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1. 发明授权

US07419786B2 Methods for monitoring PCR amplification with fluorescently labeled probes or primers for which fluorescence changes upon hybridization to a target 有权
标题翻译：用荧光标记的探针或引物监测PCR扩增的方法，在与靶标杂交时荧光发生变化
公开(公告)号：US07419786B2
公开(公告)日：2008-09-02
申请号：US11340574
申请日：2006-01-27
申请人： Ryuichiro Kurane , Takahiro Kanagawa , Yoichi Kamagata , Shinya Kurata , Kazutaka Yamada , Toyokazu Yokomaku , Osamu Koyama , Kenta Furusho
发明人： Ryuichiro Kurane , Takahiro Kanagawa , Yoichi Kamagata , Shinya Kurata , Kazutaka Yamada , Toyokazu Yokomaku , Osamu Koyama , Kenta Furusho
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6816 , C12Q1/6827 , C12Q1/6837 , C12Q1/6851 , C12Q1/6858 , C12Q2565/549 , C12Q2565/107 , C12Q2563/107 , C12Q2525/185
摘要： A method is provided for determining a concentration of a target nucleic acid by using a nucleic acid probe labeled with a fluorescent dye. The method comprises: providing, as the probe, a nucleic acid probe capable of reducing fluorescence emission from the fluorescent dye when hybridized with the target nucleic acid; hybridizing the probe to the target nucleic acid; and measuring a decrease in fluorescence emission from the fluorescent dye after the hybridization relative to fluorescence emission from the fluorescent dye before the hybridization.
摘要翻译：提供了通过使用用荧光染料标记的核酸探针来测定靶核酸的浓度的方法。该方法包括：当与靶核酸杂交时，提供能够减少来自荧光染料的荧光发射的核酸探针作为探针; 将探针与目标核酸杂交; 并测量在杂交之前相对于来自荧光染料的荧光发射的杂交后荧光染料的荧光发射的减少。

2. 发明授权

US07186302B2 Fabrication of nonpolar indium gallium nitride thin films, heterostructures and devices by metalorganic chemical vapor deposition 有权
标题翻译：通过金属有机化学气相沉积制造非极性氮化铟镓薄膜，异质结构和器件
公开(公告)号：US07186302B2
公开(公告)日：2007-03-06
申请号：US11123805
申请日：2005-05-06
申请人： Arpan Chakraborty , Benjamin A. Haskell , Stacia Keller , James Stephen Speck , Steven P. Denbaars , Shuji Nakamura , Umesh Kumar Mishra
发明人： Arpan Chakraborty , Benjamin A. Haskell , Stacia Keller , James Stephen Speck , Steven P. Denbaars , Shuji Nakamura , Umesh Kumar Mishra
IPC分类号： H01L29/04
CPC分类号： H01L21/0242 , H01L21/02378 , H01L21/02389 , H01L21/02433 , H01L21/02458 , H01L21/02502 , H01L21/0254 , H01L21/02609 , H01L21/0262 , H01L21/02647 , H01L33/0075 , H01L33/18 , Y10S438/938
摘要： A method for the fabrication of nonpolar indium gallium nitride (InGaN) films as well as nonpolar InGaN-containing device structures using metalorganic chemical vapor deposition (MOVCD). The method is used to fabricate nonpolar InGaN/GaN violet and near-ultraviolet light emitting diodes and laser diodes.
摘要翻译：制造非极性铟镓氮（InGaN）膜以及使用金属有机化学气相沉积（MOVCD）的非极性含InGaN的器件结构的方法。该方法用于制造非极性InGaN / GaN紫外线和近紫外发光二极管和激光二极管。

