专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5709676A Synergistic treatment of stenosed blood vessels using shock waves and dissolving medication 失效
标题翻译：使用冲击波和溶解药物协同治疗狭窄的血管
公开(公告)号：US5709676A
公开(公告)日：1998-01-20
申请号：US561831
申请日：1995-11-27
申请人： Eckhard Alt
发明人： Eckhard Alt
IPC分类号： A61B17/22 , A61B18/24 , A61B18/26 , A61N5/06
CPC分类号： A61B18/26 , A61B18/245 , A61B2017/22038 , A61B2017/22084
摘要： A method for removing a thrombus or plaque deposit from the wall of a blood vessel of a patient is enhanced by synergistic action of two individual procedures. A catheter is introduced into a blood vessel from which a thrombus or plaque deposit is to be removed. The first procedure is application of laser energy through an optical fiber in the catheter, in a wavelength range selected for preferred absorption by red blood cells in the blood vessel to generate a plasma-based ultrasonic shock wave in the vessel. The shock wave impacts on the thrombus or plaque deposit to open fissures therein. In the second procedure, a thrombus- or plaque-dissolving medication is injected into the blood stream in the vicinity of the plaque deposit through a lumen in the catheter, promptly after completion of the first procedure. The thrombus- or plaque-dissolving medication is used to penetrate into the fissures created in the thrombus or plaque deposit by the shock wave, to begin to break up or dissolve the thrombus or plaque of the deposit. Thereafter, the first and second procedures are repeated in the same sequence at least once, and preferably several times, to ultimately fragment the plaque deposit so that the fragments may be removed from the blood vessel through the channel in the catheter. The overall process, including several repetitions of the sequence of procedures, is carried out in about 10 minutes.
摘要翻译：通过两个单独程序的协同作用，增强了从患者血管壁上去除血栓或斑块沉积物的方法。将导管引入血管，血栓或斑块沉积物将从该血管中去除。第一个过程是通过导管中的光纤施加激光能量，其波长范围被选择用于血管中红细胞的优选吸收，以在血管中产生基于血浆的超声冲击波。冲击波影响血栓或斑块沉积物，以开裂裂缝。在第二步骤中，在第一程序完成后，通过导管中的内腔将血栓或斑块溶解药物注入到斑块沉积物附近的血流中。血栓或斑块溶解药物用于穿透冲击波在血栓或斑块沉积物中产生的裂缝，开始破裂或溶解沉积物的血栓或斑块。此后，以相同的顺序以相同的顺序重复第一和第二步骤至少一次，优选几次，以最终将斑块沉积物分裂，使得片段可以通过导管中的通道从血管中移除。整个过程，包括几个重复的程序顺序，在大约10分钟内进行。

2. 发明授权

US5653734A Method of atrial defibrillation employing a temporary implanted catheter 失效
标题翻译：使用临时植入导管的心房除颤方法
公开(公告)号：US5653734A
公开(公告)日：1997-08-05
申请号：US630907
申请日：1996-04-04
申请人： Eckhard Alt
发明人： Eckhard Alt
IPC分类号： A61N1/04 , A61N1/05 , A61N1/39
CPC分类号： A61N1/0563
摘要： Atrial fibrillation disorders are treated by locating low impedance electrodes positioned on a single catheter body passing through the pulmonary artery valve to locate the electrodes respectively in the right atrium and the pulmonary artery. Thus an electrical energy impulse of the order of three joules is passed through a heart and tissue path establishing a field gradient for resetting atrially fibrillating cells to convert atrial fibrillation into sinus rhythm. A special non-implantable catheter for temporary use provided for this treatment method is characterized by an inflatable balloon on the distal tip end, two low impedance energy discharging electrodes spaced to reside respectively in the right atrium and the pulmonary artery and a flexible polymer catheter body sheath of a diameter of the order of two millimeters. Inflating and deflating of the distal balloon facilitates the positioning of the catheter and guarantees a stable position during the application of the electrical energy shock for conversion of atrial fibrillation.
摘要翻译：通过定位穿过肺动脉瓣的单个导管体上的低阻抗电极，将电极分别定位在右心房和肺动脉中来治疗心房颤动障碍。因此，三焦耳数量级的电能脉冲通过心脏和组织路径，建立场梯度，用于重建心房纤维化细胞以将心房颤动转变为窦性心律。用于这种治疗方法的临时使用的特殊非植入式导管的特征在于远侧末端具有可膨胀气囊，两个低阻抗能量放电电极分别分开放置在右心房和肺动脉中以及柔性聚合物导管体直径约为2毫米的护套。远端球囊的充气和放气有利于导管的定位，并保证在施加用于心房颤动转化的电能冲击期间的稳定位置。

