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81. 发明授权

US08142826B2 Extract of Fraxinus excelsior seeds and therapeutic applications therefor 有权
标题翻译： Fraxinus提取物优良种子及其治疗应用
公开(公告)号：US08142826B2
公开(公告)日：2012-03-27
申请号：US12185649
申请日：2008-08-04
申请人： Kan He , Marc Roller , Antoine Bily , Naisheng Bai , Jacques Dikansky , Alvin Ibarra
发明人： Kan He , Marc Roller , Antoine Bily , Naisheng Bai , Jacques Dikansky , Alvin Ibarra
IPC分类号： A61K36/63
CPC分类号： A61K36/63 , A61K31/7088
摘要： A Fraxinus excelsior seed extract that can be administered for therapeutic treatment of a subject, including a human, by blocking fat synthesis, activating PPAR-alpha, increasing hypoglycemic activity, reducing bodyweight, controlling fasting plasma insulin levels against hyperinsulinemia, and promoting insulin sensitivity and causing a beneficial acute insulinotropic effect. The Fraxinus excelsior seed extract includes, inter alia, an isolated compound (2S,3E,4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl) oxy]-3,4-dihydro-5-(methoxycarbonyl)methyl ester, commonly called excelside A, an isolated compound (2S,3E,4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-3,4-dihydro-5-(methoxycarbonyl) 2-(4-hydroxyphenyl)ethyl ester, commonly called excelside B, and the compounds GI5, GI3, nuzhenide, and oleoside dimethyl ester.
摘要翻译：可以通过阻断脂肪合成，激活PPAR-α，增加降血糖活性，降低体重，控制空腹血浆胰岛素水平与高胰岛素血症的关系，以及促进胰岛素敏感性以及促进胰岛素敏感性的方法，将Fraxinus excelsior种子提取物用于治疗受试者（包括人）引起有益的急性促胰岛素作用。 Fraxinus excelsior种子提取物尤其包括分离的化合物（2S，3E，4S）2H-吡喃-4-乙酸-3-亚乙基-2 - [（6-O- [b] -D-吡喃葡萄糖基 - D-吡喃葡萄糖基）氧基] -3,4-二氢-5-（甲氧基羰基）甲酯，通常称为excelside A，分离的化合物（2S，3E，4S）2H-吡喃-4-乙酸-3-亚乙基 - 2 - [（6-O-和bgr-D-吡喃葡萄糖基-β-吡喃葡萄糖基）氧基] -3,4-二氢-5-（甲氧基羰基）2-（4-羟基苯基）乙酯，通常称为excelside B ，和化合物GI5，GI3，硝酸ide酯和油甙二甲酯。

82. 发明申请

US20110206787A1 Morinda Citrifolia and Iridoid Based Formulations 有权
标题翻译： Morinda Citrifolia和Iridoid基配方
公开(公告)号：US20110206787A1
公开(公告)日：2011-08-25
申请号：US13032540
申请日：2011-02-22
申请人： Brett Justin West , Claude Jarakae Jensen , Afa Kehaati Palu , Shixin Deng , Jeffery A. Wasden
发明人： Brett Justin West , Claude Jarakae Jensen , Afa Kehaati Palu , Shixin Deng , Jeffery A. Wasden
IPC分类号： A61K36/18 , A61K36/87 , A61K36/45 , A61K36/63 , A61K36/73 , A61K36/9066 , A61P19/02 , A61P3/10
CPC分类号： A61K36/746 , A61K2300/00
摘要： Embodiments of the invention relate to fortified food and dietary supplement products which may be administered to produce desirable physiological improvement. In particular, embodiments of the invention relates to the administration of products enhanced with Morinda citrifolia and iridoids.
摘要翻译：本发明的实施方案涉及可以施用以产生理想的生理学改善的强化食物和膳食补充剂产品。特别地，本发明的实施方案涉及对用Morinda citrifolia和环烯醚萜增强的产品的施用。

