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1. 发明授权

US09150596B2 Functionalized unsaturated double-decker derivatives of divinylsilsesquioxanes 有权
标题翻译：二乙烯基倍半硅氧烷的官能化不饱和双层衍生物
公开(公告)号：US09150596B2
公开(公告)日：2015-10-06
申请号：US14640618
申请日：2015-03-06
申请人： ADAM MICKIEWICZ UNIVERSITY
发明人： Marciniec Bogdan , Dudziec Beata , Zak Patrycja
IPC分类号： C07F7/21
CPC分类号： C07F7/21
摘要： The subject of the invention are new functionalized unsaturated double-decker derivatives of divinylsilsesquioxanes of the general formula 1. In the formula, R1 are the same and stand for an aryl group containing from 1 to 2 rings, R2 are the same and stand for an alkyl group containing carbon atoms from C1 to C2, substituted or unsubstituted aryl group containing from 1 to 2 rings, R3 are the same and stand for a substituted or unsubstituted aryl group containing from 1 to 2 rings or a group of the formula —R4-R5—, where R4 stands for an alkyl group containing carbon atoms from C1 to C3, while R5 stands for aryl group containing from 1 to 2 rings.
摘要翻译：本发明的主题是通式1的二乙烯基倍半硅氧烷的新的官能化不饱和双层甲基衍生物。在该式中，R 1相同，代表含有1至2个环的芳基，R 2相同并代表含C1至C2的碳原子的烷基，含有1-2个环的取代或未取代的芳基，R3相同，代表含有1至2个环的取代或未取代的芳基或式-R4- R5-，其中R4代表含有C1至C3的碳原子的烷基，R5代表含有1至2个环的芳基。

2. 发明申请

US20120157702A1 SYNTHESIS OF FLUOROCARBOFUNCTIONAL SILSESQUIOXANES 有权
标题翻译：氟代官能团硅藻糖的合成
公开(公告)号：US20120157702A1
公开(公告)日：2012-06-21
申请号：US13393380
申请日：2010-08-16
申请人： Bogdan Marciniec , Hieronim Maciejewski , Michal Dutkiewicz
发明人： Bogdan Marciniec , Hieronim Maciejewski , Michal Dutkiewicz
IPC分类号： C07F7/21
CPC分类号： C08G77/045 , C08G77/38 , C08G77/385 , C08G77/46
摘要： The subject of the invention is the method of synthesis of fluoracarbofunctional cage silsesquioxanes of the general formula in which • R1 stands for HCF2(CF2)n(CH2)mO(CH2)3Si(CH3)2O orHCF2(CF2)n(CH2)mO(CH2)3 group in which n=1-12, m=1-4; • R2, R3, R4, R5, R6, R7, R8 can be the same as R1 or different from it and stand all either for the (C1-C25) alkyl group or any aryl group, based on hydrosilylation of fluoroalkyl-allyl ether with an appropriate hydrogen-silsesquioxane in the presence of siloxide rhodium complex [{Rh(OSiMe3)(cod)}2] as a catalyst.
摘要翻译：本发明的主题是通式的氟代官能笼型倍半硅氧烷的合成方法，其中R1表示HCF2（CF2）n（CH2）mO（CH2）3Si（CH3）2O或HCF2（CF2）n（CH2） mO（CH 2）3基，其中n = 1-12，m = 1-4; R 2，R 3，R 4，R 5，R 6，R 7，R 8可以与R 1相同或不同，并且基于氟代烷基 - 烯丙基醚的氢化硅烷化，全部用于（C 1 -C 25）烷基或任何芳基在合适的氢硅倍半氧烷存在下，作为催化剂存在硅氧烷铑络合物[{Rh（OSiMe 3）（cod）} 2]。

3. 发明申请

US20190144636A1 MIXTURES OF SALTS FOR DISSOLVING CELLULOSE 审中-公开
公开(公告)号：US20190144636A1
公开(公告)日：2019-05-16
申请号：US16313823
申请日：2017-06-29
申请人： UNIVERSIDADE DE SANTIAGO DE COMPOSTELA , ADAM MICKIEWICZ UNIVERSITY FOUNDATION
发明人： Hector RODRIGUEZ MARTINEZ , Ana Maria SOTO CAMPOS , Olga STOLARSKA , Marcin SMIGLAK , Anna PAWLOWSKA
IPC分类号： C08L1/02 , C08J3/09
摘要： Mixtures of salts to dissolve cellulose. The present invention refers to a composition based in a eutectic mixture of imidazolium salts and natural biopolymers, in particular cellulose, its manufacturing process and method of use to obtain foils or films.The composition is based in a eutectic mixture of imidazolium salts with 0.1 to 50 wt % of biomass.

