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1. 发明公开

US20230348934A1 METHODS FOR SELECTIVELY MODULATING THE ACTIVITY OF DISTINCT SUBTYPES OF CELLS 审中-公开
公开(公告)号：US20230348934A1
公开(公告)日：2023-11-02
申请号：US18179269
申请日：2023-03-06
申请人： Ecole Normale Superieure De Lyon , Centre National de La Recherche Scientifique (CNRS) , Université Claude Bernard Lyon 1 , Institut National de la Santé et de la Recherche Medicale (INSERM)
发明人： Caroline COSTA FEJOZ , Els Verhoeyen , François-Loîc Cosset , Ruben Bender , Christian Buchholz , Qi Zhou
IPC分类号： C07K16/32 , C12N15/86 , C07K16/28 , A61P35/00 , C07K14/005 , C07K14/54
CPC分类号： C12N15/86 , A61P35/00 , C07K14/005 , C07K14/5418 , C07K16/2812 , C07K16/2815 , C07K16/32 , A61K2039/505 , C07K2319/03 , C07K2319/74 , C12N2740/16043 , C12N2740/16045 , C12N2760/18222 , C12N2760/18422
摘要： The present invention relates to pseudotyped retrovirus-like particles or retroviral vectors comprising both engineered envelope glycoproteins derived from a virus of the Paramyxoviridae family fused to a cell targeting domain and fused to a functional domain.
The present invention also relates to the use of said pseudotyped retrovirus-like particles or retroviral vectors to selectively modulate the activity of specific subsets of cells, in particular of specific immune cells. These pseudotyped retrovirus-like particles or retroviral vectors are particularly useful for gene therapy, immune therapy and/or vaccination.

2. 发明申请

US20110295441A1 DIGITAL CONTROL DEVICE FOR A PARALLEL PMOS TRANSISTOR BOARD 有权
标题翻译：用于并联PMOS晶体管板的数字控制器件
公开(公告)号：US20110295441A1
公开(公告)日：2011-12-01
申请号：US13141466
申请日：2009-12-17
申请人： Carlos Canudas De Wit , Carolina Albea Sanchez
发明人： Carlos Canudas De Wit , Carolina Albea Sanchez
IPC分类号： G05D9/12
CPC分类号： H03K19/0016 , H03K17/122
摘要： A digital control device for a parallel PMOS transistor board, includes: an operative memory for digitally storing error data between a target voltage and a setpoint voltage as well as control data, each datum being provided with a time marker, a digital selected order filter (36) for computing setpoint incrementation data from error data in the operative memory selected based on input error data, and for storing the input error data with a corresponding time marker in the operative memory, and a control computer (38) for computing new control data from the control incrementation data and control data in the operative memory selected based on input error data and for storing the new control data in the operative memory.
摘要翻译：一种用于并联PMOS晶体管板的数字控制装置，包括：用于数字地存储目标电压和设定点电压之间的误差数据的操作存储器以及控制数据，每个数据被提供有时间标记，数字选择顺序滤波器 36），用于从基于输入错误数据选择的操作存储器中的错误数据计算设定值增量数据，以及用于将输入错误数据与对应的时间标记存储在操作存储器中;以及控制计算机（38），用于计算新的控制数据来自基于输入错误数据选择的操作存储器中的控制增量数据和控制数据，以及用于将新的控制数据存储在操作存储器中。

3. 发明申请

US20170087591A1 Preparation of Coatings Containing At Least One In-Plane Oriented Layer of Anisotropic Shaped Objects 审中-公开
公开(公告)号：US20170087591A1
公开(公告)日：2017-03-30
申请号：US15311562
申请日：2015-05-18
申请人： Universite de Strasbourg , Centre National De La Recherche Scientifique (CNRS
发明人： Gero Decher , Rebecca Blell , Hebing Hu , Matthias Pauly , Olivier Felix , David Martel , Xiaofeng Lin , Sribharani Sekar , Diabang Seydina , Jonas Baer
IPC分类号： B05D7/00 , B05B3/14 , B05D5/00 , B05D1/02 , B05D1/36
CPC分类号： B05D7/50 , B05B3/14 , B05D1/02 , B05D1/36 , B05D5/00 , B81C1/00031
摘要： The subject matter of the present invention concerns the preparation of a coated solid surface wherein the coating contains at least one in-plane oriented layer of anisotropic shaped objects through a specific spraying method, and the device enabling this method.

