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1. 发明申请

US20140134239A1 COMPOSITIONS AND METHODS FOR TREATMENT OF THE SIDE-EFFECTS ASSOCIATED WITH ADMINISTRATION OF CANCER CHEMOTHERAPEUTIC AGENTS 有权
标题翻译：用于治疗与癌症化疗药物管理相关的副作用的组合物和方法
公开(公告)号：US20140134239A1
公开(公告)日：2014-05-15
申请号：US14162155
申请日：2014-01-23
申请人： Asymmetric Therapeutics, LLC
发明人： John P. Ford
IPC分类号： A61K31/513 , A61K31/7004 , A61K31/519 , A61K45/06 , A61K31/52 , A61K9/127
CPC分类号： A61K31/513 , A61K9/0004 , A61K9/127 , A61K31/52 , A61K31/7004 , A61K45/06 , A61K2300/00
摘要： A composition and method for the treatment of the side-effects associated with the administration of cancer chemotherapeutic agents involves the oral ingestion of a slow release capsule containing adenine. In some embodiments, the slow release capsule also contains orotate. The systemic administration of a proton pump inhibitor decreases systemic absorption of orotate, and the systemic administration of allopurinol decreases the formation of 2,8-dihydroxy adenine from adenine. In an alternative embodiment, cationic liposomes contain purine/pyrimidine precursors. The cationic liposomes bind to the cells lining the mucosa of the intestinal tract and then the contents of the cationic liposome are then taken up in the interior of the cells to prevent the metabolism of the cancer treatment drug 5-FU into a toxic species. A method for prevention of oral stomatitis and a method for treatment of dysplastic tissue are also disclosed.
摘要翻译：用于治疗与癌症化学治疗剂的给药相关的副作用的组合物和方法涉及口服摄取含有腺嘌呤的缓释胶囊。在一些实施方案中，缓释胶囊还含有乳清酸。质子泵抑制剂的全身给药减少了乳清酸的全身吸收，并且全身施用别嘌呤醇降低了腺嘌呤形成的2,8-二羟基腺嘌呤。在另一个实施方案中，阳离子脂质体含有嘌呤/嘧啶前体。阳离子脂质体结合到肠道粘膜上的细胞，然后将阳离子脂质体的内容物吸收到细胞内部，以防止癌症治疗药物5-FU的代谢成为毒性物质。还公开了预防口腔炎的方法和治疗发育不良组织的方法。

2. 发明授权

US07812030B2 Methods, compositions, and kits for organ protection during systemic anticancer therapy 有权
公开(公告)号：US07812030B2
公开(公告)日：2010-10-12
申请号：US12071648
申请日：2008-02-25
申请人： John P. Ford
发明人： John P. Ford
IPC分类号： A61K31/505
CPC分类号： A61K31/513 , A61K31/00 , A61K31/337 , A61K31/505 , A61K31/555 , A61K31/704 , A61K31/7072 , A61K2300/00
摘要： Methods, compositions, and kits are presented for local tissue protection during systemic administration of anticancer therapeutic agents.

3. 发明授权

US07662829B2 Methods, compositions, and kits for organ protection during systemic anticancer therapy 有权
标题翻译：全身抗癌治疗中器官保护的方法，组合物和试剂盒
公开(公告)号：US07662829B2
公开(公告)日：2010-02-16
申请号：US12073424
申请日：2008-03-05
申请人： John P. Ford
发明人： John P. Ford
IPC分类号： A61K31/505
CPC分类号： A61K31/513 , A61K31/00 , A61K31/337 , A61K31/505 , A61K31/555 , A61K31/704 , A61K31/7072 , A61K2300/00
摘要： Methods, compositions, and kits are presented for local tissue protection during systemic administration of anticancer therapeutic agents.
摘要翻译：在抗癌治疗剂的全身给药期间，提供了用于局部组织保护的方法，组合物和试剂盒。

4. 发明申请

US20080207656A1 Methods, compositions, and kits for organ protection during systemic anticancer therapy 有权
公开(公告)号：US20080207656A1
公开(公告)日：2008-08-28
申请号：US12071648
申请日：2008-02-25
申请人： John P. Ford
发明人： John P. Ford
IPC分类号： A61K31/513 , A61P17/00 , A61P43/00
CPC分类号： A61K31/513 , A61K31/00 , A61K31/337 , A61K31/505 , A61K31/555 , A61K31/704 , A61K31/7072 , A61K2300/00
摘要： Methods, compositions, and kits are presented for local tissue protection during systemic administration of anticancer therapeutic agents.

