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81. 发明授权

US09217027B2 Thrombin inhibitor 有权
标题翻译：凝血酶抑制剂
公开(公告)号：US09217027B2
公开(公告)日：2015-12-22
申请号：US12665256
申请日：2008-06-18
申请人： Maria Kazimtrova , R. Manjunatha Kini , Cho Yeow Koh
发明人： Maria Kazimtrova , R. Manjunatha Kini , Cho Yeow Koh
IPC分类号： A61K51/00 , A61M36/14 , G01N33/53 , C12N15/09 , C12N1/20 , C12N15/00 , C12N9/96 , C12N9/99 , A61K38/57 , C07K14/81 , C07K14/745 , A61K38/00 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61K38/04 , A61K38/36 , A61K51/08 , C07K7/06 , C07K7/08 , C12Q1/56
CPC分类号： C07K14/811 , A61K38/36 , A61K38/57 , A61K51/08 , C07K7/06 , C07K7/08 , C12Q1/56
摘要： The invention relates to thrombin inhibitors derived from the salivary glands of haematophagous arthropods and in particular to bivalent and trivalent thrombin inhibitors that act by interacting with thrombin at two or three different sites.
摘要翻译：本发明涉及来自血液节肢动物唾液腺的凝血酶抑制剂，特别涉及通过在两个或三个不同位点与凝血酶相互作用的二价和三价凝血酶抑制剂。

82. 发明授权

US09212216B2 Identification and molecular characterisation of proteins, expressed in the Ixodes ricinus salivary glands 有权
公开(公告)号：US09212216B2
公开(公告)日：2015-12-15
申请号：US14302862
申请日：2014-06-12
申请人： Bioxodes SPRL
发明人： Edmond Godfroid , Yves Decrem , Luc Vanhamme , Alex Bollen , Gerard Leboulle
IPC分类号： A61K38/00 , A61K39/00 , A61K39/002 , A61K39/38 , C07K1/00 , C07K14/00 , C07K17/00 , C07K14/81 , C07K14/435 , C07K16/38 , C07K16/18 , A61K38/57 , C12N9/99
CPC分类号： C07K14/8114 , A61K38/00 , A61K38/57 , A61K39/0003 , A61K2121/00 , C07K14/43527 , C07K14/811 , C07K16/18 , C07K16/38 , C12N9/99
摘要： The invention relates to a new polynucleotide which encodes a polypeptide expressed in the salivary glands of ticks, more particularly the Ixodes ricinus arthropod tick, during the slow-feeding phase of the blood meal have, said polynucleotide and related polypeptide may be used in different constructions and for different applications which are also included in the present invention.

83. 发明授权

US09211318B2 Use of C1 inhibitor for the prevention of ischemia-reperfusion injury 有权
标题翻译：使用C1抑制剂预防缺血再灌注损伤
公开(公告)号：US09211318B2
公开(公告)日：2015-12-15
申请号：US13776529
申请日：2013-02-25
申请人： PHARMING INTELLECTUAL PROPERTY B.V.
发明人： Maurice Mannesse , Johannes Henricus Nuijens , Frank Pieper , Maria Grazia De Simoni , Gijsbertus Johannes Ziere
IPC分类号： A61K38/57 , A61K45/06 , C07K14/00
CPC分类号： A61K38/57 , A61K45/06
摘要： The present invention relates to the therapeutic and prophylactic use of C1 inhibitor for preventing, reducing and treating ischemia and reperfusion injury. The C1 inhibitor of the present invention is still therapeutically effective when administered after an ischemic period and reperfusion and therefore particularly useful for unforeseen occurrences of ischemic reperfusion such as e.g. a stroke.
摘要翻译：本发明涉及C1抑制剂用于预防，减少和治疗缺血和再灌注损伤的治疗和预防用途。本发明的C1抑制剂在缺血期和再灌注后施用时仍然是治疗有效的，因此特别可用于缺血再灌注的预期发生，例如，中风。