83. 发明申请

US20110142973A1 Compositions and methods for treating obesity, obesity related disorders and for inhibiting the infectivity of human immunodeficiency virus 有权
标题翻译：用于治疗肥胖症，肥胖相关病症和抑制人类免疫缺陷病毒感染性的组合物和方法
公开(公告)号：US20110142973A1
公开(公告)日：2011-06-16
申请号：US12932018
申请日：2011-02-16
申请人： Sylvia Lee-Huang , Paul L. Huang , Philip Lin Huang , Dawei Zhang , John Z.H. Zhang , Young Tae Chang , Jae Wook Lee , Ju Bao , Yongtao Sun
发明人： Sylvia Lee-Huang , Paul L. Huang , Philip Lin Huang , Dawei Zhang , John Z.H. Zhang , Young Tae Chang , Jae Wook Lee , Ju Bao , Yongtao Sun
IPC分类号： A61K36/63 , A61P3/00
CPC分类号： A61K31/7048 , A61K31/05 , A61K31/155 , A61K31/175 , A61K31/351 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/427 , A61K31/435 , A61K31/4439 , A61K31/445 , A61K31/70 , A61K31/7036 , A61K36/00 , A61K38/28 , A61K45/06
摘要： The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues.
摘要翻译：本发明涉及通过给予橄榄苷，类似物或衍生物来治疗患有或倾向于发生肥胖或肥胖相关病症或抑制HIV感染性的受试者中的肥胖或肥胖相关疾病的方法和药物组合物或橄榄苦蛋白的主要代谢物，包括橄榄苷苷苷元，羟基酪醇和烯诺酸或其类似物或衍生物，环烯醚萜苷，或其类似物或衍生物，或上述物质的任何组合，包括橄榄果提取物。本发明还涉及通过测量选自PPARγ2，LPL和αP2基因的脂肪形成基因和基因产物或其它脂肪生成，脂质生成的脂肪形成基因的表达谱来筛选/诊断具有或倾向于具有肥胖症或相关病症的受试者的方法，或脂肪分解基因和基因产物。本发明进一步提供了新的橄榄苦苷类似物的筛选。

84. 发明申请

US20110129556A1 METHOD OF MAKING DISTILLED OLIVE JUICE EXTRACTS 失效
标题翻译：制备蒸馏橄榄提取物的方法
公开(公告)号：US20110129556A1
公开(公告)日：2011-06-02
申请号：US12674034
申请日：2008-08-19
申请人： Christof Wehrli
发明人： Christof Wehrli
IPC分类号： A61K36/63 , A61K8/97 , A61P39/06
CPC分类号： A61K8/97 , A23K20/10 , A23K20/111 , A23L33/105 , A23V2002/00 , A61K8/347 , A61Q19/00 , A23V2200/02 , A23V2250/2132
摘要： In accordance with this invention, new processes for making an all-natural, hydroxytyrosol-rich, non bitter olive juice extract and its distillate is presented. Also as part of this invention are novel juice extract distillate and compositions containing this novel olive juice extract distillate.
摘要翻译：根据本发明，提出了制备全天然，富含羟基酪蛋白，非苦味橄榄汁提取物及其馏出物的新方法。作为本发明的一部分，还有新颖的果汁提取物馏出物和含有这种新型橄榄汁提取物馏出物的组合物。

85. 发明申请

US20110064672A1 Articles and Compositions for Enhancing Sports Scores 失效
标题翻译：加强体育赛事的文章和作曲
公开(公告)号：US20110064672A1
公开(公告)日：2011-03-17
申请号：US12951250
申请日：2010-11-22
申请人： Alan R. Hirsch
发明人： Alan R. Hirsch
IPC分类号： A61K36/63 , A61K49/00 , A61P43/00 , B65D69/00
CPC分类号： A61K36/63 , C11B9/00
摘要： Methods and compositions for enhancing the score of an individual in a sport activity are disclosed.
摘要翻译：公开了用于增强体育活动中个人得分的方法和组合物。

86. 发明申请

US20110014308A1 NOVEL COMPOSITIONS AND USE THEREOF FOR THE TREATMENT, CO-TREATMENT OR PREVENTION OF INFLAMMATORY DISORDERS. 审中-公开
标题翻译：新的组合物及其用于治疗，并发治疗或预防炎性疾病的组合物。
公开(公告)号：US20110014308A1
公开(公告)日：2011-01-20
申请号：US12747368
申请日：2008-12-11
申请人： Daniel Raederstorff , Nathalie Richard , Joseph Schwager , Karin Wertz
发明人： Daniel Raederstorff , Nathalie Richard , Joseph Schwager , Karin Wertz
IPC分类号： A61K36/63 , A61K31/726 , C07C39/11 , A61P29/00 , A61P19/02 , A61P17/00
CPC分类号： A61K31/726 , A61K31/05 , A61K31/737 , A61K36/63 , A61K2300/00
摘要： The present invention relates to novel compositions comprising hydroxytyrosol and chondroitin as well as to the use of these compositions as a medicament, in particular as a medicament for the treatment, co-treatment or prevention of inflammatory disorders.
摘要翻译：本发明涉及包含羟基酪醇和软骨素的新型组合物以及这些组合物作为药物，特别是作为治疗，共同治疗或预防炎症性疾病的药物的用途。