5. 发明申请

US20120244211A1 Compositions And Methods For Treatment Of The Side-Effects Associated With Administration Of Cancer Chemotherapeutic Agents 有权
标题翻译：用于治疗与癌症化疗药物相关的副作用的组合物和方法
公开(公告)号：US20120244211A1
公开(公告)日：2012-09-27
申请号：US13446328
申请日：2012-04-13
申请人： John P. Ford
发明人： John P. Ford
IPC分类号： A61K31/52 , A61K9/127 , A61P1/00 , C07D473/34
CPC分类号： A61K9/127 , A61K31/513 , A61K31/7072 , A61K31/7076 , A61K45/06 , A61K2300/00
摘要： A composition and method for the treatment of the side-effects associated with the administration of cancer chemotherapeutic agents involves the oral ingestion of a slow release capsule containing adenine and orotate. The administration of a protein pump inhibitor decreases systemic absorption of orotate and the administration of allopurinol decreases the formation of 2,8-dihydroxy adenine from adenine. In an alternative embodiment, cationic liposomes contain purine/pyrimidine precursors. The cationic liposomes bind to the cells lining the mucosa of the intestinal tract and then the contents of the cationic liposome are then taken up in the interior of the cells to prevent the metabolism of the cancer treatment drug 5-FU into a toxic species.
摘要翻译：用于治疗与癌症化学治疗剂的给药相关的副作用的组合物和方法涉及口服摄取含有腺嘌呤和乳清酸的缓释胶囊。蛋白质泵抑制剂的施用降低乳清酸的全身吸收，并且施用别嘌呤醇降低腺嘌呤形成2,8-二羟基腺嘌呤。在另一个实施方案中，阳离子脂质体含有嘌呤/嘧啶前体。阳离子脂质体结合到肠道粘膜上的细胞，然后将阳离子脂质体的内容物吸收到细胞内部，以防止癌症治疗药物5-FU的代谢成为毒性物质。

6. 发明授权

US07816366B2 Compositions and methods for treating and preventing dermatoses 有权
标题翻译：用于治疗和预防皮肤病的组合物和方法
公开(公告)号：US07816366B2
公开(公告)日：2010-10-19
申请号：US12114602
申请日：2008-05-02
申请人： John P. Ford
发明人： John P. Ford
IPC分类号： A61K31/505 , A01N43/54
CPC分类号： A61K31/513 , A61K9/006 , A61K9/06 , A61K31/00 , A61K31/337 , A61K31/505 , A61K31/555 , A61K31/704 , A61K31/7072 , A61K2300/00
摘要： The invention encompasses protectant agents including uracil or a metabolite thereof that effectively prevent and/or treat the cutaneous toxicities and dermatological side-effects associated with chemotherapeutic agents. Additionally, and surprisingly compositions including uracil or a metabolite thereof are effective for treating or preventing various dermatoses.
摘要翻译：本发明包括有效预防和/或治疗与化学治疗剂相关的皮肤毒性和皮肤病学副作用的包括尿嘧啶或其代谢物的保护剂。此外，令人惊奇的是包含尿嘧啶或其代谢物的组合物对于治疗或预防各种皮肤病是有效的。

7. 发明授权

US08258147B2 Compositions and methods for treating and preventing dermatoses 有权
标题翻译：用于治疗和预防皮肤病的组合物和方法
公开(公告)号：US08258147B2
公开(公告)日：2012-09-04
申请号：US12893692
申请日：2010-09-29
申请人： John P. Ford
发明人： John P. Ford
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： A61K31/513 , A61K9/006 , A61K9/06 , A61K31/00 , A61K31/337 , A61K31/505 , A61K31/555 , A61K31/704 , A61K31/7072 , A61K2300/00
摘要： The invention encompasses protectant agents including uracil or a metabolite thereof that effectively prevent and/or treat the cutaneous toxicities and dermatological side-effects associated with chemotherapeutic agents. Additionally, and surprisingly compositions including uracil or a metabolite thereof are effective for treating or preventing various dermatoses.
摘要翻译：本发明包括有效预防和/或治疗与化学治疗剂相关的皮肤毒性和皮肤病学副作用的包括尿嘧啶或其代谢物的保护剂。此外，令人惊奇的是包含尿嘧啶或其代谢物的组合物对于治疗或预防各种皮肤病是有效的。

