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1. 发明申请

US20090157155A1 GRAPHICAL DISPLAY OF ENVIRONMENTAL MEASUREMENTS FOR IMPLANTABLE THERAPIES 审中-公开
标题翻译：用于可植入治疗的环境测量的图形显示
公开(公告)号：US20090157155A1
公开(公告)日：2009-06-18
申请号：US11959355
申请日：2007-12-18
申请人： Kerry Bradley
发明人： Kerry Bradley
IPC分类号： A61N1/05
CPC分类号： A61N1/37247 , A61N1/37
摘要： A method and system of providing therapy to a patient implanted with an array of electrodes is provided. The electrodes are configured for respectively providing electrical stimulation to tissue of the patient. The method comprises measuring physiological parameter information indicative of the coupling efficiencies between the respective electrodes of the array and the tissue, computing numerical values from the measured physiological parameter information, generating a chart representative of the computed numerical values, and displaying the chart to a user.
摘要翻译：提供了向植入电极阵列的患者提供治疗的方法和系统。电极被配置为分别向患者的组织提供电刺激。该方法包括测量指示阵列和组织的各个电极之间的耦合效率的生理参数信息，根据测量的生理参数信息计算数值，生成表示所计算的数值的图表，以及将图表显示给用户。

2. 发明申请

US20090118786A1 AUTOMATED FITTING SYSTEM FOR DEEP BRAIN STIMULATION 审中-公开
标题翻译：自动配准系统，用于深层脑刺激
公开(公告)号：US20090118786A1
公开(公告)日：2009-05-07
申请号：US11934731
申请日：2007-11-02
申请人： Paul Milton Meadows , Michael Adam Moffitt
发明人： Paul Milton Meadows , Michael Adam Moffitt
IPC分类号： A61N1/05
CPC分类号： A61N1/36185 , A61B5/0488 , A61B5/1101 , A61B5/1116 , A61B5/1126 , A61B5/1127 , A61B5/4064 , A61B5/4082 , A61B5/4094 , A61N1/0534 , A61N1/36082 , A61N1/36139 , A61N1/37235
摘要： Methods, systems, and external programmers provide therapy to a patient having a dysfunction. In one aspect, stimulation energy is conveyed from a neurostimulator to electrodes located within a tissue region of the patient, thereby changing the status of the dysfunction. A physiological end-function of the patient indicative of the changed status of the dysfunction is measured, and stimulation parameters are programmed into the neurostimulator based on the measured physiological end-function. In another aspect, electrodes are placed adjacent to a tissue region of the patient, and stimulation energy is conveyed from the electrodes to the tissue region in accordance with the stimulation parameters, thereby changing the status of the dysfunction. A physiological end-function of the patient indicative of the changed status of the dysfunction is measured, and the stimulation parameters are adjusted based on the measured physiological end-function.
摘要翻译：方法，系统和外部程序员为具有功能障碍的患者提供治疗。在一个方面，刺激能量从神经刺激器传送到位于患者组织区域内的电极，从而改变功能障碍的状态。测量指示功能障碍状态改变的患者的生理学终端功能，并且基于所测量的生理学终端功能将刺激参数编程到神经刺激器中。在另一方面，电极被放置在患者的组织区域附近，并且根据刺激参数将刺激能量从电极传送到组织区域，从而改变功能障碍的状态。测量指示功能障碍状态改变的患者的生理学终端功能，并且基于所测量的生理学终端功能来调整刺激参数。