3. 发明授权

US07087406B2 Human-derived bradeion proteins, DNA coding for the proteins, and uses thereof 失效
公开(公告)号：US07087406B2
公开(公告)日：2006-08-08
申请号：US10190555
申请日：2002-07-09
申请人： Manami Tanaka , Tomoo Tanaka
发明人： Manami Tanaka , Tomoo Tanaka
IPC分类号： C12P21/06 , C12N15/74 , C12N5/02 , C07K14/00
CPC分类号： C12Q1/6886 , C07K14/4747 , C07K14/71 , C07K14/715 , C12Q2600/158 , G01N33/57419 , G01N33/5743
摘要： A human-derived bradeion protein, which has the following properties: (i) it is a transmembranous protein; (ii) it has a structure characteristic of growth hormone and cytokine receptors even in a structure of its transmembranous portion when its structure is determined by a hydrophobicity analysis according to Kyte-Doolittle method; (iii) it is expressed at a high level in a human adult brain, and in less amount in the heart, while it is not expressed in other adult organs or fetus; (iv) it induces programmed cell death (apoptosis) when over-expressed in a cultured human nerve cell lines; (v) it induces termination of cell division and aging when over-expressed in a cultured human normal cell; (vi) it is located in cytoplasm, and forms an intracellular aggregate when overexpressed; and (vii) besides human adult neurons, it is specifically expressed in a human colorectal cancer cell line or in a skin cancer cell line, or an analogue thereof.

4. 发明授权

US07022310B2 Stable isotope-labeled amino acid and method for incorporating same into target protein 有权
标题翻译：稳定同位素标记的氨基酸和将其并入靶蛋白的方法
公开(公告)号：US07022310B2
公开(公告)日：2006-04-04
申请号：US10872163
申请日：2004-06-18
申请人： Masatsune Kainosho , Tsutomu Terauchi
发明人： Masatsune Kainosho , Tsutomu Terauchi
IPC分类号： A61B5/055 , C12P13/04 , C12P9/00 , C07K1/00
CPC分类号： C07B59/001 , C07B2200/05 , C07C51/09 , C07C229/08 , C07C229/22 , C07C229/24 , C07C229/26 , C07C229/36 , C07C323/58 , C07K1/13 , G01N24/08 , C07C57/15
摘要： The present invention provides a stable isotope-labeled amino acid which is at least one of amino acids constituting a protein and which has at least one of the following labeling patterns: (a) hydrogen atoms except at least one hydrogen atom in one or more methylene groups are deuterated, (b) hydrogen atoms in one of prochiral gem-methyl groups are completely deuterated, (c) hydrogen atoms in prochiral methyl groups are partially deuterated, and (d) all hydrogen atoms except one of them in methyl group are deuterated and hydrogen atoms in the aromatic ring are partially deuterated. With the stable isotope-labeled amino acid, the deuteration of protein can be attained without damaging the NMR sensitivity of remaining hydrogen nucleus and, in addition, the rapid, accurate analysis of NMR spectrum of a high-molecular protein which is beyond the limitation in the prior art and the determination of the stereo-structure can be performed at the same time.
摘要翻译：本发明提供了一种稳定同位素标记的氨基酸，其是构成蛋白质的氨基酸中的至少一种，并且具有以下标记模式中的至少一种：（a）氢原子，除了一个或多个亚甲基中的至少一个氢原子 de uter uter de de de de de ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated ated 并且芳环中的氢原子被部分氘化。利用稳定的同位素标记的氨基酸，可以获得蛋白质的氘化，而不会损害剩余氢核的核磁共振灵敏度，此外，快速准确地分析高分子蛋白质的NMR光谱，超过了现有技术和立体结构的确定可以同时进行。

5. 发明申请

US20060052584A1 Human-derived bradeion proteins, DNA coding for the proteins, and uses thereof 审中-公开
公开(公告)号：US20060052584A1
公开(公告)日：2006-03-09
申请号：US11224297
申请日：2005-09-13
申请人： Manami Tanaka , Tomoo Tanaka
发明人： Manami Tanaka , Tomoo Tanaka
IPC分类号： C12Q1/68 , C07H21/04 , C07K14/72 , C07K14/82
CPC分类号： C12Q1/6886 , C07K14/4747 , C07K14/71 , C07K14/715 , C12Q2600/158 , G01N33/57419 , G01N33/5743
摘要： A human-derived bradeion protein, which has the following properties: (i) it is a transmembranous protein; (ii) it has a structure characteristic of growth hormone and cytokine receptors even in a structure of its transmembranous portion when its structure is determined by a hydrophobicity analysis according to Kyte-Doolittle method; (iii) it is expressed at a high level in a human adult brain, and in less amount in the heart, while it is not expressed in other adult organs or fetus; (iv) it induces programmed cell death (apoptosis) when over-expressed in a cultured human nerve cell lines; (v) it induces termination of cell division and aging when over-expressed in a cultured human normal cell; (vi) it is located in cytoplasm, and forms an intracellular aggregate when overexpressed; and (vii) besides human adult neurons, it is specifically expressed in a human colorectal cancer cell line or in a skin cancer cell line, or an analogue thereof.

