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81. 发明授权

US4946950A Inositol glycoside 2-O-Beta-L-arabinopyranosyl-myo-inositol 失效
标题翻译：肌醇糖苷2-O-β-L-阿拉伯吡喃糖肌醇肌醇
公开(公告)号：US4946950A
公开(公告)日：1990-08-07
申请号：US153850
申请日：1988-02-08
申请人： Yukihiko Hara , Kazuo Okushio , Kanzo Sakata
发明人： Yukihiko Hara , Kazuo Okushio , Kanzo Sakata
IPC分类号： A61K36/18 , C07H15/207 , C07H15/20 , A61K31/70
CPC分类号： C07H15/207
摘要： A glycoside of inositol which has been isolated from a hot-water extract of tea leaves. The glycoside is identified from the analytical results to be 2-O-beta-L-arabinopyranosyl-myo-inositol.

82. 发明授权

US4728643A Method of treating psoriasis 失效
标题翻译：治疗牛皮癣的方法
公开(公告)号：US4728643A
公开(公告)日：1988-03-01
申请号：US667813
申请日：1984-11-02
申请人： Michael F. Holick , Julia McLaughlin
发明人： Michael F. Holick , Julia McLaughlin
IPC分类号： A61K31/59 , A61P3/02 , A61P17/00 , A61P35/00 , A61P43/00 , C07C67/00 , C07C401/00 , C07H15/207
CPC分类号： A61K31/59 , C07H15/207 , Y10S514/863
摘要： A method of treating psoriasis in a patient which comprises administering to said patient an effective amount of a vitamin D compound which is capable of stimulating the differentiation of cultured tumor cells or normal rodent or human fibroblasts or keratinocytes in vitro.
摘要翻译：一种治疗患者牛皮癣的方法，其包括向所述患者施用有效量的体外能够刺激培养的肿瘤细胞或正常啮齿动物或人成纤维细胞或角化细胞分化的维生素D化合物。

83. 发明授权

US4460767A Process for production of sugar ketals 失效
标题翻译：糖缩酮生产工艺
公开(公告)号：US4460767A
公开(公告)日：1984-07-17
申请号：US418266
申请日：1982-09-15
申请人： Koichi Matsumura , Tetsuya Aono
发明人： Koichi Matsumura , Tetsuya Aono
IPC分类号： C07H9/04 , B01J23/00 , B01J23/72 , C07B61/00 , C07D317/12 , C07H15/207 , C07H1/00 , C07C47/18
CPC分类号： C07H9/04 , C07D317/12 , C07H15/207
摘要： A process is disclosed for production of a sugar ketal, which comprises reacting a sugar with a ketone in the presence of (A) (1) copper, or an oxide, hydroxide or salt thereof and (2) hydrogen chloride or hydrogen bromide, or (B) cupric chloride or cupric bromide, said catalyst system being very effective in a small amount. The formation of unfavorable by-products can be reduced to a trace amount. The process offers the objective ketal in improved yields, and an industrially advantageous process.
摘要翻译：公开了一种生产糖缩酮的方法，其包括在（A）（1）铜或其氧化物，氢氧化物或盐存在下使糖与酮反应，和（2）氯化氢或溴化氢，或（B）氯化铜或溴化铜，所述催化剂体系在少量中非常有效。不利副产物的形成可以减少到微量。该方法提供了目标缩酮在提高产率和工业上有利的过程。

84. 发明授权

US3968100A Guanidio derivatives of kasugamycin and their production 失效
标题翻译：春日霉素的胍基衍生物及其生产
公开(公告)号：US3968100A
公开(公告)日：1976-07-06
申请号：US220374
申请日：1972-01-24
申请人： Hamao Umezawa , Yasuji Suhara
发明人： Hamao Umezawa , Yasuji Suhara
IPC分类号： C07H15/207 , C07H15/22
CPC分类号： C07H15/207
摘要： New guanidino derivatives of kasugamycin in which the oxalamidino group at the 4-position of kasugamycin molecule has been replaced by different guanidino groups are produced and found to show an improved antibacterial activity against Gram negative bacteria and a decreased toxicity to man and animals, as compared to kasugamycin itself. The new guanidino derivatives of kasugamycin may readily be produced by reacting an amine with an isourea derivative of kasugamycin which has been prepared by reacting sodium hypobromite with kasugamycin and then treating the resulting cyanamide derivative with hydrogen chloride in methanol.
摘要翻译：产生春日霉素的新胍基衍生物，其中在春日霉素分子的4位上的草酰脒基被不同的胍基取代，发现其显示出对革兰氏阴性细菌的抗菌活性改善和对人和动物的毒性降低，到春日霉素本身。春日霉素的新的胍基衍生物可以容易地通过使胺与异硫氰酸钠与春日霉素反应制备的春日霉素的异脲衍生物反应，然后用氯化氢在甲醇中处理所得的氰胺衍生物来制备。

85. 发明授权

US3652535A Kasugamycin derivatives 失效
标题翻译： KASUGAMYCIN衍生物
公开(公告)号：US3652535A
公开(公告)日：1972-03-28
申请号：US3652535D
申请日：1970-05-01
申请人： BRISTOL MYERS CO
发明人： KEIL JOHN G , SCHREIBER RICHARD H
IPC分类号： C07H15/207 , C07C47/18
CPC分类号： C07H15/207
摘要： SEMI-SYNTHETIC KASUGAMYCIN DERIVATIVES HAVE BEEN FOUND USEFUL IN THE TREATMENT OF DISEASES CAUSED BY BACTERIAL INFECTION. THESE DERIVATIVES CAN BE PREPARED BY THE USE OF THE INTERMEDIATE COMPOUND, BIOS C (5-(2-CARBOBENZOXAMIDO-2,3,4,6-TETRADEOXY - 4 - AMINO-A-D-ARABINOHEXOPYRANOSYL)-(IR:2S:3S:4R:5R:6R)-INOSITOL).

