y10T436/108331 , Y10T436/25
摘要： The formulations, systems, and methods disclosed herein permit automated preparation of specimens (e.g., biological specimens) for examination. The formulations can include a cytological fixative solution including Azure B, a surfactant, methanol, and ethylene glycol. The disclosed formulations, systems, and methods provide fast, efficient, and highly uniform specimen processing using minimal quantities of fluids. The methods include at least a fixing phase for fixing a specimen to a substrate such as a microscope slide, a staining phase for staining the specimen, and a rinsing phase for rinsing the specimen. One or more of the fixing, staining, and rinsing phases include one or more agitation phases for distributing reagents evenly and uniformly across the specimen. The systems can be implemented as a standalone device or as a component in a larger system for preparing and examining specimens.
摘要翻译：本文公开的制剂，系统和方法允许自动制备样品（例如，生物样品）用于检查。制剂可以包括包括Azure B，表面活性剂，甲醇和乙二醇的细胞学固定溶液。所公开的配方，系统和方法使用最少量的流体提供快速，有效和高度均匀的样品处理。该方法至少包括用于将样品固定到诸如显微镜载片的基底的固定阶段，用于染色样品的染色阶段和用于漂洗样品的漂洗阶段。固定，染色和漂洗阶段中的一个或多个包括一个或多个用于均匀均匀地分布试剂的搅拌相。这些系统可以作为独立设备或作为更大系统中用于准备和检查样本的组件来实现。

4. 发明申请

US20130023007A1 IDENTIFYING AND MEASURING RETICULOCYTES 有权
公开(公告)号：US20130023007A1
公开(公告)日：2013-01-24
申请号：US13549211
申请日：2012-07-13
申请人： Michael Zahniser , Russell Zahniser
发明人： Michael Zahniser , Russell Zahniser
IPC分类号： G01N21/25 , C12M1/42
CPC分类号： G01N15/1475 , G01N15/1429 , G01N15/1463 , G01N2015/0076 , G01N2015/1006 , G01N2015/1465 , G01N2015/1472 , G06K9/0014 , G06K9/46 , G06K9/4652 , G06K9/52 , G06K2009/4666 , G06T7/0012 , G06T7/62 , G06T2207/10024 , G06T2207/30004 , G06T2207/30024 , G06T2207/30242 , H04N7/18
摘要： Methods and systems for identifying reticulocytes in a blood sample deposited on a substrate include: illuminating the sample with incident light at two different wavelengths, obtaining a two-dimensional image of the sample corresponding to a first one of the wavelengths, and obtaining a two-dimensional image of the sample corresponding to a second one of the wavelengths; analyzing the images to identify a set of representative red blood cells; determining an area of each of the red blood cells in the set; determining a color value of each of the red blood cells in the set; and, for each one of the red blood cells in the set, identifying the red blood cell as a reticulocyte if the area of the red blood cell exceeds an area cutoff value and the color value of the red blood cell is less than a color cutoff value.

5. 发明申请

US20110070606A1 SYSTEMS AND METHODS FOR ANALYZING BODY FLUIDS 有权
标题翻译：用于分析体液的系统和方法
公开(公告)号：US20110070606A1
公开(公告)日：2011-03-24
申请号：US12768633
申请日：2010-04-27
申请人： James Winkelman , Milenko Tanasijevic , David Zahniser , James Linder
发明人： James Winkelman , Milenko Tanasijevic , David Zahniser , James Linder
IPC分类号： C12Q1/06 , G06K9/00 , C12M1/34 , C12Q1/02
CPC分类号： H04N7/18 , G01N1/2813 , G01N1/312 , G01N15/1475 , G01N35/00029 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1006 , G06K9/00
摘要： Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device.
摘要翻译：公开了分析体液的系统和方法，其中包含血液，骨髓，尿液，阴道组织，上皮组织，肿瘤，精液和唾液等细胞。该系统和方法利用改进的技术将单层细胞施加到载玻片上并在载玻片上产生基本均匀的细胞分布。本发明的另外方面还涉及用于利用多色显微术来提高由光接收装置捕获的图像的质量的系统和方法。