4. 发明申请

US20160024133A1 2,3'-ANHYDRO-2'-DEOXY-5-FLUOROURIDINE DERIVATIVES WITH CYTOTOXIC ACTIVITY, A MANUFACTURING PROCESS AND APPLICATION 有权
标题翻译：具有细胞毒活性的2,3'-壬基-2'-脱氧-5-氟尿嘧啶衍生物，制造方法和应用
公开(公告)号：US20160024133A1
公开(公告)日：2016-01-28
申请号：US14420487
申请日：2014-08-22
申请人： ADAM MICKIEWICZ UNIVERSITY
发明人： Lech CELEWICZ , Karol KACPRZAK , Piotr RUSZKOWSKI , Marta LEWANDOWSKA
IPC分类号： C07H19/10
CPC分类号： C07H19/10 , A61K33/42 , C07F9/24 , C07F9/6561 , C07H19/073
摘要： The subject matter of the invention is novel 2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1 where R is a trifluoromethyl, 2,2,2-trifluoroethyl, difluoromethyl, perfluoroethyl, 1-fluoroethyl, 2-fluoroethyl, 1,1 -difluoroethyl, 1,2-difluoroethyl, 2,2-difluoroethyl, 1,1,2-trifluoroethyl, 1,2,2-trifluoroethyl, 1,1,2,2-tetrafluoroethyl, 1,2,2,2-tetrafluoroethyl group. In a second aspect, the subject matter of the invention is a process for the manufacture of 2,3-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1.In a third aspect, the subject matter of the invention is an application of 2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.
摘要翻译：本发明的主题是通式1的2,3' - 脱氢-2'-脱氧-5-氟尿苷衍生物，其中R是三氟甲基，2,2,2-三氟乙基，二氟甲基，全氟乙基，1-氟乙基， 2-氟乙基，1,1-二氟乙基，1,2-二氟乙基，2,2-二氟乙基，1,1,2-三氟乙基，1,2,2-三氟乙基，1,1,2,2-四氟乙基， 2,2,2-四氟乙基。在第二方面，本发明的主题是制备通式1的2,3-脱水-2'-脱氧-5-氟尿苷衍生物的方法。在第三方面，本发明的主题是在抗癌治疗乳腺癌，宫颈癌，肺癌和鼻咽癌中应用通式1的2,3'-脱氢-2'-脱氧-5-氟尿苷衍生物。

5. 发明授权

US08680310B2 (E)-styryl-alkynylsubstituted silicon compounds and method of obtaining (E)-styryl-alkynylsubstituted silicon compounds 有权
标题翻译：（E） - 苯乙烯基 - 炔基取代的硅化合物和获得（E） - 苯乙烯基 - 炔基取代的硅化合物的方法
公开(公告)号：US08680310B2
公开(公告)日：2014-03-25
申请号：US13395196
申请日：2010-08-20
申请人： Bogdan Marciniec , Beata Dudziec , Monika Rzonsowska
发明人： Bogdan Marciniec , Beata Dudziec , Monika Rzonsowska
IPC分类号： C07F7/02 , C07F7/04
CPC分类号： C07F7/10 , C07F7/0838 , C07F7/1804 , C07F7/30
摘要： New (E)-styryl-alkynylsubstituted silicon compounds having the generalized formula 1 and A new method of obtaining (E)-styryl-alkynylsubstituted silicon compounds having the generalized formula 1. A denotes: phenylmethylsilyl, 1,4-bis(dimethylsilyl)benzene, 1,2-bis(dimethylsilyl)ethane, 1,1,3,3-tetramethyldisilazane, 1,1,3,3-tetramethyldisiloxane, R′ denotes: tri(isopropyl)silyl, 1-pentyl, 2-(trimethylsiloxy)-2-butyl, 1-(trimethylsiloxy)-1-cyclohexyl, triethylgermyl, R′ denotes: H or Cl and when A denotes phenylmethylsilyl then R″ denotes also methyl or a methoxy group. A method of obtaining (E)-styrylalkynylsubstituted silicon compounds having the generalized formula 1 where A, R′ and R″ denote the same as stated above by way of a silylative coupling reaction between a suitable substituted styrene and a suitable vinyl-alkynylsubstituted silicon compound in the presence of a ruthenium(II) complex as catalyst.
摘要翻译：具有通式1的新的（E） - 苯乙烯基 - 炔基取代的硅化合物和获得具有通式1的（E） - 苯乙烯基 - 炔基取代的硅化合物的新方法.A表示：苯基甲基甲硅烷基，1,4-双（二甲基甲硅烷基）苯，1,2-双（二甲基甲硅烷基）乙烷，1,1,3,3-四甲基二硅氮烷，1,1,3,3-四甲基二硅氧烷，R'表示三（异丙基）甲硅烷基，1-戊基，2-（三甲基甲硅烷氧基） 2-丁基，1-（三甲基甲硅烷氧基）-1-环己基，三乙基锗烷基，R'表示：H或Cl，当A表示苯基甲基甲硅烷基时，R“也表示甲基或甲氧基。一种获得具有通式1的（E） - 苯乙烯基炔基取代的硅化合物的方法，其中A，R'和R“表示与上述相同，通过合适的取代的苯乙烯和合适的乙烯基 - 炔基取代的硅化合物之间的甲硅烷基偶联反应在作为催化剂的钌（II）络合物的存在下。