3. 发明授权

US5928269A Apparatus and method for temporary atrial defibrillation with external defibrillator and implanted transvenous catheter and electrodes 失效
标题翻译：用外部去纤颤器和植入的静脉导管和电极进行临时心房除颤的装置和方法
公开(公告)号：US5928269A
公开(公告)日：1999-07-27
申请号：US906352
申请日：1997-08-05
申请人： Eckhard Alt
发明人： Eckhard Alt
IPC分类号： A61N1/05 , A61N1/39
CPC分类号： A61N1/0563
摘要： Apparatus is disclosed for temporary treatment of atrial fibrillation of a patient's heart for limited periods of time. An external control unit generates electrical shock impulses; and is electrically connected to spaced-apart defibrillation electrodes of a flexible catheter adapted for temporary implantation in the body of a patient. One of the defibrillation electrodes is positioned in the right atrium of the patient's heart and the other defibrillation electrode is positioned elsewhere proximate the heart to establish a vector through the atrial chambers. A shock impulse is selectively applied from the control unit across the electrodes with a magnitude to establish an adequate field gradient between them so as to cardiovert atrial fibrillation to sinus rhythm. Monitoring of intracardiac and/or surface ECG activity enables detection of the QRS complex to trigger the selective application for delivery of a shock impulse in synchronization with the QRS complex.
摘要翻译：公开了用于在有限时间段内暂时治疗患者心脏的心房颤动的装置。外部控制单元产生电击冲击; 并且电连接到适于临时植入患者体内的柔性导管的间隔开的除颤电极。除颤电极中的一个位于患者心脏的右心房中，另一个除颤电极位于心脏附近的其他位置，以建立通过心房的载体。选择性地从控制单元穿过电极施加冲击脉冲，其大小以在它们之间建立足够的磁场梯度，以将心房颤动转换为窦性心律。监测心内和/或表面ECG活动使得能够检测QRS复合物以触发与QRS复合体同步的递送冲击脉冲的选择性应用。

4. 发明授权

US5078133A Pacemaker methods and pacing control systems operable from a preferred one of at least two pacing rate control signals 失效
标题翻译： PACEMAKER方法和PACING控制系统可以从一个最佳两个速率控制信号
公开(公告)号：US5078133A
公开(公告)日：1992-01-07
申请号：US518511
申请日：1990-05-02
申请人： Michael E. Heinz , Heinz P. Theres
发明人： Michael E. Heinz , Heinz P. Theres
IPC分类号： A61N1/368
CPC分类号： A61N1/368
摘要： This pacing system relates to a rate varying cardiac pacemaker (1) for electrically stimulating the heart of a pacemaker wearer. The electrical cardiogenic heart depolarization is detected on a multipolar single probe with the aid of individual electrodes (7 to 10). Bipolar electrodes in the atrium allows for detection of the intra-atrial actions (P-wave) as a first rate control signal for controlling the pacemaker in the atrially triggered ventricular pacing mode (VDD). A second rate control signal other than the P-wave correlating with patient activity is determined in parallel with the P-wave control signal. The two control signals are compared to decide if the intra atrial actions (P-waves) are appropriate control signals. Pace rate control is switched between the two signals in order to produce the most beneficial pacing mode to the patient, for example, VDD or VVI rate responsive modes. This control system can respond to unreliability or instabilities of the intrinsic atrial P-wave signal, for example, fibrillation and shift control to another appropriate rate responsive mode.
摘要翻译：该起搏系统涉及用于电刺激起搏器佩戴者的心脏的速率变化心脏起搏器（1）。借助于单个电极（7至10），在多极单探针上检测电心脏心脏去极化。心房中的双极电极允许检测心房内动作（P波）作为用于控制心律起搏心室起搏模式（VDD）的起搏器的第一速率控制信号。与P波控制信号并行地确定与患者活动相关的P波以外的第二速率控制信号。比较两个控制信号以确定心房内动作（P波）是否是适当的控制信号。在两个信号之间切换速率控制，以便为患者产生最有利的起搏模式，例如VDD或VVI速率响应模式。该控制系统可以响应固有心房P波信号的不可靠性或不稳定性，例如，原纤化和换档控制到另一适当的速率响应模式。