6. 发明申请

US20140004561A1 AUTOMATED SYSTEMS AND METHODS FOR PREPARING BIOLOGICAL SPECIMENS FOR EXAMINATION 有权
标题翻译：自动化系统和准备用于检验的生物样本的方法
公开(公告)号：US20140004561A1
公开(公告)日：2014-01-02
申请号：US13858531
申请日：2013-04-08
申请人： Constitution Medical, Inc.
发明人： Daniel Lapen , David Zahniser , Mark Licari , Brian J. McKeen , Eric D. Yeaton , Dennis Poole
IPC分类号： G01N1/30
CPC分类号： G01N1/312 , G01N1/30 , G01N35/00029 , G01N35/0099 , G01N2035/00079 , G01N2035/00138 , G01N2035/00524 , G01N2035/1037
摘要： The systems and methods disclosed herein permit automated preparation of biological specimens for examination. The disclosed systems and methods provide fast, efficient, and highly uniform specimen processing using minimal quantities of fluids. The methods include at least a fixing phase for fixing a biological specimen to a substrate such as a microscope slide, a staining phase for staining the specimen, and a rinsing phase for rinsing the specimen. One or more of the fixing, staining, and rinsing phases include one or more agitation cycles for distributing reagents evenly and uniformly across the specimen. The systems can be implemented as a standalone device or as a component in a larger system for preparing and examining biological specimens.
摘要翻译：本文公开的系统和方法允许自动化制备生物标本进行检查。所公开的系统和方法使用最少量的流体提供快速，有效和高度均匀的样品处理。所述方法至少包括用于将生物样本固定到诸如显微镜载片的基底的固定阶段，用于染色样本的染色阶段和用于冲洗样本的漂洗阶段。定影，染色和漂洗阶段中的一种或多种包括一个或多个搅拌循环，用于均匀均匀地分布试剂。这些系统可以作为一个独立设备或作为更大系统中用于准备和检查生物标本的组件来实现。

7. 发明申请

US20130189729A1 FIXATIVE AND STAINING SOLUTIONS 审中-公开
公开(公告)号：US20130189729A1
公开(公告)日：2013-07-25
申请号：US13796365
申请日：2013-03-12
申请人： Constitution Medical, Inc.
发明人： Daniel Lapen , Kerri Licari
IPC分类号： G01N1/30
CPC分类号： G01N1/30 , Y10T436/10 , Y10T436/101666 , Y10T436/108331 , Y10T436/25
摘要： The formulations, systems, and methods disclosed herein permit automated preparation of specimens (e.g., biological specimens) for examination. The disclosed formulations, systems, and methods provide fast, efficient, and highly uniform specimen processing using minimal quantities of fluids. The methods include at least a fixing phase for fixing a specimen to a substrate such as a microscope slide, a staining phase for staining the specimen, and a rinsing phase for rinsing the specimen. One or more of the fixing, staining, and rinsing phases include one or more agitation phases for distributing reagents evenly and uniformly across the specimen. The systems can be implemented as a standalone device or as a component in a larger system for preparing and examining specimens.

8. 发明授权

US08488111B2 Measuring volume and constituents of cells 有权
标题翻译：测量细胞体积和成分
公开(公告)号：US08488111B2
公开(公告)日：2013-07-16
申请号：US13447045
申请日：2012-04-13
申请人： Michael Zahniser , Russell Zahniser
发明人： Michael Zahniser , Russell Zahniser
IPC分类号： G01N33/48 , G06K9/00 , A61B5/00
CPC分类号： G01N15/0227 , G01N15/1475 , G01N33/49 , G01N2015/0073 , G01N2015/1472 , G06K9/00127 , G06K9/0014 , G06T7/62 , G06T2207/10056 , G06T2207/30024
摘要： A method for determining a mean cell volume for a blood sample includes: illuminating the sample with incident light at a plurality of illumination wavelengths and obtaining a two-dimensional image of the sample at each of the plurality of illumination wavelengths; identifying a plurality of cells that appear in each of the images; for each one of the plurality of cells, determining an integrated optical density corresponding to each of the plurality of illumination wavelengths; for each one of the plurality of cells, determining a cell volume based on the integrated optical densities corresponding to each of the plurality of illumination wavelengths; and determining the mean cell volume for the blood sample from the cell volumes for each one of the plurality of cells.
摘要翻译：用于确定血液样本的平均细胞体积的方法包括：用多个照明波长的入射光照射样品，并在多个照明波长中的每一个处获得样品的二维图像; 识别出现在每个图像中的多个单元格; 对于所述多个单元中的每一个单元，确定与所述多个照明波长中的每一个相对应的积分光密度; 对于所述多个单元中的每一个单元，基于对应于所述多个照明波长中的每一个的所述积分光密度来确定单元体积; 以及从所述多个细胞中的每个细胞的细胞体积确定所述血液样品的平均细胞体积。