4. 发明授权

US10583114B2 Compositions comprising urolithins and uses thereof for the stimulation of insulin secretion 有权
公开(公告)号：US10583114B2
公开(公告)日：2020-03-10
申请号：US15029384
申请日：2014-10-15
申请人： Centre National de la Recherche Scientifique (CNRS) , Universite de Montpellier , University of Parma , Ecole Nationale Superieure de Chimie
发明人： Gerard Cros , Alan Crozier , Margherita Dall'asta , Daniele Del Rio , Richard Magous , Catherine Oiry
IPC分类号： A61K38/26 , A61K31/37 , A61K31/255
摘要： The present invention relates to a composition comprising urolithin A, urolithin B, urolithin C, urolithin D, or a combination thereof, for the stimulation of insulin secretion, and to the use of a compound chosen among urolithin A, urolithin B, urolithin C, urolithin D, or a combination thereof, intended for the stimulation of insulin secretion. The present invention also relates to a composition comprising an effective amount of urolithin B, urolithin C, urolithin D, or a combination thereof, for the treatment or the prevention of diabetes mellitus, and in particular for the treatment or the prevention of type 2 diabetes, and to the use of a compound chosen among urolithin B, urolithin C, urolithin D, and a combination thereof, intended for the treatment or the prevention of diabetes mellitus, and in particular of type 2 diabetes.

5. 发明公开

US20240319321A1 METHOD FOR IDENTIFYING A RADAR TRANSMITTER AND ASSOCIATED IDENTIFICATION SYSTEM 审中-公开
公开(公告)号：US20240319321A1
公开(公告)日：2024-09-26
申请号：US18612714
申请日：2024-03-21
申请人： BULL SAS , CENTRALESUPELEC , Centre national de la recherche scientifique , UNIVERSITE PARIS-SACLAY
发明人： Manon MOTTIER , Frédéric PASCAL , Gilles CHARDON
IPC分类号： G01S7/02 , G01S7/40
CPC分类号： G01S7/021 , G01S7/4008
摘要： The invention relates to a computer-implemented method for identifying a radar transmitter from a set of corresponding received pulses, each pulse being associated with a respective time of arrival. The method includes determining an observed signature of the radar transmitter based on a distribution of the time gaps between consecutive times of arrival. For each transmitter class among a plurality of predetermined transmitter classes, each transmitter class being associated with at least one expected signature, the method includes calculating a proximity score between the observed signature and each expected signature associated with said transmitter class. Each expected signature is a function of an expected distribution of the time gaps between consecutive times of transmission for said transmitter class, and for a predetermined pulse loss rate. The method also includes assigning the radar transmitter to the transmitter class associated with the expected signature that provides the best proximity score.

6. 发明公开

US20240317890A1 HER2 SINGLE DOMAIN ANTIBODIES VARIANTS AND CARS THEREOF 审中-公开
公开(公告)号：US20240317890A1
公开(公告)日：2024-09-26
申请号：US18269615
申请日：2022-01-14
申请人： INSTITUT CURIE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - , HONING BIOSCIENCES
发明人： Franck PEREZ , Sandrine MOUTEL , Zélia GOUVEIA
IPC分类号： C07K16/32 , A61K39/00 , C07K14/705 , C07K14/725 , G01N33/574
CPC分类号： C07K16/32 , C07K14/7051 , C07K14/70578 , G01N33/57484 , A61K2039/505 , C07K2317/24 , C07K2317/569 , C07K2317/73 , C07K2317/92 , C07K2319/03
摘要： The present invention relates to humanized HER2 single domain antibodies and variants thereof and their use in therapy and for cancer diagnosis. The invention most particularly proposes chimeric antigen receptors including said humanized HER2 sdAb in their antigen binding domain and their use in cancer cell therapy.

7. 发明公开

US20240317812A1 Mutated Glycoprotein of Vesicular Stomatitis Virus 审中-公开
公开(公告)号：US20240317812A1
公开(公告)日：2024-09-26
申请号：US18629579
申请日：2024-04-08
申请人： Centre National de la Recherche Scientifique (CNRS) , Université Paris-Saclay
发明人： Aurélie Albertini , Yves Gaudin , Hèlène Raux , Laura Belot , Jovan Nikolic
IPC分类号： C07K14/005 , C12N7/00
CPC分类号： C07K14/005 , C12N7/00 , C12N2760/20222 , C12N2760/20232 , C12N2760/20245 , C12N2760/20262
摘要： The invention relates to an isolated non-naturally occurring protein comprising the amino acid sequence as set forth in SEQ ID NO: 1, and wherein the amino acid in position 8, 47, 209 and/or 354 is substituted by any amino acid different from the amino acid indicated at that position in said sequence SEQ ID NO: 1.