87. 发明申请

US20080286390A1 Skin care composition 审中-公开
标题翻译：护肤组合物
公开(公告)号：US20080286390A1
公开(公告)日：2008-11-20
申请号：US12149153
申请日：2008-04-28
申请人： Judy Tanyi
发明人： Judy Tanyi
IPC分类号： A61K36/886 , A61K31/045 , A61K36/63 , A61Q19/00
CPC分类号： A61K36/55 , A61K8/922 , A61K8/97 , A61K36/185 , A61K36/286 , A61K36/30 , A61K36/738 , A61K36/886 , A61K2800/592 , A61Q19/007 , A61K2300/00
摘要： The skin care composition is a cream or lotion that moisturizes the skin, relieving dryness, itchiness, and eczema. The skin care composition contains moisturizers and a plurality of natural oils containing essential fatty acids, the natural oils being selected from the group consisting of borage oil, omega-3 oil, emu oil, evening primrose oil, safflower oil, hemp seed oil, flaxseed oil, and rosehip oil. The moisturizers include olive oil and glycerin. In addition, the skin care composition contains an anti-inflammatory agent, preferably aloe vera juice and aloe extract, and emulsifiers, stabilizers, emollients for softening the skin, and water. The skin care composition may also contain a fragrance and a preservative. Optionally, the skin care composition may contain menthol crystal.
摘要翻译：皮肤护理组合物是一种可以滋润皮肤，缓解干燥，瘙痒和湿疹的乳膏或乳液。护肤组合物含有保湿剂和多种含有必需脂肪酸的天然油，天然油选自琉璃苣油，ω-3油，em油，月见草油，红花油，大麻籽油，亚麻籽油和玫瑰果油。保湿剂包括橄榄油和甘油。此外，护肤组合物含有抗炎剂，优选芦荟汁和芦荟提取物，以及乳化剂，稳定剂，软化皮肤的润肤剂和水。护肤组合物还可以含有香料和防腐剂。任选地，护肤组合物可以含有薄荷醇晶体。

88. 发明申请

US20080193492A1 COMPLEMENTARY PERSONAL LUBRICANT COMPOSITIONS 有权
标题翻译：补充个人润滑剂组合物
公开(公告)号：US20080193492A1
公开(公告)日：2008-08-14
申请号：US11842487
申请日：2007-08-21
申请人： Nawaz Ahmad , Cheng-Ji Cui , Bryant Ison
发明人： Nawaz Ahmad , Cheng-Ji Cui , Bryant Ison
IPC分类号： A61K36/906 , A61K31/047 , A61K31/16 , A61K31/167 , A61K31/235 , A61K31/245 , A61K9/00 , A61Q99/00 , A61K31/445 , A61K31/455 , A61K36/61 , A61K36/63 , A61K36/81
CPC分类号： A61K31/047 , A61K9/0034 , A61K31/16 , A61K31/167 , A61K31/235 , A61K31/245 , A61K31/355 , A61K31/445 , A61K31/455 , A61K36/61 , A61K36/63 , A61K36/81 , A61K36/906 , A61K36/9068 , A61K45/06 , B65D81/3205 , B65D2303/00 , A61K2300/00
摘要： This invention relates to novel compositions and methods of use by which the compositions of this invention are applied topically to one or more body parts of at least two individuals who bring said body parts into contact with the other individual and, when said body parts come into contact with each other, permit the formulations to interact and thereby achieve an unexpected sensation to each individual.
摘要翻译：本发明涉及新颖的组合物和使用方法，通过该组合物和使用方法，将本发明的组合物局部应用于使所述身体部分与另一个人接触的至少两个个体的一个或多个身体部位，并且当所述身体部位进入彼此接触，允许制剂相互作用，从而实现对每个人的意想不到的感觉。

89. 发明申请

US20070020350A1 Vegetation water composition for treatment of inflammatory skin conditions 有权
标题翻译：用于治疗炎症皮肤病症的植被水组合物
公开(公告)号：US20070020350A1
公开(公告)日：2007-01-25
申请号：US11185246
申请日：2005-07-19
申请人： Fujio Numano , Roberto Crea , Tokuko Wiedemann , Catherine Bitler
发明人： Fujio Numano , Roberto Crea , Tokuko Wiedemann , Catherine Bitler
IPC分类号： A61K36/63
CPC分类号： A61K36/63 , A61K9/2059 , A61K31/05
摘要： Compositions obtained from vegetation water from olives and methods for treating patients suffering from an inflammatory skin disease with the compositions are described. Included are hydroxytyrosol rich compounds obtained from olive vegetation water.
摘要翻译：描述从橄榄植物水中获得的组合物和用该组合物治疗患有炎性皮肤病的患者的方法。包括从橄榄植物水中获得的富含羟基酪素的化合物。

90. 发明申请

US20070015690A1 Cyclosporin compositions 有权
公开(公告)号：US20070015690A1
公开(公告)日：2007-01-18
申请号：US11181178
申请日：2005-07-13
申请人： James Chang , Orest Olejnik , Bruce Firestone
发明人： James Chang , Orest Olejnik , Bruce Firestone
IPC分类号： A61K38/13 , A61K36/23 , A61K36/63 , A61K36/534 , A61K36/899 , A61K36/31 , A61K36/48 , A61K36/28
CPC分类号： A61K47/44 , A61K9/0048 , A61K9/107 , A61K38/13 , Y10S514/912 , Y10S514/975
摘要： A composition comprising from about 0.001% to about 0.4% cyclosporin A, a surfactant, and an oil having a specific gravity from 0.8 to 0.95 is disclosed herein.

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