9. 发明申请

US20130020175A1 SAMPLE TRANSPORT SYSTEMS AND METHODS 有权
标题翻译：样本运输系统和方法
公开(公告)号：US20130020175A1
公开(公告)日：2013-01-24
申请号：US13548844
申请日：2012-07-13
申请人： Brian J. McKeen , Eric D. Yeaton , James L. Dowling
发明人： Brian J. McKeen , Eric D. Yeaton , James L. Dowling
IPC分类号： B65G37/00
CPC分类号： G01N35/04 , G01N1/31 , G01N35/00029 , G01N35/0099 , G01N35/02 , G01N2035/00039 , G01N2035/041
摘要： Sample transport systems are described that move a sample carrier from one station to a next station in a sample processing systems. The systems include: a translating member; two or more sample carrier retaining devices attached to the translating member, wherein each of the two or more sample carrier retaining devices can include a retainer portion to temporarily retain one or more sample carriers; and a movement mechanism to move the translating member and the attached sample carrier retaining devices between a first position and a second position; wherein the sample carrier retaining devices are controlled and moved simultaneously to retain a sample carrier when the translating member reaches the first position and to release a sample carrier when the translating member reaches the second position to successively advance sample carriers in the sample processing systems.
摘要翻译：描述了样本传送系统，其将样本载体从样本处理系统中的一个站移动到下一个站。系统包括：翻译成员; 两个或更多个样品载体保持装置附接到平移构件，其中两个或更多个样品载体保持装置中的每一个可以包括暂时保持一个或多个样品载体的保持器部分; 以及移动机构，用于在第一位置和第二位置之间移动所述平移构件和附接的样品载体保持装置; 其中当所述平移构件到达所述第一位置时，所述样品载体保持装置被同时控制和移动以保持样品载体，并且当所述平移构件到达所述第二位置时释放样品载体，以连续地提取所述样品处理系统中的样品载体。

10. 发明授权

US08339586B2 Measuring volume and constituents of cells 有权
标题翻译：测量细胞体积和成分
公开(公告)号：US08339586B2
公开(公告)日：2012-12-25
申请号：US13446996
申请日：2012-04-13
申请人： Michael Zahniser , Russell Zahniser
发明人： Michael Zahniser , Russell Zahniser
IPC分类号： G01N33/48 , G06K9/00 , A61B5/00
CPC分类号： G01N15/0227 , G01N15/1475 , G01N33/49 , G01N2015/0073 , G01N2015/1472 , G06K9/00127 , G06K9/0014 , G06T7/62 , G06T2207/10056 , G06T2207/30024
摘要： A method of determining a volume of a platelet includes: (a) illuminating the platelet with incident light at a plurality of illumination wavelengths; (b) obtaining at least one two-dimensional image of the platelet corresponding to each illumination wavelength; (c) for each illumination wavelength, determining a mean optical density and a maximum optical density for the platelet; (d) determining an area of the platelet; (e) for each illumination wavelength, determining a volume of the platelet; (f) for each illumination wavelength, determining an integrated optical density for the platelet; and (g) determining the volume of the platelet based on a weighted combination of the area of the platelet, the volumes of the platelet corresponding to each of the illumination wavelengths, and the integrated optical densities for the platelet corresponding to each of the illumination wavelengths.
摘要翻译：确定血小板体积的方法包括：（a）用多个照明波长的入射光照射血小板; （b）获得对应于每个照明波长的血小板的至少一个二维图像; （c）对于每个照明波长，确定血小板的平均光密度和最大光密度; （d）确定血小板的面积; （e）对于每个照明波长，确定血小板的体积; （f）对于每个照明波长，确定血小板的综合光密度; 和（g）基于血小板面积，对应于每个照明波长的血小板的体积和对应于每个照明波长的血小板的积分光密度的加权组合来确定血小板的体积。

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