86. 发明授权

US3607657A Process for the production of kasugamycin 失效
标题翻译：生产KASUGAMYCIN的方法
公开(公告)号：US3607657A
公开(公告)日：1971-09-21
申请号：US3607657D
申请日：1968-03-20
申请人： HAMAO UMEZAWA , YOSHIRO OKAMI , TOMIO TAKEUCHI , MASA HAMADA
发明人： UMEZAWA HAMAO , OKAMI YOSHIRO , TAKEUCHI TOMIO , HAMADA MASA
IPC分类号： C07H15/207 , C12D9/00
CPC分类号： C07H15/207 , Y10S435/886 , Y10S435/911
摘要： Kasugamycin is produced by fermentation of a new species of streptomyces which has been named Streptomyces kasugaspinus.

87. 发明公开

US20240140976A1 PROCESS FOR PREPARING AN E-SELECTIN INHIBITOR INTERMEDIATE 审中-公开
公开(公告)号：US20240140976A1
公开(公告)日：2024-05-02
申请号：US18546609
申请日：2022-02-17
申请人： GLYCOMIMETICS, INC.
发明人： Indranath GHOSH
IPC分类号： C07H15/207
CPC分类号： C07H15/207
摘要： A process is provided for the synthesis of an intermediate which is useful in the synthesis of E-selectin inhibitors. Also provided are useful intermediates obtained from the process.

88. 发明授权

US11952530B2 Aryl-substituted saccharides or glycosides and use thereof in a drilling fluid composition 有权
公开(公告)号：US11952530B2
公开(公告)日：2024-04-09
申请号：US16966870
申请日：2019-11-29
申请人： CHINA PETROLEUM & CHEMICAL CORPORATION , Sinopec Petroleum Engineering Technology Service Co., Ltd. , Drilling Engineering Technology Research Inst. of Sinopec Zhongyuan Petroleum Engineering Co., LTD , SINOPEC ZHONGYUAN PETROLEUM ENGINEERING CO., LTD
发明人： Xiqiang Si , Zhonghua Wang , Weiting Li , Jun Wei , Zhongjin Wang , Yuebin Lv
IPC分类号： C09K8/08 , C07H15/207
CPC分类号： C09K8/08 , C07H15/207
摘要： An aryl-substituted saccharide or glycoside or a mixture of a plurality of aryl-substituted saccharides or glycosides have at least good resistance to high temperatures and salt, and lower filtration loss. These aryl-substituted saccharide or glycoside are used in making a drilling fluid composition. The aryl-substituted saccharide or glycoside or the mixture of a plurality of aryl-substituted saccharides or glycosides each or in combination bears a substituent A and a substituent B, wherein the substituent A contains a unit —O—R6— in its structure and the substituent B contains a unit

in its structure, and the substituents and the numbers are defined in the description.

89. 发明公开

US20230406877A1 COMPOUNDS COMPRISING CLEAVABLE LINKER AND USES THEREOF 审中-公开
公开(公告)号：US20230406877A1
公开(公告)日：2023-12-21
申请号：US18203326
申请日：2023-05-30
申请人： IntoCell, Inc.
发明人： Taekyo Park , Sung Ho Woo , Sunyoung Kim , Suho Park , Jongun Cho , Doohwan Jung , Donghoon Seo , Jaeho Lee , Sangkwang Lee , Sanghyeon Yun , Hyang Sook Lee , Okku Park , Beomseok Seo
IPC分类号： C07H15/207 , A61K47/68 , A61P35/00 , A61K47/54 , A61K51/04
CPC分类号： C07H15/207 , A61K47/6835 , A61P35/00 , A61K47/549 , A61K51/04 , A61K47/6803
摘要： Provided are a compound including a cleavable linker, a use thereof, and an intermediate compound for preparing the same, and more particularly, the compound including a cleavable linker of the present invention may include an active agent (for example, a drug, a toxin, a ligand, a probe for detection, etc.) having a specific function or activity, a SO2 functional group which is capable of selectively releasing the active agent, and a functional group which triggers a chemical reaction, a physicochemical reaction and/or a biological reaction by external stimulation, and may further include a ligand (for example, oligopeptide, polypeptide, antibody, etc.) having binding specificity for a desired target receptor.

90. 发明公开

US20230265118A1 SALT OF CURCUMIN MONOGLUCURONIDE 审中-公开
公开(公告)号：US20230265118A1
公开(公告)日：2023-08-24
申请号：US18004023
申请日：2021-07-02
申请人： THERABIOPHARMA INC.
发明人： Atsushi IMAIZUMI , Hitomi UMETA , Yasumichi FUKUDA
IPC分类号： C07H15/207
CPC分类号： C07H15/207
摘要： Provided are a derivative of curcumin monoglucuronide excellent in solubility and chemical stability, which can be provided as pharmaceuticals, and a method for producing the same. A salt of curcumin monoglucuronide represented by Chemical Formula 1,

wherein M represents a pharmaceutically acceptable cation, a hydrate thereof, or a solvate thereof.

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