3. 发明申请

US20080319497A1 Architectures for an Implantable Medical Device System 失效
标题翻译：可植入医疗器械系统的架构
公开(公告)号：US20080319497A1
公开(公告)日：2008-12-25
申请号：US11767636
申请日：2007-06-25
申请人： Paul J. Griffith , Jordi Parramon , Goran N. Marnfeldt , Daniel Aghassian , Kiran Nimmagadda , Emanuel Feldman , Jess W. Shi
发明人： Paul J. Griffith , Jordi Parramon , Goran N. Marnfeldt , Daniel Aghassian , Kiran Nimmagadda , Emanuel Feldman , Jess W. Shi
IPC分类号： A61N1/08
CPC分类号： A61N1/36125 , A61N1/025 , A61N1/0551 , A61N1/0553 , A61N1/36071
摘要： An improved architecture for an implantable medical device such as an implantable pulse generator (IPG) is disclosed. In one embodiment, the various functional blocks for the IPG are incorporated into a signal integrated circuit (IC). Each of the functional blocks communicate with each other, and with other off-chip devices if necessary, via a centralized bus governed by a communication protocol. To communicate with the bus and to adhere to the protocol, each circuit block includes bus interface circuitry adherent with that protocol. Because each block complies with the protocol, any given block can easily be modified or upgraded without affecting the design of the other blocks, facilitating debugging and upgrading of the IPG circuitry. Moreover, because the centralized bus can be taken off the integrated circuit, extra circuitry can easily be added off chip to modify or add functionality to the IPG without the need for a major redesign of the main IPG IC.
摘要翻译：公开了一种用于植入式医疗装置（例如植入式脉冲发生器（IPG））的改进的架构。在一个实施例中，用于IPG的各种功能块被并入到信号集成电路（IC）中。每个功能块通过由通信协议管理的集中式总线彼此通信，并且如果需要，与其他片外设备通信。为了与总线进行通信并遵守协议，每个电路块包括与该协议相关的总线接口电路。由于每个块符合协议，任何给定的块都可以轻松修改或升级，而不影响其他块的设计，便于IPG电路的调试和升级。此外，由于集中式总线可以从集成电路中取出，所以额外的电路可以轻松地从芯片上添加到IPG中，以便对IPG进行主要的重新设计。

4. 发明申请

US20080294211A1 COUPLED MONOPOLAR AND MULTIPOLAR PULSING FOR CONDITIONING AND STIMULATION 有权
标题翻译：用于调节和刺激的联合单调和多重脉冲
公开(公告)号：US20080294211A1
公开(公告)日：2008-11-27
申请号：US11752898
申请日：2007-05-23
申请人： Michael A. Moffitt
发明人： Michael A. Moffitt
IPC分类号： A61N1/362
CPC分类号： A61N1/36146 , A61N1/0553 , A61N1/36017 , A61N1/36071 , A61N1/36167
摘要： A method and neurostimulation system of providing therapy to a patient is provided. A plurality of electrodes are placed in contact with tissue of a patient, a conditioning pulse is conveyed from the plurality of electrodes in one of a monopolar manner and a multipolar manner, and a stimulation pulse is conveyed from the plurality of electrodes in a different one of the monopolar manner and the multipolar manner. As one example, the sub-threshold conditioning pulse may be a depolarizing pulse conveyed from the plurality of electrodes to render a first region of the tissue less excitable to stimulation, and the stimulation pulse may be conveyed from the plurality of electrodes to stimulate a second different region of the tissue.
摘要翻译：提供了向患者提供治疗的方法和神经刺激系统。将多个电极放置成与患者的组织接触，以单极方式和多极方式从多个电极传送调理脉冲，并且从多个电极以不同的方式传送刺激脉冲的单极方式和多极方式。作为一个示例，子阈值调节脉冲可以是从多个电极传送的去极化脉冲，以使得组织的第一区域不太可兴奋地进行刺激，并且刺激脉冲可以从多个电极传送以刺激第二个组织的不同区域。

5. 发明申请

US20080196939A1 Lead anchoring assembly 有权
标题翻译：导线组装
公开(公告)号：US20080196939A1
公开(公告)日：2008-08-21
申请号：US11706702
申请日：2007-02-15
申请人： Timothy R. Lubenow , Kenny Kinyen Chinn , Christopher Ewan Gillespie , John M. Barker
发明人： Timothy R. Lubenow , Kenny Kinyen Chinn , Christopher Ewan Gillespie , John M. Barker
IPC分类号： A61N1/02
CPC分类号： A61N1/057 , A61N1/056
摘要： An electrical lead anchoring assembly comprising a body comprising at least one recess and at least one channel therethrough for receiving at least one electrical lead, at least one arm pivotably coupled to the body and moveable between an open and a closed position wherein the arm is at least partially disposed within the recess such that the arm intrudes into the channel and frictionally abuts at least a portion of the length of electrical lead disposed in the channel to couple the lead to the body.
摘要翻译：一种电引线锚固组件，其包括主体，所述主体包括至少一个凹部和穿过其中的至少一个通道，用于容纳至少一个电引线，至少一个臂，其可枢转地联接到所述主体并且可在所述臂处于打开位置和闭合位置之间移动至少部分地设置在所述凹部内，使得所述臂进入所述通道并且摩擦地邻接设置在所述通道中的所述电线长度的至少一部分以将所述引线耦合到所述主体。