6. 发明申请

US20120165565A1 SYNTHESIS OF FLUOROCARBOFUNCTIONAL ALKOXYSILANES AND CHLOROSILANES 审中-公开
标题翻译：氟代烷氧基硅烷和氯代硅烷的合成
公开(公告)号：US20120165565A1
公开(公告)日：2012-06-28
申请号：US13393371
申请日：2010-08-16
申请人： Bogdan Marciniec , Hieronim Maciejewski , Michal Dutkiewicz , Izabela Dabek , Joanna Karasiewicz
发明人： Bogdan Marciniec , Hieronim Maciejewski , Michal Dutkiewicz , Izabela Dabek , Joanna Karasiewicz
IPC分类号： C07F7/18 , C07F7/12
CPC分类号： C07F7/1876 , C07F7/14
摘要： The subject of invention is the method of synthesis of fluorocarbofunctional alkoxysilanes and chlorosilanes of the general formula HCF2(CF2)n(CH2)mOC3H7SiR1R2R3 in which -n takes values from 1 to 12, m takes values from 1 to 4,—R1 stands for an alkoxy group or halogen, if R1 stands for an alkoxy group, then R2 and R3 can be the same or different and stand for an alkoxy group containing C=1-4, alkyl group containing C=1-12 or an aryl group, if R1 stands for a halogen, then R2 and R3 can be the same or different and stand for based on hydrosilylation of an appropriate fluoroalkyl-allyl ether with an appropriate trisubstituted silane of the general formula HSiR1R2R3 in the presence of siloxide rhodium complex [{Rh(OSiMe3)(cod)}2] as a catalyst.
摘要翻译：本发明的主题是通式为HCF2（CF2）n（CH2）mOC3H7SiR1R2R3的氟代官能团烷氧基硅烷和氯硅烷的合成方法，其中-n取值为1至12，m取值为1至4，-R 1表示烷氧基或卤素，如果R1代表烷氧基，则R2和R3可以相同或不同，代表含C = 1-4的烷氧基，含C = 1-12的烷基或芳基，如果R1代表卤素，则R2和R3可以相同或不同，并且基于合适的氟代烷基 - 烯丙基醚与适当的三取代硅烷通式为HSiR1R2R3在硅氧烷铑络合物[{Rh （OSiMe 3）（cod）} 2]作为催化剂。

7. 发明授权

US09518069B2 Catalytic method for obtaining substituted (triorganosilyl)alkynes and their derivatives 有权
公开(公告)号：US09518069B2
公开(公告)日：2016-12-13
申请号：US14796370
申请日：2015-07-10
申请人： ADAM MICKIEWICZ UNIVERSITY
发明人： Ireneusz Kownacki , Bogdan Marciniec , Beata Dudziec , Agnieszka Kownacka , Mariusz Majchrzak , Mateusz Szulc , Bartosz Orwat
IPC分类号： C07F17/00 , C07F7/08 , C07F7/18 , C07F17/02 , C07F7/10 , C07F13/00
CPC分类号： C07F7/0827 , C07F7/0805 , C07F7/081 , C07F7/0838 , C07F7/0876 , C07F7/0896 , C07F7/10 , C07F7/1804 , C07F7/1876 , C07F7/188 , C07F7/1892 , C07F13/00 , C07F17/02
摘要： New (triorganosilyl)alkynes and their derivatives having general formula R1—C≡C—Z are provided along with methods for the preparation of (triorganosilyl)alkynes and their derivatives having the general formula R1—C≡C—Z. The methods may include silylative coupling of terminal alkynes with halogenotriorganosilanes in the presence of an iridium catalyst and a tertiary amine.