6. 发明授权

US06858694B2 Stimuli-responsive polymer utilizing keto-enol tautomerization and stimuli-responsive separating material and chemical-releasing capsule comprising the same 有权
标题翻译：利用酮 - 烯醇互变异构化和刺激响应性分离材料的刺激响应性聚合物和包含其的化学释放胶囊
公开(公告)号：US06858694B2
公开(公告)日：2005-02-22
申请号：US10869967
申请日：2004-06-18
申请人： Noriyuki Ohnishi , Kazumi Aoshima , Kazunori Kataoka , Katsuhiko Ueno
发明人： Noriyuki Ohnishi , Kazumi Aoshima , Kazunori Kataoka , Katsuhiko Ueno
IPC分类号： B01J20/26 , C07C231/08 , C07C231/10 , C07C233/18 , C07C233/90 , C08F20/52 , C08F220/52 , G01N30/54 , C08F26/00
CPC分类号： G01N30/482 , B01J20/26 , B01J2220/54 , C07C231/08 , C07C231/10 , C07C233/18 , C08F20/52 , C08F220/52 , G01N30/54 , C07C233/90
摘要： A stimuli-responsive polymer derivative utilizing keto-enol tautomerization. Also disclosed are a simple process for producing an N-acyl(meth)acrylamide derivative which can be used as a monomer for the stimuli-responsive polymer, a process for the production of an intermediate thereof, and an intermediate thus produced.
摘要翻译：一种利用酮 - 烯醇互变异构化的刺激响应性聚合物衍生物。还公开了可用作刺激响应性聚合物的单体的N-酰基（甲基）丙烯酰胺衍生物的简单方法，其中间体的制备方法和由此制备的中间体。

7. 发明授权

US06858428B2 Human and animal cell culture medium containing antithrombin III for suppressing cell death 失效
标题翻译：含有抗凝血酶III的人和动物细胞培养基用于抑制细胞死亡
公开(公告)号：US06858428B2
公开(公告)日：2005-02-22
申请号：US10214303
申请日：2002-08-08
申请人： Takao Saito , Sumio Maeda , Hidetoshi Inagaki
发明人： Takao Saito , Sumio Maeda , Hidetoshi Inagaki
IPC分类号： C12N9/74 , C12N5/00 , C12N5/02 , C12N5/07 , C12N5/077 , C12N5/09 , C12N5/10
CPC分类号： C12N5/0037 , C12N2501/70
摘要： The present invention provides low serum or serum free liquid culture media for human or animal cells, and the present invention relates to culture media containing antithrombin III and optionally heparin for the low-serum or serum-free culture of human or animal cells to suppress cell death. The antithrombin III is purified from human, bovine, or other animal serum, or antithrombin III derived from recombinant bacteria or cells containing the full length of the antithrombin III gene.
摘要翻译：本发明提供用于人或动物细胞的低血清或无血清液体培养基，本发明涉及含有抗凝血酶III和任选的肝素用于人或动物细胞的低血清或无血清培养物以抑制细胞的培养基死亡。来自人，牛或其他动物血清的抗凝血酶III或衍生自重组细菌或含有全长抗凝血酶III基因的细胞的抗凝血酶III。