84. 发明申请

US20150320846A1 METHODS OF TREATMENT USING ALPHA-1-ANTITRYPSIN COMPOSITIONS 审中-公开
标题翻译：使用ALPHA-1-抗菌素组合物治疗的方法
公开(公告)号：US20150320846A1
公开(公告)日：2015-11-12
申请号：US14802885
申请日：2015-07-17
申请人： CSL Behring L.L.C.
发明人： Scott M. KEE , Paul I. COOK , James R. SMITH , Robert KLING , Scott A. FOWLER , David WEBER
IPC分类号： A61K38/57
CPC分类号： A61K38/57 , A61K9/19 , B01D15/327 , B01D15/363 , C07K14/8125 , G01N30/461
摘要： A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitante. Separation of the solid absorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.
摘要翻译：提供了从含有AAT的蛋白质混合物（例如Coh级分IV沉淀）中纯化α-1-抗胰蛋白酶（AAT）的流线型方法。在本发明的方法中，通过用不影响AAT的还原剂如二硫醇裂解二硫键，污染蛋白质不稳定。然后将不稳定的蛋白质优先吸附在固体蛋白质吸附材料上，而不添加盐作为沉淀物。固体吸收剂与溶液的分离留下直接适用于色谱纯化的纯化的AAT溶液，而不需像现有技术方法那样进行广泛的脱盐。还描述了一种以商业规模提供高产量的药物级AAT的方法。

85. 发明申请

US20150258184A1 NOVEL PROTEIN MATERIAL 审中-公开
标题翻译：新蛋白质材料
公开(公告)号：US20150258184A1
公开(公告)日：2015-09-17
申请号：US14418276
申请日：2012-07-31
申请人： Aiko Ohmachi , Hiroaki Matsuyama , Yoshikazu Morita , Yuko Ishida , Takayuki Nara , Ken Kato , Atsushi Serizawa
发明人： Aiko Ohmachi , Hiroaki Matsuyama , Yoshikazu Morita , Yuko Ishida , Takayuki Nara , Ken Kato , Atsushi Serizawa
IPC分类号： A61K38/57 , C12P21/06 , A23L1/305 , A61K38/46
CPC分类号： A61K38/57 , A23L33/17 , A23L33/18 , A23V2002/00 , A23V2200/00 , A61K38/01 , A61K38/22 , A61K38/465 , C12P21/06 , C12Y301/27 , A23V2200/306
摘要： The invention relates to a protein material includes angiogenin and/or angiogenin hydrolysate in an amount of 2 to 15 mg/100 mg, and cystatin and/or cystatin hydrolysate in the mass ratio to angiogenin and/or angiogenin hydrolysate of 0.003 to 0.6.
摘要翻译：本发明涉及一种蛋白质材料，其包含2至15mg / 100mg量的血管生成素和/或血管生成素水解产物，以及与血管生成素和/或血管生成素水解产物的质量比为0.003至0.6的半胱氨酸蛋白酶抑制剂和/或半胱氨酸蛋白酶抑制剂水解产物。

86. 发明授权

US09107928B2 Compositions and methods for treating ophthalmic disorders 有权
标题翻译：用于治疗眼科疾病的组合物和方法
公开(公告)号：US09107928B2
公开(公告)日：2015-08-18
申请号：US12792393
申请日：2010-06-02
申请人： Pierre Belichard
发明人： Pierre Belichard
IPC分类号： A61K38/00 , A61P27/02 , C07K2/00 , A61K38/57
CPC分类号： C07K16/40 , A61K9/0048 , A61K38/57 , A61K47/30 , A61K2039/505 , C07K2317/55
摘要： The present invention relates to compositions and methods for treating ophthalmic disorders of humans or animals. The present compositions and methods are highly suitable for intraocular administration into the interior of an eye and provide therapeutic effects to the eye as they are effective in stabilizing, enhancing and/or improving a patient's vision. More specifically, the present invention relates to compositions and methods for treating ophthalmic diseases or disorders with exudative, hemorrhagic and/or inflammatory conditions. Even more specifically, the present invention relates to compositions and methods for treating retinal diseases or disorders, and more specifically ophthalmic diseases or disorders related to impaired retinal vessel permeability and/or integrity.
摘要翻译：本发明涉及治疗人或动物眼科疾病的组合物和方法。本发明的组合物和方法非常适合于眼内施用于眼睛内部并且对眼睛提供治疗效果，因为它们有效地稳定，增强和/或改善患者的视力。更具体地，本发明涉及用渗出性，出血性和/或炎性病症治疗眼科疾病或病症的组合物和方法。更具体地，本发明涉及用于治疗视网膜疾病或病症的组合物和方法，更具体地涉及与视网膜血管渗透性受损和/或完整性相关的眼科疾病或病症。

