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1. 发明授权

US08207510B2 Method and arrangement for collimated microscopic imaging 有权
标题翻译：准直显微镜成像的方法和布置
公开(公告)号：US08207510B2
公开(公告)日：2012-06-26
申请号：US13042137
申请日：2011-03-07
申请人： Michael Kempe , Gerhard Krampert , Matthias Wald , Ralf Wolleschensky
发明人： Michael Kempe , Gerhard Krampert , Matthias Wald , Ralf Wolleschensky
IPC分类号： G01J1/58
CPC分类号： G02B21/16 , G01N21/6458 , G02B21/0032 , G02B21/0072 , G02B21/0076
摘要： A method and arrangement for collimated microscopic imaging, including a first illumination of a sample in at least one region for exciting fluorescence, and a spatially resolving detection of the sample light by detector elements, the detection being associated with the region, wherein by means of a second illumination a sub-division of the region into separate fluorescent partial regions occurs, which are associated with the detector elements. The separation of the partial regions is carried out by the spatial separation of the fluorescent regions by means of intermediate regions having reduced fluorescence or no fluorescence, and/or by means of different spectral properties of the fluorescence from the partial regions.
摘要翻译：一种用于准直显微镜成像的方法和装置，包括用于激发荧光的至少一个区域中的样品的第一照明，以及由检测器元件对样品光进行空间分辨检测，所述检测与所述区域相关联，其中通过发生与检测器元件相关联的区域的分割成分离的荧光部分区域的第二照明。部分区域的分离是通过荧光区域通过具有减少的荧光或无荧光的中间区域和/或通过来自部分区域的荧光的不同光谱性质的空间分离来进行的。

2. 发明授权

US07593581B2 Process for the acquisition of images from a sample with a microscope 有权
标题翻译：用显微镜从样品采集图像的过程
公开(公告)号：US07593581B2
公开(公告)日：2009-09-22
申请号：US10967332
申请日：2004-10-19
申请人： Frank Hecht , Ralf Engelmann , Ralf Wolleschensky
发明人： Frank Hecht , Ralf Engelmann , Ralf Wolleschensky
IPC分类号： G06K9/36
CPC分类号： G06T9/004 , G06T9/007
摘要： Process for the acquisition of images from a sample with a microscope, wherein detected image data that correspond to three dimensional probe regions are detected and stored to memory, wherein data compression ensues in that the data of images lying next to one another and over one another on the probe are taken into consideration during compression. A stack of images is advantageously recorded and images that are respectively adjacent in the image stack are consulted for the compression of data. Temporally and/or spectrally detected and stored data shall be consulted for the compression of data.
摘要翻译：用于利用显微镜从样品中获取图像的处理，其中检测到对应于三维探针区域的检测到的图像数据并将其存储到存储器，其中数据压缩是因为彼此相邻并且彼此相邻的图像的数据在压缩过程中考虑到探头。有利地记录一叠图像，并且参考图像堆叠中分别相邻的图像用于压缩数据。临时和/或频谱检测和存储的数据应参考压缩数据。

3. 发明授权

US07593158B2 Method and apparatus for the examination of specimens 有权
标题翻译：检测标本的方法和装置
公开(公告)号：US07593158B2
公开(公告)日：2009-09-22
申请号：US11330384
申请日：2006-01-12
申请人： Stefan Wilhelm , Eva Simbürger , Michael Kempe
发明人： Stefan Wilhelm , Eva Simbürger , Michael Kempe
IPC分类号： G02B21/06
CPC分类号： G01N21/6458 , G02B21/0032 , G02B21/0076 , G02B21/008 , G02B21/16 , Y10S359/90
摘要： A method in which specimens are examined using a microscope. For an illuminated specimen, spatially coherent light with at least one continuous wavelength range or a continuously tunable wavelength range is generated, and one or more wavelengths or wavelength ranges in the illumination light are selected in dependence on the prespecified method of examination. The specimen is then illuminated with the illumination light with the selected wavelengths or wavelength ranges, the illumination light and the emission light coming from the specimen are then subsequently separated, whereby the back radiated illumination light is suppressed in the detection beam before the detection and the emission light is detected. In such a method, the selection of the wavelengths or the wavelength ranges of the illumination light is tuned by means of the separation of the detection light and the illumination light and the suppression of the illumination light in such a manner that a prespecified control variable (R) is optimized.
摘要翻译：使用显微镜检查样品的方法。对于照射的样本，产生具有至少一个连续波长范围或连续可调波长范围的空间相干光，并且根据预先指定的检查方法来选择照明光中的一个或多个波长或波长范围。然后用所选择的波长或波长范围的照明光照射样本，随后分离照明光和来自样本的发射光，从而在检测之前在检测光束中抑制背面照射光，并且检测出发光。在这种方法中，通过检测光和照明光的分离以及照明光的抑制来调节照明光的波长或波长范围的选择，使得预先指定的控制变量（ R）优化。

4. 发明授权

US08280131B2 Method and configuration for optically detecting an illuminated specimen 有权
标题翻译：用于光学检测被照射样品的方法和结构
公开(公告)号：US08280131B2
公开(公告)日：2012-10-02
申请号：US12323123
申请日：2008-11-25
申请人： Michael Kempe , Ralf Wolleschensky
发明人： Michael Kempe , Ralf Wolleschensky
IPC分类号： G06K9/00 , G01J1/42 , G02B21/00
CPC分类号： G02B21/0032 , G02B21/0048 , G02B21/0056
摘要： A configuration for the optical detection of a specimen, wherein the specimen or at least part of the specimen is scanned by means of linear illumination by scanning means, means for linear beam shaping of the illuminating light are provided, and the illuminating light has a preferably periodic structure in at least one spatial direction in that means for generating the structure are disposed in the illuminating beam path, light coming from the specimen is detected and images of the specimen are generated therefrom, at least one optical sectional image through the specimen and/or one image with increased resolution is/are calculated from the images, and means for generating the structure are disposed downstream of the scanning means in the direction of the illumination.
摘要翻译：提供了一种用于通过扫描装置通过线性照明扫描样本或样本的至少一部分的样本的光学检测的结构，用于照明光的线性光束成形的装置，并且照明光具有优选的在所述照明光束路径中设置用于产生所述结构的装置中的至少一个空间方向上的周期性结构，并且检测来自所述样本的光并且从其产生所述样本的图像，通过所述样本的至少一个光学截面图像和/ 或者从图像计算一个具有增加的分辨率的图像，并且用于产生该结构的装置设置在扫描装置的照明方向的下游。

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