8. 发明申请

US20040116048A1 Ultra fine particle film forming method and apparatus 有权
标题翻译：超细颗粒成膜方法和装置
公开(公告)号：US20040116048A1
公开(公告)日：2004-06-17
申请号：US10690431
申请日：2003-10-20
申请人： SECRETARY OF AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY
发明人： Jun Akedo
IPC分类号： B24C001/00
CPC分类号： H05K3/14 , B24C1/00 , B24C1/10 , B24C5/04 , C23C4/18 , C23C24/00 , C23C24/04 , H01L41/314 , H05K3/102 , H05K2203/0143 , H05K2203/025 , H05K2203/0257 , H05K2203/0278 , H05K2203/105 , H05K2203/1344
摘要： A ultra fine particle film forming apparatus is provided which is capable of forming a ultra fine particle film which has ultra fine particles sufficiently bonded together, sufficient density, flat surface and uniform density. A planarized ultra fine particle film forming method for forming a planarized ultra fine particle film from a deposited film of ultra fine particles formed by supplying the ultra fine particles to a substrate, the method comprising one or more of a planarizing step of planarizing a surface of the deposited film of the ultra fine particles supplied to the substrate.
摘要翻译：提供了一种超细颗粒成膜装置，其能够形成具有充分粘合在一起的足够密度，平坦表面和均匀密度的超细颗粒的超细颗粒膜。一种平面化的超细颗粒膜形成方法，用于从通过将超细颗粒供给到基底而形成的超细颗粒的沉积膜形成平坦化超细颗粒膜，所述方法包括一个或多个平坦化步骤，提供给基板的超细颗粒的沉积膜。

9. 发明申请

US20020026032A1 3, 5-Dioxa-12-azawurtzitane compound and process of preparing same 有权
标题翻译： 3,5-二氧基-12-氮杂唑烷烷化合物及其制备方法
公开(公告)号：US20020026032A1
公开(公告)日：2002-02-28
申请号：US09733063
申请日：2000-12-11
申请人： SECRETARY OF AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY AND Hiroshi IZUMI
发明人： Hiroshi Izumi , Shigeru Futamura
IPC分类号： C07K014/00 , C07K005/00 , C07D491/08
CPC分类号： C07D498/22
摘要： A 3,5-dioxa-12-azawurtzitane compound represented by the formula (I) shown in the specification. The dioxaazawurtzitane compound may be prepared by reacting an amino acid, an oligo- or polypeptide or a polyamino acid with a trialdehyde represented by formula (II) shown in the specification.
摘要翻译：由说明书中所示的式（I）表示的3,5-二氧杂-10-氮杂异丙叉烷化合物。二恶氮杂芽孢杆菌化合物可以通过使氨基酸，寡聚物或多肽或聚氨基酸与说明书中所示的式（II）表示的戊醛反应来制备。

10. 发明申请

US20010041530A1 Local clean method and local clean processing and treating apparatus 审中-公开
标题翻译：局部清洁方法和本地清洁加工处理设备
公开(公告)号：US20010041530A1
公开(公告)日：2001-11-15
申请号：US09751982
申请日：2000-12-29
申请人： SECRETARY OF AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY
发明人： Shiro Hara
IPC分类号： B01L001/04
CPC分类号： H01L21/67017 , F24F3/161 , H01L21/67772
摘要： The present invention provides a method which when a semi-finished product requiring cleanliness is transported between a processing and treating apparatus and a sealed vessel, maintains cleanliness of atmosphere without cleaning outside. When the transported sealed vessel is connected to an air lock means provided on the processing and treating apparatus, space of the air lock means is blocked from the outside such as cleanroom. After that, the air lock space is removed of contaminated external atmosphere. Then, transfer of the semi-finished product is performed between the vessel and the processing and treating apparatus. During this time, the sealed vessel and the processing and treating apparatus is maintained in the cleanliness. This invention localizes and saves the clean plenum needed for clean fabrication, which realizes the reduction of environmental cleanliness in a clean factory. Also, compared with the minienvironment method, this invention saves the footprints of fabrication apparatuses.
摘要翻译：本发明提供一种方法，当在加工处理装置和密封容器之间输送需要清洁的半成品时，保持清洁气氛而不需要在外部清洗。当运送的密封容器连接到设置在处理和处理装置上的气锁装置时，空气锁定装置的空间被阻挡在诸如洁净室之外的外部。之后，空气密封空间被污染的外界气氛除去。然后，在容器和处理和处理装置之间进行半成品的转移。在此期间，密封容器和加工处理装置保持清洁。本发明定位并节省清洁制造所需的清洁增压室，实现了清洁工厂环境清洁度的降低。此外，与环境保护方法相比，本发明节省了制造装置的占地面积。

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