6. 发明申请

US20080195179A1 SYSTEMS AND METHODS FOR DETERMINING A THRESHOLD CURRENT LEVEL REQUIRED TO EVOKE A STAPEDIAL MUSCLE REFLEX 有权
标题翻译：用于确定阈值电流水平的系统和方法，用于实现肌肉收缩反应
公开(公告)号：US20080195179A1
公开(公告)日：2008-08-14
申请号：US11779265
申请日：2007-07-17
申请人： Andrew P. Quick
发明人： Andrew P. Quick
IPC分类号： A61N1/36
CPC分类号： A61B5/121 , A61B5/6846 , A61N1/36036
摘要： Exemplary cochlear implant systems include an implantable cochlear stimulator configured to be implanted within a patient and generate a stimulation current having an adjustable current level, one or more electrodes communicatively coupled to the stimulator and configured to apply the stimulation current to one or more locations within an ear of the patient, and a sound processor configured to derive an acoustic reflectance of the patient's ear. The implantable cochlear stimulator is configured to adjust the current level of the stimulation current until the sound processor detects a change in the acoustic reflectance above a threshold.24
摘要翻译：示例性的耳蜗植入系统包括植入式耳蜗刺激器，其被配置为植入患者体内并产生具有可调电流水平的刺激电流，一个或多个电极通信地耦合到刺激器并且被配置为将刺激电流施加到一个或多个位置内患者的耳朵以及被配置为导出患者耳朵的声反射率的声音处理器。可植入人工耳蜗刺激器被配置为调节刺激电流的当前水平，直到声音处理器检测到高于阈值的声反射率的变化。

7. 发明申请

US20080140168A1 ELECTRODE ARRANGEMENTS FOR TISSUE STIMULATION AND METHODS OF USE AND MANUFACTURE 有权
标题翻译：用于组织刺激的电极装置及其使用和制造方法
公开(公告)号：US20080140168A1
公开(公告)日：2008-06-12
申请号：US11609586
申请日：2006-12-12
申请人： Jeryle L. Walter , Greg Terterian , Matthew Flowers , Robert R. Tong
发明人： Jeryle L. Walter , Greg Terterian , Matthew Flowers , Robert R. Tong
IPC分类号： A61N1/05
CPC分类号： A61N1/0553 , A61N1/0558
摘要： A lead has a paddle body with a non-conductive material and multiple electrodes disposed within the non-conductive material. At least one of the electrodes includes one or more anchoring arrangement, such as opening(s) through the electrode through which the non-conductive material can pass; anchors that extend away from the electrode and into the non-conductive material of the paddle body; or flow-through anchors attached to the electrode with an opening through which the non-conductive material may pass.
摘要翻译：引线具有带有非导电材料的桨体和设置在非导电材料内的多个电极。电极中的至少一个包括一个或多个锚定布置，例如通过非导电材料可以穿过的电极的开口; 锚定件远离电极延伸到桨体的非导电材料中; 或连接到电极的流通锚固件具有非导电材料可以通过的开口。

8. 发明申请

US20080097554A1 Orientation-Independent Implantable Pulse Generator 有权
标题翻译：定向无关种植脉冲发生器
公开(公告)号：US20080097554A1
公开(公告)日：2008-04-24
申请号：US11550733
申请日：2006-10-18
申请人： David H. Payne , Matthew I. Haller
发明人： David H. Payne , Matthew I. Haller
IPC分类号： A61N1/375
CPC分类号： A61N1/3787
摘要： An improved structure for an implantable medical device, such as an implantable pulse generator, is disclosed. The improved device includes a charging coil for wirelessly receiving energy via induction from an external charger. The charging coil in the device is located substantially equidistantly from the two planar sides of the device case. Because the coil is substantially equidistant within the thickness of the case of the device, the device's orientation within the patient is irrelevant, at least from the standpoint of the efficiency of charging the device using the external charger. Accordingly, charging is not adversely affected if the device is implanted in the patient with the wrong orientation, or if the device flips within the patient after implantation. Moreover, because the central portion of the device naturally corresponds to the largest lateral extent within the case due to the case's curved edges, the charging coil can be made larger in area, which improves its gain vis-à-vis the external charger.
摘要翻译：公开了一种用于可植入医疗装置的改进的结构，例如可植入脉冲发生器。改进的装置包括用于通过来自外部充电器的感应无线地接收能量的充电线圈。装置中的充电线圈与装置壳体的两个平面侧基本上等距离地设置。由于线圈在器件外壳的厚度范围内基本上是等距的，所以至少从使用外部充电器的设备充电效率的观点来看，器件在患者体内的取向是无关紧要的。因此，如果将装置以错误的方向植入患者中，或者如果装置在植入后在患者体内翻转，则不会不利地影响充电。此外，由于装置的中心部分由于壳体的弯曲边缘而自然地对应于壳体内的最大横向范围，因此可以使充电线圈的面积更大，这相对于外部充电器而言增益更大。