8. 发明公开

US20240316005A1 GENE SIGNATURES FOR PREDICTING SURVIVAL TIME IN PATIENTS SUFFERING FROM RENAL CELL CARCINOMA 审中-公开
公开(公告)号：US20240316005A1
公开(公告)日：2024-09-26
申请号：US18575431
申请日：2022-07-04
申请人： INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE , UNIVERSITÉ DE BORDEAUX , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITÉ COTE D'AZUR
发明人： Andreas BIKFALVI , Wilfried SOULEYREAU , Lindsay COOLEY , Marie NIKOLSKI , Justine RUDEWICZ , Gilles PAGES , Maeva DUFIES
IPC分类号： A61K31/404 , A61K39/395 , A61P35/00 , C07K16/28 , C12Q1/6886
CPC分类号： A61K31/404 , A61K39/3955 , A61P35/00 , C07K16/2818 , C12Q1/6886 , C07K2317/21 , C12Q2600/118 , C12Q2600/158
摘要： Renal Cell Carcinoma (RCC) is difficult to treat with 5-year survival rate of 10% in metastatic patients. Main reasons of therapy failure are lack of validated biomarkers and scarce knowledge of the biological processes occurring during RCC progression. Thus, the investigation of mechanisms regulating RCC progression is fundamental to improve RCC therapy. In order to identify molecular markers and gene processes involved in the steps of RCC progression, the inventors generated several cell lines of higher aggressiveness by serially passaging mouse renal cancer RENCA cells in mice and, concomitantly, performed functional genomics analysis of the cells. Multiple cell lines depicting the major steps of tumor progression (including primary tumor growth, survival in the blood circulation and metastatic spread) were generated and analyzed by large-scale transcriptome, genome and methylome analyses. Importantly, transcriptome analysis revealed distinct signatures of tumor aggressiveness which were validated in the TCGA-KIRC cohort. The signatures are particularly suitable for determining the survival time of the patients and predicting response to the therapies.

9. 发明公开

US20240309422A1 METHOD FOR DETECTING A PHAGE OR ANTIBIOTIC SENSITIVITY WITH RESPECT TO A BACTERIAL STRAIN 审中-公开
公开(公告)号：US20240309422A1
公开(公告)日：2024-09-19
申请号：US18604656
申请日：2024-03-14
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , UNIVERSITE GRENOBLE ALPES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT POLYTECHNIQUE DE GRENOBLE
发明人： Pierre MARCOUX , Yoann ROUPIOZ , Marc ZELSMANN , Emmanuel PICARD , Larry O’CONNELL
IPC分类号： C12Q1/18 , C12M1/00 , C12M1/32 , C12Q1/70
CPC分类号： C12Q1/18 , C12M23/12 , C12M23/22 , C12M23/34 , C12M41/06 , C12Q1/70
摘要： A method for detecting a lytic activity of one or more types of phages or of the activity of one or more antibiotics with respect to a bacterial strain, the method including using a first multiwell plate, each well receiving a sample containing phages or antibiotics, making at least one deposit on a transparent area of a support, the deposit containing bacteria of the bacterial strain, applying the first plate against the support so that each sample in each well comes into contact with the deposit, for each well, determining, using the detection means, the activity or absence of activity of the phage or antibiotic with respect to the bacterial strain, taking into account the intensity of light signals transmitted through each well and/or the variation thereof over time.

10. 发明授权

US12095068B2 Rechargeable non-aqueous lithium-air battery cell comprising a solid organic catalyst 有权
公开(公告)号：US12095068B2
公开(公告)日：2024-09-17
申请号：US17794129
申请日：2020-01-20
申请人： TOYOTA MOTOR EUROPE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE NANTES , Steven Renault , Marco Carboni
发明人： Steven Renault , Marco Carboni , Fanny Jeanne Julie Barde , Philippe Poizot
IPC分类号： H01M12/08 , H01M4/86 , H01M4/90 , H01M4/96 , H01M12/02
CPC分类号： H01M12/08 , H01M4/8652 , H01M4/8668 , H01M4/9008 , H01M4/96 , H01M12/02 , H01M2004/8689 , H01M2220/10 , H01M2220/20 , H01M2220/30
摘要： A lithium-air battery cell wherein the positive electrode includes a solid p-type electroactive organic catalyst lithium salt and a battery pack including several lithium-air battery cells. The use of a battery pack as a rechargeable battery for vehicles, such as electric vehicles and hybrid vehicles, electronic devices, and stationary power generating devices. Finally, a vehicle, an electronic device, and a stationary power generating device, including a battery pack.

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