专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07094791B2 Derivatives of 3-hydroxy-pyrrole-2,4-dicarboxylic acid and uses thereof 失效
标题翻译： 3-羟基 - 吡咯-2,4-二羧酸的衍生物及其用途
公开(公告)号：US07094791B2
公开(公告)日：2006-08-22
申请号：US10631887
申请日：2003-07-31
申请人： Wieslaw M. Cholody , Valentina Petukhova , Sean O'Brien , Norman Ohler , Stanislaw Pikul
发明人： Wieslaw M. Cholody , Valentina Petukhova , Sean O'Brien , Norman Ohler , Stanislaw Pikul
IPC分类号： A61K31/445 , C07D207/00
CPC分类号： C07D401/12 , C07D207/36 , C07D405/12 , C07D453/02 , C07D487/08
摘要： Chemical agents of the general formula (I) and (II), such as derivatives of 3-hydroxy-pyrrole containing hydroxamic acid, and including salts thereof, that modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.
摘要翻译：公开了通式（I）和（II）的化学试剂，例如含有羟基异羟肟酸的3-羟基 - 吡咯衍生物及其盐，其调节细胞系统中包括癌细胞的基因表达水平制备这种试剂的方法，以及含有这些试剂如活性成分的药物组合物和使用它们作为治疗剂的方法。

2. 发明申请

US20070059697A1 Determining cancer-linked genes and therapeutic targets using molecular cytogenetic methods 审中-公开
标题翻译：使用分子细胞遗传学方法确定癌症相关基因和治疗靶点
公开(公告)号：US20070059697A1
公开(公告)日：2007-03-15
申请号：US10553098
申请日：2004-04-15
申请人： Jeffrey Strovel , Colyn Cain , Stephen Horrigan , Meena Augustus
发明人： Jeffrey Strovel , Colyn Cain , Stephen Horrigan , Meena Augustus
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16
摘要： Methods for identifying potential therapeutic agents, such as anti-tumor agents, based on their modulation of the expression of specified genes, especially genes mapping to specific chromosomal regions, are disclosed. Also described are methods for diagnosing cancerous, or potentially cancerous, conditions as a result of the expression, or patterns of expression, of such genes, including detecting changes in levels of gene copy number and/or level of amplification of the said gene, or sets of genes, to detect and/or diagnose the cancer. Methods for detecting or determining functionally related genes, as well as methods for treating cancer based on targeting expression products of such genes, determining genes involved in the cancerous process and the success and/or response rates and survival statistics for cancer patients on treatment are encompassed by the invention. Also encompassed are methods involving determining the modulated expression of the genes in these regions of interest (ROIs) as pharmacodynamic/pharmacogenetic /surrogate markers and/or for patient profiling prior to accrual for clinical trials/treatments based on the identification of these genes as validated gene/drug targets in various cancer tissue types.
摘要翻译：公开了基于其对特定基因的表达调控，特别是映射到特定染色体区域的基因的潜在治疗剂如抗肿瘤剂的方法。还描述了作为这些基因的表达或表达模式的癌症或潜在癌症病症的诊断方法，包括检测所述基因的基因拷贝数和/或扩增水平的变化，或一组基因，以检测和/或诊断癌症。包括用于检测或确定功能相关基因的方法，以及基于这些基因的靶向表达产物治疗癌症的方法，确定参与癌症过程的基因以及癌症患者治疗的成功和/或应答率和存活统计数据。通过本发明。还包括涉及将这些感兴趣区域（ROI）中的基因的调节表达作为药效学/药物代谢/替代标记物确定的方法和/或基于鉴定这些被验证的临床试验/治疗之前的患者分析基因/药物靶标在各种癌组织类型。

3. 发明申请

US20070270504A1 Identification of Therapeutic Agents Using Genetic Fingerprinting 审中-公开
标题翻译：使用遗传指纹识别治疗剂
公开(公告)号：US20070270504A1
公开(公告)日：2007-11-22
申请号：US10561372
申请日：2004-06-17
申请人： Paul Young , Qin Zong , Stephen Horrigan
发明人： Paul Young , Qin Zong , Stephen Horrigan
IPC分类号： C12Q1/68 , A61K45/00 , A61P35/00 , C07H21/02 , C07H21/04 , C12N5/10
CPC分类号： C12Q1/6886 , A61K45/06 , C12N2503/02 , C12Q2600/136
摘要： Methods for identifying compounds having similar biological activity based on similarity in genetic expression profile in cells contacted with one or more of said compounds, along with specifically identified compounds, are disclosed.
摘要翻译：基于与一种或多种所述化合物接触的细胞中遗传表达谱的相似性以及特异性鉴定的化合物，鉴定具有相似生物学活性的化合物的方法。

4. 发明授权

US07427473B2 Chemo-centric selection of disease-related genetic profiles 失效
标题翻译：以化学为中心的疾病相关遗传图谱选择
公开(公告)号：US07427473B2
公开(公告)日：2008-09-23
申请号：US10590256
申请日：2005-02-24
申请人： Jeffrey W. Strovel , David Bol , Paul E. Young
发明人： Jeffrey W. Strovel , David Bol , Paul E. Young
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： Methods for the identification of disease-related gene sets and expression nprofiles, based on common chemical modulation using a specific chemical compound are disclosed.
摘要翻译：公开了基于使用特定化合物的常规化学调节的鉴定疾病相关基因组和表达谱的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式