5. 发明授权

US4979507A Energy saving cardiac pacemaker 失效
标题翻译：节能心脏起搏器
公开(公告)号：US4979507A
公开(公告)日：1990-12-25
申请号：US347435
申请日：1989-05-03
申请人： Michael E. Heinz , Heinz P. Theres
发明人： Michael E. Heinz , Heinz P. Theres
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/37
摘要： This invention has as an objective the universal matching of individual patient-pacemaker-implant electrode interface conditions to follow dynamic changes occurring in use, from pacemaker to pacemaker and from patient to patient to control the pacing pulse energy in operation most efficiently to prolong battery life. Information from the implanted stimulation electrode is analyzed to discriminate the energy level of pulses effective and ineffective to stimulate a heartbeat for at least two different stimulation pulse characteristics. This analyzed information is automatically processed in logic circuits to conform with the requirements of particular pacemaker adjustments to develop an optimized energy pacing pulse with adequate safety margin. Programming and logic equipment can be in the pacemaker, but additional energy saving with those calculations takes place when it is external to the pacemaker and bidirectional communication of information takes place with the pacemaker. Periodic automatic programming can take place in implanted pacemaker installations for continuous long term monitoring and control to obtain the optimum battery life and adequate safety standards.
摘要翻译：本发明的目的是将个体患者起搏器 - 植入物电极界面条件的普遍匹配跟随使用中发生的动态变化，从起搏器到起搏器和患者到患者，以最有效地控制起搏脉冲能量以最有效地延长电池寿命。分析来自植入的刺激电极的信息以区分有效和无效的脉冲的能量水平以刺激至少两个不同的刺激脉冲特性的心跳。该分析的信息在逻辑电路中自动处理，以符合特定起搏器调整的要求，以开发具有足够安全余量的优化的能量起搏脉冲。编程和逻辑设备可以在起搏器中，但是如果在起搏器外部进行计算，则可以额外节省能量，并且与起搏器进行信息的双向通信。定期自动编程可以在植入式起搏器安装中进行，用于连续的长期监测和控制，以获得最佳的电池寿命和足够的安全标准。

6. 发明授权

US6001054A Method and apparatus for differential energy application for local dose enhancement of ionizing radiation 失效
标题翻译：用于电离辐射局部剂量增强的差分能量应用的方法和装置
公开(公告)号：US6001054A
公开(公告)日：1999-12-14
申请号：US81954
申请日：1998-05-19
申请人： D. F. Regulla , Eckhard Alt
发明人： D. F. Regulla , Eckhard Alt
IPC分类号： A61N5/10 , A61N5/00
CPC分类号： A61N5/1001 , A61N2005/1098 , A61N5/1002
摘要： A method for treating a site in a human body to inhibit abnormal proliferation of tissue at the site includes introducing into the body at the site a metal surface which generally conforms in shape to the shape of tissue to be treated at the site. Tissue at the site is then irradiated with ionizing radiation directed onto the metal surface from a point external to the surface so as to obtain locally enhanced radiation therapy by an amplification of the radiation dosage delivered to tissue adjacent to the metal surface as a result of backscattered radiation from the metal surface. Irradiating the tissue is performed by directing a beam of radiation with an energy content selected to have a value in a range from about 10 KeV to about 400 KeV, preferably about 40 KeV, from a point external to the body toward the metal surface and onto the tissue to be treated. The metal surface, which may be solid or composed of spaced apart particles, is selected to incorporate a metal or metal ions having an atomic number greater than 20 and of at least about 40. A synergistic effect may be achieved by employing at least one of a cytostatic drug therapy and a genetically based therapy to treat the tumor, in combination with the locally enhanced radiation therapy.
摘要翻译：用于治疗人体内部位以抑制组织在该部位的异常增生的方法包括在该部位的身体中引入通常符合形状的金属表面与该部位待处理组织的形状。然后在该部位的组织用从表面外部的点向金属表面照射的电离辐射照射，以便通过放射由于反向散射而传递到邻近金属表面的组织的辐射剂量的扩大来获得局部增强的放射治疗来自金属表面的辐射。通过将能量含量选择为具有约10KeV至约400KeV，优选约40KeV的值的辐射束，从身体外部的位置朝向金属表面引导辐射束并进入待处理的组织。选择可以是实心的或由间隔开的颗粒组成的金属表面，以引入原子序数大于20并且至少约40的金属或金属离子。可以通过使用以下中的至少一种来实现协同效应：结合局部增强放射治疗，进行细胞抑制药物治疗和基因治疗肿瘤治疗。