8. 发明授权

US09119855B2 Compositions and methods for treatment of the side-effects associated with administration of cancer chemotherapeutic agents 有权
标题翻译：用于治疗与癌症化学治疗剂的给药相关的副作用的组合物和方法
公开(公告)号：US09119855B2
公开(公告)日：2015-09-01
申请号：US14162155
申请日：2014-01-23
申请人： Asymmetric Therapeutics, LLC
发明人： John P. Ford
IPC分类号： A61K31/513 , A61K31/519 , A61K31/52 , A61K31/7004 , A61K9/127 , A61K45/06 , A61K9/00
CPC分类号： A61K31/513 , A61K9/0004 , A61K9/127 , A61K31/52 , A61K31/7004 , A61K45/06 , A61K2300/00
摘要： A composition and method for the treatment of the side-effects associated with the administration of cancer chemotherapeutic agents involves the oral ingestion of a slow release capsule containing adenine. In some embodiments, the slow release capsule also contains orotate. The systemic administration of a proton pump inhibitor decreases systemic absorption of orotate, and the systemic administration of allopurinol decreases the formation of 2,8-dihydroxy adenine from adenine. In an alternative embodiment, cationic liposomes contain purine/pyrimidine precursors. The cationic liposomes bind to the cells lining the mucosa of the intestinal tract and then the contents of the cationic liposome are then taken up in the interior of the cells to prevent the metabolism of the cancer treatment drug 5-FU into a toxic species. A method for prevention of oral stomatitis and a method for treatment of dysplastic tissue are also disclosed.
摘要翻译：用于治疗与癌症化学治疗剂的给药相关的副作用的组合物和方法涉及口服摄取含有腺嘌呤的缓释胶囊。在一些实施方案中，缓释胶囊还含有乳清酸。质子泵抑制剂的全身给药减少了乳清酸的全身吸收，并且全身施用别嘌呤醇降低了腺嘌呤形成的2,8-二羟基腺嘌呤。在另一个实施方案中，阳离子脂质体含有嘌呤/嘧啶前体。阳离子脂质体结合到肠道粘膜上的细胞，然后将阳离子脂质体的内容物吸收到细胞内部，以防止癌症治疗药物5-FU的代谢成为毒性物质。还公开了预防口腔炎的方法和治疗发育不良组织的方法。

9. 发明授权

US09084788B2 Compositions and methods for treating and preventing dermatoses 有权
标题翻译：用于治疗和预防皮肤病的组合物和方法
公开(公告)号：US09084788B2
公开(公告)日：2015-07-21
申请号：US13566632
申请日：2012-08-03
申请人： John P. Ford
发明人： John P. Ford
IPC分类号： A01N43/54 , A61K31/505 , A61K31/513 , A61K31/00 , A61K31/337 , A61K31/555 , A61K31/704 , A61K31/7072
CPC分类号： A61K31/513 , A61K9/006 , A61K9/06 , A61K31/00 , A61K31/337 , A61K31/505 , A61K31/555 , A61K31/704 , A61K31/7072 , A61K2300/00
摘要： The invention encompasses protectant agents including uracil or a metabolite thereof that effectively treat the cutaneous toxicities and dermatological side-effects associated with chemotherapeutic agents. Specifically, and surprisingly, the compositions of the invention including uracil or a metabolite thereof are effective for treating various dermatoses including atopic dermatitis, irritant contact dermatitis, radiation-induced dermatitis, dry skin dermatitis, papulopustular rashes, xerosis, pruitus, actinic keratosis, and genital warts.
摘要翻译：本发明包括有效治疗与化学治疗剂相关的皮肤毒性和皮肤病学副作用的包括尿嘧啶或其代谢物的保护剂。具体而且令人惊奇的是，包括尿嘧啶或其代谢物的本发明组合物可有效治疗各种皮肤病，包括特应性皮炎，刺激性接触性皮炎，辐射诱发的皮炎，干性皮肤皮炎，丘疹性腮腺炎，干燥症，瘙痒症，光化性角化病和生殖器疣。

10. 发明授权

US08653090B2 Compositions and methods for treatment of the side-effects associated with administration of cancer chemotherapeutic agents 有权
标题翻译：用于治疗与癌症化学治疗剂的给药相关的副作用的组合物和方法
公开(公告)号：US08653090B2
公开(公告)日：2014-02-18
申请号：US13446328
申请日：2012-04-13
申请人： John P. Ford
发明人： John P. Ford
IPC分类号： A01N43/90 , A61K31/52 , C07D473/00 , A61K9/127
CPC分类号： A61K9/127 , A61K31/513 , A61K31/7072 , A61K31/7076 , A61K45/06 , A61K2300/00
摘要： A composition and method for the treatment of the side-effects associated with the administration of cancer chemotherapeutic agents involves the oral ingestion of a slow release capsule containing adenine and orotate. The administration of a protein pump inhibitor decreases systemic absorption of orotate and the administration of allopurinol decreases the formation of 2,8-dihydroxy adenine from adenine. In an alternative embodiment, cationic liposomes contain purine/pyrimidine precursors. The cationic liposomes bind to the cells lining the mucosa of the intestinal tract and then the contents of the cationic liposome are then taken up in the interior of the cells to prevent the metabolism of the cancer treatment drug 5-FU into a toxic species.
摘要翻译：用于治疗与癌症化学治疗剂的给药相关的副作用的组合物和方法涉及口服摄取含有腺嘌呤和乳清酸的缓释胶囊。蛋白质泵抑制剂的施用降低乳清酸的全身吸收，并且施用别嘌呤醇降低腺嘌呤形成2,8-二羟基腺嘌呤。在另一个实施方案中，阳离子脂质体含有嘌呤/嘧啶前体。阳离子脂质体结合到肠道粘膜上的细胞，然后将阳离子脂质体的内容物吸收到细胞内部，以防止癌症治疗药物5-FU的代谢成为毒性物质。

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