87. 发明授权

US09084728B2 Process for making dry and stable hemostatic compositions 有权
标题翻译：制备干燥稳定的止血组合物的方法
公开(公告)号：US09084728B2
公开(公告)日：2015-07-21
申请号：US13151048
申请日：2011-06-01
申请人： Andreas Goessl , Atsushi Edward Osawa , Cary J. Reich
发明人： Andreas Goessl , Atsushi Edward Osawa , Cary J. Reich
IPC分类号： A61K38/57 , A61K9/16 , A61K9/00 , A61K9/19 , A61K38/48 , A61L24/04 , A61L24/10
CPC分类号： A61L24/043 , A61K9/0014 , A61K9/1658 , A61K9/19 , A61K38/39 , A61K38/4833 , A61L24/0015 , A61L24/10 , A61L24/106 , A61L2300/418 , A61L2300/802 , A61L2400/04 , A61L2400/06 , B65B3/003 , B65B5/12 , B65B55/02 , C12Y304/21005 , Y10T428/13
摘要： Described is a process for making a dry and stable hemostatic composition, said process comprising a) providing a first component comprising a dry preparation of a coagulation inducing agent, b) providing a second component comprising a dry preparation of a biocompatible polymer suitable for use in hemostasis, c) providing said first component and said second component in a combined form in a final container, c1) either by filling said first component and said second component into said final container so as to obtain a dry mixture in said final container, c2) or by providing said first component or said second component in said final container and adding said second component or said first component so as to obtain a combination of said first component with said second component in said final container, d) finishing the final container to a storable pharmaceutical device containing said first component and said second component in a combined form as a dry and stable hemostatic composition.
摘要翻译：描述了制备干燥和稳定的止血组合物的方法，所述方法包括a）提供包含凝结诱导剂的干制剂的第一组分，b）提供第二组分，其包含适于用于止血，c）以最终容器中的组合形式提供所述第一组分和所述第二组分，c1）通过将所述第一组分和所述第二组分填充到所述最终容器中以在所述最终容器中获得干混合物，c2 ）或通过在所述最终容器中提供所述第一组分或所述第二组分并加入所述第二组分或所述第一组分以便获得所述第一组分与所述最终容器中的所述第二组分的组合，d）将最终容器整理成一种包含所述第一组分和所述第二组分的可储存药物装置，其为组合形式，为干和稳定的止血组合物。

88. 发明授权

US09078904B2 Methods for increasing plasmin activity and promoting plaque regression in the treatment of atherosclerosis 有权
标题翻译：在动脉粥样硬化的治疗中增加纤溶酶活性和促进斑块退化的方法
公开(公告)号：US09078904B2
公开(公告)日：2015-07-14
申请号：US13982830
申请日：2012-02-03
申请人： Mary Jo Mulligan-Kehoe
发明人： Mary Jo Mulligan-Kehoe
IPC分类号： A61K38/57 , A61K38/48 , C07K14/81 , A61K38/55 , C07K14/47 , A61K38/17 , A61K38/42 , A61K35/16 , C07K14/775 , A61K38/00 , C07K14/745
CPC分类号： A61K38/57 , A01K2217/05 , A61K35/16 , A61K38/00 , A61K38/1709 , A61K38/177 , A61K38/42 , A61K38/484 , A61K38/55 , C07K14/47 , C07K14/745 , C07K14/775 , C07K14/81 , C07K14/811 , C07K14/8132
摘要： The present invention provides the use of recombinant plasminogen activator inhibitor-1 (PAI-1) isoform 23 in methods of increasing plasmin activity, inhibiting angiogenic vasa vasorum, promoting plaque regression and treating atherosclerosis by administering to a subject in need of treatment an effective amount of recombinant plasminogen activator inhibitor type isoform 23 (rPAI-123). In some embodiments, rPAI-123 is set forth in SEQ ID NOs:5-8. In other embodiments, rPAI-123 is administered at a dose in the range of approximately 2.5 μg/kg/day to 20 μg/kg/day. In further embodiments, the effective amount achieves a ratio of rPAI-123 to PAI-1 is in the range of approximately 1:2 to 3:1.
摘要翻译：本发明提供重组纤溶酶原激活物抑制剂-1（PAI-1）同种型23在增加纤溶酶活性，抑制血管生成性血管舒张，促进斑块回归和治疗动脉粥样硬化的方法中的用途，其通过对需要治疗的受试者施用有效量的重组纤溶酶原激活物抑制剂型同种型23（rPAI-123）。在一些实施方案中，rPAI-123如SEQ ID NO：5-8所示。在其它实施方案中，rPAI-123以约2.5μg/ kg /天至20μg/ kg /天的剂量施用。在另外的实施方案中，有效量达到rPAI-123与PAI-1的比例在约1:2至3:1的范围内。