9. 发明申请

US20080097529A1 Multi-Electrode Implantable Stimulator Device with a Single Current Path Decoupling Capacitor 有权
标题翻译：具有单电流路径去耦电容器的多电极植入式刺激器装置
公开(公告)号：US20080097529A1
公开(公告)日：2008-04-24
申请号：US11550655
申请日：2006-10-18
申请人： Jordi Parramon , Kiran Nimmagadda , Emanuel Feldman , Yuping He
发明人： Jordi Parramon , Kiran Nimmagadda , Emanuel Feldman , Yuping He
IPC分类号： A61N1/00
CPC分类号： A61N1/36125 , A61N1/025 , A61N1/08 , A61N1/372 , A61N1/37205 , A61N1/3756
摘要： Disclosed herein are circuits and methods for a multi-electrode implantable stimulator device incorporating one decoupling capacitor in the current path established via at least one cathode electrode and at least one anode electrode. In one embodiment, the decoupling capacitor may be hard-wired to a dedicated anode on the device. The cathodes are selectively activatable via stimulation switches. In another embodiment, any of the electrodes on the devices can be selectively activatable as an anode or cathode. In this embodiment, the decoupling capacitor is placed into the current path via selectable anode and cathode stimulation switches. Regardless of the implementation, the techniques allow for the benefits of capacitive decoupling without the need to associate decoupling capacitors with every electrode on the multi-electrode device, which saves space in the body of the device. Although of particular benefit when applied to microstimulators, the disclosed technique can be used with space-saving benefits in any stimulator device.
摘要翻译：本文公开了用于在经由至少一个阴极电极和至少一个阳极电极建立的电流路径中并入一个去耦电容器的多电极可植入刺激器装置的电路和方法。在一个实施例中，去耦电容器可以硬连接到器件上的专用阳极。阴极可以通过刺激开关选择性地激活。在另一个实施例中，器件上的任何电极可以选择性地激活为阳极或阴极。在该实施例中，去耦电容通过可选择的阳极和阴极刺激开关放置在电流路径中。不管实施方案如何，这些技术允许电容去耦的优点，而不需要将去耦电容器与多电极器件上的每个电极相关联，这节省了器件体内的空间。虽然在应用于微型激励器时特别有益，但是所公开的技术可以在任何刺激器装置中具有节省空间的优点。

10. 发明授权

US07337003B2 Implantable pulse generator case 有权
标题翻译：植入脉冲发生器箱
公开(公告)号：US07337003B2
公开(公告)日：2008-02-26
申请号：US11043651
申请日：2005-01-25
申请人： Zdzislaw B. Malinowski
发明人： Zdzislaw B. Malinowski
IPC分类号： A61N1/375
CPC分类号： A61N1/375 , A61N1/3752 , A61N1/3754 , A61N1/3758 , Y10T29/49002 , Y10T29/49169
摘要： An implantable medical device, e.g., a stimulator, having a sealed housing and method of making the same. An exemplary embodiment of the device includes a case frame defining a cavity, the cavity extending at least substantially through the case frame, which cavity may contain electronics or a power source, and at least one lid configured to be sealingly coupled to the case frame. A feedthru opening may also be included in the case frame.
摘要翻译：一种具有密封外壳的可植入医疗装置，例如刺激器及其制造方法。该装置的示例性实施例包括限定空腔的壳体框架，空腔至少基本上延伸穿过壳体框架，该空腔可以包含电子器件或电源，以及至少一个盖子，其被配置为密封地联接到壳体框架。进给开口也可以包括在壳体框架中。

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