7. 发明授权

US5980566A Vascular and endoluminal stents with iridium oxide coating 失效
标题翻译：血管和腔内支架与氧化铱涂层
公开(公告)号：US5980566A
公开(公告)日：1999-11-09
申请号：US59054
申请日：1998-04-11
申请人： Eckhard Alt , Lawrence J. Stotts
发明人： Eckhard Alt , Lawrence J. Stotts
IPC分类号： A61F2/00 , A61F2/91 , A61F2/915 , A61N5/10 , A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2210/0095 , A61F2310/00598 , A61F2310/0088 , A61N5/1002
摘要： A vascular stent adapted to be implanted in a blood vessel of a human patient to enhance the flow of blood therethrough, includes an elongate biocompatible metal member of cylindrical shape and tubular sidewall with a pattern of multiple openings therethrough and open ends. The stent has an insertion outer diameter sufficiently small to enable it to be inserted into and advanced through a portion of the vascular system of the body to a preselected point within a coronary artery. The sidewall has a thin adherent coating of iridium oxide covering substantially its entire exposed surface, including the outward-facing surface between openings, the edges of the openings, the inward-facing surface between openings, and the edge of each of the open ends. The coating is of substantially uniform thickness throughout its coverage of the surface of the sidewall, and serves to reduce irritation of tissue of the inner lining of the vessel wall into which the outward-facing surface of the stent comes into contact. The tissue may project as well into the openings in the sidewall to contact the edges thereof. The iridium oxide coating has a biodegradable carrier of drugs applied thereto for beneficial localized action, as by incorporating into the carrier along the inward-facing surface an anticoagulant drug to reduce attachment of thrombi with blood flow through the lumen of the stent. Although it may be composed of multiple layers, the iridium oxide coating is sufficiently thin and flexible to resist flaking during deployment, and the core member has sufficient rigidity when so deployed to resist collapse.
摘要翻译：适于被植入人类患者的血管中以增强血液通过其中的血管支架包括细长的圆柱形生物相容性金属构件和管状侧壁，其具有穿过其和开口端的多个开口的图案。支架具有足够小的插入外径，使得其能够插入和推进通过身体的血管系统的一部分到冠状动脉内的预选点。侧壁具有覆盖基本上其整个暴露表面的氧化铱的薄粘附涂层，包括开口之间的向外的表面，开口的边缘，开口之间的向内的表面以及每个开口端的边缘。涂层在整个侧壁表面的覆盖范围内具有基本上均匀的厚度，并且用于减少支架的面向外的表面与其接触的容器壁的内衬的组织的刺激。组织也可以突出到侧壁中的开口中以接触其边缘。氧化铱涂层具有用于有益的局部作用的药物的可生物降解的载体，如通过沿内向表面掺入载体中的抗凝血剂药物，以减少凝血血栓与支架内腔的血流的附着。虽然它可以由多层组成，但是氧化铱涂层足够薄且柔软以抵抗在展开期间的剥落，并且当构造成抵抗塌陷时，芯构件具有足够的刚性。

8. 发明授权

US5571159A Temporary atrial defibrillation catheter and method 失效
标题翻译：临时心房除颤导管及方法
公开(公告)号：US5571159A
公开(公告)日：1996-11-05
申请号：US222242
申请日：1994-04-04
申请人： Eckhard Alt
发明人： Eckhard Alt
IPC分类号： A61N1/04 , A61N1/05
CPC分类号： A61N1/0563
摘要： Atrial fibrillation disorders are treated by locating low impedance electrodes positioned on a single catheter body passing through the pulmonary artery valve to locate the electrodes respectively in the right atrium and the pulmonary artery. Thus an electrical energy impulse of the order of three joules is passed through a heart and tissue path establishing a field gradient for resetting atrially fibrillating cells to convert atrial fibrillation into sinus rhythm. A special non-implantable catheter for temporary use provided for this treatment method is characterized by an inflatable balloon on the distal tip end, two low impedance energy discharging electrodes spaced to reside respectively in the right atrium and the pulmonary artery and a flexible polymer catheter body sheath of a diameter of the order of two millimeters. Inflating and deflating of the distal balloon facilitates the positioning of the catheter and guarantees a stable position during the application of the electrical energy shock for conversion of atrial fibrillation.
摘要翻译：通过定位穿过肺动脉瓣的单个导管体上的低阻抗电极，将电极分别定位在右心房和肺动脉中来治疗心房颤动障碍。因此，三焦耳数量级的电能脉冲通过心脏和组织路径，建立场梯度，用于重建心房纤维化细胞以将心房颤动转变为窦性心律。用于这种治疗方法的临时使用的特殊非植入式导管的特征在于远侧末端具有可膨胀气囊，两个低阻抗能量放电电极分别分开放置在右心房和肺动脉中以及柔性聚合物导管体直径约为2毫米的护套。远端球囊的充气和放气有利于导管的定位，并保证在施加用于心房颤动转化的电能冲击期间的稳定位置。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式