89. 发明申请

US20150190484A1 METHODS FOR REDUCING CELLULAR SENESCENCE MEDIATED BY DNA DAMAGING AGENTS 审中-公开
标题翻译：用于减少由DNA破坏剂介导的细胞感受的方法
公开(公告)号：US20150190484A1
公开(公告)日：2015-07-09
申请号：US14661686
申请日：2015-03-18
申请人： Trustees of Dartmouth College , The Government of the United States, as represented by the Secretary, Department of Health
发明人： Mary Jo Mulligan-Kehoe , Deborah Eva Citrin , Eunjoo S. Chung , James Mitchell
IPC分类号： A61K38/57
CPC分类号： A61K38/57 , C07K14/8132
摘要： A method for reducing cellular senescence in a subject, in particular a subject exposed to or at risk of being exposed to a DNA damaging agents, e.g., radiation, by inhibiting PAI-1 activity in the subject with a truncated PAI-1 agent, rPAI-123.
摘要翻译：通过用截短的PAI-1剂rPAI抑制受试者的PAI-1活性，减少受试者，特别是暴露于或有暴露于DNA损伤剂（例如放射）的风险的受试者的细胞衰老的方法 -123。

90. 发明申请

US20150174221A1 SYSTEMS, COMPOSITIONS, AND METHODS FOR TRANSPLANTATION 审中-公开
标题翻译：系统，组合物和运输方法
公开(公告)号：US20150174221A1
公开(公告)日：2015-06-25
申请号：US14380234
申请日：2013-02-21
申请人： CYTONICS CORPORATION
发明人： Lewis Hanna , John David Laughlin , Shawn Robert Browning
IPC分类号： A61K38/57 , A61K35/16 , A61M1/34 , A61K35/19 , A61K45/06 , A61K38/17 , A61K35/28
CPC分类号： A61K38/57 , A61K35/16 , A61K35/19 , A61K35/28 , A61K38/1722 , A61K45/06 , A61M1/34 , C07K14/8107
摘要： Systems and methods for purification and concentration of autologous alpha-2-macroglobulin (A2M) from whole blood are provided. Also provided are diagnostic methods for identifying sites in the synovial joints, spine, tendons or ligaments for treatment of pain, degeneration, or inflammation with autologous A2M. Methods for utilizing autologous A2M in combination with other autologous treatments (e.g. platelets and other growth factors) are provided in addition to combinations with exogenous drugs or carriers. Also provided is a method of producing recombinant A2M wild type or variants thereof where the bait region was modified to enhance the inhibition characteristics of A2M and/or to prolong the half life of the protein in joints and spine disc or epidural space.
摘要翻译：提供了从全血中纯化和浓缩自体α-2-巨球蛋白（A2M）的系统和方法。还提供了用于鉴定滑膜关节，脊柱，腱或韧带中用于用自体A2M治疗疼痛，变性或炎症的部位的诊断方法。除了与外源性药物或载体的组合之外，还提供了利用自体A2M与其它自体治疗（例如血小板和其他生长因子）组合的方法。还提供了一种生产重组A2M野生型或其变体的方法，其中诱饵区被修饰以增强A2M的抑制特性和/或延长关节和脊椎盘或硬膜外腔中的蛋白质的半衰期。

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