8. 发明申请

US20160244473A1 2', 5' -DIDEOXY-5-FLUOROURIDINE DERIVATIVES HAVING CYTOTOXIC ACTIVITY, A PROCESS FOR THE MANUFACTURE THEREOF AND APPLICATION THEREOF 有权
标题翻译：具有细胞毒活性的2'，5'-二氧代-5-氟尿嘧啶衍生物，其制备方法及其应用
公开(公告)号：US20160244473A1
公开(公告)日：2016-08-25
申请号：US14413618
申请日：2014-03-04
申请人： ADAM MICKIEWICZ UNIVERSITY
发明人： Lech CELEWICZ , Karol KACPRZAK , Marta LEWANDOWSKA , Piotr RUSZKOWSKI , Natalia KLECZEWSKA
IPC分类号： C07H19/06
CPC分类号： C07H19/06 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072
摘要： The subject matter of the invention is novel 2′,5′-dideoxy-5-fluorouridine derivatives of general formula 1. wherein R1 denotes cinchona alkaloid fragment with defined absolute configuration at C-8 and C-9 atoms.In a second aspect, the subject matter of the invention is a process for the manufacture of 2′,5′-dideoxy-5-fluorouridine derivatives of general formula 1.In a third aspect, the subject matter of the invention is an application of 2′,5′-dideoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.
摘要翻译：本发明的主题是通式1的新的2'，5'-二脱氧-5-氟尿苷衍生物。其中R1表示在C-8和C-9原子具有确定的绝对构型的cinchona生物碱片段。在第二方面，本发明的主题是制备通式1的2'，5'-二脱氧-5-氟尿苷衍生物的方法。在第三方面，本发明的主题是 2'，5'-二脱氧-5-氟尿苷衍生物在乳癌，宫颈癌，肺癌和鼻咽癌的抗癌治疗中的应用。

9. 发明授权

US09249167B1 Monovinylgermasilsesquioxanes 有权
标题翻译：单乙烯基硅氧烷倍半硅氧烷
公开(公告)号：US09249167B1
公开(公告)日：2016-02-02
申请号：US14677125
申请日：2015-04-02
申请人： ADAM MICKIEWICZ UNIVERSITY
发明人： Dawid Frackowiak , Patrycja Żak , Bogdan Marciniec
IPC分类号： C07F7/30
CPC分类号： C07F7/30
摘要： A new cage monovinylgermasilsesquioxanes of the general formula 1, in which R1 are the same and represent a C1 to C6 alkyl group or a cyclopentyl or cyclohexyl group or a phenyl group. The invention also relates to the method of synthesis of cage monovinylgermasilsesquioxanes of the general formula 1.
摘要翻译：一种通式1的新型笼型单乙烯基硅氧烷倍半硅氧烷，其中R 1相同并且表示C1-C6烷基或环戊基或环己基或苯基。本发明还涉及通式1的笼式单乙烯基倍半硅氧烷的合成方法。

10. 发明授权

US08816117B2 Synthesis of fluorocarbofunctional silsesquioxanes 有权
标题翻译：氟代官能团倍半硅氧烷的合成
公开(公告)号：US08816117B2
公开(公告)日：2014-08-26
申请号：US13393380
申请日：2010-08-16
申请人： Bogdan Marciniec , Hieronim Maciejewski , Michal Dutkiewicz
发明人： Bogdan Marciniec , Hieronim Maciejewski , Michal Dutkiewicz
IPC分类号： C07F7/21 , C08G77/04 , C08G77/38
CPC分类号： C08G77/045 , C08G77/38 , C08G77/385 , C08G77/46
摘要： The subject of the invention is the method of synthesis of fluoracarbofunctional cage silsesquioxanes of the general formula in which•R1 stands for HCF2(CF2)n(CH2)mO(CH2)3Si(CH3)2O or HCF2(CF2)n(CH2)mO(CH2)3 group in which n=1-12, m=1-4;•R2, R3, R4, R5, R6, R7, R8 can be the same as R1 or different from it and stand all either for the (C1-C25) alkyl group or any aryl group, based on hydrosilylation of fluoroalkyl-allyl ether with an appropriate hydrogen-silsesquioxane in the presence of siloxide rhodium complex [{Rh(OSiMe3)(cod)}2] as a catalyst.
摘要翻译：本发明的主题是通式的氟代官能笼型倍半硅氧烷的合成方法，其中R1表示HCF2（CF2）n（CH2）mO（CH2）3Si（CH3）2O或HCF2（CF2）n（CH2） mO（CH 2）3基，其中n = 1-12，m = 1-4;•R 2，R 3，R 4，R 5，R 6，R 7，R 8可以与R 1相同或不同，（C 1 -C 25）烷基或任何芳基，基于氟烷基 - 烯丙基醚与合适的氢倍半硅氧烷在硅化铑络合物[{Rh（OSiMe 3）（cod）} 2]的存在下作为催化剂的氢化硅烷化。

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